All Relations between learning and memory and ko

Publication Sentence Publish Date Extraction Date Species
Joshua Sariñana, Susumu Tonegaw. Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory. Hippocampus. vol 26. issue 1. 2016-10-13. PMID:26174222. because f-d1r ko mice showed water-maze deficits we tested the necessity of hippocampal d1r activation for spatial learning and memory. 2016-10-13 2023-08-13 mouse
Mei Qin, Zachary Zeidler, Kristen Moulton, Leland Krych, Zengyan Xia, Carolyn B Smit. Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome. Behavioural brain research. vol 291. 2016-03-28. PMID:25979787. in a mouse model (fmr1 knockout (ko)) of fxs, a deficit in performance on the passive avoidance test of learning and memory is a robust phenotype. 2016-03-28 2023-08-13 mouse
Qiaoqiao Shi, Kenneth J Colodner, Sarah B Matousek, Katherine Merry, Soyon Hong, Jessica E Kenison, Jeffrey L Frost, Kevin X Le, Shaomin Li, Jean-Cosme Dodart, Barbara J Caldarone, Beth Stevens, Cynthia A Lemer. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 38. 2015-12-29. PMID:26400934. aged c3 ko mice also performed better on learning and memory tests than aged wt mice. 2015-12-29 2023-08-13 mouse
Michael Bubser, Thomas M Bridges, Ditte Dencker, Robert W Gould, Michael Grannan, Meredith J Noetzel, Atin Lamsal, Colleen M Niswender, J Scott Daniels, Michael S Poslusney, Bruce J Melancon, James C Tarr, Frank W Byers, Jürgen Wess, Mark E Duggan, John Dunlop, Michael W Wood, Nicholas J Brandon, Michael R Wood, Craig W Lindsley, P Jeffrey Conn, Carrie K Jone. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25137629. vu0467154 produced a robust dose-dependent reversal of mk-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions, including the touchscreen pairwise visual discrimination task in wild-type mice, but failed to reverse these stimulant-induced deficits in m4 ko mice. 2015-11-02 2023-08-13 mouse
Eric Detrait, Tangui Maurice, Etienne Hanon, Karine Leclercq, Yves Lambert. Lack of synaptic vesicle protein SV2B protects against amyloid-β₂₅₋₃₅-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Behavioural brain research. vol 271. 2015-08-14. PMID:24937053. sv2b ko mice showed normal learning and memory abilities in absence of aβ25-35 injection. 2015-08-14 2023-08-13 mouse
Kui Li, Ji-Wei Liu, Zhi-Chuan Zhu, Hong-Tao Wang, Yong Zu, Yong-Jie Liu, Yan-Hong Yang, Zhi-Qi Xiong, Xu Shen, Rui Chen, Jing Zheng, Ze-Lan H. DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test. International journal of clinical and experimental pathology. vol 7. issue 10. 2015-07-09. PMID:25400726. in water maze test, however, the dstyk homozygous ko mice show impaired capabilities of learning and memory compared with the dstyk heterozygous ko mice. 2015-07-09 2023-08-13 mouse
Li-Yun Tsai, Yu-Wei Chang, Pei-Yi Lin, Hsin-Jung Chou, Ta-Jen Liu, Ping-Tao Lee, Wen-Hsuan Huang, Yueh-Liang Tsou, Yi-Shuian Huan. CPEB4 knockout mice exhibit normal hippocampus-related synaptic plasticity and memory. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386439. no difference was found in the anxiety level, motor coordination, hippocampus-dependent learning and memory between the ko mice and their wild-type (wt) littermates. 2015-02-23 2023-08-12 mouse
Balapal S Basavarajappa, Nagaraja N Nagre, Shan Xie, Shivakumar Subbann. Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice. Hippocampus. vol 24. issue 7. 2015-01-26. PMID:24648181. here the effects of aea on long-term potentiation (ltp), hippocampal-dependent learning and memory tasks, perk1/2, pcamkiv, and pcreb signaling events in both cannabinoid receptor type 1 (cb1r) wild-type (wt) and knockout (ko) mice were assessed following administration of urb597, an inhibitor of the fatty acid amide hydrolase (faah). 2015-01-26 2023-08-12 mouse
Celia González-Castillo, Daniel Ortuño-Sahagún, Carolina Guzmán-Brambila, Mercè Pallàs, Argelia Esperanza Rojas-Mayorquí. Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus. Frontiers in cellular neuroscience. vol 8. 2015-01-26. PMID:25620911. specifically in hippocampus, recent evidence from ptn knock-out (ko) mice involves ptn functioning in learning and memory. 2015-01-26 2023-08-13 mouse
Xiaojuan He, Masato Ishizeki, Naoki Mita, Seitaro Wada, Yoshifumi Araki, Hiroo Ogura, Manabu Abe, Maya Yamazaki, Kenji Sakimura, Katsuhiko Mikoshiba, Takafumi Inoue, Toshio Ohshim. Cdk5/p35 is required for motor coordination and cerebellar plasticity. Journal of neurochemistry. vol 131. issue 1. 2014-11-21. PMID:24802945. we previously showed that p35(-/-) (p35 ko) mice exhibited a subtle abnormality in brain structure and impaired spatial learning and memory. 2014-11-21 2023-08-13 mouse
