| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jerrold S Meyer, Brian J Piper, Valerie E Vancolli. Development and characterization of a novel animal model of intermittent MDMA ("Ecstasy") exposure during adolescence. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991859. |
intermittent adolescent mdma exposure causes later deficits in object-recognition memory, increased impulsivity in the elevated plus-maze, and reduced sensitivity to a 5-ht(1a) agonist challenge. |
2008-12-09 |
2023-08-12 |
human |
| Marika Paaver, Triin Kurrikoff, Niklas Nordquist, Lars Oreland, Jaanus Harr. The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18495314. |
impulsivity has been related to low serotonin turnover, poor regulation of affect, and problems in the family, including child maltreatment. |
2008-11-05 |
2023-08-12 |
Not clear |
| Marika Paaver, Triin Kurrikoff, Niklas Nordquist, Lars Oreland, Jaanus Harr. The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 5. 2008-11-05. PMID:18495314. |
the current study explored the effect of the 5-httlpr polymorphism in the serotonin transporter gene and adverse family environment on impulsivity in adolescents. |
2008-11-05 |
2023-08-12 |
Not clear |
| Gerard J Mare. Cortical 5-hydroxytryptamine2A-receptor mediated excitatory synaptic currents in the rat following repeated daily fluoxetine administration. Neuroscience letters. vol 438. issue 3. 2008-09-26. PMID:18486339. |
the question of 5-ht(2a) receptor sensitivity during chronic administration of antidepressants is important since activation of 5-ht(2a) receptors is associated with impulsivity. |
2008-09-26 |
2023-08-12 |
rat |
| Klaus A Miczek, Sara Faccidomo, Rosa M M De Almeida, Makoto Bannai, Eric W Fish, Joseph F Debol. Escalated aggressive behavior: new pharmacotherapeutic approaches and opportunities. Annals of the New York Academy of Sciences. vol 1036. 2008-08-08. PMID:15817748. |
the long-established role of brain serotonin in impulsive and escalated forms of aggressive behavior continues to be a focus of preclinical studies. |
2008-08-08 |
2023-08-12 |
Not clear |
| Saori C Tanaka, Nicolas Schweighofer, Shuji Asahi, Kazuhiro Shishida, Yasumasa Okamoto, Shigeto Yamawaki, Kenji Doy. Serotonin differentially regulates short- and long-term prediction of rewards in the ventral and dorsal striatum. PloS one. vol 2. issue 12. 2008-08-08. PMID:18091999. |
although previous animal experiments on impulsivity have suggested a role of serotonin in behaviors requiring prediction of delayed rewards, the underlying neural mechanism is unclear. |
2008-08-08 |
2023-08-12 |
Not clear |
| M Tõnissaar, L Herm, M Eller, K Kõiv, A Rinken, J Harr. Rats with high or low sociability are differently affected by chronic variable stress. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18343596. |
in ls-rats stress increased ex vivo dopamine levels and reduced 5-ht levels in the frontal cortex, suggesting that the increased behavioral activity after stress may be related to increased impulsivity. |
2008-08-07 |
2023-08-12 |
rat |
| Molly J Crockett, Luke Clark, Golnaz Tabibnia, Matthew D Lieberman, Trevor W Robbin. Serotonin modulates behavioral reactions to unfairness. Science (New York, N.Y.). vol 320. issue 5884. 2008-07-15. PMID:18535210. |
serotonin (5-ht) has long been implicated in social behavior and impulsivity, but the mechanisms through which it modulates self-control remain unclear. |
2008-07-15 |
2023-08-12 |
human |
| Tommy Pattij, Louk J M J Vanderschure. The neuropharmacology of impulsive behaviour. Trends in pharmacological sciences. vol 29. issue 4. 2008-07-08. PMID:18304658. |
historically, deficits in central serotonin neurotransmission are thought to underlie impulsivity. |
2008-07-08 |
2023-08-12 |
Not clear |
| Rachel Navarra, Thomas A Comery, Radka Graf, Sharon Rosenzweig-Lipson, Mark Da. The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test. Behavioural brain research. vol 188. issue 2. 2008-06-20. PMID:18191235. |
the 5-ht(2c) receptor agonist way-163909 decreases impulsivity in the 5-choice serial reaction time test. |
2008-06-20 |
2023-08-12 |
Not clear |
| Rachel Navarra, Thomas A Comery, Radka Graf, Sharon Rosenzweig-Lipson, Mark Da. The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test. Behavioural brain research. vol 188. issue 2. 2008-06-20. PMID:18191235. |
