All Relations between learning and memory and ko

Publication Sentence Publish Date Extraction Date Species
Wanting Li, Yan Yu, Dongze Li, Na Xu, Jidong Fang, Yeying Sun, Maolei Xu, Xi Wang, Xin Han, Xiuli Zhang, Changjun Lv, Fang Ha. TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits. International immunopharmacology. vol 81. 2021-01-06. PMID:32058931. in this study, wild-type (wt) and tlr2 knock out (ko) mice were exposed to cih for 8 weeks, and their social novelty discrimination, spatial learning and memory were severely compromised. 2021-01-06 2023-08-13 mouse
Zhu Zhu, Wu Yichen, Zhang Ziheng, Ge Dinghao, Lu Ming, Liu Wei, Shan Enfang, Hu Gang, Hiroaki Honda, Yang Jia. The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling. Aging. vol 11. issue 24. 2020-11-10. PMID:31884423. but there is no significant difference in spatial learning and memory skills between wt and dec1 ko mice. 2020-11-10 2023-08-13 mouse
Rotem Volkman, Tali Ben-Zur, Anat Kahana, Ben Zion Garty, Daniel Offe. Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer's Disease. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31611761. behavioral examinations of 5xfad-mpo ko showed significant superior performance in spatial learning and memory, associative learning, and anxiety/risk assessment behavior, as compared to 5xfad mice transplanted with wt cells (5xfad-wt). 2020-09-30 2023-08-13 mouse
Claudia Fuchs, Norma Fustini, Stefania Trazzi, Laura Gennaccaro, Roberto Rimondini, Elisabetta Cian. Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice. The European journal of neuroscience. vol 47. issue 9. 2019-11-19. PMID:29603837. using a cdkl5 knockout (ko) mouse model, we recently demonstrated that deficiency of cdkl5 causes defects in postnatal hippocampal development and hippocampus-dependent learning and memory. 2019-11-19 2023-08-13 mouse
Kento Usuda, Takahiro Kawase, Yuko Shigeno, Susumu Fukuzawa, Kazuki Fujii, Haolin Zhang, Takamitsu Tsukahara, Shozo Tomonaga, Gen Watanabe, Wanzhu Jin, Kentaro Nagaok. Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory. Scientific reports. vol 8. issue 1. 2019-10-17. PMID:30038322. compared to wild-type mice, lao1 ko mice exhibited impaired fear learning and memory function in a passive avoidance test. 2019-10-17 2023-08-13 mouse
Kento Usuda, Takahiro Kawase, Yuko Shigeno, Susumu Fukuzawa, Kazuki Fujii, Haolin Zhang, Takamitsu Tsukahara, Shozo Tomonaga, Gen Watanabe, Wanzhu Jin, Kentaro Nagaok. Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory. Scientific reports. vol 8. issue 1. 2019-10-17. PMID:30038322. based on our findings, we propose that lao1 ko mice exhibited impaired fear learning and memory owing to low hippocampal acetylcholine levels. 2019-10-17 2023-08-13 mouse
Kirstan Gimse, Ryan C Gorzek, Andrew Olin, Sue Osting, Corinna Burge. Hippocampal Homer1b/c is necessary for contextual fear conditioning and group I metabotropic glutamate receptor mediated long-term depression. Neurobiology of learning and memory. vol 156. 2019-09-16. PMID:30336208. we have previously found that overexpression of hippocampal homer1c is sufficient to rescue learning and memory ability in aged learning impaired rats and in homer1 knockout (ko) mice, and to rescue group i metabotropic glutamate receptor (mglur1/5) mediated long-term potentiation in ko mice. 2019-09-16 2023-08-13 mouse
Sujin Kim, Boyoung Lee, Jung-Hwa Choi, Jong-Hyun Kim, Cheol-Hee Kim, Hee-Sup Shi. Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice. Scientific reports. vol 7. issue 1. 2019-07-12. PMID:29184127. sam3 ko mice did not exhibit changes in other behaviors, including locomotor activities, fear learning and memory, and object recognition memory. 2019-07-12 2023-08-13 mouse
Su-Man Kim, Bo-Ram Mun, Sun-Jun Lee, Yechan Joh, Hwa-Youn Lee, Kon-Young Ji, Ha-Rim Choi, Eun-Hee Lee, Eun-Mi Kim, Ji-Hye Jang, Hyeong-Woo Song, Inhee Mook-Jung, Won-Seok Choi, Hyung-Sik Kan. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28894284. we found that learning and memory functions were improved in aged trem2 tg mice, with the opposite effects in ko mice. 2019-06-11 2023-08-13 mouse
Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. behavioral testing for spatial learning and memory on the morris water maze (mwm) revealed that while bhlhe40 ko mice performed similarly to wt controls initially, when the hidden platform was moved to the opposite quadrant bhlhe40 ko mice showed impairments in relearning, consistent with decreased hippocampal synaptic plasticity. 2018-07-30 2023-08-13 mouse
