| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias E Liechti, Athina Marko. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17113075. |
we also hypothesized that blocking postsynaptic actions of glutamate on mglu5 receptors would exacerbate nicotine withdrawal-induced reward deficits, and that this effect would be attenuated by co-administration of the mglu2/3 receptor antagonist ly341495. |
2007-03-06 |
2023-08-12 |
rat |
| Matthias E Liechti, Athina Marko. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17113075. |
thus, increasing glutamate transmission via mglu2/3 autoreceptor blockade reduces the effects of mglu5 receptor blockade on nicotine self-administration and mpep-induced exacerbation of brain reward deficits associated with nicotine withdrawal. |
2007-03-06 |
2023-08-12 |
rat |
| Yasmin L Hur. Perspectives on current directions in the neurobiology of addiction disorders relevant to genetic risk factors. CNS spectrums. vol 11. issue 11. 2007-02-06. PMID:17075557. |
common neurobiological candidates for drug abuse include genes related to dopamine, opioid neuropeptide, and glutamate transmission that play important roles in drug reward and inhibitory control. |
2007-02-06 |
2023-08-12 |
Not clear |
| Wei Zhu, Bihua Bie, Zhizhong Z Pa. Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 2. 2007-02-02. PMID:17215388. |
involvement of non-nmda glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behavior. |
2007-02-02 |
2023-08-12 |
rat |
| Mark S Todtenkopf, Aram Parsegian, Alipi Naydenov, Rachael L Neve, Christine Konradi, William A Carlezo. Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 45. 2006-11-28. PMID:17093088. |
drugs of abuse alter expression of ampa-type glutamate receptor subunits (glurs) in the nucleus accumbens (nac), a key component of brain reward systems. |
2006-11-28 |
2023-08-12 |
rat |
| Feng C Zhou, Robert N Sahr, Youssef Sari, Kamran Behbahan. Glutamate and dopamine synaptic terminals in extended amygdala after 14-week chronic alcohol drinking in inbred alcohol-preferring rats. Alcohol (Fayetteville, N.Y.). vol 39. issue 1. 2006-10-06. PMID:16938628. |
alcohol has been shown to affect glutamate (glu) and dopamine (da) release and their correlated receptors in the key reward center--extended amygdala--which includes the shell of nucleus accumbens (snac) and central nucleus of amygdala (camg). |
2006-10-06 |
2023-08-12 |
rat |
| Christopher C Lapish, Jeremy K Seamans, L Judson Chandle. Glutamate-dopamine cotransmission and reward processing in addiction. Alcoholism, clinical and experimental research. vol 30. issue 9. 2006-10-02. PMID:16930207. |
if glutamate is in fact coreleased with da as some evidence now suggests, this may have significant implications for advancing our understanding of the interactive role that these 2 neurotransmitters play in cognitive and reward processes. |
2006-10-02 |
2023-08-12 |
Not clear |
| Christopher C Lapish, Jeremy K Seamans, L Judson Chandle. Glutamate-dopamine cotransmission and reward processing in addiction. Alcoholism, clinical and experimental research. vol 30. issue 9. 2006-10-02. PMID:16930207. |
in particular, we describe a recently proposed model in which coreleased glutamate transmits a temporally precise prediction error signal of reward described by schultz et al., whereas the function of coreleased da is to exert prolonged modulatory influences on neuronal activity. |
2006-10-02 |
2023-08-12 |
Not clear |
| Anton Bespalov, Olga Dravolina, Irina Belozertseva, Bartosz Adamcio, Edwin Zvarta. Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists. Behavioural pharmacology. vol 17. issue 4. 2006-09-15. PMID:16914947. |
lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and n-methyl-d-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists. |
2006-09-15 |
2023-08-12 |
rat |
| Anton Bespalov, Olga Dravolina, Irina Belozertseva, Bartosz Adamcio, Edwin Zvarta. Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists. Behavioural pharmacology. vol 17. issue 4. 2006-09-15. PMID:16914947. |
to further evaluate the effects of combined administration of adenosine receptor antagonist caffeine and various nmda and non-nmda glutamate receptor antagonists on brain stimulation reward (discrete-trial threshold current intensity titration procedure), rats with electrodes implanted into the ventral tegmental area were tested after pretreatment with nmda receptor channel blocker mk-801 (0.01-0.3 mg/kg), competitive antagonist d-cppene (0.3-5.6 mg/kg), glycine site antagonist l-701,324 (1.25-5 mg/kg), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (ampa) receptor antagonist gyki-53655 (1-10 mg/kg), metabotropic glutamate receptor 5 (mglur5) antagonist mpep (1-10 mg/kg) alone and in combination with caffeine (1-30 mg/kg). |
2006-09-15 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Jeremy G Gilbert, Xiao-Qing Peng, Arlene C Pak, Xia Li, Eliot L Gardne. Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 33. 2006-09-12. PMID:16914679. |
