| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Giatti, Lucia Cioffi, Silvia Diviccaro, Gabriela Chrostek, Rocco Piazza, Roberto Cosimo Melcang. Transcriptomic Profile of the Male Rat Hypothalamus and Nucleus Accumbens After Paroxetine Treatment and Withdrawal: Possible Causes of Sexual Dysfunction. Molecular neurobiology. 2024-11-04. PMID:39495228. |
moreover, degs related to neurotransmitters with a role in sexual behavior and the reward system, such as dopamine (e.g., sialyltransferase 8b-st8sia3), glutamate (e.g., glutamate receptor ionotropic delta-2-grid2) and gaba (e.g., glutamate decarboxylase type 2-gad2) or associated with neurexin and neuroligin pathways and brain-derived neurotrophic factor (bdnf) signaling, were reported to be dysregulated in the nac, further confirming dysfunction in this brain area. |
2024-11-04 |
2024-11-06 |
rat |
| Melissa C Knouse, Alyssa R Kniffin, Erin A English, William Cuadrado, Troy M Houser, Lisa A Brian. PKMζ alters oxycodone-taking in a dose- and sex-dependent manner. Addiction neuroscience. vol 12. 2024-10-26. PMID:39449991. |
opioid use disorder involves disruptions to glutamate homeostasis and dendritic spine density in the reward system. |
2024-10-26 |
2024-10-28 |
mouse |
| Casey A Wilson, Bailey W Miller, Rachel M Renton, Kevin D Lominac, Karen K Szumlinsk. Investigation into the biomolecular bases of blunted cocaine-induced glutamate release within the nucleus accumbens elicited by adolescent exposure to phenylpropanolamine. Drug and alcohol dependence. vol 264. 2024-10-20. PMID:39427535. |
previously, we showed that a sensitization of cocaine-induced glutamate release within the nucleus accumbens (nac) and the expression of cocaine-conditioned reward is not apparent in adult mice with a prior history of repeated ppa exposure during adolescence. |
2024-10-20 |
2024-10-23 |
mouse |
| Casey A Wilson, Bailey W Miller, Rachel M Renton, Kevin D Lominac, Karen K Szumlinsk. Investigation into the biomolecular bases of blunted cocaine-induced glutamate release within the nucleus accumbens elicited by adolescent exposure to phenylpropanolamine. Drug and alcohol dependence. vol 264. 2024-10-20. PMID:39427535. |
as nac glutamate is a purported driver of cocaine reward and reinforcement, the present study employed in vivo microdialysis and immunoblotting approaches to inform as to the receptor and transporter anomalies that might underpin the disrupted glutamate response to cocaine in adolescent ppa-exposed mice. |
2024-10-20 |
2024-10-23 |
mouse |
| Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella Cruz-Rentas, Marian Sepulveda-Orengo, Richard J Noe. Astrocytic HIV-1 Nef expression decreases glutamate transporter expression in the nucleus accumbens and increases cocaine-seeking behavior in rats. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416088. |
this study investigates the relationship that exists between nef, glutamate homeostasis, and cocaine in the nac, a critical brain region associated with drug motivation and reward. |
2024-10-17 |
2024-10-19 |
rat |
| Alyssa R Kniffin, Lisa A Brian. Sex differences in glutamate transmission and plasticity in reward related regions. Frontiers in behavioral neuroscience. vol 18. 2024-10-03. PMID:39359325. |
sex differences in glutamate transmission and plasticity in reward related regions. |
2024-10-03 |
2024-10-05 |
Not clear |
| Alyssa R Kniffin, Lisa A Brian. Sex differences in glutamate transmission and plasticity in reward related regions. Frontiers in behavioral neuroscience. vol 18. 2024-10-03. PMID:39359325. |
disruptions in glutamate homeostasis within the mesolimbic reward circuitry may play a role in the pathophysiology of various reward related disorders such as major depressive disorders, anxiety, and substance use disorders. |
2024-10-03 |
2024-10-05 |
Not clear |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
rodent drug self-administration leads to compromised ability of astrocytes to maintain glutamate homeostasis within the brain's reward circuitry, as well as reductions in surface area, volume, and synaptic colocalization of astrocyte membranes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Taylor Hawthorne Walters, Sonita Wiah, Aryan Shekarabi, Mia Milton, Samhitha Reddy, Pingwei Zhao, Prateek S Mokkarala, Raghava Potula, Scott M Rawl. Clavulanic acid inhibits methamphetamine locomotor sensitization in mice and normalizes methamphetamine-induced changes in glutaminase mRNA levels in the nucleus accumbens. Physiology & behavior. 2024-07-25. PMID:39053627. |
