| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Uramura, H Funahashi, S Muroya, S Shioda, M Takigawa, T Yad. Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area. Neuroreport. vol 12. issue 9. 2001-08-23. PMID:11435917. |
mesolimbic dopamine neurons in the ventral tegmental area (vta) are implicated in the regulation of reward and wakefulness/sleep, in the present study, we examined the effect of orexin-a on cytosolic [ca2+]i concentration ([ca2+]) in the isolated rat vta dopamine neurons. |
2001-08-23 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
blockade of d1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. |
2001-08-16 |
2023-08-12 |
rat |
| R Ranaldi, R A Wis. Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 15. 2001-08-16. PMID:11466456. |
these data suggest a role for dendritically released dopamine, presumably acting through d1 receptors located on the axons of gabaergic or glutamatergic inputs to the vta, in the effectiveness of cocaine reward. |
2001-08-16 |
2023-08-12 |
rat |
| J Vanakoski, M Virkkunen, H Naukkarinen, D Goldma. No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. Psychiatry research. vol 102. issue 1. 2001-08-09. PMID:11368834. |
one of its several functions is to modulate the release of dopamine in brain areas involved in reinforcement and reward behavior. |
2001-08-09 |
2023-08-12 |
human |
| P Waelti, A Dickinson, W Schult. Dopamine responses comply with basic assumptions of formal learning theory. Nature. vol 412. issue 6842. 2001-07-26. PMID:11452299. |
both behavioural and neuronal learning occurred predominantly when dopamine neurons registered a reward prediction error at the time of the reward. |
2001-07-26 |
2023-08-12 |
Not clear |
| C L Dockstader, M Rubinstein, D K Grandy, M J Low, D van der Koo. The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice. The European journal of neuroscience. vol 13. issue 5. 2001-07-12. PMID:11264672. |
according to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. |
2001-07-12 |
2023-08-12 |
mouse |
| J Yeomans, G Forster, C Blah. M5 muscarinic receptors are needed for slow activation of dopamine neurons and for rewarding brain stimulation. Life sciences. vol 68. issue 22-23. 2001-06-21. PMID:11392612. |
mesopontine cholinergic neurons (ch5 and ch6 cell groups) activate the cerebral cortex via thalamic projections, and activate locomotion and reward via dopamine neurons in the substantia nigra and ventral tegmental area (vta). |
2001-06-21 |
2023-08-12 |
mouse |
| M Radel, D Goldma. Pharmacogenetics of alcohol response and alcoholism: the interplay of genes and environmental factors in thresholds for alcoholism. Drug metabolism and disposition: the biological fate of chemicals. vol 29. issue 4 Pt 2. 2001-06-14. PMID:11259338. |
genes for proteins involved in alcohol-mediated reward include genes for transporters and receptors for dopamine, serotonin, opioids, and gaba. |
2001-06-14 |
2023-08-12 |
mouse |
| I Sora, F S Hall, A M Andrews, M Itokawa, X F Li, H B Wei, C Wichems, K P Lesch, D L Murphy, G R Uh. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11320258. |
molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. |
2001-05-21 |
2023-08-12 |
mouse |
| C L Cunningham, M A Howard, S J Gill, M Rubinstein, M J Low, D K Grand. Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice. Pharmacology, biochemistry, and behavior. vol 67. issue 4. 2001-05-17. PMID:11166059. |
overall, this study strongly supports the conclusion that dopamine d2 receptors normally influence ethanol reward in mice. |
2001-05-17 |
2023-08-12 |
mouse |
| A M Kindlundh, J Lindblom, L Bergström, J E Wikberg, F Nyber. The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain. The European journal of neuroscience. vol 13. issue 2. 2001-05-10. PMID:11168533. |
the present study aimed to assess whether anabolic-androgenic steroids (aas) would affect the density of the dopamine receptors in areas implicated in reward and behaviour in the male rat brain. |