preclinical evidence has demonstrated that antagonism of the serotonin 5-ht(2c) receptor may act to increase impulsivity, leading to the hypothesis that an agonist may exert reciprocal effects and attenuate impulsive behavior. |
2008-06-20 |
2023-08-12 |
Not clear |
| Rachel Navarra, Thomas A Comery, Radka Graf, Sharon Rosenzweig-Lipson, Mark Da. The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test. Behavioural brain research. vol 188. issue 2. 2008-06-20. PMID:18191235. |
the 5-ht(2c) agonist, way-163909, was evaluated in the present paper using a variable stimulus duration and inter-trial interval manipulation in the 5-choice serial reaction time test designed to increase impulsivity and decrease attention. |
2008-06-20 |
2023-08-12 |
Not clear |
| Rachel Navarra, Thomas A Comery, Radka Graf, Sharon Rosenzweig-Lipson, Mark Da. The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test. Behavioural brain research. vol 188. issue 2. 2008-06-20. PMID:18191235. |
way-163909 treatment selectively and dose-dependently decreased impulsivity suggesting that agonism of the 5-ht(2c) receptor may be useful for modulating impulsivity in disease states where impulsivity is a pathological feature. |
2008-06-20 |
2023-08-12 |
Not clear |
| Luca Passamonti, Antonio Cerasa, Maria Cecilia Gioia, Angela Magariello, Maria Muglia, Aldo Quattrone, Francesco Fer. Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. NeuroImage. vol 40. issue 3. 2008-06-17. PMID:18261931. |
although with conflicting findings, the monoamine oxidase-a (maoa) and the serotonin transporter (5htt) gene polymorphisms have been associated with an increased risk to develop impulsive and aggressive behaviour. |
2008-06-17 |
2023-08-12 |
mouse |
| Luca Passamonti, Antonio Cerasa, Maria Cecilia Gioia, Angela Magariello, Maria Muglia, Aldo Quattrone, Francesco Fer. Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. NeuroImage. vol 40. issue 3. 2008-06-17. PMID:18261931. |
multivariate analysis demonstrated an individual effect of both maoa and 5htt polymorphisms and a strong allele-allele interaction in the anterior cingulate cortex (acc), a key region implicated in cognitive control and in the pathophysiology of impulsive and aggressive behaviour. |
2008-06-17 |
2023-08-12 |
mouse |
| A Quante, S Röpke, A Merkl, I Anghelescu, C-H Lammer. [Psychopharmacologic treatment of personality disorders]. Fortschritte der Neurologie-Psychiatrie. vol 76. issue 3. 2008-06-03. PMID:18240112. |
for the treatment of depressive syndromes or impulsivity a medical therapy with serotonin reuptake inhibitors, for the treatment of psychotic syndromes a medication with atypical antipsychotics is recommended. |
2008-06-03 |
2023-08-12 |
Not clear |
| Elizabeth E Caldwell, Klaus A Micze. Long-term citalopram maintenance in mice: selective reduction of alcohol-heightened aggression. Psychopharmacology. vol 196. issue 3. 2008-05-30. PMID:17952412. |
selective serotonin reuptake inhibitors (ssris) alleviate many affective disturbances in human clinical populations and are used in animal models to study the influence of serotonin (5-ht) on aggressive behavior and impulsivity. |
2008-05-30 |
2023-08-12 |
mouse |
| Zrnka Kovacic, Neven Henigsberg, Nela Pivac, Gordana Nedic, Andrea Boroveck. Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 2. 2008-05-30. PMID:18055084. |
serotonin (5-hydroxytryptamine, 5-ht) controls emotional behavior, anxiety, impulsivity and aggression, and nearly all known antidepressants and antianxiety drugs affect 5-ht transmission. |
2008-05-30 |
2023-08-12 |
human |
| Nicolas Schweighofer, Mathieu Bertin, Kazuhiro Shishida, Yasumasa Okamoto, Saori C Tanaka, Shigeto Yamawaki, Kenji Doy. Low-serotonin levels increase delayed reward discounting in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 17. 2008-05-20. PMID:18434531. |
previous human studies under serotonin manipulation, however, have been either inconclusive on the effect on impulsivity or have shown an effect in the speed of action-reward learning or the optimality of action choice. |
2008-05-20 |
2023-08-12 |
human |
| F D Zepf, M Holtmann, C Stadler, L Demisch, M Schmitt, L Wöckel, F Poustk. Diminished serotonergic functioning in hostile children with ADHD: tryptophan depletion increases behavioural inhibition. Pharmacopsychiatry. vol 41. issue 2. 2008-05-13. PMID:18311686. |
serotonergic (5-ht) functioning has been shown to account for a variety of behavioural characteristics, in particular aggressive and impulsive behaviour. |
2008-05-13 |
2023-08-12 |
Not clear |