| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul J Kenny, Benjamin Boutrel, Fabrizio Gasparini, George F Koob, Athina Marko. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology. vol 179. issue 1. 2005-10-24. PMID:15602687. |
metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. |
2005-10-24 |
2023-08-12 |
rat |
| Jennifer M Bossert, Shirley Y Liu, Lin Lu, Yavin Shaha. A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 47. 2005-07-05. PMID:15564590. |
ly379268, which acts centrally to reduce evoked glutamate release, was injected systemically or directly into the ventral tegmental area (vta), a brain area involved in opiate reward and conditioned drug effects. |
2005-07-05 |
2023-08-12 |
human |
| Shin Hye Kim, Yu Mi Choi, Sungkwon Chung, Dae Yong Uhm, Myoung Kyu Par. Two different Ca2+-dependent inhibitory mechanisms of spontaneous firing by glutamate in dopamine neurons. Journal of neurochemistry. vol 91. issue 4. 2005-05-25. PMID:15525352. |
the excitatory neurotransmitter, glutamate, generates a characteristic burst-pause type of firing in midbrain dopamine neurons in association with the reward behavior, but the cellular mechanism by which glutamate generates these bursts is unknown. |
2005-05-25 |
2023-08-12 |
Not clear |
| Margaret J Bradbury, Una Campbell, Darlene Giracello, Deborah Chapman, Chris King, Lida Tehrani, Nicholas D P Cosford, Jeff Anderson, Mark A Varney, Alison M Strac. Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. The Journal of pharmacology and experimental therapeutics. vol 313. issue 1. 2005-05-19. PMID:15590770. |
the metabotropic glutamate receptor subtype mglu5 modulates central reward pathways. |
2005-05-19 |
2023-08-12 |
mouse |
| David W Self, Kwang-Ho Cho. Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. Stress (Amsterdam, Netherlands). vol 7. issue 3. 2005-04-28. PMID:15764012. |
we previously reported that extinction training, a form of inhibitory learning that progressively reduces cocaine-seeking behaviour when reward is withheld, reverses this deficit by up-regulating glur1 and glur2/3 subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) glutamate receptors in the nac. |
2005-04-28 |
2023-08-12 |
Not clear |
| Kwang-Ho Choi, Robert L H Clements, Andrew J Greensha. Simultaneous AMPA/kainate receptor blockade and dopamine D(2/3) receptor stimulation in the nucleus accumbens decreases brain stimulation reward in rats. Behavioural brain research. vol 158. issue 1. 2005-04-25. PMID:15680196. |
interactions between dopamine (da) and glutamate (glu) in the mesocorticolimbic pathway of the brain may influence motivation and reward. |
2005-04-25 |
2023-08-12 |
rat |
| Natalia B Saulskaya, Nina A Soloviov. Tetrodotoxin-dependent glutamate release in the rat nucleus accumbens during concurrent presentation of appetitive and conditioned aversive stimuli. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589329. |
the data obtained suggest that behavioral responses to unpredicted change in motivational value of expected reward appear to be associated with an increase of the extracellular glutamate level in the nucleus accumbens, and impulse-dependent synaptic release, rather than non-vesicular glutamate release via cystine/glutamate exchange, is responsible for this phenomenon. |
2005-04-12 |
2023-08-12 |
rat |
| G C Harris, M Wimmer, R Byrne, G Aston-Jone. Glutamate-associated plasticity in the ventral tegmental area is necessary for conditioning environmental stimuli with morphine. Neuroscience. vol 129. issue 3. 2005-03-07. PMID:15541905. |
these data indicate that the vta is an important site for synaptic modifications involved in the learning and memory of environmental cues predicting reward, and that glutamate input and pka activation are crucial to this process. |
2005-03-07 |
2023-08-12 |
rat |
| Karen K Szumlinski, Marlin H Dehoff, Shin H Kang, Kelly A Frys, Kevin D Lominac, Matthias Klugmann, Jason Rohrer, William Griffin, Shigenobu Toda, Nicolas P Champtiaux, Thomas Berry, Jian C Tu, Stephanie E Shealy, Matthew J During, Lawrence D Middaugh, Paul F Worley, Peter W Kaliva. Homer proteins regulate sensitivity to cocaine. Neuron. vol 43. issue 3. 2004-11-02. PMID:15294147. |
here, we report that deletion of homer1 or homer2 in mice caused the same increase in sensitivity to cocaine-induced locomotion, conditioned reward, and augmented extracellular glutamate in nucleus accumbens as that elicited by withdrawal from repeated cocaine administration. |
2004-11-02 |
2023-08-12 |
mouse |
