| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Biewald, H J Bromme, R Nilius, J Langne. Effects of twelve months ethanol feeding on rat liver metabolic activity. International journal of molecular medicine. vol 3. issue 3. 2000-10-13. PMID:10028052. |
to determine the possible metabolic disturbances caused by chronic ethanol feeding in blood we measured in blood metabolic parameters, and in a liver perfusion assay the hepatic insulin clearance and hepatic urea production in these animals. |
2000-10-13 |
2023-08-12 |
rat |
| F W Scott, E Olivares, A Sener, W J Malaiss. Dietary effects on insulin and nutrient metabolism in mesenteric lymph node cells, splenocytes, and pancreatic islets of BB rats. Metabolism: clinical and experimental. vol 49. issue 9. 2000-10-12. PMID:11016889. |
feeding the hc diet increased islet insulin content (p < .01) by 13% in bbdp and 23% in bbc rats; other metabolic and hormonal variables were unaffected. |
2000-10-12 |
2023-08-12 |
rat |
| F W Scott, E Olivares, A Sener, W J Malaiss. Dietary effects on insulin and nutrient metabolism in mesenteric lymph node cells, splenocytes, and pancreatic islets of BB rats. Metabolism: clinical and experimental. vol 49. issue 9. 2000-10-12. PMID:11016889. |
we conclude that the protection afforded by feeding bbdp rats a hc diet is associated with increased insulin in target beta cells and downregulation of metabolic activity in gut-associated mln cells. |
2000-10-12 |
2023-08-12 |
rat |
| A Milewicz, E Mikulski, B Bidzińsk. Plasma insulin, cholecystokinin, galanin, neuropeptide Y and leptin levels in obese women with and without type 2 diabetes mellitus. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 24 Suppl 2. 2000-10-10. PMID:10997641. |
experimental studies provided evidences that leptin, cholecystokinin (cck), galanin (gal), neuropeptide y (npy) and insulin are involved in feeding behaviour. |
2000-10-10 |
2023-08-12 |
human |
| J C Brüning, D Gautam, D J Burks, J Gillette, M Schubert, P C Orban, R Klein, W Krone, D Müller-Wieland, C R Kah. Role of brain insulin receptor in control of body weight and reproduction. Science (New York, N.Y.). vol 289. issue 5487. 2000-10-10. PMID:11000114. |
however, female nirko mice showed increased food intake, and both male and female mice developed diet-sensitive obesity with increases in body fat and plasma leptin levels, mild insulin resistance, elevated plasma insulin levels, and hypertriglyceridemia. |
2000-10-10 |
2023-08-12 |
mouse |
| K J Kaiyala, R L Prigeon, S E Kahn, S C Woods, M W Schwart. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes. vol 49. issue 9. 2000-09-25. PMID:10969837. |
we hypothesized that high-fat feeding, which both reduces insulin sensitivity in peripheral tissues and favors weight gain, reduces the efficiency of insulin uptake from plasma into the cns. |
2000-09-25 |
2023-08-12 |
Not clear |
| K J Kaiyala, R L Prigeon, S E Kahn, S C Woods, M W Schwart. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes. vol 49. issue 9. 2000-09-25. PMID:10969837. |
to test this hypothesis, we estimated parameters for cerebrospinal fluid (csf) insulin uptake and clearance during an intravenous insulin infusion using compartmental modeling in 10 dogs before and after 7 weeks of high-fat feeding. |
2000-09-25 |
2023-08-12 |
Not clear |
| K J Kaiyala, R L Prigeon, S E Kahn, S C Woods, M W Schwart. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes. vol 49. issue 9. 2000-09-25. PMID:10969837. |
these parameters, together with 24-h plasma insulin levels measured during ad libitum feeding, also permitted estimates of relative cns insulin concentrations. |
2000-09-25 |
2023-08-12 |
Not clear |
| K J Kaiyala, R L Prigeon, S E Kahn, S C Woods, M W Schwart. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes. vol 49. issue 9. 2000-09-25. PMID:10969837. |
the percent changes of adiposity, body weight, and food intake after high-fat feeding were each inversely associated with the percent changes of the parameter k1k2, which reflects the efficiency of cns insulin uptake from plasma (r = -0.74, -0.69, -0.63; p = 0.015, 0.03, and 0.05, respectively). |
2000-09-25 |
2023-08-12 |
Not clear |
| K J Kaiyala, R L Prigeon, S E Kahn, S C Woods, M W Schwart. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes. vol 49. issue 9. 2000-09-25. PMID:10969837. |
during high-fat feeding, there was a 60% reduction of the estimated cns insulin level (p = 0.04), and this estimate was inversely associated with percent changes in body weight (r = -0.71, p = 0.03). |
