| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Hadamitzky, Malte Feja, Thorsten Becker, Michael Koc. Effects of acute systemic administration of serotonin2A/C receptor ligands in a delay-based decision-making task in rats. Behavioural pharmacology. vol 20. issue 5-6. 2009-12-04. PMID:19730369. |
serotonin (5-hydoxytryptamine; 5-ht) has been implicated in the regulation of impulsivity, and high levels of impulsive behavior are associated with certain neuropsychiatric disorders. |
2009-12-04 |
2023-08-12 |
rat |
| Martin Hadamitzky, Malte Feja, Thorsten Becker, Michael Koc. Effects of acute systemic administration of serotonin2A/C receptor ligands in a delay-based decision-making task in rats. Behavioural pharmacology. vol 20. issue 5-6. 2009-12-04. PMID:19730369. |
this study investigated the effects of the 5-ht(2a/c) receptor agonist doi [(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropan hydrochloride] and the 5-ht(2a) receptor antagonist ketanserin on impulsive behavior measured in a delay-based decision-making task. |
2009-12-04 |
2023-08-12 |
rat |
| Martin Hadamitzky, Michael Koc. Effects of acute intra-cerebral administration of the 5-HT(2A/C) receptor ligands DOI and ketanserin on impulse control in rats. Behavioural brain research. vol 204. issue 1. 2009-12-01. PMID:19467270. |
simultaneous bilateral infusion of the 5-ht(2a/c) receptor agonist doi (5 microg/0.3 microl) into the ofc and the bla significantly increased impulsive responding in the 5-csrtt. |
2009-12-01 |
2023-08-12 |
rat |
| A Veronica Witte, Agnes Flöel, Patrycja Stein, Markus Savli, Leonhard-Key Mien, Wolfgang Wadsak, Christoph Spindelegger, Ulrike Moser, Martin Fink, Andreas Hahn, Markus Mitterhauser, Kurt Kletter, Siegfried Kasper, Rupert Lanzenberge. Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects. Human brain mapping. vol 30. issue 8. 2009-09-28. PMID:19086022. |
various studies indicate that serotonin regulates impulsivity and the inhibitory control of aggression. |
2009-09-28 |
2023-08-12 |
human |
| Vikas Duvvuri, Victoria B Risbrough, Walter H Kaye, Mark A Geye. 5-HT1A receptor activation is necessary for 5-MeODMT-dependent potentiation of feeding inhibition. Pharmacology, biochemistry, and behavior. vol 93. issue 3. 2009-09-16. PMID:19490926. |
we propose a translational approach to the study of anorexia nervosa (an) based on our human subject studies where there are characteristic elevations in 5-ht(1a) receptor binding, associated harm avoidance behaviors, reduced impulsivity, and comorbid anxiety disorders. |
2009-09-16 |
2023-08-12 |
mouse |
| D Erritzoe, V G Frokjaer, S Haugbol, L Marner, C Svarer, K Holst, W F C Baaré, P M Rasmussen, J Madsen, O B Paulson, G M Knudse. Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use. NeuroImage. vol 46. issue 1. 2009-08-19. PMID:19457377. |
manipulations of the serotonin levels in the brain can affect impulsive behavior and influence our reactivity to conditioned reinforcers. |
2009-08-19 |
2023-08-12 |
human |
| Paul J Fletcher, John W Chambers, Zoë Rizos, Araba F Chinto. Effects of 5-HT depletion in the frontal cortex or nucleus accumbens on response inhibition measured in the 5-choice serial reaction time test and on a DRL schedule. Behavioural brain research. vol 201. issue 1. 2009-08-13. PMID:19428621. |
previous work has shown that global depletion of brain serotonin (5-ht) using the neurotoxin 5,7-dihydroxytryptamine (5,7-dht) increases impulsive like behaviour measured as premature responding on the 5-choice serial reaction time (5-csrt) test, and inefficient responding on a drl20 schedule of food reinforcement. |
2009-08-13 |
2023-08-12 |
rat |
| M Catalina Cervantes, Yvon Delvill. Serotonin 5-HT1A and 5-HT3 receptors in an impulsive-aggressive phenotype. Behavioral neuroscience. vol 123. issue 3. 2009-08-13. PMID:19485565. |
the data indicate a convergence of impulsive and aggressive characteristics to one phenotype that is associated with various aspects of serotonin function, such as serotonin release and differential expression of 5-ht1a and 5-ht3 receptors. |
2009-08-13 |
2023-08-12 |
Not clear |
| Emil F Coccaro, Royce J Lee, Richard J Kavouss. A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder. The Journal of clinical psychiatry. vol 70. issue 5. 2009-07-22. PMID:19389333. |
since central serotonergic (5-ht) system dysfunction is related to impulsive aggressive behavior, pharmacologic enhancement of 5-ht activity should reduce impulsive aggressive behavior in individuals with ied. |
2009-07-22 |
2023-08-12 |
Not clear |
| D Leo, W Adriani, C Cavaliere, G Cirillo, E M Marco, E Romano, U di Porzio, M Papa, C Perrone-Capano, G Laviol. Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology. Genes, brain, and behavior. vol 8. issue 3. 2009-07-14. PMID:19243449. |