Robert K Filipkowski, Leszek Kaczmare. Severely impaired adult brain neurogenesis in cyclin D2 knock-out mice produces very limited phenotypic changes. Progress in neuro-psychopharmacology & biological psychiatry. vol 80. issue Pt A. 2018-07-05. PMID:28433461. surprisingly, the studies have revealed that cyclin d2 ko mice did not show major deficits in several behavioral paradigms assessing hippocampal learning and memory. 2018-07-05 2023-08-13 mouse
Teresa M Ferrara-Bowens, Jessica K Chandler, Michelle A Guignet, James F Irwin, Kevin Laitipaya, Devin D Palmer, Lukas J Shumway, Laura B Tucker, Joseph T McCabe, Matthew D Wegner, Erik A Johnso. Neuropathological and behavioral sequelae in IL-1R1 and IL-1Ra gene knockout mice after soman (GD) exposure. Neurotoxicology. vol 63. 2018-06-25. PMID:28866071. compared to wt mice, il-1r1 and il-1ra ko mice had spatial learning and memory impairments in the barnes maze. 2018-06-25 2023-08-13 mouse
Matthias Fischer, Victoria Cabello, Sandy Popp, Sven Krackow, Leif Hommers, Jürgen Deckert, Klaus-Peter Lesch, Angelika G Schmitt-Böhre. Rsk2 Knockout Affects Emotional Behavior in the IntelliCage. Behavior genetics. vol 47. issue 4. 2018-03-22. PMID:28585192. the rsk2 ko mouse model was shown to have learning and memory defects. 2018-03-22 2023-08-13 mouse
Morris H Scantlebury, Kyoung-Chul Chun, Shun-Chieh Ma, Jong M Rho, Do Young Ki. Adrenocorticotropic hormone protects learning and memory function in epileptic Kcna1-null mice. Neuroscience letters. vol 645. 2017-10-10. PMID:28249786. we tested whether acth can ameliorate the intrinsic impairment of hippocampal-based learning and memory in epileptic kcna1-null (ko) mice. 2017-10-10 2023-08-13 mouse
Courtney Lane-Donovan, Wen Mai Wong, Murat S Durakoglugil, Catherine R Wasser, Shan Jiang, Xunde Xian, Joachim Her. Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 39. 2017-08-22. PMID:27683909. we found that these brain apoe knock-out (beko) mice had synaptic loss and dysfunction similar to that of apoe ko mice; however, the beko mice did not have the learning and memory impairment observed in apoe ko mice. 2017-08-22 2023-08-13 mouse
Thomas C Jaramillo, Haley E Speed, Zhong Xuan, Jeremy M Reimers, Shunan Liu, Craig M Powel. Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism. Autism research : official journal of the International Society for Autism Research. vol 9. issue 3. 2017-01-11. PMID:26559786. behaviorally, both shank3(e4-9) heterozygous (het) and shank3(e4-9) ko mice display increased repetitive grooming, deficits in novel and spatial object recognition learning and memory, and abnormal ultrasonic vocalizations. 2017-01-11 2023-08-13 mouse
Sandy Blin, Ismail Ben Soussia, Eun-Jin Kim, Frédéric Brau, Dawon Kang, Florian Lesage, Delphine Biche. Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 15. 2016-12-13. PMID:27035965. trek/traak ko mice display altered phenotypes related to nociception, neuroprotection afforded by polyunsaturated fatty acids, learning and memory, mood control, and sensitivity to general anesthetics. 2016-12-13 2023-08-13 mouse
R Michelle Saré, Merlin Levine, Carolyn Beebe Smit. Behavioral Phenotype of Fmr1 Knock-Out Mice during Active Phase in an Altered Light/Dark Cycle. eNeuro. vol 3. issue 2. 2016-12-13. PMID:27294193. we report that phase did not alter the fmr1 ko phenotype in open field activity, anxiety, and learning and memory. 2016-12-13 2023-08-13 mouse
Laura K Fonken, Andrew D Gaudet, Kristopher R Gaier, Randy J Nelson, Phillip G Popovic. MicroRNA-155 deletion reduces anxiety- and depressive-like behaviors in mice. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26555429. mir-155 ko mice had no deficiencies in learning and memory (barnes maze) or social preference/novelty suggesting that changes in mood were specific. 2016-10-19 2023-08-13 mouse
Siyiti Amuti, Yuchun Tang, Shuang Wu, Lifen Liu, Liang Huang, Haibo Zhang, Huanhuan Li, Fen Jiang, Geying Wang, Xiaoqing Liu, Qionglan Yua. Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway. Neurobiology of learning and memory. vol 127. 2016-10-19. PMID:26691780. to test this hypothesis, we generated np65 knock-out (ko) mice and found that the null mice exhibited enhanced hippocampus-dependent learning and memory as manifested by morris water maze test and step-through passive avoidance test, but showed anxiety-like behaviors as manifested by open field test and light/dark exploration test. 2016-10-19 2023-08-13 mouse