| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mihai G Netea, Leo A B Joosten, Eli Lewis, Dalan R Jensen, Peter J Voshol, Bart Jan Kullberg, Cees J Tack, Han van Krieken, Soo-Hyun Kim, Anton F Stalenhoef, Fons A van de Loo, Ineke Verschueren, Leslie Pulawa, Shizuo Akira, Robert H Eckel, Charles A Dinarello, Wim van den Berg, Jos W M van der Mee. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nature medicine. vol 12. issue 6. 2006-09-07. PMID:16732281. |
insulin resistance was secondary to obesity induced by increased food intake and occurred at the liver level as well as at the muscle and fat-tissue level. |
2006-09-07 |
2023-08-12 |
mouse |
| Min-Seon Kim, Youngmi K Pak, Pil-Geum Jang, Cherl Namkoong, Yon-Sik Choi, Jong-Chul Won, Kyung-Sup Kim, Seung-Whan Kim, Hyo-Soo Kim, Joong-Yeol Park, Young-Bum Kim, Ki-Up Le. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nature neuroscience. vol 9. issue 7. 2006-09-05. PMID:16783365. |
these hormones' effects on feeding are inhibited when hypothalamic foxo1 is activated, establishing a new signaling pathway through which insulin and leptin regulate food intake in hypothalamic neurons. |
2006-09-05 |
2023-08-12 |
mouse |
| Curtis Triplitt, Alison Wright, Elaine Chiquett. Incretin mimetics and dipeptidyl peptidase-IV inhibitors: potential new therapies for type 2 diabetes mellitus. Pharmacotherapy. vol 26. issue 3. 2006-09-01. PMID:16503716. |
in particular, the glucoregulatory actions of the incretin hormone glp-1 include enhancement of glucosedependent insulin secretion, suppression of inappropriately elevated glucagon secretion, slowing of gastric emptying, and reduction of food intake. |
2006-09-01 |
2023-08-12 |
Not clear |
| Brian D Green, Kerry S Lavery, Nigel Irwin, Finbarr P M O'harte, Patrick Harriott, Brett Greer, Clifford J Bailey, Peter R Flat. Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16648370. |
once-daily subcutaneous administration of (val8)glp-1 (25 nmol/kg) for 21 days reduced plasma glucose concentrations, increased plasma insulin, and reduced body weight more than native glp-1 without a significant change in daily food intake. |
2006-08-31 |
2023-08-12 |
mouse |
| Brian D Green, Kerry S Lavery, Nigel Irwin, Finbarr P M O'harte, Patrick Harriott, Brett Greer, Clifford J Bailey, Peter R Flat. Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16648370. |
furthermore, (val8)glp-1 improved glucose tolerance, reduced the glycemic excursion after feeding, increased the plasma insulin response to glucose and feeding, and improved insulin sensitivity. |
2006-08-31 |
2023-08-12 |
mouse |
| Guenther Bode. Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. Current diabetes reports. vol 6. issue 3. 2006-08-25. PMID:16898568. |
thus, elevated ffa levels (due to obesity or to high-fat feeding) cause insulin resistance in skeletal muscle and liver, which contributes to the development of t2dm, and produce low-grade inflammation, which contributes to the development of atherosclerotic vascular diseases and nafld. |
2006-08-25 |
2023-08-12 |
Not clear |
| Gilles Mithieux, Fabienne Rajas, Carine Zitou. Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin. Biochemical pharmacology. vol 72. issue 2. 2006-08-22. PMID:16737687. |
the aim of this work was: (1) to estimate the role of si glucose fluxes in glucose homeostasis in insulin resistance states (induced by high-fat (hf) feeding); (2) to assess the effect of metformin, an anti-diabetic molecule, on these fluxes. |
2006-08-22 |
2023-08-12 |
rat |
| J M A Hannan, L Ali, J Khaleque, M Akhter, P R Flatt, Y H A Abdel-Waha. Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption. The British journal of nutrition. vol 96. issue 1. 2006-08-22. PMID:16870001. |
in 28 d chronic feeding studies in type 2 diabetic rat models, the extract reduced serum atherogenic lipids and nefa but had no effect on plasma insulin and total antioxidant status. |
2006-08-22 |
2023-08-12 |
rat |
| Nigel Irwin, Brian D Green, Victor A Gault, Roslyn S Cassidy, Finbarr P M O'Harte, Patrick Harriott, Peter R Flat. Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice. Peptides. vol 27. issue 4. 2006-08-11. PMID:16181707. |
daily injection of n-acgip(lyspal37) (25 nmol/kg body weight) for 14 days had no significant effect on food intake, body weight, glycated hemoglobin levels, non-fasting plasma glucose and insulin concentrations compared to saline treated controls. |
2006-08-11 |
2023-08-12 |
mouse |
| Nigel Irwin, Brian D Green, Victor A Gault, Roslyn S Cassidy, Finbarr P M O'Harte, Patrick Harriott, Peter R Flat. Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice. Peptides. vol 27. issue 4. 2006-08-11. PMID:16181707. |
