| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Hinerth, H A Collins, M Baniecki, R N Hanson, B L Waszcza. Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse (New York, N.Y.). vol 38. issue 3. 2000-11-28. PMID:11020233. |
we conclude that electrophysiological testing of putative "anti-cocaine" drugs for their abilities to inhibit the firing of vta dopamine neurons, and to block their inhibitory responses to cocaine, may provide a rapid in vivo screen for compounds expected to behave as functional cocaine antagonists in the dopamine reward system. |
2000-11-28 |
2023-08-12 |
rat |
| A Dickinson, J Smith, J Mirenowic. Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists. Behavioral neuroscience. vol 114. issue 3. 2000-11-20. PMID:10883798. |
the administration of the dopamine antagonists, pimozide and alpha-flupenthixol, to rats reduced pavlovian-instrumental transfer when a conditioned stimulus (cs) that had been paired with a noncontingent food reward was tested on instrumental performance. |
2000-11-20 |
2023-08-12 |
rat |
| T E Robinson, K C Berridg. The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction (Abingdon, England). vol 95 Suppl 2. 2000-10-05. PMID:11002906. |
we also discuss the role that mesolimbic dopamine systems play in reward, evidence that neural sensitization happens in humans, and the implications of incentive-sensitization for the development of therapies in the treatment of addiction. |
2000-10-05 |
2023-08-12 |
Not clear |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
nmda, but not dopamine d(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. |
2000-08-31 |
2023-08-12 |
rat |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
the present study sought to explore whether signals transmitted via the nmda subtype of glutamate receptors and via dopamine d(2) receptors in the nucleus accumbens (nac) are critical for the determination of reaction times (rts) of instrumental responses by the expectancy of future reward. |
2000-08-31 |
2023-08-12 |
rat |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
the shortening of rts by stimuli predictive of high reward to be obtained was dose-dependently impaired by bilateral intra-nac infusion of the competitive nmda antagonist dl-2-amino-5-phosphonovaleric acid (apv) (1, 2, or 10 microg in 0.5 microl/side), but not by infusion of the preferential dopamine d(2) antagonist haloperidol (5 and 12.5 microg in 0.5 microl/side) or by infusion of vehicle (0.5 microl/side). |
2000-08-31 |
2023-08-12 |
rat |
| W Hauber, I Bohn, C Giertle. NMDA, but not dopamine D(2), receptors in the rat nucleus accumbens areinvolved in guidance of instrumental behavior by stimuli predicting reward magnitude. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934279. |
in conclusion, the data reveal that in well trained animals stimulation of intra-nac nmda, but not of dopamine d(2), receptors, is critically involved in guiding the speed of instrumental responses according to stimuli predictive of the upcoming reward magnitude. |
2000-08-31 |
2023-08-12 |
rat |
| G Di Chiar. Role of dopamine in the behavioural actions of nicotine related to addiction. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771025. |
these effects of nicotine resemble those of a reward like food except that nicotine-induced release of dopamine does not undergo single-trial, long-lasting habituation. |
2000-08-11 |
2023-08-12 |
Not clear |
| S Jones, J L Kornblum, J A Kaue. Amphetamine blocks long-term synaptic depression in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908593. |
the ltd we have discovered in the vta is likely to be an important component of excitatory control of the reward pathway; amphetamine will inhibit ltd, removing this normal brake on the glutamatergic drive to dopamine neurons. |
2000-08-10 |
2023-08-12 |
Not clear |
| J C Horvit. Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience. vol 96. issue 4. 2000-05-31. PMID:10727783. |
while it has previously been assumed that mesolimbic dopamine neurons carry a reward signal, recent data from single-unit, microdialysis and voltammetry studies suggest that these neurons respond to a large category of salient and arousing events, including appetitive, aversive, high intensity, and novel stimuli. |
2000-05-31 |
2023-08-12 |
Not clear |
| J C Horvit. Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience. vol 96. issue 4. 2000-05-31. PMID:10727783. |
however, because dopamine neurons respond to a category of salient events that extend beyond that of reward stimuli, dopamine levels are not likely to code for the reward value of encountered events. |
2000-05-31 |
2023-08-12 |
Not clear |
| M R Kilpatrick, M B Rooney, D J Michael, R M Wightma. Extracellular dopamine dynamics in rat caudate-putamen during experimenter-delivered and intracranial self-stimulation. Neuroscience. vol 96. issue 4. 2000-05-31. PMID:10727788. |
this paradigm is thought to stimulate brain reward pathways and, as such, has been used to clarify the role of dopamine in reward. |
2000-05-31 |
2023-08-12 |
rat |
| X Wu, E D Frenc. Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698005. |
since ventral tegmental dopamine neurons play a pivotal role in drug reinforcement and reward, and possibly in the euphorigenic quality of marijuana, the present study sought to determine whether tolerance develops to the neurophysiological response elicited in these neurons by delta9-thc. |
2000-05-16 |
2023-08-12 |
rat |
| W Schultz, L Tremblay, J R Hollerma. Reward processing in primate orbitofrontal cortex and basal ganglia. Cerebral cortex (New York, N.Y. : 1991). vol 10. issue 3. 2000-04-27. PMID:10731222. |
this article reviews and interprets neuronal activities related to the expectation and delivery of reward in the primate orbitofrontal cortex, in comparison with slowly discharging neurons in the striatum (caudate, putamen and ventral striatum, including nucleus accumbens) and midbrain dopamine neurons. |
2000-04-27 |
2023-08-12 |
Not clear |
| W Schultz, L Tremblay, J R Hollerma. Reward processing in primate orbitofrontal cortex and basal ganglia. Cerebral cortex (New York, N.Y. : 1991). vol 10. issue 3. 2000-04-27. PMID:10731222. |
dopamine neurons responded to rewards and reward-predicting stimuli, and coded an error in the prediction of reward. |
2000-04-27 |
2023-08-12 |
Not clear |
| R J Bainton, L T Tsai, C M Singh, M S Moore, W S Neckameyer, U Heberlei. Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Current biology : CB. vol 10. issue 4. 2000-04-25. PMID:10704411. |
drugs of abuse have a common property in mammals, which is their ability to facilitate the release of the neurotransmitter and neuromodulator dopamine in specific brain regions involved in reward and motivation. |
2000-04-25 |
2023-08-12 |
drosophila_melanogaster |
| M Filio. Physiologic basis of dyskinesia. Annals of neurology. vol 47. issue 4 Suppl 1. 2000-04-21. PMID:10762130. |
a major criterion for selection in the basal ganglia is prediction of reward, materialized by release of dopamine. |
2000-04-21 |
2023-08-12 |
Not clear |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
cocaine reward and mptp toxicity: alteration by regional variant dopamine transporter overexpression. |
2000-02-14 |
2023-08-12 |
mouse |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| B Söderpalm, M Ericson, M Bohlooly, J A Engel, J Törnel. Bovine growth hormone transgenic mice display alterations in locomotor activity and brain monoamine neurochemistry. Endocrinology. vol 140. issue 12. 1999-12-20. PMID:10579325. |
in the present study we have investigated whether bovine gh (bgh) transgenic mice and nontransgenic controls differ in spontaneous locomotor activity, a behavioral response related to brain dopamine (da) and reward mechanisms, as well as in locomotor activity response to drugs of abuse known to interfere with brain da systems. |
1999-12-20 |
2023-08-12 |
mouse |