| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fujio Umehara, Kenichi Mishima, Nobuaki Egashira, Ayumi Ogata, Katsunori Iwasaki, Michihiro Fujiwar. Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice. Behavioural brain research. vol 174. issue 1. 2006-11-28. PMID:16952407. |
to investigate the functional role of desert hedgehog (dhh) gene in the nervous system, we examined motor, sensory, learning and memory functions as well as mood in dhh knockout (ko) mice. |
2006-11-28 |
2023-08-12 |
mouse |
| F X Brennan, D S Albeck, R Paylo. Fmr1 knockout mice are impaired in a leverpress escape/avoidance task. Genes, brain, and behavior. vol 5. issue 6. 2006-11-01. PMID:16923151. |
unfortunately, a number of studies have found no consistent, robust learning and memory impairment in the fmr1 ko mice. |
2006-11-01 |
2023-08-12 |
mouse |
| Takeshi Yamashita, Seiji Inui, Kazuhiko Maeda, Ding Rong Hua, Katsumasa Takagi, Kohji Fukunaga, Nobuo Sakaguch. Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory. Brain research. vol 1082. issue 1. 2006-07-13. PMID:16516168. |
this n-alpha4 ko mouse showed impaired learning and memory in a water maze and also shuttle-box avoidance test. |
2006-07-13 |
2023-08-12 |
mouse |
| Alma Rodenas-Ruano, Miguel A Perez-Pinzon, Edward J Green, Mark Henkemeyer, Daniel J Lieb. Distinct roles for ephrinB3 in the formation and function of hippocampal synapses. Developmental biology. vol 292. issue 1. 2006-05-11. PMID:16466709. |
consistent with previous reports, we find that ephrinb3(ko) null mutant mice exhibit a striking reduction in ca3-ca1 ltp that is associated with defective learning and memory tasks. |
2006-05-11 |
2023-08-12 |
mouse |
| Jérôme Jourquin, Evelyne Tremblay, Anne Bernard, Gérard Charton, Franck A Chaillan, Evelyne Marchetti, François S Roman, Paul D Soloway, Vincent Dive, Athanasios Yiotakis, Michel Khrestchatisky, Santiago River. Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. The European journal of neuroscience. vol 22. issue 10. 2006-01-17. PMID:16307599. |
in addition, we demonstrate that learning and memory are impaired in untreated ko mice. |
2006-01-17 |
2023-08-12 |
mouse |
| Liselotte Kirchner, Rachel Weitzdoerfer, Harald Hoeger, Angelika Url, Peter Schmidt, Mario Engelmann, Santiago Rosell Villar, Michael Fountoulakis, Gert Lubec, Barbara Lube. Impaired cognitive performance in neuronal nitric oxide synthase knockout mice is associated with hippocampal protein derangements. Nitric oxide : biology and chemistry. vol 11. issue 4. 2005-05-04. PMID:15604044. |
we therefore decided to study learning and memory functions and cognitive flexibility in the morris water maze (mwm) in 1-month-old male mice lacking nnos (nnos ko). |
2005-05-04 |
2023-08-12 |
mouse |
| Jean Chen Shi. Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B. Neurotoxicology. vol 25. issue 1-2. 2004-04-01. PMID:14697877. |
mao a ko mice showed increased emotional learning and memory and aggressive behavior, but the vesicular monoamine transporter (vmat2), 5-ht1a, 5-ht2a and 5-ht2c receptors were down regulated. |
2004-04-01 |
2023-08-12 |
mouse |
| Junfang Wu, Kuo-Ping Huang, Freesia L Huan. Participation of NMDA-mediated phosphorylation and oxidation of neurogranin in the regulation of Ca2+- and Ca2+/calmodulin-dependent neuronal signaling in the hippocampus. Journal of neurochemistry. vol 86. issue 6. 2003-10-17. PMID:12950461. |
these findings support the hypothesis that the derangement of hippocampal signal transduction cascades in ng ko mice causes the deficits in synaptic plasticity, learning and memory that occur in these mice. |
2003-10-17 |
2023-08-12 |
mouse |
| Mei Qin, Julia Kang, Carolyn Beebe Smit. Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 24. 2003-01-14. PMID:12427968. |
our finding of impaired performance of fmr1 ko mice on a passive avoidance task is suggestive of a deficit in learning and memory. |
2003-01-14 |
2023-08-12 |
mouse |
| Junfang Wu, Junfa Li, Kuo-Ping Huang, Freesia L Huan. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse. The Journal of biological chemistry. vol 277. issue 22. 2002-07-02. PMID:11912190. |
97, 11232-11237) that these ko mice displayed no obvious neuroanatomical abnormality, but exhibited deficits in learning and memory and activation of ca(2+)/cam-dependent protein kinase ii. |
2002-07-02 |
2023-08-12 |
mouse |
| Junfang Wu, Junfa Li, Kuo-Ping Huang, Freesia L Huan. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse. The Journal of biological chemistry. vol 277. issue 22. 2002-07-02. PMID:11912190. |
these results suggest that ng plays a pivotal role in regulating both pkc- and pka-mediated signaling pathways, and that the deficits in learning and memory of spatial tasks detected in the ko mice may be the result of defects in the signaling pathways leading to the phosphorylation of creb. |
2002-07-02 |
2023-08-12 |
mouse |
| Z Sarnyai, E L Sibille, C Pavlides, R J Fenster, B S McEwen, M Tot. Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11121072. |
to test whether a deficit in 5-ht(1a) receptors impairs hippocampus-related functions, we studied hippocampal-dependent learning and memory, synaptic plasticity in the hippocampus, and limbic neuronal excitability in 5-ht(1a)-knockout (ko) mice. |
2001-02-15 |
2023-08-12 |
mouse |