Ricky Maung, Melanie M Hoefer, Ana B Sanchez, Natalia E Sejbuk, Kathryn E Medders, Maya K Desai, Irene C Catalan, Cari C Dowling, Cyrus M de Rozieres, Gwenn A Garden, Rossella Russo, Amanda J Roberts, Roy Williams, Marcus Kau. CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. Journal of immunology (Baltimore, Md. : 1950). vol 193. issue 4. 2014-10-21. PMID:25031461. the ccr5 knockout (ko) also rescues spatial learning and memory in gp120-transgenic mice. 2014-10-21 2023-08-13 mouse
Balapal S Basavarajappa, Shivakumar Subbann. CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations. Hippocampus. vol 24. issue 2. 2014-09-23. PMID:24123667. here, we evaluated the effects of jwh-081 on pcamkiv, pcreb, and perk1/2 signaling events followed by long-term potentiation (ltp), hippocampal-dependent learning and memory tasks using cb1 receptor wild-type (wt) and knockout (ko) mice. 2014-09-23 2023-08-12 mouse
Joaquin N Lugo, Gregory D Smith, Jessica B Morrison, Jessika Whit. Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 12. 2014-07-01. PMID:24241749. we used delayed fear conditioning and trace fear conditioning to determine learning and memory deficits in neuron subset-specific pten (ns-pten) conditional knockout (ko) mice. 2014-07-01 2023-08-12 mouse
Hsu-Wen Chao, Li-Yun Tsai, Yi-Ling Lu, Pei-Yi Lin, Wen-Hsuan Huang, Hsin-Jung Chou, Wen-Hsin Lu, Hsiu-Chen Lin, Ping-Tao Lee, Yi-Shuian Huan. Deletion of CPEB3 enhances hippocampus-dependent memory via increasing expressions of PSD95 and NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155305. to understand whether cpeb3 plays a part in learning and memory, we generated cpeb3 knock-out (ko) mice and found that the null mice exhibited enhanced hippocampus-dependent, short-term fear memory in the contextual fear conditioning test and long-term spatial memory in the morris water maze. 2013-12-23 2023-08-12 mouse
E Azzopardi, M Typlt, B Jenkins, S Schmi. Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice. Genes, brain, and behavior. vol 12. issue 4. 2013-12-11. PMID:23521765. short- and long-term habituation was normal in ko mice for both types of behaviours, evoked or motivated, and they also showed normal learning and memory in the barnes maze. 2013-12-11 2023-08-12 mouse
Roopali Yadav, Brandon G Hillman, Subhash C Gupta, Pratyush Suryavanshi, Jay M Bhatt, Ratnamala Pavuluri, Dustin J Stairs, Shashank M Dravi. Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning. PloS one. vol 8. issue 4. 2013-09-16. PMID:23560106. in the present study we evaluated glud1 ko in learning and memory tests. 2013-09-16 2023-08-12 mouse
Junbing Wu, Shengyi Peng, Rong Wu, Yumin Hao, Guangju Ji, Zengqiang Yua. Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression. Protein & cell. vol 3. issue 6. 2013-06-27. PMID:22723178. however, both the male and female of elderly calhm1 knockout (ko) mice showed similar ability to their wild type littermates in spatial learning and memory retrieving. 2013-06-27 2023-08-12 mouse
Osama Mohamad, Mingke Song, Ling Wei, Shan Ping Y. Regulatory roles of the NMDA receptor GluN3A subunit in locomotion, pain perception and cognitive functions in adult mice. The Journal of physiology. vol 591. issue 1. 2013-06-13. PMID:23006484. glun3a ko mice also showed enhanced recognition and spatial learning and memory functions. 2013-06-13 2023-08-12 mouse
Ying Chen, Christine P Curran, Daniel W Nebert, Krishna V Patel, Michael T Williams, Charles V Vorhee. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. Neurotoxicology and teratology. vol 34. issue 4. 2013-05-22. PMID:22580179. compared with wt, ko mice exhibited: subnormal anxiety in the elevated zero maze; normal overall exploratory open-field activity, but slightly more activity in the peripheral zones; normal acoustic startle and prepulse inhibition reactions; normal novel object recognition with increased time attending to the stimulus objects; slightly reduced latencies to reach a random marked platform in the morris water maze; normal spatial learning and memory in multiple phases of the morris water maze; and significantly greater hyperactivity in response to methamphetamine in the open field. 2013-05-22 2023-08-12 mouse
M Waseem Akhtar, Mi-Sung Kim, Megumi Adachi, Michael J Morris, Xiaoxia Qi, James A Richardson, Rhonda Bassel-Duby, Eric N Olson, Ege T Kavalali, Lisa M Monteggi. In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PloS one. vol 7. issue 4. 2012-08-23. PMID:22496871. we next generated mef2a and mef2d brain-specific double ko (mef2a/ddko) mice and observed deficits in motor coordination and enhanced hippocampal short-term synaptic plasticity, however there were no alterations in learning and memory, schaffer collateral pathway long-term potentiation, or the number of dendritic spines. 2012-08-23 2023-08-12 mouse