All Relations between learning and memory and ko

Publication Sentence Publish Date Extraction Date Species
Joaquin N Lugo, Amy L Brewster, Corinne M Spencer, Anne E Anderso. Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning & memory (Cold Spring Harbor, N.Y.). vol 19. issue 5. 2012-08-14. PMID:22505720. using kv4.2 knockout (ko) mice, we examined the role of kv4.2 in hippocampal-dependent learning and memory. 2012-08-14 2023-08-12 mouse
Joaquin N Lugo, Amy L Brewster, Corinne M Spencer, Anne E Anderso. Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning & memory (Cold Spring Harbor, N.Y.). vol 19. issue 5. 2012-08-14. PMID:22505720. in an attempt to decipher whether increased tonic inhibition contributed to the learning and memory deficits in kv4.2 ko mice, we administered picrotoxin to block gaba(a) receptors (gaba(a)r), and thereby tonic inhibition. 2012-08-14 2023-08-12 mouse
Atsushi Oyagi, Shigeki Moriguchi, Atsumi Nitta, Kenta Murata, Yasuhisa Oida, Kazuhiro Tsuruma, Masamitsu Shimazawa, Kohji Fukunaga, Hideaki Har. Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation. Brain research. vol 1419. 2012-08-03. PMID:21945083. in this study, we assessed the role of hb-egf in learning and memory by testing hb-egf conditional knock-out mice (ko) in two different learning tasks, and evaluated the long-term potentiation (ltp) in hippocampus slices from these mice. 2012-08-03 2023-08-12 mouse
Vincent Fournet, Annie Schweitzer, Caroline Chevarin, Jean-Christophe Deloulme, Michel Hamon, Bruno Giros, Annie Andrieux, Marie-Pascale Martre. The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22146001. in addition, although stop ko mice had a preserved very short-term memory, they failed to perform well in all other learning and memory tasks. 2012-05-03 2023-08-12 mouse
Theodoros Tsetsenis, Thomas J Younts, Chiayu Q Chiu, Pascal S Kaeser, Pablo E Castillo, Thomas C Südho. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 34. 2011-10-27. PMID:21844341. behaviorally, we found that rab3b ko mice exhibit no detectable changes in all basic parameters tested, including the initial phase of learning and memory. 2011-10-27 2023-08-12 mouse
Deepa V Venkitaramani, Paula J Moura, Marina R Picciotto, Paul J Lombros. Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory. The European journal of neuroscience. vol 33. issue 12. 2011-10-24. PMID:21501258. to demonstrate the functional importance of step in learning and memory, we generated step knockout (ko) mice and examined the effect of deletion of step on behavioral performance, as well as the phosphorylation and expression of its substrates. 2011-10-24 2023-08-12 mouse
Emilie Faivre, Victor A Gault, Bernard Thorens, Christian Hölsche. Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. Journal of neurophysiology. vol 105. issue 4. 2011-09-29. PMID:21273318. impairment of recognition and spatial learning and memory of gipr ko mice were found in the object recognition task and a spatial water maze task, respectively. 2011-09-29 2023-08-12 mouse
R M Rodriguiz, K Gadnidze, A Ragnauth, N Dorr, M Yanagisawa, W C Wetsel, L A Dev. Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. Genes, brain, and behavior. vol 7. issue 4. 2011-07-25. PMID:21450041. as ece-2 has been implicated in alzheimer's disease, the deficits in learning and memory in the ko mice may provide unique insights into processes that may contribute to this disease and possible other disorders of cognition. 2011-07-25 2023-08-12 mouse
K B Baker, S P Wray, R Ritter, S Mason, T H Lanthorn, K V Saveliev. Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments. Genes, brain, and behavior. vol 9. issue 6. 2010-12-27. PMID:20398059. our results suggest that procedural factors, such as the use of albino mice, may help to reliably detect spatial learning and memory impairments in both sexes of fmr1 ko mice, making it more useful for understanding fxs and a platform for evaluating potential therapeutics. 2010-12-27 2023-08-12 mouse
Florian Duclot, Chantal Jacquet, Céline Gongora, Tangui Mauric. Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background. Neuroscience letters. vol 475. issue 3. 2010-06-30. PMID:20371377. the possible involvement of pcaf in learning and memory processes or mood disorders was recently assessed by characterizing the behavioural phenotype of pcaf ko mice bred on a cd1 background and revealed short-term memory deficits that evolved with age towards long-term memory alteration and an exaggerated response to stress [10]. 2010-06-30 2023-08-12 mouse