2001-05-10 |
2023-08-12 |
rat |
| E A Kiyatkin, G V Rebe. Impulse activity of ventral tegmental area neurons during heroin self-administration in rats. Neuroscience. vol 102. issue 3. 2001-05-03. PMID:11226694. |
with respect to long-spike units, a candidate group of presumed dopamine neurons, our data agree with the view that mesocorticolimbic dopamine activation is important for the activational and/or motivational aspects of heroin-taking behavior and suggest the role of an abrupt termination of dopamine activation for drug reinforcement (reward). |
2001-05-03 |
2023-08-12 |
rat |
| K Blum, E R Braverman, J M Holder, J F Lubar, V J Monastra, D Miller, J O Lubar, T J Chen, D E Coming. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of psychoactive drugs. vol 32 Suppl. 2001-04-26. PMID:11280926. |
the dopaminergic system, and in particular the dopamine d2 receptor, has been implicated in reward mechanisms. |
2001-04-26 |
2023-08-12 |
Not clear |
| K Blum, E R Braverman, J M Holder, J F Lubar, V J Monastra, D Miller, J O Lubar, T J Chen, D E Coming. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of psychoactive drugs. vol 32 Suppl. 2001-04-26. PMID:11280926. |
the net effect of neurotransmitter interaction at the mesolimbic brain region induces "reward" when dopamine (da) is released from the neuron at the nucleus accumbens and interacts with a dopamine d2 receptor. |
2001-04-26 |
2023-08-12 |
Not clear |
| C A Paladini, C D Fiorillo, H Morikawa, J T William. Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons. Nature neuroscience. vol 4. issue 3. 2001-04-05. PMID:11224544. |
through this mechanism, amphetamine may enhance phasic release of dopamine, which is important in the neural processing of reward. |
2001-04-05 |
2023-08-12 |
Not clear |
| C L Wyvell, K C Berridg. Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward "wanting" without enhanced "liking" or response reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 21. 2001-02-22. PMID:11050134. |
we conclude that nucleus accumbens dopamine specifically mediates the ability of reward cues to trigger "wanting" (incentive salience) for their associated rewards, independent of both hedonic impact and response reinforcement. |
2001-02-22 |
2023-08-12 |
rat |
| F Subhan, P N Deslandes, D M Pache, R D Sewel. Do antidepressants affect motivation in conditioned place preference? European journal of pharmacology. vol 408. issue 3. 2001-02-22. PMID:11090642. |
the role of serotonin in reward pathways and differences in serotonin, noradrenaline and dopamine reuptake-inhibiting properties of these compounds may explain why only the serotonin-selective reuptake inhibitors produced place preference in this study. |
2001-02-22 |
2023-08-12 |
rat |
| D E Comings, R Gade-Andavolu, N Gonzalez, S Wu, D Muhleman, H Blake, M B Mann, G Dietz, G Saucier, J P MacMurra. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clinical genetics. vol 58. issue 5. 2001-02-22. PMID:11140838. |
he suggested that novelty seeking primarily utilized dopamine pathways, harm avoidance utilized serotonin pathways, and reward dependence utilized norepinephrine pathways. |
2001-02-22 |
2023-08-12 |
Not clear |
| M Koch, A Schmid, H U Schnitzle. Role of muscles accumbens dopamine D1 and D2 receptors in instrumental and Pavlovian paradigms of conditioned reward. Psychopharmacology. vol 152. issue 1. 2001-02-15. PMID:11041317. |
role of muscles accumbens dopamine d1 and d2 receptors in instrumental and pavlovian paradigms of conditioned reward. |
2001-02-15 |
2023-08-12 |
Not clear |
| M Koch, A Schmid, H U Schnitzle. Role of muscles accumbens dopamine D1 and D2 receptors in instrumental and Pavlovian paradigms of conditioned reward. Psychopharmacology. vol 152. issue 1. 2001-02-15. PMID:11041317. |
this study investigated the role of nucleus accumbens dopamine d1 and d2 receptors in two different paradigms of conditioned reward. |
2001-02-15 |
2023-08-12 |
Not clear |