| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Neuhofer, Peter Kaliva. Differential modulation of GABAergic and glutamatergic neurons in the ventral pallidum by GABA and neuropeptides. eNeuro. 2023-07-06. PMID:37414552. |
the ventral pallidum (vp) is an integral locus in the reward circuitry and a major target of gabaergic innervation of both d1-medium spiny neurons (msns) and d2-msns from the nucleus accumbens (nac). |
2023-07-06 |
2023-08-14 |
mouse |
| Federica Lucantonio, Shuwen Li, Jaden Lu, Jacob Roeglin, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatell. Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333325. |
here, we show that the nucleus accumbens (nac), a major hub of the reward circuitry, is essential for ketamine's effect in rescuing anhedonia in mice subjected to chronic stress, a critical risk factor in the genesis of depression in humans. |
2023-06-19 |
2023-08-14 |
mouse |
| David Levcik, Adam H Sugi, Marcelo Aguilar-Rivera, José A Pochapski, Gabriel Baltazar, Laura N Pulido, Cyrus Villas Boas, Romulo Fuentes-Flores, Saleem M Nicola, Claudio Da Cunh. Nucleus accumbens shell neurons encode the kinematics of reward approach locomotion. Neuroscience. 2023-06-17. PMID:37330195. |
the nucleus accumbens (nac) is considered an interface between motivation and action, with nac neurons playing an important role in promoting reward approach. |
2023-06-17 |
2023-08-14 |
rat |
| Kyle D Ketchesin, Darius D Becker-Krail, Xiangning Xue, Rashaun S Wilson, TuKiet T Lam, Kenneth R Williams, Angus C Nairn, George C Tseng, Ryan W Loga. Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome. Journal of proteome research. 2023-06-13. PMID:37311105. |
repeated use of substances such as psychostimulants and opioids may lead to significant alterations in molecular rhythms in the nucleus accumbens (nac), a brain region central to reward and motivation. |
2023-06-13 |
2023-08-14 |
mouse |
| Zhaosong Chu, Lijin Yuan, Mengxin He, Yuqi Cheng, Yi Lu, Xiufeng Xu, Zonglin She. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270840. |
evidence from previous literature suggests that the nucleus accumbens (nac), hippocampus, and amygdala play critical roles in the reward circuit. |
2023-06-04 |
2023-08-14 |
human |
| Pengbo Jing, Qiang Sha. Exogenous oxytocin microinjection into the nucleus accumbens shell attenuates social dominance in group-housed male mice. Physiology & behavior. 2023-06-03. PMID:37270150. |
the nucleus accumbens (nac), a part of the brain's limbic system, is involved in a variety of brain functions, including reward motivation and social hierarchy. |
2023-06-03 |
2023-08-14 |
mouse |
| Ruijie Jin, Shanbin Sun, Yang Hu, Hongfei Zhang, Xiangrong Su. Neuropeptides Modulate Feeding via the Dopamine Reward Pathway. Neurochemical research. 2023-05-26. PMID:37233918. |
the reward system comprises the ventral tegmental area (vta), nucleus accumbens (nac), hypothalamus, and limbic system. |
2023-05-26 |
2023-08-14 |
Not clear |
| Anna I Dunigan, Aaron G Roseberr. Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards. Addiction neuroscience. vol 2. 2023-05-23. PMID:37220637. |
in this review, we summarize the effects of a selected set of feeding-related peptides and hormones acting within the ventral tegmental area and nucleus accumbens to alter feeding, as well as food, drug, and social reward. |
2023-05-23 |
2023-08-14 |
Not clear |
| Julia M Kirkland, Erin L Edgar, Ishan Patel, Ashley M Kope. Impaired microglia-mediated synaptic pruning in the nucleus accumbens during adolescence results in persistent dysregulation of familiar, but not novel social interactions in sex-specific ways. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205324. |
the nucleus accumbens (nac) is an intermediate reward relay center that develops during adolescence and mediates both social behaviors and dopaminergic signaling. |
2023-05-19 |
2023-08-14 |
human |
| J M Kirkland, Ishan Patel, Monali S Ardeshna, Ashley M Kope. Microglial synaptic pruning in the nucleus accumbens during adolescence sex-specifically influences splenic immune outcomes. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205376. |
we published that microglia-mediated synaptic pruning occurs in the nucleus accumbens (nac) reward region during adolescence to mediate social development in male and female rats. |
2023-05-19 |
2023-08-14 |
rat |
| J M Kirkland, Ishan Patel, Ashley M Kope. Microglia-mediated synaptic pruning in the nucleus accumbens during adolescence: A preliminary study of the proteomic consequences and putative female-specific pruning target. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205455. |
