| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin T Saunders, Terry E Robinso. The role of dopamine in the accumbens core in the expression of Pavlovian-conditioned responses. The European journal of neuroscience. vol 36. issue 4. 2012-12-20. PMID:22780554. |
the data support the view that dopamine in the accumbens core is not necessary for learning stimulus-reward associations, but for attributing incentive salience to reward cues, transforming predictive conditional stimuli into incentive stimuli with powerful motivational properties. |
2012-12-20 |
2023-08-12 |
Not clear |
| Atsuko Nagano-Saito, Paul Cisek, Andrea S Perna, Fatemeh Z Shirdel, Chawki Benkelfat, Marco Leyton, Alain Daghe. From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion study. Journal of neurophysiology. vol 108. issue 2. 2012-12-12. PMID:22552189. |
these observations provide direct evidence that some reward-related functional mri signals in the striatum are the result of dopamine neuron activity and demonstrate that mesolimbic dopamine transmission can influence perceptual and decision-making neural processes engaged to maximize reward harvest. |
2012-12-12 |
2023-08-12 |
human |
| Robert H Howlan. Baclofen for the treatment of alcohol dependence. Journal of psychosocial nursing and mental health services. vol 50. issue 10. 2012-12-07. PMID:22998536. |
the mesolimbic dopamine system is a major component of the brain's reward pathways, and gaba neurons are part of this system, decreasing the activity of dopamine neurons through the inhibitory effects of gaba-b receptors. |
2012-12-07 |
2023-08-12 |
human |
| Elsmarieke van de Giessen, Susanne E la Fleur, Kora de Bruin, Wim van den Brink, Jan Booi. Free-choice and no-choice high-fat diets affect striatal dopamine D2/3 receptor availability, caloric intake, and adiposity. Obesity (Silver Spring, Md.). vol 20. issue 8. 2012-11-29. PMID:22307070. |
this study assesses whether different hf diets differentially affect striatal dopamine d(2/3) receptor (drd(2/3)) availability, as decreased striatal drd(2/3) availability has been implicated in obesity in relation to reward deficiency for food. |
2012-11-29 |
2023-08-12 |
rat |
| Shao Wan. [Reward, homeostasis and the habenula]. Sheng li ke xue jin zhan [Progress in physiology]. vol 39. issue 4. 2012-11-26. PMID:19119608. |
lateral habenula neurons are excited while the unpredictable reward exists, and the dopamine neurons are strongly inhibited. |
2012-11-26 |
2023-08-12 |
human |
| Stefano Palminteri, Anne-Hélène Clair, Luc Mallet, Mathias Pessiglion. Similar improvement of reward and punishment learning by serotonin reuptake inhibitors in obsessive-compulsive disorder. Biological psychiatry. vol 72. issue 3. 2012-11-20. PMID:22325972. |
an influential theory has suggested that dopamine and serotonin represent opponent systems respectively driving reward and punishment learning. |
2012-11-20 |
2023-08-12 |
Not clear |
| Ajna Hamidovic, Robert J Goodloe, Andrew W Bergen, Neal L Benowitz, Mindi A Styn, Jay L Kasberger, Helene Choquet, Taylor R Young, Yan Meng, Cameron Palmer, Mark Pletcher, Stefan Kertesz, Brian Hitsman, Bonnie Spring, Eric Jorgenso. Gene-centric analysis of serum cotinine levels in African and European American populations. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 4. 2012-11-19. PMID:22089314. |
it has been previously shown that psychostimulant self-administration is reduced in animals with lower insulin because of interference with dopamine transmission in the brain reward centers. |
2012-11-19 |
2023-08-12 |
human |
| Helga Nagy, Einat Levy-Gigi, Zsuzsanna Somlai, Annamária Takáts, Dániel Bereczki, Szabolcs Kér. The effect of dopamine agonists on adaptive and aberrant salience in Parkinson's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 4. 2012-11-19. PMID:22089321. |
results indicated that dopamine agonists increased both adaptive and aberrant salience in pd patients, that is, formation of real and illusory associations between conditioned stimuli and reward, respectively. |
2012-11-19 |
2023-08-12 |
Not clear |
| Helga Nagy, Einat Levy-Gigi, Zsuzsanna Somlai, Annamária Takáts, Dániel Bereczki, Szabolcs Kér. The effect of dopamine agonists on adaptive and aberrant salience in Parkinson's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 4. 2012-11-19. PMID:22089321. |
these results suggest that dopamine agonists may increase psychotic-like experiences in young patients with pd, possibly by facilitating dopaminergic transmission in the ventral striatum, which results in aberrant associations between conditioned stimuli and reward. |
2012-11-19 |
2023-08-12 |
Not clear |
| C Nocjar, J Zhang, P Feng, J Panksep. The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. Neuroscience. vol 218. 2012-11-16. PMID:22626650. |
two brain neuropeptides that have been implicated in anhedonia symptomology in preclinical depression models are dynorphin and orexin; which are concentrated along lateral hypothalamic dopamine reward pathways. |
