| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B I Ghanaye. NTP technical report on the toxicity studies of methacrylonitrile (CAS No. 126-98-7). Administered by gavage to F344/N rats and B6C3F1 mice. Toxicity report series. issue 47. 2002-02-19. PMID:11803706. |
male and female rats administered 60 mg/kg and females administered 120 mg/kg had significantly greater incidences of metaplasia of the nasal olfactory epithelium on day 32 and at the end of the study than did the vehicle controls; incidences of olfactory epithelial necrosis were also significantly greater in females in the 60 and 120 mg/kg groups than in the vehicle controls on day 32. |
2002-02-19 |
2023-08-12 |
mouse |
| E L Coate. Olfactory CO(2) chemoreceptors. Respiration physiology. vol 129. issue 1-2. 2002-02-12. PMID:11738656. |
in amphibians, it has been shown that inhibition of the enzyme, carbonic anhydrase (ca), attenuates the response of co(2)-sensitive olfactory receptors to transient changes in nasal co(2). |
2002-02-12 |
2023-08-12 |
rat |
| E L Coate. Olfactory CO(2) chemoreceptors. Respiration physiology. vol 129. issue 1-2. 2002-02-12. PMID:11738656. |
the objectives of this review are to, (1) summarize the current state of knowledge of olfactory co(2) receptors in amphibians, reptiles, and mammals; (2) present results from an experiment designed to determine the distribution and density of ca activity within the rat nasal cavity; (3) show results from an experiment that recorded the olfactory receptor response to co(2) in areas of the rat nasal cavity exhibiting the highest densities of ca activity; and (4) discuss the presumed role of the olfactory co(2) receptors in the control of breathing and in abnormalities of breathing, such as sudden infant death syndrome (sids). |
2002-02-12 |
2023-08-12 |
rat |
| D E Hornung, D J Smith, D B Kurtz, T White, D A Leopol. Effect of nasal dilators on nasal structures, sniffing strategies, and olfactory ability. Rhinology. vol 39. issue 2. 2002-01-24. PMID:11486444. |
effect of nasal dilators on nasal structures, sniffing strategies, and olfactory ability. |
2002-01-24 |
2023-08-12 |
Not clear |
| D E Hornung, D J Smith, D B Kurtz, T White, D A Leopol. Effect of nasal dilators on nasal structures, sniffing strategies, and olfactory ability. Rhinology. vol 39. issue 2. 2002-01-24. PMID:11486444. |
this paper describes the effects that nasal dilators have on olfactory ability. |
2002-01-24 |
2023-08-12 |
Not clear |
| E Sacerdote de Lustig, A D Josiowic. [Olfactory mucosa: a continuous source of neurons]. Medicina. vol 61. issue 5 Pt 1. 2002-01-22. PMID:11721332. |
we suggest the use of neuronal precursor cells from the nasal olfactory mucosa as an alternative source for transplantation therapy, since these peripheric cells exhibit stem cell characteristics. |
2002-01-22 |
2023-08-12 |
Not clear |
| K Fujihashi, H Kato, F W van Ginkel, T Koga, P N Boyaka, R J Jackson, R Kato, Y Hagiwara, Y Etani, I Goma, K Fujihashi, H Kiyono, J R McGhe. A revisit of mucosal IgA immunity and oral tolerance. Acta odontologica Scandinavica. vol 59. issue 5. 2001-12-28. PMID:11680650. |
when we examined the potential toxicity of ct for the central nervous system, both ct and ct-b accumulated in the olfactory nerves/epithelium and olfactory bulbs of mice when given by the nasal route. |
2001-12-28 |
2023-08-12 |
mouse |
| J E Cometto-Muñiz, W S Cain, M H Abraham, J M Gol. Ocular and nasal trigeminal detection of butyl acetate and toluene presented singly and in mixtures. Toxicological sciences : an official journal of the Society of Toxicology. vol 63. issue 2. 2001-12-12. PMID:11568367. |
(to avoid olfactory biases, nasal pungency was measured in a group of anosmics, i.e., persons lacking a functional sense of smell.) |
2001-12-12 |
2023-08-12 |
Not clear |
| T Koujitani, K Yasuhara, K Toyosawa, A Shimada, H Onodera, H Takagi, T Tamura, M Hirose, K Mitsumor. Immunohistochemical and ultrastructural studies of 2,6-dimethylaniline-induced nasal proliferative lesions in a rat two-stage nasal carcinogenesis model initiated with N-bis(2-hydroxypropyl)nitrosamine. Toxicologic pathology. vol 29. issue 3. 2001-12-04. PMID:11442016. |
these nasal lesions mostly arose in the olfactory mucosa of the nasal cavity. |
2001-12-04 |
2023-08-12 |
rat |
| S I Vento, M Simola, L O Ertama, C H Malmber. Sense of smell in long-standing nasal polyposis. American journal of rhinology. vol 15. issue 3. 2001-12-04. PMID:11453501. |
in a forward stepwise multiple regression analysis of all the polyposis patients, the degree of opacity of ethmoidal sinuses seen in computed tomography (ct), polyposis visible in anterior rhinoscopy, total nasal resistance, and gender had a significant association with olfactory threshold. |
2001-12-04 |
2023-08-12 |
Not clear |
