| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sudarat Nimitvilai, Devinder S Arora, Mark S Brodi. Reversal of dopamine inhibition of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase C. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21976045. |
reversal of dopamine inhibition of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase c. adaptation of putative dopaminergic (pda) neurons in the ventral tegmental area (vta) to drugs of abuse may alter information processing related to reward and reinforcement and is an important factor in the development of addiction. |
2012-04-17 |
2023-08-12 |
rat |
| Michael D Roberts, Leigh Gilpin, Kyle E Parker, Thomas E Childs, Matthew J Will, Frank W Boot. Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances. Physiology & behavior. vol 105. issue 3. 2012-04-16. PMID:22001493. |
dopamine signaling in the nucleus accumbens (nac) has been postulated to influence reward development towards drugs of abuse and exercise. |
2012-04-16 |
2023-08-12 |
rat |
| Ting Chen, Die Zhang, Andrei Dragomir, Kunikazu Kobayashi, Yasemin Akay, Metin Aka. Investigating the influence of PFC transection and nicotine on dynamics of AMPA and NMDA receptors of VTA dopaminergic neurons. Journal of neuroengineering and rehabilitation. vol 8. 2012-04-05. PMID:22018308. |
all drugs of abuse, including nicotine, activate the mesocorticolimbic system that plays critical roles in nicotine reward and reinforcement development and triggers glutamatergic synaptic plasticity on the dopamine (da) neurons in the ventral tegmental area (vta). |
2012-04-05 |
2023-08-12 |
Not clear |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. |
2012-04-04 |
2023-08-12 |
rat |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
unpredicted reward and reward-predictive cues evoke phasic increases in the firing rate of the majority of midbrain dopamine neurons--results that predict uniformly broadcast increases in dopamine concentration throughout the striatum. |
2012-04-04 |
2023-08-12 |
rat |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
however, measurement of dopamine concentration changes during reward has cast doubt on this prediction. |
2012-04-04 |
2023-08-12 |
rat |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
we used fast-scan cyclic voltammetry in awake and behaving rats, which measures changes in dopamine on a similar timescale to the electrophysiological recordings that established a relationship between phasic dopamine activity and reward. |
2012-04-04 |
2023-08-12 |
rat |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
unlike the responses of midbrain dopamine neurons, unpredicted food reward and reward-predictive cues evoked a phasic increase in dopamine that was subregion specific. |
2012-04-04 |
2023-08-12 |
rat |
| Holden D Brown, James E McCutcheon, Jackson J Cone, Michael E Ragozzino, Mitchell F Roitma. Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. The European journal of neuroscience. vol 34. issue 12. 2012-04-04. PMID:22122410. |
in rats trained on a discriminative stimulus paradigm, both unpredicted reward and reward-predictive cues evoked robust phasic dopamine in the core and dms. |
2012-04-04 |
2023-08-12 |
rat |
| Dong V Wang, Joe Z Tsie. Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations. PloS one. vol 6. issue 2. 2012-04-02. PMID:21347237. |
here we study how the vta dopamine neuron population may process fearful and negative experiences as well as reward information in freely behaving mice. |
2012-04-02 |
2023-08-12 |
mouse |
| Dong V Wang, Joe Z Tsie. Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations. PloS one. vol 6. issue 2. 2012-04-02. PMID:21347237. |
using multi-tetrode recording, we find that up to 89% of the putative dopamine neurons in the vta exhibit significant activation in response to the conditioned tone that predict food reward, while the same dopamine neuron population also respond to the fearful experiences such as free fall and shake events. |
2012-04-02 |
2023-08-12 |
mouse |