2012-11-16 |
2023-08-12 |
rat |
| E W Lamont, Z Patterson, T Rodrigues, O Vallejos, I D Blum, A Abizai. Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm. Neuroscience. vol 218. 2012-11-16. PMID:22641088. |
ghrelin is also important for food-related motivation and seems to have direct effects in the mesocorticolimbic dopamine reward system. |
2012-11-16 |
2023-08-12 |
mouse |
| George F Koo. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Current topics in behavioral neurosciences. vol 13. 2012-11-13. PMID:21744309. |
specific neurochemical elements in these structures include not only decreases in reward neurotransmission, such as decreased dopamine and γ-aminobutyric acid function in the ventral striatum, but also recruitment of brain stress systems, such as corticotropin-releasing factor (crf), in the extended amygdala. |
2012-11-13 |
2023-08-12 |
Not clear |
| Maria Cristina Porfirio, Adriana Lo-Castro, Grazia Giana, Silvia Giovinazzo, Diane Purper Ouakil, Cinzia Galasso, Paolo Curatol. Attention-deficit hyperactivity disorder and binge eating disorder in a patient with 2q21.1-q22.2 deletion. Psychiatric genetics. vol 22. issue 4. 2012-11-08. PMID:22517382. |
the deletion, here first associated with this complex phenotype, encompasses several genes with a putative role in different domains of behavioral control and neurocognitive functions; their deregulated expression may influence metabolic pathways and the role of dopamine in reward, explaining the complex psychiatric phenotype and the pharmacotherapy response described in our patient. |
2012-11-08 |
2023-08-12 |
Not clear |
| E M Tunbridge, A Huber, S M Farrell, K Stumpenhorst, P J Harrison, M E Walto. The role of catechol-O-methyltransferase in reward processing and addiction. CNS & neurological disorders drug targets. vol 11. issue 3. 2012-11-06. PMID:22483300. |
one such example is reward processing, for which dopamine is a critical mediator, and in which the striatum and corticostriatal circuitry are implicated. |
2012-11-06 |
2023-08-12 |
Not clear |
| Fiorenzo Mignini, Valerio Napolioni, Claudia Codazzo, Francesco M Carpi, Mario Vitali, Marina Romeo, Mauro Ceccant. DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy. Neuroscience letters. vol 522. issue 2. 2012-11-05. PMID:22698582. |
since dopamine neurotransmission has been shown to be involved in drug reward, related genes are plausible candidates for susceptibility to ad. |
2012-11-05 |
2023-08-12 |
human |
| Julia Schiemann, Falk Schlaudraff, Verena Klose, Markus Bingmer, Susumu Seino, Peter J Magill, Kareem A Zaghloul, Gaby Schneider, Birgit Liss, Jochen Roepe. K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nature neuroscience. vol 15. issue 9. 2012-11-05. PMID:22902720. |
phasic activation of the dopamine (da) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. |
2012-11-05 |
2023-08-12 |
mouse |
| M R Hutchinson, A L Northcutt, T Hiranita, X Wang, S S Lewis, J Thomas, K van Steeg, T A Kopajtic, L C Loram, C Sfregola, E Galer, N E Miles, S T Bland, J Amat, R R Rozeske, T Maslanik, T R Chapman, K A Strand, M Fleshner, R K Bachtell, A A Somogyi, H Yin, J L Katz, K C Rice, S F Maier, L R Watkin. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895704. |
collectively, these data indicate that the actions of opioids at classical opioid receptors, together with their newly identified tlr4/md2 actions, affect the mesolimbic dopamine system that amplifies opioid-induced elevations in extracellular dopamine levels, therefore possibly explaining altered opioid reward behaviors. |
2012-11-02 |
2023-08-12 |
mouse |
| Lauren V Riter. The role of motivation and reward neural systems in vocal communication in songbirds. Frontiers in neuroendocrinology. vol 33. issue 2. 2012-10-29. PMID:22569510. |
past studies show that dopamine and opioids in the medial preoptic nucleus (mpoa) and ventral tegmental area (vta) play distinct roles in motivation and reward. |
2012-10-29 |
2023-08-12 |
Not clear |
| Giovanni Hernandez, Ivan Trujillo-Pisanty, Marie-Pierre Cossette, Kent Conover, Peter Shizga. Role of dopamine tone in the pursuit of brain stimulation reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 32. 2012-10-26. PMID:22875936. |
role of dopamine tone in the pursuit of brain stimulation reward. |
2012-10-26 |
2023-08-12 |
human |
| Giovanni Hernandez, Ivan Trujillo-Pisanty, Marie-Pierre Cossette, Kent Conover, Peter Shizga. Role of dopamine tone in the pursuit of brain stimulation reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 32. 2012-10-26. PMID:22875936. |
whereas the effect of psychomotor stimulants on icss has long been attributed to dopaminergic action at early stages of the reward pathway, the results reported here imply that increased dopamine tone boosts reward pursuit by acting at or beyond the output of the circuitry that temporally and spatially summates the output of the directly stimulated neurons underlying icss. |
2012-10-26 |
2023-08-12 |
human |