| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie Puig, Xiangning Xue, Ryan Salisbury, Micah A Shelton, Sam-Moon Kim, Mariah A Hildebrand, Jill R Glausier, Zachary Freyberg, George C Tseng, Anastasia K Yocum, David A Lewis, Marianne L Seney, Matthew L MacDonald, Ryan W Loga. Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens. Molecular psychiatry. 2023-09-06. PMID:37674018. |
previous work indicated molecular rhythm disruptions in the human brain associated with oud, highlighting synaptic alterations in the dorsolateral prefrontal cortex (dlpfc) and nucleus accumbens (nac)-key brain regions involved in cognition and reward, and heavily implicated in the pathophysiology of oud. |
2023-09-06 |
2023-10-07 |
human |
| Pingping Zhao, Xing Chen, Arash Bellafard, Avaneesh Murugesan, Jonathan Quan, Daniel Aharoni, Peyman Golshan. Accelerated social representational drift in the nucleus accumbens in a model of autism. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577515. |
how the nucleus accumbens (nac), as a key hub of reward circuitry, encodes social interaction and whether these representations are altered in asd remain poorly understood. |
2023-08-14 |
2023-08-16 |
Not clear |
| Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C Nairn, Paul Greengard, Marc Flajolet, Denis Hervé, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Giraul. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin. Biological psychiatry. 2023-08-14. PMID:37579933. |
these effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (nac). |
2023-08-14 |
2023-09-07 |
Not clear |
| Anushree N Karkhanis, Alyssa M West, Sara R Jone. Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core. Basic & clinical pharmacology & toxicology. 2023-08-04. PMID:37539456. |
the nucleus accumbens core (nac core) is involved in regulating stress and shaping reward seeking behaviors. |
2023-08-04 |
2023-08-14 |
mouse |
| Anushree N Karkhanis, Alyssa M West, Sara R Jone. Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core. Basic & clinical pharmacology & toxicology. 2023-08-04. PMID:37539456. |
given the importance of nac core, particularly the interaction between kors and dopamine, in regulating reward seeking behaviors we examined the impact of kor activation on dopamine release and uptake along the rostro-caudal axis in the nac core of male and female mice. |
2023-08-04 |
2023-08-14 |
mouse |
| Samah Shahen-Zoabi, Reem Smoum, Alexey Bingor, Etty Grad, Alina Nemirovski, Tawfeeq Shekh-Ahmad, Raphael Mechoulam, Rami Yak. N-oleoyl glycine and N-oleoyl alanine attenuate alcohol self-administration and preference in mice. Translational psychiatry. vol 13. issue 1. 2023-07-31. PMID:37524707. |
we first measured the ecbs and ecb-ls levels in different brain reward system regions following chronic alcohol self-administration using lc-ms. we have found that following chronic intermittent alcohol consumption, n-oleoyl glycine (olgly) levels were significantly elevated in the prefrontal cortex (pfc), and n-oleoyl alanine (olala) was significantly elevated in the pfc, nucleus accumbens (nac) and ventral tegmental area (vta) in a region-specific manner. |
2023-07-31 |
2023-08-14 |
mouse |
| Juan Enriquez-Traba, Hector E Yarur-Castillo, Rodolfo J Flores, Tenley Weil, Snehashis Roy, Ted B Usdin, Christina T LaGamma, Miguel Arenivar, Huikun Wang, Valerie S Tsai, Amy E Moritz, David R Sibley, Rosario Moratalla, Zachary Z Freyberg, Hugo A Tejed. Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425766. |
dopamine release in striatal circuits, including the nucleus accumbens (nac), tracks separable features of reward such as motivation and reinforcement. |
2023-07-10 |
2023-08-14 |
Not clear |
| Juan Enriquez-Traba, Hector E Yarur-Castillo, Rodolfo J Flores, Tenley Weil, Snehashis Roy, Ted B Usdin, Christina T LaGamma, Miguel Arenivar, Huikun Wang, Valerie S Tsai, Amy E Moritz, David R Sibley, Rosario Moratalla, Zachary Z Freyberg, Hugo A Tejed. Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425766. |
paralleling dissociable roles in reward function, we report non-overlapping physiological actions of d3r and d1r signaling in nac neurons. |
2023-07-10 |
2023-08-14 |
Not clear |
| Daniela Neuhofer, Peter Kaliva. Differential modulation of GABAergic and glutamatergic neurons in the ventral pallidum by GABA and neuropeptides. eNeuro. 2023-07-06. PMID:37414552. |
the ventral pallidum (vp) is an integral locus in the reward circuitry and a major target of gabaergic innervation of both d1-medium spiny neurons (msns) and d2-msns from the nucleus accumbens (nac). |
2023-07-06 |
2023-08-14 |
mouse |
| Mathilde C C Guillaumin, Paulius Viskaitis, Eva Bracey, Denis Burdakov, Daria Peleg-Raibstei. Disentangling the role of NAc D1 and D2 cells in hedonic eating. Molecular psychiatry. 2023-07-04. PMID:37402855. |
