| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenneth Blum, Marcelo Febo, Panayotis K Thanos, David Baron, James Fratantonio, Mark Gol. Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner? Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25750061. |
however, while it is universally agreed that dopamine is a major neurotransmitter in terms of reward dependence, there remains controversy regarding how to modulate its role clinically to treat and prevent relapse for both substance and non-substance-related addictive behaviors. |
2016-08-30 |
2023-08-13 |
Not clear |
| Kenneth Blum, Marcelo Febo, Panayotis K Thanos, David Baron, James Fratantonio, Mark Gol. Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner? Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25750061. |
while the existing fda-approved medications promote blocking dopamine, we argue that a more prudent paradigm shift should be biphasic-short-term blockade and long-term upregulation, enhancing functional connectivity of brain reward circuits. |
2016-08-30 |
2023-08-13 |
Not clear |
| Cynthia El Hage, Anne-Marie Bédard, Anne-Noël Samah. Antipsychotic treatment leading to dopamine supersensitivity persistently alters nucleus accumbens function. Neuropharmacology. vol 99. 2016-08-30. PMID:25823912. |
hal-treated rats were dopamine supersensitive, as indicated by sensitization to systemic amph-induced potentiation of both locomotor activity and operant responding for a conditioned reward (cr). |
2016-08-30 |
2023-08-13 |
rat |
| Magdalena Sustkova-Fiserova, Pavel Jerabek, Tereza Havlickova, Kamila Syslova, Petr Kace. Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. Psychopharmacology. vol 233. issue 3. 2016-08-29. PMID:26507196. |
in addition to dopamine, endocannabinoids are thought to participate in neural reward mechanisms of opioids. |
2016-08-29 |
2023-08-13 |
rat |
| Nicole M Enman, Kayti Arthur, Sara J Ward, Shane A Perrine, Ellen M Unterwal. Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder. Biological psychiatry. vol 78. issue 12. 2016-08-24. PMID:26115790. |
anhedonia, reduced cocaine reward, and dopamine dysfunction in a rat model of posttraumatic stress disorder. |
2016-08-24 |
2023-08-13 |
rat |
| Nicole M Enman, Kayti Arthur, Sara J Ward, Shane A Perrine, Ellen M Unterwal. Anhedonia, Reduced Cocaine Reward, and Dopamine Dysfunction in a Rat Model of Posttraumatic Stress Disorder. Biological psychiatry. vol 78. issue 12. 2016-08-24. PMID:26115790. |
dopamine reward dysfunction also may be relevant to the mechanisms underlying the ptsd symptoms of anhedonia and emotional numbing. |
2016-08-24 |
2023-08-13 |
rat |
| Sarah H Lockie, Tara Dinan, Andrew J Lawrence, Sarah J Spencer, Zane B Andrew. Diet-induced obesity causes ghrelin resistance in reward processing tasks. Psychoneuroendocrinology. vol 62. 2016-08-24. PMID:26292268. |
however, ghrelin promotes feeding through actions at both the hypothalamus and mesolimbic dopamine reward pathways. |
2016-08-24 |
2023-08-13 |
mouse |
| Toshiharu Ichinose, Yoshinori Aso, Nobuhiro Yamagata, Ayako Abe, Gerald M Rubin, Hiromu Tanimot. Reward signal in a recurrent circuit drives appetitive long-term memory formation. eLife. vol 4. 2016-08-22. PMID:26573957. |
dopamine signals reward in animal brains. |
2016-08-22 |
2023-08-13 |
drosophila_melanogaster |
| Toshiharu Ichinose, Yoshinori Aso, Nobuhiro Yamagata, Ayako Abe, Gerald M Rubin, Hiromu Tanimot. Reward signal in a recurrent circuit drives appetitive long-term memory formation. eLife. vol 4. 2016-08-22. PMID:26573957. |
a single presentation of a sugar reward to drosophila activates distinct subsets of dopamine neurons that independently induce short- and long-term olfactory memories (stm and ltm, respectively). |
2016-08-22 |
2023-08-13 |
drosophila_melanogaster |
| Tara J Aitken, Venuz Y Greenfield, Kate M Wassu. Nucleus accumbens core dopamine signaling tracks the need-based motivational value of food-paired cues. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26715366. |
here, we used fast-scan cyclic voltammetry to monitor dopamine concentration changes in the nac core of rats during a pavlovian-to-instrumental transfer task in which the motivating influence of two cues, each signaling a distinct food reward (sucrose or food pellets), over an action earning a third unique food reward (polycose) was assessed in a state of hunger and of satiety. |
2016-08-22 |
2023-08-13 |
rat |
