| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Marc Fakhoury, Giovanni Hernandez, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area. Behavioural brain research. vol 393. 2021-10-25. PMID:32593543.' |
in light of previous evidence implicating glutamate transmission in the regulation of midbrain da neuronal activity, we first assessed the impact of intra-tvta microinjection of nbqx (0.8 nmol/side) and pppa (0.825 nmol/side), respectively ampa and nmda receptor antagonists, on reward induced by intracranial self-stimulation (icss) and on locomotor activity. |
2021-10-25 |
2023-08-13 |
Not clear |
| Y Sar. Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence. OA alcohol. vol 1. issue 1. 2021-10-21. PMID:24409344. |
alcohol-seeking behaviour is promoted by increased glutamate transmission in key regions of the mesocorticolimbic reward circuit, including the nucleus accumbens and prefrontal cortex. |
2021-10-21 |
2023-08-12 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
diminished reward responsiveness is associated with lower reward network glucest: an ultra-high field glutamate imaging study. |
2021-10-11 |
2023-08-13 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
this study employed ultra-high field glutamate chemical exchange saturation transfer (glucest) imaging to investigate the hypothesis that glutamatergic deficits within the reward network contribute to low rr. |
2021-10-11 |
2023-08-13 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
the glucest contrast, a measure sensitive to local glutamate concentration, was quantified in a meta-analytically defined reward network comprised of cortical, subcortical, and brainstem regions. |
2021-10-11 |
2023-08-13 |
human |
| Valerie J Sydnor, Bart Larsen, Christian Kohler, Andrew J D Crow, Sage L Rush, Monica E Calkins, Ruben C Gur, Raquel E Gur, Kosha Ruparel, Joseph W Kable, Jami F Young, Sanjeev Chawla, Mark A Elliott, Russell T Shinohara, Ravi Prakash Reddy Nanga, Ravinder Reddy, Daniel H Wolf, Theodore D Satterthwaite, David R Roal. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33479514. |
this study thus provides new evidence that reward network glutamate levels contribute to individual differences in rr. |
2021-10-11 |
2023-08-13 |
human |
| Natasha L Mason, Eef L Theunissen, Nadia R P W Hutten, Desmond H Y Tse, Stefan W Toennes, Jacobus F A Jansen, Peter Stiers, Johannes G Ramaeker. Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:31865628. |
in occasional users, cannabis induced significant neurometabolic alterations in reward circuitry, namely, decrements in functional connectivity and increments in striatal glutamate concentrations, which were associated with increases in subjective high and decreases in performance on a sustained attention task. |
2021-10-05 |
2023-08-13 |
Not clear |
| Marta Marszalek-Grabska, Irena Smaga, Paulina Surowka, Pawel Grochecki, Tymoteusz Slowik, Malgorzata Filip, Jolanta H Kotlinsk. Memantine Prevents the WIN 55,212-2 Evoked Cross-Priming of Ethanol-Induced Conditioned Place Preference (CPP). International journal of molecular sciences. vol 22. issue 15. 2021-09-09. PMID:34360704. |
the activation of the endocannabinoid system controls the release of many neurotransmitters involved in the brain reward pathways, including glutamate. |
2021-09-09 |
2023-08-13 |
Not clear |
| Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A Knackstedt, Małgorzata Filip, Edmund Przegalińsk. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics. vol 221. 2021-08-26. PMID:33359590. |
the present review summarizes the changes in glutamate levels in the reward system (the prefrontal cortex, nucleus accumbens, dorsal striatum, hippocampus, and ventral tegmental area) observed in preclinical studies at different stages of cocaine exposure and withdrawal as well as after reinstatement of cocaine-seeking behavior. |
2021-08-26 |
2023-08-13 |
Not clear |
| Sudie E Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L Jones, Amber M Jarnecke, Jane E Joseph, James Prisciandaro, Therese Killeen, Delisa G Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C Flanagan, Peter W Kaliva. N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial. Contemporary clinical trials. vol 91. 2021-08-04. PMID:32087337. |
nac is a cysteine pro-drug that stimulates the cystine-glutamate exchanger, normalizes glial glutamate transporters, and restores glutamatergic tone on presynaptic receptors in reward regions of the brain. |
2021-08-04 |
2023-08-13 |
Not clear |
| Kate Beecher, Joshua Wang, Angela Jacques, Nicholas Chaaya, Fatemeh Chehrehasa, Arnauld Belmer, Selena E Bartlet. Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice. Frontiers in molecular neuroscience. vol 14. 2021-07-16. PMID:34262435. |
