| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
the fmr1 ko mice exhibited stereotypical behavior, impaired social ability, and learning and memory impairment, while rapamycin treatment improved behavioral disorders in fmr1 ko mice. |
2024-06-08 |
2024-06-11 |
mouse |
| Dilan Wellalage Don, Tae-Yoon Kim, Bin Na Hong, Jeong-Soo Lee, Tong Ho Kang, Robert Gerlai, Cheol-Hee Ki. A Simple Tube Escape Assay to Test Learning and Memory in Zebrafish with Minimized Habituation. Zebrafish. 2024-05-15. PMID:38748396. |
we also studied learning and memory of a gene knockout (ko) zebrafish that showed social impairments related to autism. |
2024-05-15 |
2024-05-27 |
zebrafish |
| Chunling Chen, Ronald A Merrill, Chian Ju Jong, Stefan Strac. Driving Mitochondrial Fission Improves Cognitive, but not Motor Deficits in a Mouse Model of Ataxia of Charlevoix-Saguenay. Cerebellum (London, England). 2024-05-12. PMID:38735882. |
however, our studies identified profound learning and memory deficits in aged sacs ko mice. |
2024-05-12 |
2024-05-27 |
mouse |
| Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsa. mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS. EMBO molecular medicine. 2024-02-20. PMID:38374465. |
when evaluating the animals' behavior, we showed that treatment of amn082 reduces repetitive behavior and improves learning and memory in fmr1 ko mice. |
2024-02-20 |
2024-02-22 |
mouse |
| Troy N Trevino, Ali A Almousawi, KaReisha F Robinson, Avital B Fogel, Jake Class, Richard D Minshall, Leon M Tai, Justin M Richner, Sarah E Lut. Caveolin-1 mediates blood-brain barrier permeability, neuroinflammation, and cognitive impairment in SARS-CoV-2 infection. Journal of neuroimmunology. vol 388. 2024-02-09. PMID:38335781. |
moreover, cav-1 ko mice were protected from the learning and memory deficits caused by sars-cov-2 infection. |
2024-02-09 |
2024-02-12 |
mouse |
| Yun-Chieh Tsai, Sheng-Min Huang, Hsu-Hsia Peng, Shu-Wha Lin, Shu-Rung Lin, Ting-Yu Chin, Shih-Ming Huan. Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. Neurobiology of aging. vol 135. 2024-01-04. PMID:38176125. |
the crmp1 knockout (ko) mice display impaired spatial learning and memory, and this phenomenon seemingly tends to deteriorate with age. |
2024-01-04 |
2024-01-07 |
mouse |
| Tayo Katano, Kohtarou Konno, Keizo Takao, Manabu Abe, Akari Yoshikawa, Tsuyoshi Miyakawa, Kenji Sakimura, Masahiko Watanabe, Seiji Ito, Takuya Kobayash. Brain-enriched guanylate kinase-associated protein, a component of the post-synaptic density protein complexes, contributes to learning and memory. Scientific reports. vol 13. issue 1. 2023-12-12. PMID:38086879. |
behavioral tests were performed using begain-knockout (ko) mice to determine the contribution of begain toward learning and memory. |
2023-12-12 |
2023-12-17 |
mouse |
| Troy N Trevino, Avital B Fogel, Richard Minshall, Justin M Richner, Sarah E Lut. Caveolin-1 mediates neuroinflammation and cognitive impairment in SARS-CoV-2 infection. bioRxiv : the preprint server for biology. 2023-10-31. PMID:37905019. |
moreover, cav-1 ko mice were protected from the learning and memory deficits caused by sars-cov-2 infection. |
2023-10-31 |
2023-11-08 |
mouse |
| Hong Ni, Zhongzhao Guo, Yue Wu, Jie Wang, Yang Yang, Zilu Zhu, Deheng Wan. The crucial role that hippocampus Cyclooxygenase-2 plays in memory. The European journal of neuroscience. 2023-10-23. PMID:37867375. |
we found cox-2 gene knockout (ko) could significantly impact the learning and memory ability, cause neuronal structure disorder and influence gamma oscillations. |
2023-10-23 |
2023-11-08 |
Not clear |
| Sergio Vicencio-Jimenez, Paul H Delano, Natalia Madrid, Gonzalo Terreros, Juan C Maass, Carolina Delgado, Pascal Jorrat. Maintained Spatial Learning and Memory Functions in Middle-Aged α9 Nicotinic Receptor Subunit Knock-Out Mice. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239266. |
here, we explored spatial learning and memory performance in middle-aged wild-type (wt) and α9-nachr subunit knock-out (ko) mice using the barnes maze and measured auditory brainstem response (abr) thresholds and the number of cochlear hair cells as a proxy of cochlear aging. |
2023-05-27 |
2023-08-14 |
mouse |
| Dan Xu, Yiqiang Zhi, Xinyi Liu, Le Guan, Jurui Yu, Dan Zhang, Weiya Zhang, Yaqing Wang, Wucheng Tao, Zhiheng X. WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice. Neuroscience bulletin. 2022-12-26. PMID:36571716. |
our study showed that wdr62 knockout (ko) led to reduced brain size with impaired learning and memory, as well as asd-like behaviors in mice. |
2022-12-26 |
2023-08-14 |
mouse |
| Jiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soohyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi, Jong-Hwan Kim, Mirang Kim, Seon-Young Kim, Sun-Kyung Lee, Joohong Ahnn, Hyewhon Rhim, Dong-Gyu Jo, Eunjoon Kim, Mikyoung Par. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway. Molecular psychiatry. 2022-11-26. PMID:36434054. |
in accordance with enhanced ltp, ccny ko mice showed improved spatial learning and memory. |
2022-11-26 |
2023-08-14 |
mouse |
| Jiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soohyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi, Jong-Hwan Kim, Mirang Kim, Seon-Young Kim, Sun-Kyung Lee, Joohong Ahnn, Hyewhon Rhim, Dong-Gyu Jo, Eunjoon Kim, Mikyoung Par. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway. Molecular psychiatry. 2022-11-26. PMID:36434054. |
furthermore, viral-mediated overexpression of a phosphomimetic cofilin-s3e in hippocampal ca1 regions enhanced ltp, weakened ltd, and improved spatial learning and memory flexibility, thus mirroring the phenotype of ccny ko mice. |
2022-11-26 |
2023-08-14 |
mouse |
| Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshim. Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons. Molecular brain. vol 15. issue 1. 2022-04-28. PMID:35484559. |
several lines of conditional cdk5 knockout mice (ko) have been generated and have shown different outcomes for learning and memory. |
2022-04-28 |
2023-08-13 |
mouse |
| Ho Jung Bae, Jaehoon Kim, Hyo Jeoung Bae, Keontae Park, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Se Jin Park, Jong Hoon Ry. Effects of repetitive training on learning and memory performance of TLR2 KO mice. Behavioural brain research. 2022-03-12. PMID:35278481. |
effects of repetitive training on learning and memory performance of tlr2 ko mice. |
2022-03-12 |
2023-08-13 |
mouse |
| Hyun-Ju Lee, Tae-Ik Choi, Yong-Min Kim, Soonje Lee, Bing Han, In Seon Bak, Sun Ae Moon, Dae-Yeul Yu, Ki Soon Shin, Yunhee Kim Kwon, Cheil Moon, Jae Hwan Ryu, Hyang-Sook Hoe, Cheol-Hee Kim, Insop Shi. Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system. Molecular psychiatry. vol 26. issue 8. 2021-10-28. PMID:32989244. |
gng8 ko mice exhibited deficiency in learning and memory in passive avoidance and morris water maze tests. |
2021-10-28 |
2023-08-13 |
mouse |
| Leda Mygind, Marianne Skov-Skov Bergh, Vivien Tejsi, Ramanan Vaitheeswaran, Kate L Lambertsen, Bente Finsen, Athanasios Metaxa. Tumor Necrosis Factor (TNF) Is Required for Spatial Learning and Memory in Male Mice under Physiological, but Not Immune-Challenged Conditions. Cells. vol 10. issue 3. 2021-10-22. PMID:33803476. |
here, we examined the effects of developmental tnf deletion on spatial learning and memory using 11-13-month-old tnf knockout (ko) and c57bl6/j wild-type (wt) mice. |
2021-10-22 |
2023-08-13 |
mouse |
| Maria Gomis-González, Lorena Galera-López, Marc Ten-Blanco, Arnau Busquets-Garcia, Thomas Cox, Rafael Maldonado, Andrés Ozait. Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32996086. |
within the different pkc isoforms, pkc-gamma has been specifically associated with learning and memory since mice lacking this isoform (pkc-gamma ko mice) showed mild cognitive impairment and deficits in hippocampal synaptic plasticity. |
2021-09-01 |
2023-08-13 |
mouse |
| Yulia K Komleva, Olga L Lopatina, Iana V Gorina, Anton N Shuvaev, Anatoly Chernykh, Ilia V Potapenko, Alla B Salmin. NLRP3 deficiency-induced hippocampal dysfunction and anxiety-like behavior in mice. Brain research. vol 1752. 2021-07-22. PMID:33358726. |
these include the following: anxious behavior and deterioration in learning and memory of fear conditioning; impairment of adult neurogenesis; reduction and altered morphology of astrocytes in the brain; hyperexcitability in basolateral amygdala (bla); impaired activation in axons of pyramidal cells of ca1 hippocampal zone in nlrp3 ko mice particularly via the schaffer collateral pathway; and impaired synaptic transduction in pyramidal cells mediated by an embarrassment of neurotransmitter release from presynaptic site in ca3 hippocampal zone. |
2021-07-22 |
2023-08-13 |
mouse |
| Alexandra Badea, Robert Schmalzigaug, Woojoo Kim, Pamela Bonner, Umer Ahmed, G Allan Johnson, Gary Cofer, Mark Foster, Robert J Anderson, Cristian Badea, Richard T Premon. Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging. Magnetic resonance imaging. vol 76. 2021-03-11. PMID:33010377. |
g protein-coupled receptor kinase-interacting protein-1 (git1) regulates neuronal functions, including cell and axon migration and synapse formation and maintenance, and git1 knockout (ko) mice exhibit learning and memory deficits. |
2021-03-11 |
2023-08-13 |
mouse |