here, we probed the roles of nac d1 and d2 cells in these processes using cell-specific recording and optogenetic manipulation in diverse behavioral paradigms that disentangle reward traits of 'liking' and 'wanting' related to food choice and overeating in healthy mice. |
2023-07-04 |
2023-08-14 |
mouse |
| Laura Santana Cordón, Domingo Afonso-Oramas, Alejandro Lemus Mesa, Miriam González-Gómez, Pedro Barroso-Chine. Morphological study of neuropeptide Y expression in human and mouse anterior insular cortex: overexpression in the insular cortex and nucleus accumbens in obese mice on a long-term obesogenic diet. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2023-06-24. PMID:37355144. |
brain reward circuits are altered in response to continued intake, in particular the dopaminergic projections from the ventral tegmental area (vta) to the nac. |
2023-06-24 |
2023-08-14 |
mouse |
| Federica Lucantonio, Shuwen Li, Jaden Lu, Jacob Roeglin, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatell. Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333325. |
here, we show that the nucleus accumbens (nac), a major hub of the reward circuitry, is essential for ketamine's effect in rescuing anhedonia in mice subjected to chronic stress, a critical risk factor in the genesis of depression in humans. |
2023-06-19 |
2023-08-14 |
mouse |
| David Levcik, Adam H Sugi, Marcelo Aguilar-Rivera, José A Pochapski, Gabriel Baltazar, Laura N Pulido, Cyrus Villas Boas, Romulo Fuentes-Flores, Saleem M Nicola, Claudio Da Cunh. Nucleus accumbens shell neurons encode the kinematics of reward approach locomotion. Neuroscience. 2023-06-17. PMID:37330195. |
the nucleus accumbens (nac) is considered an interface between motivation and action, with nac neurons playing an important role in promoting reward approach. |
2023-06-17 |
2023-08-14 |
rat |
| David Levcik, Adam H Sugi, Marcelo Aguilar-Rivera, José A Pochapski, Gabriel Baltazar, Laura N Pulido, Cyrus Villas Boas, Romulo Fuentes-Flores, Saleem M Nicola, Claudio Da Cunh. Nucleus accumbens shell neurons encode the kinematics of reward approach locomotion. Neuroscience. 2023-06-17. PMID:37330195. |
these findings suggest that these three classes of nac neurons influence the time course of speed changes during locomotor approach to reward. |
2023-06-17 |
2023-08-14 |
rat |
| Kyle D Ketchesin, Darius D Becker-Krail, Xiangning Xue, Rashaun S Wilson, TuKiet T Lam, Kenneth R Williams, Angus C Nairn, George C Tseng, Ryan W Loga. Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome. Journal of proteome research. 2023-06-13. PMID:37311105. |
repeated use of substances such as psychostimulants and opioids may lead to significant alterations in molecular rhythms in the nucleus accumbens (nac), a brain region central to reward and motivation. |
2023-06-13 |
2023-08-14 |
mouse |
| Zhaosong Chu, Lijin Yuan, Mengxin He, Yuqi Cheng, Yi Lu, Xiufeng Xu, Zonglin She. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270840. |
evidence from previous literature suggests that the nucleus accumbens (nac), hippocampus, and amygdala play critical roles in the reward circuit. |
2023-06-04 |
2023-08-14 |
human |
| Pengbo Jing, Qiang Sha. Exogenous oxytocin microinjection into the nucleus accumbens shell attenuates social dominance in group-housed male mice. Physiology & behavior. 2023-06-03. PMID:37270150. |
the nucleus accumbens (nac), a part of the brain's limbic system, is involved in a variety of brain functions, including reward motivation and social hierarchy. |
2023-06-03 |
2023-08-14 |
mouse |
| Ruijie Jin, Shanbin Sun, Yang Hu, Hongfei Zhang, Xiangrong Su. Neuropeptides Modulate Feeding via the Dopamine Reward Pathway. Neurochemical research. 2023-05-26. PMID:37233918. |
the reward system comprises the ventral tegmental area (vta), nucleus accumbens (nac), hypothalamus, and limbic system. |
2023-05-26 |
2023-08-14 |
Not clear |
| Ruijie Jin, Shanbin Sun, Yang Hu, Hongfei Zhang, Xiangrong Su. Neuropeptides Modulate Feeding via the Dopamine Reward Pathway. Neurochemical research. 2023-05-26. PMID:37233918. |
according to recent literature, neuropeptides released from the hypothalamus and other brain regions regulate reward feeding predominantly through dopaminergic neurons projecting from the vta to the nac. |
2023-05-26 |
2023-08-14 |
Not clear |
| Julianna Cavallaro, Jenna Yeisley, Başak Akdoǧan, Ronald E Salazar, Joseph R Floeder, Peter D Balsam, Eduardo F Gall. Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-05-23. PMID:37221325. |
here, we show that d2r upregulation in cins of the mouse nac increases impulsive choice as measured in a delay discounting task without affecting reward magnitude sensitivity or interval timing. |
2023-05-23 |
2023-08-14 |
mouse |