Paul A Adlard, Jacqui M Parncutt, David I Finkelstein, Ashley I Bus. Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease? The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 5. 2010-03-05. PMID:20130173. here, we report that znt3 ko mice exhibit age-dependent deficits in learning and memory that are manifest at 6 months but not at 3 months of age. 2010-03-05 2023-08-12 mouse
Jacqueline Blundell, Cory A Blaiss, Mark R Etherton, Felipe Espinosa, Katsuhiko Tabuchi, Christopher Walz, Marc F Bolliger, Thomas C Südhof, Craig M Powel. Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147539. nl1 knock-out (ko) mice display deficits in spatial learning and memory that correlate with impaired hippocampal long-term potentiation. 2010-03-05 2023-08-12 mouse
Piotr Jaholkowski, Anna Kiryk, Paulina Jedynak, Nada M Ben Abdallah, Ewelina Knapska, Anna Kowalczyk, Agnieszka Piechal, Kamilla Blecharz-Klin, Izabela Figiel, Victoria Lioudyno, Ewa Widy-Tyszkiewicz, Grzegorz M Wilczynski, Hans-Peter Lipp, Leszek Kaczmarek, Robert K Filipkowsk. New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning. Learning & memory (Cold Spring Harbor, N.Y.). vol 16. issue 7. 2009-09-07. PMID:19553382. we used a novel approach, cyclin d2 knockout mice (d2 ko mice), specifically lacking adult brain neurogenesis to verify its importance in learning and memory. 2009-09-07 2023-08-12 mouse
Yann Senechal, Peter H Kelly, Kumlesh K De. Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning. Behavioural brain research. vol 186. issue 1. 2008-02-12. PMID:17884188. app knockout (ko) animals have been described previously and show deficits in grip strength, reduced locomotor activity and impaired learning and memory in a conditioned avoidance test and the morris water-maze. 2008-02-12 2023-08-12 mouse
Peter Curzon, David J Anderson, Arthur L Nikkel, Gerard B Fox, Murali Gopalakrishnan, Michael W Decker, Robert S Bitne. Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment. Neuroscience letters. vol 410. issue 1. 2007-01-23. PMID:17055644. these data demonstrate the ability of this aon to reduce hippocampal and cortical alpha7 nicotinic receptor densities associated with impaired mwm performance and support the specific involvement of the alpha7 nachr in spatial learning and memory, a phenotype not affected in alpha7 ko mice. 2007-01-23 2023-08-12 mouse
Fujio Umehara, Kenichi Mishima, Nobuaki Egashira, Ayumi Ogata, Katsunori Iwasaki, Michihiro Fujiwar. Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice. Behavioural brain research. vol 174. issue 1. 2006-11-28. PMID:16952407. to investigate the functional role of desert hedgehog (dhh) gene in the nervous system, we examined motor, sensory, learning and memory functions as well as mood in dhh knockout (ko) mice. 2006-11-28 2023-08-12 mouse
F X Brennan, D S Albeck, R Paylo. Fmr1 knockout mice are impaired in a leverpress escape/avoidance task. Genes, brain, and behavior. vol 5. issue 6. 2006-11-01. PMID:16923151. unfortunately, a number of studies have found no consistent, robust learning and memory impairment in the fmr1 ko mice. 2006-11-01 2023-08-12 mouse
Takeshi Yamashita, Seiji Inui, Kazuhiko Maeda, Ding Rong Hua, Katsumasa Takagi, Kohji Fukunaga, Nobuo Sakaguch. Regulation of CaMKII by alpha4/PP2Ac contributes to learning and memory. Brain research. vol 1082. issue 1. 2006-07-13. PMID:16516168. this n-alpha4 ko mouse showed impaired learning and memory in a water maze and also shuttle-box avoidance test. 2006-07-13 2023-08-12 mouse
Alma Rodenas-Ruano, Miguel A Perez-Pinzon, Edward J Green, Mark Henkemeyer, Daniel J Lieb. Distinct roles for ephrinB3 in the formation and function of hippocampal synapses. Developmental biology. vol 292. issue 1. 2006-05-11. PMID:16466709. consistent with previous reports, we find that ephrinb3(ko) null mutant mice exhibit a striking reduction in ca3-ca1 ltp that is associated with defective learning and memory tasks. 2006-05-11 2023-08-12 mouse
Jérôme Jourquin, Evelyne Tremblay, Anne Bernard, Gérard Charton, Franck A Chaillan, Evelyne Marchetti, François S Roman, Paul D Soloway, Vincent Dive, Athanasios Yiotakis, Michel Khrestchatisky, Santiago River. Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. The European journal of neuroscience. vol 22. issue 10. 2006-01-17. PMID:16307599. in addition, we demonstrate that learning and memory are impaired in untreated ko mice. 2006-01-17 2023-08-12 mouse