we published that microglia-c3-mediated synaptic pruning also occurs in the nucleus accumbens (nac) reward region during adolescence to mediate social development in male and female rats. |
2023-05-19 |
2023-08-14 |
rat |
| Amanda G Iglesias, Alvin S Chiu, Jason Wong, Paolo Campus, Fei Li, Zitong Nemo Liu, Shiv A Patel, Karl Deisseroth, Huda Akil, Christian R Burgess, Shelly B Flage. Inhibition of dopamine neurons prevents incentive value encoding of a reward cue: With revelations from deep phenotyping. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205506. |
prior work suggests that the behavior of sign-trackers is dopamine-dependent, and cue-elicited dopamine in the nucleus accumbens is believed to encode the incentive value of reward cues. |
2023-05-19 |
2023-08-14 |
rat |
| Tara M Chaplin, Timothy W Curby, Stefanie F Gonçalves, Mallory A Kisner, Claire E Niehaus, James C Thompso. Sex Differences in Emotion- and Reward-Related Neural Responses Predicting Increases in Substance Use in Adolescence. Behavioural brain research. 2023-05-18. PMID:37201893. |
for boys, blunted left nucleus accumbens and bilateral ventromedial prefrontal cortex responses to monetary reward predicted growth in substance use frequency. |
2023-05-18 |
2023-08-14 |
Not clear |
| Cheng-Bo He, Yuan Jin, Yan Li, Qian Zhang, Bai Yang, Mang Xu, Juan Yang, Xi-Nan Yi, Yu-Lin Dong, Jian Wang, Yun-Qing L. Collateral projections from the ventral tegmental area/substantia nigra pars compacta to the nucleus accumbens and insular cortex in the rat. Anatomical science international. 2023-05-10. PMID:37160827. |
previous studies demonstrated that the vta/snc to nucleus accumbens (nac) pathway is critical in reward and motivation. |
2023-05-10 |
2023-08-14 |
rat |
| Cristina E Maria-Rios, Geoffrey G Murphy, Jonathan D Morro. Subregional Differences in Medium Spiny Neuron Intrinsic Excitability Properties between Nucleus Accumbens Core and Shell in Male Rats. eNeuro. 2023-05-08. PMID:37156609. |
the nucleus accumbens (nac) is known for its central role in reward and motivation (day and carelli, 2007; floresco, 2015; salgado and kaplitt, 2015). |
2023-05-08 |
2023-08-14 |
rat |
| Parth Bhatia, Lite Yang, Jay X J Luo, Mengyi Xu, William Rentha. Epigenomic profiling of mouse nucleus accumbens at single-cell resolution. Molecular and cellular neurosciences. 2023-05-03. PMID:37137383. |
the nucleus accumbens (nac) is a key brain region involved in reward processing and is linked to multiple neuropsychiatric conditions such as substance use disorder, depression, and chronic pain. |
2023-05-03 |
2023-08-14 |
mouse |
| Alexandra Sobczak, Mushfa Yousuf, Nico Bunzec. Anticipating social feedback involves basal forebrain and mesolimbic functional connectivity. NeuroImage. 2023-04-24. PMID:37094625. |
therefore, this study investigated regional responses and interregional functional connectivity of the lateral (l), medial (m), and ventral (v) substantia nigra (sn), nucleus accumbens (nacc), nucleus basalis of meynert (nbm), and medial septum/diagonal band (ms/db) during reward and punishment anticipation in a social incentive delay task with neutral, positive, and negative feedback using high-resolution fmri (1.5mm |
2023-04-24 |
2023-08-14 |
Not clear |
| Michał Sobstyl, Angelika Stapińska-Synie. Deep brain stimulation of the medial forebrain bundle for treatment-resistant depression - a narrative literature review. Postepy psychiatrii neurologii. vol 30. issue 3. 2023-04-21. PMID:37082768. |
the main nucleus of the reward circuit is the nucleus accumbens (nac), which plays a critical role in reward-seeking behavior, motivation, and addiction. |
2023-04-21 |
2023-08-14 |
Not clear |
| Lee-Anne Morris, Samuel J Harrison, Tracy R Melzer, John C Dalrymple-Alford, Tim J Anderson, Michael R MacAskill, Campbell J Le Hero. Altered nucleus accumbens functional connectivity precedes apathy in Parkinson's disease. Brain : a journal of neurology. 2023-04-05. PMID:37019846. |
in particular, the nucleus accumbens and anterior cingulate cortex are recognized as key network nodes underlying decisions of whether to exert effort for reward, to drive behaviour. |
2023-04-05 |
2023-08-14 |
human |
| Timothy A Krausz, Alison E Comrie, Loren M Frank, Nathaniel D Daw, Joshua D Berk. Dual credit assignment processes underlie dopamine signals in a complex spatial environment. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993482. |
dopamine in the nucleus accumbens helps motivate behavior based on expectations of future reward ("values"). |
2023-03-30 |
2023-08-14 |
rat |