because increased glutamate transmission in brain reward circuits facilitates methamphetamine (meth) locomotor activation and sensitization, we tested the hypothesis that clav inhibits acute and sensitized locomotor responses to meth in mice and investigated effects of clav on meth-induced changes in glutaminase, the major glutamate-producing enzyme in the brain. |
2024-07-25 |
2024-07-28 |
mouse |
| Ahmed Alotaibi, Shelby Travaglianti, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sar. Effects of MC-100093 on ethanol drinking and the expression of astrocytic glutamate transporters in the mesocorticolimbic brain regions of male and female alcohol-preferring rats. Neuroscience. 2024-06-23. PMID:38909675. |
chronic ethanol consumption increased extracellular glutamate concentrations in several reward brain regions. |
2024-06-23 |
2024-06-26 |
rat |
| Lauren Faget, Lucie Oriol, Wen-Chun Lee, Vivien Zell, Cody Sargent, Andrew Flores, Nick G Hollon, Dhakshin Ramanathan, Thomas S Hnask. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. Nature communications. vol 15. issue 1. 2024-05-18. PMID:38762463. |
here, we found that both vp gaba and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. |
2024-05-18 |
2024-05-27 |
human |
| Nazanin Kahvandi, Zahra Ebrahimi, Maryam Sharifi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Rasool Haddadi, Abdolrahman Sarih. S-3,4-DCPG, a potent orthosteric agonist for the mGlu8 receptor, facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Pharmacology, biochemistry, and behavior. 2024-04-23. PMID:38653345. |
this effect may be associated with the modulation of glutamate engagement within the nac and the plasticity of reward pathways at the synaptic level. |
2024-04-23 |
2024-04-26 |
rat |
| Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sar. Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol. Brain research bulletin. 2024-04-03. PMID:38570076. |
chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mpfc) and nucleus accumbens (nac), and consequently leading to oxidative stress and neuroinflammation. |
2024-04-03 |
2024-04-06 |
rat |
| Cassandra Avila, Martin Sarte. Cortico-striatal action control inherent of opponent cognitive-motivational styles. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559086. |
in contrast, in sts, glutamate release from dms glutamatergic terminals is regulated by other striatal circuitry, preferably mediating cued suppression of action and reward tracking. |
2024-04-01 |
2024-04-04 |
rat |
| Tolulope Adeyelu, Tashonda Vaughn, Olalekan M Ogundel. VTA excitatory neurons impact reward-driven behavior by modulating infralimbic cortical firing. Neuroscience. 2024-03-21. PMID:38513762. |
pairing vta glutamate inhibition with reward acquisition events reduced the weight of reward-target association expressed as a lower affinity for previously rewarded targets. |
2024-03-21 |
2024-03-24 |
mouse |
| Tolulope Adeyelu, Tashonda Vaughn, Olalekan M Ogundel. VTA excitatory neurons impact reward-driven behavior by modulating infralimbic cortical firing. Neuroscience. 2024-03-21. PMID:38513762. |
together, we conclude that vta glutamate neurons are likely involved in establishing il inhibition states that encode reward acquisition, and subsequent reward-target association when a reward is omitted. |
2024-03-21 |
2024-03-24 |
mouse |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. |
2024-02-20 |
2024-02-23 |
rat |
| Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchid. Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons. Neuron. 2024-01-26. PMID:38278147. |
glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons. |
2024-01-26 |
2024-01-29 |
mouse |
| Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchid. Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons. Neuron. 2024-01-26. PMID:38278147. |
we found that glutamate inputs exhibit virtually all of the characteristics of rpe rather than conveying a specific component of rpe computation, such as reward or expectation. |
2024-01-26 |
2024-01-29 |
mouse |
| Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchid. Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons. Neuron. 2024-01-26. PMID:38278147. |
notably, whereas glutamate inputs were transiently inhibited by reward omission, they were excited by aversive stimuli. |
2024-01-26 |
2024-01-29 |
mouse |