| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuyan Zhu, Sora Q Kim, Yuan Zhang, Qing Liu, Kee-Hong Ki. Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake. Metabolism: clinical and experimental. vol 123. 2021-11-09. PMID:34371065. |
pharmacological inhibition of acyl-coenzyme a:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake. |
2021-11-09 |
2023-08-13 |
mouse |
| Heng Yang, Shuo Wang, Yingchun Ye, Min Xie, Yubin Li, Hong Jin, Jing Li, Ling Ga. GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice. Neuropeptides. vol 85. 2021-11-08. PMID:33307381. |
glp-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice. |
2021-11-08 |
2023-08-13 |
mouse |
| Olga Barca-Mayo, Miguel Lópe. Astrocyte Clocks and Glucose Homeostasis. Frontiers in endocrinology. vol 12. 2021-11-08. PMID:33815298. |
in mammals, the circadian clock governs rhythmic physiological and behavioral processes, including the daily oscillation in glucose metabolism, food intake, energy expenditure, and whole-body insulin sensitivity. |
2021-11-08 |
2023-08-13 |
Not clear |
| Joseph M Elsakr, Sifang Kathy Zhao, Valerie Ricciardi, Tyler A Dean, Diana L Takahashi, Elinor Sullivan, Stephanie R Wesolowski, Carrie E McCurdy, Paul Kievit, Jacob E Friedman, Kjersti M Aagaard, Digna R Velez Edwards, Maureen Ganno. Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34155315. |
however, with (1) prolonged wsd feeding, (2) multiple diet switches, and/or (3) increasing age and parity, wsd was associated with increasingly higher insulin levels during glucose tolerance testing, indicative of insulin resistance. |
2021-11-08 |
2023-08-13 |
monkey |
| Zhengxi Huang, Jialing Tang, Kai J. Exercise prevents HFD-induced insulin resistance risk: involvement of TNF-α level regulated by vagus nerve-related anti-inflammatory pathway in the spleen. Diabetology & metabolic syndrome. vol 13. issue 1. 2021-11-05. PMID:34717724. |
this study was carried out to address whether insulin resistance improvement by exercise is involved in an anti-inflammatory pathway in the spleen in high-fat diet (hfd) feeding mice. |
2021-11-05 |
2023-08-13 |
mouse |
| Elise Mank, Letty van Toledo, Annemieke C Heijboer, Chris H P van den Akker, Johannes B van Goudoeve. Insulin Concentration in Human Milk in the First Ten Days Postpartum: Course and Associated Factors. Journal of pediatric gastroenterology and nutrition. vol 73. issue 5. 2021-11-03. PMID:34183615. |
insulin, which is naturally present in hm but not in formula, has been suggested as a key factor for feeding tolerance, as it appears to stimulate intestinal maturation. |
2021-11-03 |
2023-08-13 |
human |
| Stephanie Kullmann, Julia Hummel, Robert Wagner, Corinna Dannecker, Andreas Vosseler, Louise Fritsche, Ralf Veit, Konstantinos Kantartzis, Jürgen Machann, Andreas L Birkenfeld, Norbert Stefan, Hans-Ulrich Häring, Andreas Peter, Hubert Preissl, Andreas Fritsche, Martin Hen. Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial. Diabetes care. 2021-10-30. PMID:34716213. |
insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass and its distribution. |
2021-10-30 |
2023-08-13 |
human |
| Jens Juul Hols. Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture. Diabetes. vol 70. issue 11. 2021-10-29. PMID:34711671. |
after a brief discussion of their effect on insulin sensitivity, i describe their immediate actions in patients with type 2 diabetes and emphasize the actions of glp-1 on β-cell glucose sensitivity, followed by a discussion of their extrapancreatic actions, including effects on appetite and food intake in humans. |
2021-10-29 |
2023-08-13 |
Not clear |
| Chee W Chia, Josephine M Ega. Role and development of GLP-1 receptor agonists in the management of diabetes. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 2. 2021-10-28. PMID:20148188. |
exogenous glp-1 administration at pharmacological doses results in many effects that are beneficial for treating type 2 diabetes, these include: (1) an increase in insulin secretion from beta cells; (2) a suppression of glucagon secretion from alpha cells in the presence of hyperglycemia but not hypoglycemia; (3) a delay in gastric emptying and gut motility which in turns delays absorption of ingested nutrients and dampens post-prandial glucose excursion; and (4) an increase in the duration of postprandial satiety therefore suppressing appetite and decreasing food intake which eventually leads to weight loss. |
2021-10-28 |
2023-08-12 |
human |