although serotonin and glutamate co-localisation has been implicated in reward processing, it is still unknown how chronic sucrose consumption changes this transmission in regions associated with executive control over feeding-such as the prefrontal cortex (pfc) and dentate gyrus (dg) of the hippocampus. |
2021-07-16 |
2023-08-13 |
mouse |
| Shoupeng Wei, Sarah Hertle, Rainer Spanagel, Ainhoa Bilba. NMDA Receptors in Accumbal D1 Neurons Influence Chronic Sugar Consumption and Relapse. eNeuro. vol 8. issue 3. 2021-07-02. PMID:33906970. |
although well-established for drugs of abuse, it is not clear whether glutamate receptors within the mesolimbic system are involved in mediating chronic consumption and relapse following abstinence from a non-drug reward. |
2021-07-02 |
2023-08-13 |
mouse |
| Ewa Galaj, Robert Ranald. Neurobiology of reward-related learning. Neuroscience and biobehavioral reviews. vol 124. 2021-06-25. PMID:33581225. |
we propose that vta da neurons receive both a strong unconditioned stimulus signal (acetylcholine stimulation of da cells) from the primary reward capable of unconditionally activating da cells and a weak stimulus signal (glutamate stimulation of da cells) from the neutral stimulus. |
2021-06-25 |
2023-08-13 |
Not clear |
| Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Abdolrahman Sarih. The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats. BMC neuroscience. vol 22. issue 1. 2021-06-17. PMID:33743609. |
in addition, metabotropic glutamate receptors (mglurs) in nac play important roles in the reward pathways. |
2021-06-17 |
2023-08-13 |
rat |
| Li-Min Mao, John Q Wan. Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in Striatal Neurons in a Depression Model. Neuroscience. vol 433. 2021-05-14. PMID:32145272. |
the sfk member fyn is enriched at synaptic sites in the limbic reward circuit and plays a pivotal role in the regulation of glutamate receptors. |
2021-05-14 |
2023-08-13 |
rat |
| Francisca Villavicencio-Tejo, Osvaldo Flores-Bastías, Lucas Marambio-Ruiz, Diliana Pérez-Reytor, Eduardo Karahania. Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959021. |
neuroinflammation decreases glutamate transporter (glt-1) expression, increasing levels of glutamate that trigger dopamine release at the corticolimbic reward areas, driving long-term drinking behavior. |
2021-05-08 |
2023-08-13 |
rat |
| Solange Bandiera, Felipe Borges Almeida, Alana Witt Hansen, Rianne Remus Pulcinelli, Greice Caletti, Leonardo Fernandes de Paula, Mauricio Schüler Nin, Fernanda Urruth Fontella, Roberto Farina Almeida, Helena Maria Tannhauser Barros, Rosane Gome. Combined use of alcohol and cigarette increases locomotion and glutamate levels in the cerebrospinal fluid without changes on GABA Behavioural brain research. vol 380. 2021-05-03. PMID:31866463. |
combined use of alcohol and cigarette increases locomotion and glutamate levels in the cerebrospinal fluid without changes on gaba interactions on neurotransmitter systems in the reward pathways may explain the high frequency of combined use of alcohol and cigarettes in humans. |
2021-05-03 |
2023-08-13 |
rat |
| Francesca Mottarlini, Giorgia Bottan, Benedetta Tarenzi, Alessandra Colciago, Fabio Fumagalli, Lucia Caffin. Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats. Nutrients. vol 12. issue 12. 2021-04-21. PMID:33260714. |
since evidence exists that a dysregulation of the glutamate system in the nac influences reward and taking advantage of the activity-based anorexia (aba) rat model, which closely mimics the hallmarks of an, we investigated the involvement of the glutamatergic signaling in the nac in this experimental model. |
2021-04-21 |
2023-08-13 |
rat |
| Farzaneh Saebi Rad, Abbas Haghparast, Afsaneh Eliass. Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats. Basic and clinical neuroscience. vol 11. issue 6. 2021-04-16. PMID:33850614. |
ventral tegmental area (vta) dopamine neurons play an important role in reward mechanisms of food intake, and vta dopamine receptors exist on the terminal of glutamatergic and gabaergic neurons and regulate gamma-aminobutyric acid (gaba) and glutamate release. |
2021-04-16 |
2023-08-13 |
rat |
| Jennifer C Felger, Ebrahim Haroon, Trusharth A Patel, David R Goldsmith, Evanthia C Wommack, Bobbi J Woolwine, Ngoc-Anh Le, Rachel Feinberg, Malu G Tansey, Andrew H Mille. What does plasma CRP tell us about peripheral and central inflammation in depression? Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:29895893. |
furthermore, increased peripheral blood crp in mdd has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. |
2021-03-09 |
2023-08-13 |
Not clear |