| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng-Bo He, Yuan Jin, Yan Li, Qian Zhang, Bai Yang, Mang Xu, Juan Yang, Xi-Nan Yi, Yu-Lin Dong, Jian Wang, Yun-Qing L. Collateral projections from the ventral tegmental area/substantia nigra pars compacta to the nucleus accumbens and insular cortex in the rat. Anatomical science international. 2023-05-10. PMID:37160827. |
previous studies demonstrated that the vta/snc to nucleus accumbens (nac) pathway is critical in reward and motivation. |
2023-05-10 |
2023-08-14 |
rat |
| Cristina E Maria-Rios, Geoffrey G Murphy, Jonathan D Morro. Subregional Differences in Medium Spiny Neuron Intrinsic Excitability Properties between Nucleus Accumbens Core and Shell in Male Rats. eNeuro. 2023-05-08. PMID:37156609. |
the nucleus accumbens (nac) is known for its central role in reward and motivation (day and carelli, 2007; floresco, 2015; salgado and kaplitt, 2015). |
2023-05-08 |
2023-08-14 |
rat |
| Parth Bhatia, Lite Yang, Jay X J Luo, Mengyi Xu, William Rentha. Epigenomic profiling of mouse nucleus accumbens at single-cell resolution. Molecular and cellular neurosciences. 2023-05-03. PMID:37137383. |
the nucleus accumbens (nac) is a key brain region involved in reward processing and is linked to multiple neuropsychiatric conditions such as substance use disorder, depression, and chronic pain. |
2023-05-03 |
2023-08-14 |
mouse |
| Michał Sobstyl, Angelika Stapińska-Synie. Deep brain stimulation of the medial forebrain bundle for treatment-resistant depression - a narrative literature review. Postepy psychiatrii neurologii. vol 30. issue 3. 2023-04-21. PMID:37082768. |
the main nucleus of the reward circuit is the nucleus accumbens (nac), which plays a critical role in reward-seeking behavior, motivation, and addiction. |
2023-04-21 |
2023-08-14 |
Not clear |
| Zahra Ebrahimi, Nazanin Kahvandi, Elahe Shahriari, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Maryam Sharifi, Abdolrahman Sarih. VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Brain research bulletin. 2023-03-30. PMID:36997034. |
nucleus accumbens (nac) neurons appear to be at the hub of the reward circuit. |
2023-03-30 |
2023-08-14 |
rat |
| Zahra Fatahi, Mohammad Fatahi, Mirmohammadali Mirramezani Alizamini, Ahmad Ghorbani, Mohammad Ismail Zibaii, Abbas Haghparas. Exogenous Cannabinoids Impair Effort-Related Decision-Making via Affecting Neural Synchronization between the Anterior Cingulate Cortex and Nucleus Accumbens. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979223. |
in this study, neural synchronization and functional connectivity between the nac and acc while endeavor-related decision-making and reaching reward were evaluated. |
2023-03-29 |
2023-08-14 |
Not clear |
| Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C Nairn, Paul Greengard, Marc Flajolet, Denis Herv, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Giraul. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945487. |
these effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (nac). |
2023-03-22 |
2023-08-14 |
Not clear |
| Kyle D Ketchesin, Darius D Becker-Krail, Xiangning Xue, Rashaun S Wilson, TuKiet T Lam, Kenneth R Williams, Angus C Nairn, George C Tseng, Ryan W Loga. Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909659. |
repeated use of substances such as psychostimulants and opioids may lead to significant alterations in molecular rhythms in the nucleus accumbens (nac), a brain region central to reward and motivation. |
2023-03-13 |
2023-08-14 |
mouse |
| Yajie Jiang, Manshu Zou, Yeqing Wang, Yuhong Wan. Nucleus Accumbens in the Pathogenesis of Major Depressive Disorder: A Brief Review. Brain research bulletin. 2023-03-08. PMID:36889362. |
nac,a region critical for reward and motivation,dysregulation of its activity seems to be a hallmark of this mood disorder. |
2023-03-08 |
2023-08-14 |
Not clear |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. |
these results imply, that the ghs-r1a antagonist/jmv2959 might reduce/prevent some of the memory-linked molecular changes elicited by methamphetamine addiction within brain structures associated with memory (hipp), reward (nac), and motivation (mpfc), which may contribute to the previously observed significant jmv2959-induced reduction of the methamphetamine self-administration and drug-seeking behavior in the same animals. |