| Jong Han Lee, Chuo Fang, Xin Li, Chia Shan Wu, Ji Yeon Noh, Xiangcang Ye, Robert S Chapkin, Kai Sun, Yuxiang Su. GHS-R suppression in adipose tissues protects against obesity and insulin resistance by regulating adipose angiogenesis and fibrosis. International journal of obesity (2005). vol 45. issue 7. 2021-10-27. PMID:33903722. |
ghrelin is an orexigenic hormone that increases food intake, adiposity, and insulin resistance through its receptor growth hormone secretagogue receptor (ghs-r). |
2021-10-27 |
2023-08-13 |
Not clear |
| Tian Tian, Markus Heine, Ioannis Evangelakos, Michelle Y Jaeckstein, Nicola Schaltenberg, Tobias Stähler, Friedrich Koch-Nolte, Manju Kumari, Joerg Heere. The P2X7 ion channel is dispensable for energy and metabolic homeostasis of white and brown adipose tissues. Purinergic signalling. vol 16. issue 4. 2021-10-26. PMID:33025427. |
however, p2x7 expression does not alter body weight, insulin resistance, and hyperglycemia associated with high-fat diet feeding on both genetic backgrounds. |
2021-10-26 |
2023-08-13 |
mouse |
| Andressa Reginato, Beatriz Piatezzi Siqueira, Josiane Érica Miyamoto, Mariana Portovedo, Suleyma de Oliveira Costa, Thaís de Fante, Hosana Gomes Rodrigues, Letícia Martins Ignácio-Souza, Márcio Alberto Torsoni, Adriana Souza Torsoni, Hervé Le Stunff, Denise D Belsham, Marciane Milansk. Acute effects of fatty acids on autophagy in NPY neurones. Journal of neuroendocrinology. vol 32. issue 10. 2021-10-25. PMID:33040385. |
high-fat diet (hfd) feeding is deleterious to hypothalamic tissue, leading to inflammation and lipotoxicity, as well as contributing to central insulin resistance. |
2021-10-25 |
2023-08-13 |
Not clear |
| Ming Miao, Bruce R Hamake. Food Matrix Effects for Modulating Starch Bioavailability. Annual review of food science and technology. vol 12. 2021-10-25. PMID:33395539. |
starch is the major source of glucose in the human diet and can have diverse effects, depending on its rate and extent of digestion in the small intestine, on postprandial glycemic response, which over time is associated with blood glucose abnormalities, insulin sensitivity, and even appetitive response and food intake. |
2021-10-25 |
2023-08-13 |
human |
| Sorabh Sharm. High fat diet and its effects on cognitive health: alterations of neuronal and vascular components of brain. Physiology & behavior. vol 240. 2021-10-25. PMID:34260890. |
further, it discuss the key mechanisms that are altered by hfd feeding, such as, insulin resistance, oxidative stress, neuro-inflammation, transcriptional dysregulation and loss of synaptic plasticity. |
2021-10-25 |
2023-08-13 |
Not clear |
| Tetsuya Shiuchi, Airi Otsuka, Noriyuki Shimizu, Sachiko Chikahisa, Hiroyoshi Sé. Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639172. |
feeding rhythm-induced hypothalamic agouti-related protein elevation via glucocorticoids leads to insulin resistance in skeletal muscle. |
2021-10-25 |
2023-08-13 |
mouse |
| Tetsuya Shiuchi, Airi Otsuka, Noriyuki Shimizu, Sachiko Chikahisa, Hiroyoshi Sé. Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639172. |
circadian phase shifts in peripheral clocks induced by changes in feeding rhythm often result in insulin resistance. |
2021-10-25 |
2023-08-13 |
mouse |
| Tetsuya Shiuchi, Airi Otsuka, Noriyuki Shimizu, Sachiko Chikahisa, Hiroyoshi Sé. Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639172. |
however, whether the hypothalamic control system for energy metabolism is involved in the feeding rhythm-related development of insulin resistance is unknown. |
2021-10-25 |
2023-08-13 |
mouse |
| Tetsuya Shiuchi, Airi Otsuka, Noriyuki Shimizu, Sachiko Chikahisa, Hiroyoshi Sé. Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639172. |
evening feeding during the active dark period increased hypothalamic agrp expression and skeletal muscle insulin resistance in mice. |
2021-10-25 |
2023-08-13 |
mouse |
| Tetsuya Shiuchi, Airi Otsuka, Noriyuki Shimizu, Sachiko Chikahisa, Hiroyoshi Sé. Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639172. |
agrp-producing neuron-specific glucocorticoid receptor-knockout (agrp-gr-ko) mice had normal skeletal muscle insulin sensitivity even under evening feeding schedules. |
2021-10-25 |
2023-08-13 |
mouse |
| Tetsuya Shiuchi, Airi Otsuka, Noriyuki Shimizu, Sachiko Chikahisa, Hiroyoshi Sé. Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle. International journal of molecular sciences. vol 22. issue 19. 2021-10-25. PMID:34639172. |
the findings of this study indicate that feeding in the late active period may affect hypothalamic agrp expression via glucocorticoids and induce skeletal muscle insulin resistance. |
2021-10-25 |
2023-08-13 |
mouse |