| Janel M Boyce-Rustay, Christopher L Cunningha. The role of NMDA receptor binding sites in ethanol place conditioning. Behavioral neuroscience. vol 118. issue 4. 2004-09-20. PMID:15301608. |
little is known about the specific role of glutamate, in particular its actions at n-methyl-d-aspartate (nmda) receptors, in ethanol reward. |
2004-09-20 |
2023-08-12 |
mouse |
| Mario van der Stelt, Vincenzo Di Marz. The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623357. |
by activating presynaptic cannabinoid cb1 receptors, they can reduce glutamate release in dorsal and ventral striatum (nucleus accumbens) and alter synaptic plasticity, thereby modulating neurotransmission in the basal ganglia and in the mesolimbic reward system. |
2004-07-22 |
2023-08-12 |
Not clear |
| George F Koo. Neuroadaptive mechanisms of addiction: studies on the extended amygdala. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 13. issue 6. 2004-03-01. PMID:14636960. |
neuropharmacologic studies in animal models of addiction have provided evidence for the dysregulation of specific neurochemical mechanisms not only in specific brain reward circuits (opioid peptides, gamma-aminobutyric acid, glutamate and dopamine) but also recruitment of brain stress systems (corticotropin-releasing factor) that provide the negative motivational state that drives addiction, and also are localized in the extended amygdala. |
2004-03-01 |
2023-08-12 |
Not clear |
| P J Kenny, N E Paterson, B Boutrel, S Semenova, A A Harrison, F Gasparini, G F Koob, P D Skoubis, A Marko. Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Annals of the New York Academy of Sciences. vol 1003. 2004-02-13. PMID:14684476. |
metabotropic glutamate 5 receptor antagonist mpep decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. |
2004-02-13 |
2023-08-12 |
rat |
| John F Cryan, Fabrizio Gasparini, Gino van Heeke, Athina Marko. Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion. Drug discovery today. vol 8. issue 22. 2004-02-10. PMID:14690633. |
these strategies focus on altering reward processes in the brain by modulating various neurotransmitter systems: the most promising include dopamine d(3) receptor antagonists, noradrenaline reuptake inhibitors, gaba(b) receptor agonists, metabotropic glutamate 5 (mglur5) receptor antagonists, cannabinoid cb1 receptor antagonists, and corticotropin releasing factor (crf) 1 receptor antagonists. |
2004-02-10 |
2023-08-12 |
Not clear |
| Christian Giertler, Ines Bohn, Wolfgang Haube. The rat nucleus accumbens is involved in guiding of instrumental responses by stimuli predicting reward magnitude. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622231. |
thus, stimulation of intra-acb ionotropic glutamate receptors is critically involved in modulating the speed of instrumental responding to cues predictive for reward magnitude, but is not required for intact performance of previously learned instrumental behaviour. |
2003-12-19 |
2023-08-12 |
rat |
| John H Krystal, Ismene L Petrakis, Graeme Mason, Louis Trevisan, D Cyril D'Souz. N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacology & therapeutics. vol 99. issue 1. 2003-11-24. PMID:12804700. |
n-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. |
2003-11-24 |
2023-08-12 |
human |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
group ii metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. |
2003-10-03 |
2023-08-12 |
rat |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
this study investigated the role of ionotropic and metabotropic glutamate receptors in the deficits in brain reward function, as measured by elevations in intracranial self-stimulation (icss) reward thresholds, associated with nicotine withdrawal. |
2003-10-03 |
2023-08-12 |
rat |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
the group ii metabotropic glutamate (mgluii) receptor agonist ly314582 [a racemic mixture of ly354740 ([+]-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid])] (2.5-7.5 mg/kg) precipitated withdrawal-like elevations in icss thresholds, a sensitive measure of reward function, in nicotine-dependent but not control rats. |
2003-10-03 |
2023-08-12 |
rat |
| Paul J Kenny, Fabrizio Gasparini, Athina Marko. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. The Journal of pharmacology and experimental therapeutics. vol 306. issue 3. 2003-10-03. PMID:12805481. |
to investigate whether mgluii receptors contributed to nicotine withdrawal by decreasing glutamatergic transmission, we next examined whether direct blockade of postsynaptic glutamate receptors precipitated withdrawal-like reward deficits in nicotine-dependent rats. |
2003-10-03 |
2023-08-12 |
rat |