no significant differences in post-prandial plasma glucose and insulin concentrations were observed between the two groups following 15 min feeding. |
2006-08-11 |
2023-08-12 |
mouse |
| Sietse Jan Koopmans, Zdzislaw Mroz, Ruud Dekker, Henk Corbijn, Mariette Ackermans, Hans Sauerwei. Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model. Metabolism: clinical and experimental. vol 55. issue 7. 2006-08-09. PMID:16784971. |
association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model. |
2006-08-09 |
2023-08-12 |
Not clear |
| Helena A Walz, Linda Härndahl, Nils Wierup, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, Vincent C Manganiello, Thorkil Ploug, Frank Sundler, Eva Degerman, Bo Ahrén, Lena Stenson Hols. Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B. The Journal of endocrinology. vol 189. issue 3. 2006-08-07. PMID:16731793. |
early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3b. |
2006-08-07 |
2023-08-12 |
mouse |
| Helena A Walz, Linda Härndahl, Nils Wierup, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, Vincent C Manganiello, Thorkil Ploug, Frank Sundler, Eva Degerman, Bo Ahrén, Lena Stenson Hols. Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B. The Journal of endocrinology. vol 189. issue 3. 2006-08-07. PMID:16731793. |
we found that rip-pde3b/2 mice early and rapidly develop glucose intolerance and insulin resistance, as compared with wild-type littermates, after 2 months of high-fat feeding. |
2006-08-07 |
2023-08-12 |
mouse |
| V J Taylor, D E Beever, M J Bryant, D C Wathe. Pre-pubertal measurements of the somatotrophic axis as predictors of milk production in Holstein-Friesian dairy cows. Domestic animal endocrinology. vol 31. issue 1. 2006-08-03. PMID:16219444. |
insulin-like growth factor-i (igf-i), insulin and glucose concentrations were measured in relation to time of feeding. |
2006-08-03 |
2023-08-12 |
Not clear |
| Tadahisa Fujita, Masahiro Kajita, Hiroaki San. Responses of whole body protein synthesis, nitrogen retention and glucose kinetics to supplemental starch in goats. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 144. issue 2. 2006-08-03. PMID:16580858. |
the wbps and glucose ilr during 5 to 7 h after feeding were measured by a primed-continuous infusion of [2h5]phenylalanine, [2h2]tyrosine, [2h4]tyrosine and [13c6]glucose for 4 h, with measurements of plasma concentrations of metabolites and insulin. |
2006-08-03 |
2023-08-12 |
Not clear |
| Rebecca C Steiner, Hansen M Hsiung, Marina R Picciott. Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice. Behavioural brain research. vol 171. issue 1. 2006-08-03. PMID:16621045. |
cart is also known to participate in a wider range of physiological functions including feeding, anxiety, bone resorption, and insulin regulation. |
2006-08-03 |
2023-08-12 |
mouse |
| Bernard Bec. Intracerebroventricular injection of proinsulin C-peptide does not influence food consumption in male Long-Evans rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 38. issue 5. 2006-07-27. PMID:16718627. |
in the brain, insulin inhibits food intake through hypothalamic receptors. |
2006-07-27 |
2023-08-12 |
rat |
| Bernard Bec. Intracerebroventricular injection of proinsulin C-peptide does not influence food consumption in male Long-Evans rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 38. issue 5. 2006-07-27. PMID:16718627. |
thus, we conclude that contrary to insulin, c-peptide does not regulate feeding behaviour in normal rats whatever their insulin status. |
2006-07-27 |
2023-08-12 |
rat |
| R Baldelli, S Bellone, N Castellino, A Petri, A Rapa, D Vivenza, J Bellone, F Broglio, E Ghigo, G Bon. Oral glucose load inhibits circulating ghrelin levels to the same extent in normal and obese children. Clinical endocrinology. vol 64. issue 3. 2006-07-21. PMID:16487433. |
ghrelin secretion is increased by fasting and energy restriction, decreased by food intake, glucose load, insulin and somatostatin in normal adults; however, food intake is not able to inhibit circulating ghrelin levels in children, suggesting that the profile of ghrelin secretion in children is different from that in adults. |
2006-07-21 |
2023-08-12 |
Not clear |
| Guoqing Sheng, Guo-qing Chang, John Y Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A Lipton, Shi-Hua Li, Gang Tong, Sarah F Leibowitz, Xiao-Jiang L. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature medicine. vol 12. issue 5. 2006-07-18. PMID:16604089. |
the hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. |
2006-07-18 |
2023-08-12 |
mouse |