2000-09-25 |
2023-08-12 |
Not clear |
| K J Kaiyala, R L Prigeon, S E Kahn, S C Woods, M W Schwart. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes. vol 49. issue 9. 2000-09-25. PMID:10969837. |
these results demonstrate that increased food intake and weight gain during high-fat feeding are associated with and may be causally related to reduced insulin delivery into the cns. |
2000-09-25 |
2023-08-12 |
Not clear |
| M Orosco, C Rouch, K Gerozissi. Activation of hypothalamic insulin by serotonin is the primary event of the insulin-serotonin interaction involved in the control of feeding. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924676. |
activation of hypothalamic insulin by serotonin is the primary event of the insulin-serotonin interaction involved in the control of feeding. |
2000-09-20 |
2023-08-12 |
rat |
| M Orosco, C Rouch, K Gerozissi. Activation of hypothalamic insulin by serotonin is the primary event of the insulin-serotonin interaction involved in the control of feeding. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924676. |
in previous experiments, we reported a close parallelism in the responses of both serotonin (5-ht) and insulin in the hypothalamic pvn-vmh region of freely-moving rats during feeding. |
2000-09-20 |
2023-08-12 |
rat |
| B A Ellis, A Poynten, A J Lowy, S M Furler, D J Chisholm, E W Kraegen, G J Coone. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. American journal of physiology. Endocrinology and metabolism. vol 279. issue 3. 2000-09-19. PMID:10950822. |
fasting rats for 18 h significantly elevated the three major lcacoa species in muscle (p < 0.001), whereas high-fat feeding of rats with a safflower oil (18:2) diet produced insulin resistance and increased total lcacoa content (p < 0.0001) by specifically increasing 18:2-coa. |
2000-09-19 |
2023-08-12 |
human |
| S F Akana, A M Strack, E S Hanson, C J Horsley, E D Milligan, S Bhatnagar, M F Dallma. Interactions among chronic cold, corticosterone and puberty on energy intake and deposition. Stress (Amsterdam, Netherlands). vol 3. issue 2. 2000-09-14. PMID:10938575. |
by decreasing signals that act centrally to inhibit food intake (insulin, leptin and testosterone) cold allows b to stimulate food intake; 2. |
2000-09-14 |
2023-08-12 |
rat |
| A F Delgado, H M Kimura, A L Cardoso, D Uehara, F R Carrazz. Nutritional follow-up of critically ill infants receiving short term parenteral nutrition. Revista do Hospital das Clinicas. vol 55. issue 1. 2000-09-06. PMID:10881072. |
these included: clinical data (food intake and anthropometric measurements), haematological data (lymphocyte count), biochemical tests (albumin, transferrin, fibronectin, prealbumin, retinol-binding protein) and hormone assays (cortisol, insulin, glucagon). |
2000-09-06 |
2023-08-12 |
Not clear |
| W Long, L Saffer, L Wei, E J Barret. Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin. American journal of physiology. Endocrinology and metabolism. vol 279. issue 2. 2000-08-31. PMID:10913029. |
this effect is not dependent on increases in plasma insulin and simulates the activation of protein synthesis that accompanies normal feeding. |
2000-08-31 |
2023-08-12 |
rat |
| J E McMinn, C W Wilkinson, P J Havel, S C Woods, M W Schwart. Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression. American journal of physiology. Regulatory, integrative and comparative physiology. vol 279. issue 2. 2000-08-31. PMID:10938261. |
chronic alpha-msh infusion reduced cumulative food intake by 10.7% (p < 0.05 vs. saline) and body weight by 4.3% (p < 0.01 vs. saline), which in turn lowered plasma insulin levels by 29.3% (p < 0.05 vs. saline). |
2000-08-31 |
2023-08-12 |
rat |
| D Spanswick, M A Smith, S Mirshamsi, V H Routh, M L Ashfor. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nature neuroscience. vol 3. issue 8. 2000-08-15. PMID:10903566. |
insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, zucker rats. |
2000-08-15 |
2023-08-12 |
rat |
| M J Holness, A Kraus, R A Harris, M C Sugde. Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding. Diabetes. vol 49. issue 5. 2000-08-07. PMID:10905486. |
the data suggest that a positive correlation exists between increases in pdk4 expression and the propensity with which muscles use lipid-derived fuels as respiratory substrates rather than with the degree of insulin resistance induced in skeletal muscles by high-fat feeding. |
2000-08-07 |
2023-08-12 |
Not clear |