2023-03-04 |
2023-08-14 |
rat |
| Eric Y Choi, Daniela Franco, Catherine A Stapf, Madeleine Gordin, Amanda Chow, Kara K Cover, Ramesh Chandra, Mary Kay Lob. Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-02-27. PMID:36849419. |
the nucleus accumbens (nac) is a major brain hub mediating reward behavior. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hillary A Wadsworth, Elizabeth Q Anderson, Benjamin M Williams, Joakim W Ronström, Janna K Moen, Anna M Lee, J Michael McIntosh, Jie Wu, Jordan T Yorgason, Scott C Steffense. Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens. Molecular neurobiology. 2023-02-21. PMID:36802012. |
the prevailing view is that enhancement of dopamine (da) transmission in the mesolimbic system, consisting of da neurons in the ventral tegmental area (vta) that project to the nucleus accumbens (nac), underlies the reward properties of ethanol (etoh) and nicotine (nic). |
2023-02-21 |
2023-08-14 |
mouse |
| Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zh. Distinct reward processing by subregions of the nucleus accumbens. Cell reports. vol 42. issue 2. 2023-02-08. PMID:36753418. |
the nucleus accumbens (nac) plays an important role in motivation and reward processing. |
2023-02-08 |
2023-08-14 |
Not clear |
| Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zh. Distinct reward processing by subregions of the nucleus accumbens. Cell reports. vol 42. issue 2. 2023-02-08. PMID:36753418. |
however, how reward is encoded in individual nac neurons remains unclear. |
2023-02-08 |
2023-08-14 |
Not clear |
| Gaowei Chen, Shishi Lai, Guo Bao, Jincan Ke, Xiaogao Meng, Shanshan Lu, Xiaocong Wu, Hua Xu, Fengyi Wu, Yu Xu, Fang Xu, Guo-Qiang Bi, Guangdun Peng, Kuikui Zhou, Yingjie Zh. Distinct reward processing by subregions of the nucleus accumbens. Cell reports. vol 42. issue 2. 2023-02-08. PMID:36753418. |
using in vivo single-cell resolution calcium imaging, we find diverse patterns of reward encoding in the medial and lateral shell subdivision of the nac (nacmed and naclat, respectively). |
2023-02-08 |
2023-08-14 |
Not clear |
| Qiang Lyu, Hecun Zou, Li Luo, Wei Liu, Xiang He, Fei-Fei Shan. The Role of eIF5A1 in LPS-Induced Neuronal Remodeling of the Nucleus Accumbens in the Depression. Journal of integrative neuroscience. vol 22. issue 1. 2023-02-01. PMID:36722231. |
the nucleus accumbens (nac) is a key region in the brain that integrates reward signals. |
2023-02-01 |
2023-08-14 |
Not clear |
| Julianna Cavallaro, Jenna Yeisley, Başak Akdoǧan, Joseph Floeder, Peter D Balsam, Eduardo F Gall. Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711450. |
here, we show that d2r upregulation in cins of the mouse nac increases impulsive choice as measured in a delay discounting task without affecting reward magnitude sensitivity or interval timing. |
2023-01-30 |
2023-08-14 |
mouse |
| Yu-Chen Chan, Tai-Li Cho. Effective connectivity of the amygdala during the consumption of erotic, sexual humor, and monetary rewards with a DCM-PEB approach. PloS one. vol 17. issue 12. 2022-12-29. PMID:36580445. |
the amygdala, nac, and lofc are major dopaminergic targets with known roles in the reward circuitry. |
2022-12-29 |
2023-08-14 |
Not clear |
| Hong Zhou, Jiayu Zhu, Jie Jia, Wei Xiang, Hualing Peng, Yuejin Zhang, Bo Liu, Yangling Mu, Yisheng L. The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus. Neurobiology of stress. vol 21. 2022-12-19. PMID:36532368. |
the nucleus accumbens (nac) is a crucial region in the reward circuit and is related to anhedonia, the pivotal symptom of major depression disorder (mdd). |
2022-12-19 |
2023-08-14 |
mouse |
| He Chen, Limei Chen, Zhirong Yuan, Jiajie Yuan, Yitong Li, Yuesi Xu, Jieyi Wu, Lu Zhang, Guohua Wang, Juan L. Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity. Frontiers in cellular neuroscience. vol 16. 2022-11-21. PMID:36406750. |
in the nac, d1-medium spiny neurons (msns) encode cocaine reward, whereas d2-msns encode aversive responses in drug addiction. |
2022-11-21 |
2023-08-14 |
Not clear |