| Yashasvi Matam, Bruce D Ray, Horia I Petrach. Direct affinity of dopamine to lipid membranes investigated by Nuclear Magnetic Resonance spectroscopy. Neuroscience letters. vol 618. 2016-08-22. PMID:26960008. |
dopamine, a naturally occurring neurotransmitter, plays an important role in the brain's reward system and acts on sensory receptors in the brain. |
2016-08-22 |
2023-08-13 |
Not clear |
| Joshua D Larkin, Nicole L Jenni, Stan B Floresc. Modulation of risk/reward decision making by dopaminergic transmission within the basolateral amygdala. Psychopharmacology. vol 233. issue 1. 2016-08-18. PMID:26432096. |
dopamine (da) transmission within cortico-limbic-striatal circuitry is integral in modulating decisions involving reward uncertainty. |
2016-08-18 |
2023-08-13 |
Not clear |
| Kaviraja Udupa, Robert Che. Deeper understanding of the role of dopamine in reward, learning, and motivation. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 4. 2016-08-18. PMID:27030473. |
deeper understanding of the role of dopamine in reward, learning, and motivation. |
2016-08-18 |
2023-08-13 |
Not clear |
| Elizabeth N Holly, Christopher O Boyson, Sandra Montagud-Romero, Dirson J Stein, Kyle L Gobrogge, Joseph F DeBold, Klaus A Micze. Episodic Social Stress-Escalated Cocaine Self-Administration: Role of Phasic and Tonic Corticotropin Releasing Factor in the Anterior and Posterior Ventral Tegmental Area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053215. |
reward and stress both activate ventral tegmental area (vta) dopamine neurons, increasing downstream extracellular dopamine concentration in the medial prefrontal cortex and nucleus accumbens. |
2016-08-15 |
2023-08-13 |
rat |
| Anja Richter, Aleksandra Petrovic, Esther K Diekhof, Sarah Trost, Sarah Wolter, Oliver Grube. Hyperresponsivity and impaired prefrontal control of the mesolimbic reward system in schizophrenia. Journal of psychiatric research. vol 71. 2016-08-10. PMID:26522867. |
the neurotransmitter dopamine is responsible for the transmission of reward signals and also known to be involved in the mechanism of psychosis. |
2016-08-10 |
2023-08-13 |
human |
| Elizabeth N Holly, Klaus A Micze. Ventral tegmental area dopamine revisited: effects of acute and repeated stress. Psychopharmacology. vol 233. issue 2. 2016-08-08. PMID:26676983. |
this is in apparent contradiction to a wealth of literature demonstrating that most vta dopamine neurons are strongly activated by reward and reward-predictive cues while inhibited by aversive stimuli. |
2016-08-08 |
2023-08-13 |
Not clear |
| Masroor Shariff, Maryka Quik, Joan Holgate, Michael Morgan, Omkar L Patkar, Vincent Tam, Arnauld Belmer, Selena E Bartlet. Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake. PloS one. vol 11. issue 3. 2016-08-08. PMID:27028298. |
interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (nac), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. |
2016-08-08 |
2023-08-13 |
Not clear |
| Masroor Shariff, Maryka Quik, Joan Holgate, Michael Morgan, Omkar L Patkar, Vincent Tam, Arnauld Belmer, Selena E Bartlet. Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake. PloS one. vol 11. issue 3. 2016-08-08. PMID:27028298. |
we report that varenicline, an fda-approved nicotinic acetylcholine receptor (nachr) partial agonist that modulates dopamine in the mesolimbic reward pathway of the brain, significantly reduces sucrose consumption, especially in a long-term consumption paradigm. |
2016-08-08 |
2023-08-13 |
Not clear |
| George F Koo. Neurocircuitry of alcohol addiction: synthesis from animal models. Handbook of clinical neurology. vol 125. 2016-07-28. PMID:25307567. |
the negative emotional state that drives such negative reinforcement is hypothesized to derive from decreases in reward neurotransmission in the ventral striatum, such as decreased dopamine and opioid peptide function in the nucleus accumbens (ventral striatum), but also recruitment of brain stress systems, such as corticotropin-releasing factor (crf), in the extended amygdala. |
2016-07-28 |
2023-08-13 |
Not clear |
| Lauri Tuominen, Jetro Tuulari, Henry Karlsson, Jussi Hirvonen, Semi Helin, Paulina Salminen, Riitta Parkkola, Jarmo Hietala, Pirjo Nuutila, Lauri Nummenma. Aberrant mesolimbic dopamine-opiate interaction in obesity. NeuroImage. vol 122. 2016-07-22. PMID:26260431. |
dopamine and opioid neurotransmitter systems share many functions such as regulation of reward and pleasure. |
2016-07-22 |
2023-08-13 |
human |