| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
furthermore, it is likely that mgluii receptors generate this reward deficit, at least in part, by decreasing glutamate transmission at ampa/kainate receptors. |
2003-10-03 |
2023-08-12 |
rat |
| Charles A Dackis, Kevin G Lynch, Elmer Yu, Frederick F Samaha, Kyle M Kampman, James W Cornish, Amy Rowan, Sabrina Poole, Lenae White, Charles P O'Brie. Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study. Drug and alcohol dependence. vol 70. issue 1. 2003-09-03. PMID:12681523. |
in addition, the neurotransmitter actions of modafinil are opposite to cocaine-induced neuroadaptations affecting dopamine and glutamate reward circuits. |
2003-09-03 |
2023-08-12 |
human |
| Piotr Popik, Ewa Kozela, Malgorzata Wróbel, Krystyna M Wozniak, Barbara S Slushe. Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 3. 2003-05-07. PMID:12629525. |
morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase ii (gcp ii, naaladase) inhibitor, 2-pmpa. |
2003-05-07 |
2023-08-12 |
mouse |
| P Popik, M Wróbe. Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527470. |
in the present study we examined the effect of mpep [2-methyl-6-(phenylethynyl)-pyridine] a potent, selective and systemically active metabotropic glutamate receptor (mglur) type i (subtype mglur5) antagonist on conditioned morphine reward in mice. |
2003-03-28 |
2023-08-12 |
mouse |
| Jon C Horvit. Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum. Behavioural brain research. vol 137. issue 1-2. 2003-03-03. PMID:12445716. |
a da signal of salient unexpected event occurrence, from this framework, gates the throughput of the orbitofrontal glutamate reward input to the striatum just as it gates the throughput of corticostriatal sensory and motor signals needed for normal response execution. |
2003-03-03 |
2023-08-12 |
Not clear |
| Michael A Sutton, Eric F Schmidt, Kwang-Ho Choi, Christina A Schad, Kim Whisler, Diana Simmons, David A Karanian, Lisa M Monteggia, Rachael L Neve, David W Sel. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature. vol 421. issue 6918. 2003-01-30. PMID:12511956. |
here we show that extinction training during withdrawal from chronic cocaine self-administration induces experience-dependent increases in the glur1 and glur2/3 subunits of ampa (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) glutamate receptors in the nucleus accumbens shell, a brain region that is critically involved in cocaine reward. |
2003-01-30 |
2023-08-12 |
Not clear |
| George Panagis, Andreas Kastellaki. The effects of ventral tegmental administration of GABA(A), GABA(B), NMDA and AMPA receptor agonists on ventral pallidum self-stimulation. Behavioural brain research. vol 131. issue 1-2. 2002-05-03. PMID:11844578. |
thus, the vta--vp projection activated by gaba modulates vp stimulation reward, while the projection activated by glutamate may be involved in reward-unrelated effects, rather than in the processing of reward. |
2002-05-03 |
2023-08-12 |
Not clear |
| R A Chambers, J H Krystal, D W Sel. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological psychiatry. vol 50. issue 2. 2001-12-10. PMID:11526998. |
in this model, disturbances in drug reward are mediated, in part, by dysregulated neural integration of dopamine and glutamate signaling in the nucleus accumbens resulting form frontal cortical and hippocampal dysfunction. |
2001-12-10 |
2023-08-12 |
Not clear |
| R E See, P J Kruzich, J W Grim. Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior. Psychopharmacology. vol 154. issue 3. 2001-09-20. PMID:11351937. |
dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior. |
2001-09-20 |
2023-08-12 |
rat |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
the present study sought to explore whether signals transmitted via the nmda subtype of glutamate receptors and via dopamine d(2) receptors in the nucleus accumbens (nac) are critical for the determination of reaction times (rts) of instrumental responses by the expectancy of future reward. |
2000-08-31 |
2023-08-12 |
rat |
| W C Gamberino, M S Gol. Neurobiology of tobacco smoking and other addictive disorders. The Psychiatric clinics of North America. vol 22. issue 2. 1999-08-12. PMID:10385935. |
considerable evidence shows that these dopaminergic projections are involved in the positive brain reward, which drives addictive disorders; however, recent studies also implicate the neurotransmitters glutamate and serotonin in learning and sensitization to drug use. |
1999-08-12 |
2023-08-12 |
Not clear |
| T M Tzschentk. Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Progress in neurobiology. vol 56. issue 6. 1999-03-23. PMID:9871940. |
transmitter systems that have been investigated with respect to their involvement in brain reward mechanisms include dopamine, opioids, acetylcholine, gaba, serotonin, glutamate, substance p, and cholecystokinin, the motivational significance of which has been examined either directly, by using respective agonist or antagonist drugs, or indirectly, by studying the effects of these drugs on the reward induced by other drugs. |
1999-03-23 |
2023-08-12 |
Not clear |
| G F Koob, S Rassnick, S Heinrichs, F Weis. Alcohol, the reward system and dependence. EXS. vol 71. 1994-08-12. PMID:7913351. |
evidence is presented to show that multiple neurotransmitter systems of the brain reward systems including gaba, glutamate, dopamine, serotonin and opioid peptides are involved in alcohol reinforcement. |
1994-08-12 |
2023-08-12 |
Not clear |
| J A Angulo, B S McEwe. Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. Brain research. Brain research reviews. vol 19. issue 1. 1994-06-01. PMID:7909470. |
in the corpus striatum and nucleus accumbens, neuropeptides participate along with conventional neurotransmitters such as dopamine, gamma-aminobutyric acid (gaba), acetylcholine and glutamate in the regulation of locomotor activity, stereotyped motor behaviors and neural events related to reward and affective state. |
1994-06-01 |
2023-08-12 |
Not clear |
| L J Herberg, I C Ros. The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward. Psychopharmacology. vol 99. issue 1. 1989-10-25. PMID:2550989. |
the effect of mk-801 and other antagonists of nmda-type glutamate receptors on brain-stimulation reward. |
1989-10-25 |
2023-08-11 |
Not clear |