given the importance of dopamine, glutamate, and gaba in cocaine reward and relapse, we studied the effects of am251 [n-(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1h-pyrazole-3-carboxamide], a novel highly selective cb1 receptor antagonist, on cocaine-primed reinstatement of drug-seeking behavior and on cocaine-induced changes in extracellular da, glutamate, and gaba in the nucleus accumbens (nac) under reinstatement conditions. |
2006-09-12 |
2023-08-12 |
rat |
| Zhen Li, Lin Gao, Qiang Liu, Cong Cao, Xiu Lan Sun, Jian Hua Ding, Gang H. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16797122. |
therefore, aqp4 may play a role in regulating extracellular cocaine-induced dopamine and glutamate release in the brain reward center, and in turn aqp4 deletion may attenuate cocaine reinforcement and dependence. |
2006-09-01 |
2023-08-12 |
mouse |
| Qiang Liu, Zhen Li, Jian-Hua Ding, Su-Yi Liu, Jie Wu, Gang H. Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats. Brain research. vol 1085. issue 1. 2006-08-10. PMID:16647046. |
therefore, ipt may serve as a novel compound to block nicotine-induced dopamine and glutamate release in the brain reward center, in turn decreasing nicotine reinforcement and dependence. |
2006-08-10 |
2023-08-12 |
rat |
| Alexander W Johnson, David M Bannerman, Nicholas P Rawlins, Rolf Sprengel, Mark A Goo. Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor glutamate receptor 1 subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 9. 2006-03-31. PMID:15745962. |
the present study evaluated the proposal that mice with a targeted deletion of the glutamate receptor 1 (glur1) subunit of the ampa receptor are impaired in using an instrumental or pavlovian signal to gain access to a representation of the sensory-specific motivational properties of a primary reward. |
2006-03-31 |
2023-08-12 |
mouse |
| Antonieta Lavin, Lourdes Nogueira, Christopher C Lapish, R Mark Wightman, Paul E M Phillips, Jeremy K Seaman. Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 20. 2006-03-23. PMID:15901782. |
we suggest that the mesocortical system might transmit fast signals about reward or salience via corelease of glutamate, whereas the simultaneous prolonged da-mediated modulation of firing biases the long-term processing dynamics of pfc networks. |
2006-03-23 |
2023-08-12 |
Not clear |
| R L H Clements, A J Greensha. Facilitation of brain stimulation reward by MK-801 (dizocilpine) may be independent of D2-like dopamine receptor stimulation in rats. Psychopharmacology. vol 182. issue 1. 2006-02-22. PMID:16133130. |
dopamine (da) and glutamate (glu) interactions in the mesocorticolimbic pathway may regulate motivation and reward and contribute to schizophrenia and drug abuse. |
2006-02-22 |
2023-08-12 |
rat |
| Valerie G Olson, Cyrus P Zabetian, Carlos A Bolanos, Scott Edwards, Michel Barrot, Amelia J Eisch, Thomas Hughes, David W Self, Rachael L Neve, Eric J Nestle. Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 23. 2006-02-17. PMID:15944383. |
we also measured expression levels of tyrosine hydroxylase and the ampa glutamate receptor subunit glur1, both of which are known to contribute to drug reward in the vta, and found that both of these genes are upregulated following the expression of creb-gfp and downregulated following expression of mcreb-gfp, raising the possibility that creb may exert its effects on drug reward, in part, via regulation of these genes. |
2006-02-17 |
2023-08-12 |
Not clear |
| Volker Herzig, Eleonora M I Capuani, Karl-Artur Kovar, Werner J Schmid. Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats. Addiction biology. vol 10. issue 3. 2006-02-08. PMID:16109585. |
recent studies have revealed the effectiveness of 2-methyl-6-(phenylethynyl)pyridine (mpep), a highly selective antagonist of metabotropic glutamate receptors subtype 5 (mglur5), in conditioned drug reward. |
2006-02-08 |
2023-08-12 |
rat |
| Richard A Depue, Jeannine V Morrone-Strupinsk. A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. The Behavioral and brain sciences. vol 28. issue 3. 2006-01-20. PMID:16209725. |
we next explicate the manner in which da and glutamate interact in both the vta and nas to form incentive-encoded contextual memory ensembles that are predictive of reward derived from affiliative objects. |
2006-01-20 |
2023-08-12 |
human |
| Ewa Kozela, Malgorzata Wrobel, Tomasz Kos, Jacek Wojcikowski, Wladyslawa A Daniel, Krystyna M Wozniak, Barbara S Slusher, Piotr Popi. 2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice. Psychopharmacology. vol 183. issue 3. 2006-01-04. PMID:16220328. |
we have recently reported that conditioned morphine reward and tolerance to its antinociceptive effect, but not expression of morphine dependence, were attenuated by 2-(phosphonomethyl)pentanedioic acid (2-pmpa), a prototypic inhibitor of glutamate carboxipeptidase ii (gcp ii), which is an enzyme responsible for the supply of glutamate. |
2006-01-04 |
2023-08-12 |
mouse |