| Adriana Galistu, Paolo S D'Aquil. Effect of the dopamine D1-like receptor antagonist SCH 23390 on the microstructure of ingestive behaviour in water-deprived rats licking for water and NaCl solutions. Physiology & behavior. vol 105. issue 2. 2012-03-26. PMID:21864553. |
based on the different effects of the dopamine d1-like and d2-like receptor antagonists sch 23390 and raclopride on licking for sucrose, in particular the failure of the former to reduce bout size and the ability of the latter to induce a within-session decrement of bout number resembling either reward devaluation or neuroleptics on instrumental responding, we suggested that activation of reward-associated responses depends on dopamine d1-like receptor stimulation, and its level is updated on the basis of a dopamine d2-like receptor-mediated reward evaluation. |
2012-03-26 |
2023-08-12 |
human |
| José Martínez-Hernández, Enrique Lanuza, Fernando Martínez-Garcí. Lesions of the dopaminergic innervation of the nucleus accumbens medial shell delay the generation of preference for sucrose, but not of sexual pheromones. Behavioural brain research. vol 226. issue 2. 2012-03-25. PMID:22019343. |
therefore, dopamine in the medial shell of the nucleus accumbens has a different role on the reward of sexual pheromones and sucrose. |
2012-03-25 |
2023-08-12 |
mouse |
| H Morikawa, C A Paladin. Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. Neuroscience. vol 198. 2012-03-22. PMID:21872647. |
dopamine neurons must integrate sensory, motor, and cognitive information online to inform the organism to pursue outcomes with the highest reward probability. |
2012-03-22 |
2023-08-12 |
Not clear |
| Kia J Jackson, Xiangning Chen, Michael F Miles, JoLynne Harenza, M Imad Dama. The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 11. 2012-03-20. PMID:21796100. |
here, using mouse models of nicotine reward and withdrawal, we show that there is a significant correlation between mecamylamine-precipitated nicotine withdrawal somatic signs and basal galanin or galanin receptor 1 (galr1) expression in mesolimbocortical dopamine regions across the bxd battery of recombinant inbred mouse lines. |
2012-03-20 |
2023-08-12 |
mouse |
| Jeremiah Y Cohen, Sebastian Haesler, Linh Vong, Bradford B Lowell, Naoshige Uchid. Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature. vol 482. issue 7383. 2012-03-15. PMID:22258508. |
dopamine has a central role in motivation and reward. |
2012-03-15 |
2023-08-12 |
mouse |
| Erin Green, Aaron Jacobson, Lori Haase, Claire Murph. Reduced nucleus accumbens and caudate nucleus activation to a pleasant taste is associated with obesity in older adults. Brain research. vol 1386. 2012-03-12. PMID:21362414. |
significant associations between a hypofunctioning reward response and obesity suggest the hypothesis that decreased dopamine functioning may be a plausible mechanism for weight gain in older adults. |
2012-03-12 |
2023-08-12 |
Not clear |
| Nora D Volkow, Gene-Jack Wang, Dardo Tomasi, Scott H Kollins, Tim L Wigal, Jeffrey H Newcorn, Frank W Telang, Joanna S Fowler, Jean Logan, Christopher T Wong, James M Swanso. Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 3. 2012-03-09. PMID:22262882. |
our findings indicate that dopamine enhancement in ventral striatum (the brain region involved with reward and motivation) was associated with therapeutic response to methylphenidate, further corroborating the relevance of the dopamine reward/motivation circuitry in adhd. |
2012-03-09 |
2023-08-12 |
Not clear |
| M-A Enoch, E Gorodetsky, C Hodgkinson, A Roy, D Goldma. Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20838391. |
the 5-ht3 receptor is rapidly potentiated by ethanol and mediates fast excitatory serotonin (5-ht) transmission that modulates dopamine release in the reward circuitry. |
2012-03-05 |
2023-08-12 |
Not clear |
| M-A Enoch, E Gorodetsky, C Hodgkinson, A Roy, D Goldma. Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20838391. |
one possible explanation of our findings is that increased synaptic 5-ht coupled with increased 5-ht3 receptor responsiveness may result in enhanced dopamine transmission in the reward pathway, a predictor of increased risk for addiction. |
2012-03-05 |
2023-08-12 |
Not clear |