we show that these modifications include a marked increment of serotonin (5-hydroxy-tryptamine) receptor type 7 (htr7) expression and synaptic contacts, mainly in the nucleus accumbens, and a reduction of basal behavioral impulsivity. |
2009-07-14 |
2023-08-12 |
rat |
| Teresa Biermann, Nikolaos Stilianakis, Stefan Bleich, Norbert Thürauf, Johannes Kornhuber, Udo Reulbac. The hypothesis of an impact of ozone on the occurrence of completed and attempted suicides. Medical hypotheses. vol 72. issue 3. 2009-04-28. PMID:19027246. |
biologically, ozone is able to influence the immune system, is a strong trigeminal irritant and might influence neurotransmitter systems such as serotonin, which are known to vary with season and play a major role in impulsivity, aggression, depression and thereby suicidality. |
2009-04-28 |
2023-08-12 |
human |
| L Clark, J P Roiser, T W Robbins, B J Sahakia. Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18515464. |
evidence for serotonin involvement in impulsivity has generated interest in the measurement of impulsivity in regular ecstasy users, who are thought to display serotonergic dysfunction. |
2009-04-03 |
2023-08-12 |
human |
| L Clark, J P Roiser, T W Robbins, B J Sahakia. Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18515464. |
however, the lack of effects in the two ecstasy groups suggests that the relationship between serotonin function, ecstasy use and impulsivity is more complex. |
2009-04-03 |
2023-08-12 |
human |
| Espen Walderhaug, Nils Inge Landrø, Andres Magnusso. A synergic effect between lowered serotonin and novel situations on impulsivity measured by CPT. Journal of clinical and experimental neuropsychology. vol 30. issue 2. 2009-01-08. PMID:18938672. |
a synergic effect between lowered serotonin and novel situations on impulsivity measured by cpt. |
2009-01-08 |
2023-08-12 |
human |
| Paul A Ardayfio, Mark J Benvenga, Stephen F Chaney, Patrick L Love, John Catlow, Steven P Swanson, Gerard J Mare. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18772320. |
previous work has suggested that n-methyl-d-aspartate (nmda) receptor antagonism and 5-hydroxytryptamine (5-ht)(2a) receptor blockade may enhance and attenuate, respectively, certain types of impulsivity mediated by corticothalamostriatal circuits. |
2009-01-05 |
2023-08-12 |
rat |
| Paul A Ardayfio, Mark J Benvenga, Stephen F Chaney, Patrick L Love, John Catlow, Steven P Swanson, Gerard J Mare. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18772320. |
more specifically, past demonstrations of synergistic "antidepressant-like" effects of a 5-ht(2a) receptor antagonist and fluoxetine on differential-reinforcement-of-low-rate (drl) 72-s schedule of operant reinforcement may speak to the role of 5-ht(2a) receptor blockade with respect to response inhibition as an important prefrontal cortical executive function relating to motor impulsivity. |
2009-01-05 |
2023-08-12 |
rat |
| Paul A Ardayfio, Mark J Benvenga, Stephen F Chaney, Patrick L Love, John Catlow, Steven P Swanson, Gerard J Mare. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18772320. |
to examine the dynamic range over which 5-ht(2a) receptor blockade may exert effects on impulsivity, [r-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol] (m100907) was examined both alone and in combination with the psychotomimetic nmda receptor antagonist dizocilpine [e.g., (-)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine maleate; mk-801] and two different antidepressants, the tricyclic antidepressant desmethylimipramine (dmi) and the monoamine oxidase inhibitor tranylcypromine in rats performing under a drl 72-s schedule. |
2009-01-05 |
2023-08-12 |
rat |
| Paul A Ardayfio, Mark J Benvenga, Stephen F Chaney, Patrick L Love, John Catlow, Steven P Swanson, Gerard J Mare. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18772320. |
therefore, it may be that a tonic excitation of 5-ht(2a) receptors modulates impulsivity and function of corticothalamostriatal circuits over an extensive dynamic range. |
2009-01-05 |
2023-08-12 |
rat |
| Emma S J Robinson, Jeffrey W Dalley, David E H Theobald, Jeffrey C Glennon, Marie A Pezze, Emily R Murphy, Trevor W Robbin. Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 10. 2008-12-22. PMID:18046307. |
studies manipulating 5-ht function in the rodent brain indicate that 5-ht receptors regulate distinct forms of impulsive behavior, including impulsive responding in the 5-choice serial reaction time task (5csrtt). |
2008-12-22 |
2023-08-12 |
rat |
| Emma S J Robinson, Jeffrey W Dalley, David E H Theobald, Jeffrey C Glennon, Marie A Pezze, Emily R Murphy, Trevor W Robbin. Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 10. 2008-12-22. PMID:18046307. |
these data reveal opposing effects on impulsivity following 5-ht(2a) and 5-ht(2c) blockade in the nac. |
2008-12-22 |
2023-08-12 |
rat |