| T Green, R Lee, A Toghill, S Meadowcroft, V Lund, J Foste. The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans. Chemico-biological interactions. vol 137. issue 2. 2001-12-04. PMID:11551533. |
in this study, the nasal tissues of mice exposed to 40 and 160 ppm styrene 6 h/day for 3 days had a number of degenerative changes including atrophy of the olfactory mucosa and loss of normal cellular organisation. |
2001-12-04 |
2023-08-12 |
mouse |
| M Mezler, J Fleischer, S Conzelmann, A Korchi, P Widmayer, H Breer, I Boekhof. Identification of a nonmammalian Golf subtype: functional role in olfactory signaling of airborne odorants in Xenopus laevis. The Journal of comparative neurology. vol 439. issue 4. 2001-12-04. PMID:11596062. |
the selective expression of different galpha subtypes in the two anatomically separated and functionally specialized nasal compartments parallels the expression of distinct classes of olfactory receptors. |
2001-12-04 |
2023-08-12 |
human |
| B Rydzewski, A Pruszewicz, W J Sulkowsk. Assessment of smell and taste in patients with allergic rhinitis. Acta oto-laryngologica. vol 120. issue 2. 2001-12-04. PMID:11603799. |
there was a statistically significant relationship between the olfactory thresholds and levels of eosinophils in blood and in nasal discharge. |
2001-12-04 |
2023-08-12 |
Not clear |
| V J Feron, J H Arts, C F Kuper, P J Slootweg, R A Wouterse. Health risks associated with inhaled nasal toxicants. Critical reviews in toxicology. vol 31. issue 3. 2001-11-01. PMID:11405443. |
health risks of inhaled nasal toxicants were reviewed with emphasis on chemically induced nasal lesions in humans, sensory irritation, olfactory and trigeminal nerve toxicity, nasal immunopathology and carcinogenesis, nasal responses to chemical mixtures, in vitro models, and nasal dosimetry- and metabolism-based extrapolation of nasal data in animals to humans. |
2001-11-01 |
2023-08-12 |
human |
| V J Feron, J H Arts, C F Kuper, P J Slootweg, R A Wouterse. Health risks associated with inhaled nasal toxicants. Critical reviews in toxicology. vol 31. issue 3. 2001-11-01. PMID:11405443. |
against the background of chemoperception as a dominant window of the brain on the outside world, nasal neurotoxicology is rapidly developing, focusing on olfactory and trigeminal nerve toxicity. |
2001-11-01 |
2023-08-12 |
human |
| Y Suzuki, M Takeda, N Obara, Y Naga. A comparative study of an olfactory epithelial area lacking olfactory neurons and a nearby presence of TGF-alpha-like immunoreactive olfactory neurons. Anatomy and embryology. vol 203. issue 4. 2001-10-25. PMID:11396851. |
our previous study has shown that ddy mice have special patches of nasal epithelium in the posterior roof of the nasal cavity that exclusively consists of olfactory supporting cells and horizontal basal cells. |
2001-10-25 |
2023-08-12 |
mouse |
| M Dahlin, B Jansson, E Björ. Levels of dopamine in blood and brain following nasal administration to rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 14. issue 1. 2001-10-18. PMID:11457653. |
the aim of this study was to investigate the levels of [(3)h]dopamine in blood, the cerebrospinal fluid (csf) and brain tissue samples in rats and to find out whether the drug is transferred along the olfactory pathway to the central nervous system following nasal administration. |
2001-10-18 |
2023-08-12 |
rat |
| J C Walker, M Kendal-Reed, M J Utell, W S Cai. Human breathing and eye blink rate responses to airborne chemicals. Environmental health perspectives. vol 109 Suppl 4. 2001-10-18. PMID:11544155. |
experiments with very brief nasal-only presentations also suggest the value of breathing changes as sensitive markers of irritation: (a) tidal volume is inversely related to perceived nasal irritation (ni) intensity in both normal and anosmic (lacking olfactory input) individuals, although normals exhibit greater ni sensitivity. |
2001-10-18 |
2023-08-12 |
human |
| P Bonfils, R Jankowski, A Werne. [Smell dysfunction in nasal and paranasal sinus disease: a review of the literature (I)]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris. vol 118. issue 3. 2001-10-04. PMID:11431587. |
benign and malignant neoplasms can obstruct the nasal chamber and thereby alter airflow to the olfactory receptors without damaging the olfactory neuroepithelium. |
2001-10-04 |
2023-08-12 |
Not clear |
| P Bonfils, R Jankowski, P Faulco. [Smell dysfunction in nasal and paranasal sinus disease: a review of the literature (II)]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris. vol 118. issue 3. 2001-10-04. PMID:11431588. |
benign and malignant neoplasms can obstruct the nasal chamber and thereby alter airflow to the olfactory receptors without damaging the olfactory neuroepithelium. |
2001-10-04 |
2023-08-12 |
Not clear |