| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyriaki Gerozissi. Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies. European journal of pharmacology. vol 585. issue 1. 2008-10-31. PMID:18407262. |
the anorexic peptides insulin, leptin and the neurotransmitter serotonin share common signalling pathways involved in food intake, in particular the insulin receptor substrate, phosphatidylinositol-3-kinase (pi3k) pathway. |
2008-10-31 |
2023-08-12 |
Not clear |
| Asif R Pathan, Anil Bhanudas Gaikwad, Bhoomi Viswanad, Poduri Ramara. Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18602098. |
the present study was designed to test the hypothesis that insulin resistance plays a role in high fat diet feeding induced cognitive deficits. |
2008-10-24 |
2023-08-12 |
rat |
| Asif R Pathan, Anil Bhanudas Gaikwad, Bhoomi Viswanad, Poduri Ramara. Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18602098. |
our data demonstrate that the insulin sensitizers can overcome the cognitive deficits arising from high fat diet feeding, which may be in part mediated through the development of peripheral insulin resistance. |
2008-10-24 |
2023-08-12 |
rat |
| I Vervuert, K Voigt, T Hollands, D Cuddeford, M Coene. Effects of processing barley on its digestion by horses. The Veterinary record. vol 162. issue 21. 2008-10-17. PMID:18503068. |
the highest peak serum glucose and serum insulin concentrations were observed after feeding the extruded barley, lower concentrations were observed after feeding the micronised barley and the lowest concentrations were observed after feeding the rolled barley. |
2008-10-17 |
2023-08-12 |
Not clear |
| V R Punithavathi, R Anuthama, P Stanely Mainzen Princ. Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. Journal of applied toxicology : JAT. vol 28. issue 6. 2008-10-14. PMID:18344197. |
stz-induced diabetic rats showed significant increase in blood glucose, water intake, food intake and glycated hemoglobin and significant decrease in plasma insulin, total hemoglobin, body weight and liver glycogen. |
2008-10-14 |
2023-08-12 |
rat |
| C Rosak, R Jung, U Hofman. Insulin glargine maintains equivalent glycemic control and better lipometabolic control than NPH insulin in type 1 diabetes patients who missed a meal. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 40. issue 8. 2008-10-10. PMID:18493882. |
during the period without insulin or food intake, blood glucose decreased with glargine (-25.8 mg/dl) and increased with nph (+9.1 mg/dl; p=0.0284). |
2008-10-10 |
2023-08-12 |
Not clear |
| P Li, T Koike, B Qin, M Kubota, Y Kawata, Y J Jia, Y Oshid. A high-fructose diet impairs Akt and PKCzeta phosphorylation and GLUT4 translocation in rat skeletal muscle. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 40. issue 8. 2008-10-10. PMID:18500676. |
the molecular mechanism of insulin resistance induced by high-fructose feeding is not fully understood. |
2008-10-10 |
2023-08-12 |
rat |
| Ilya R Bederman, Stephen F Previ. Hormonal regulation of intracellular lipolysis in C57BL/6J mice: effect of diet-induced adiposity and data normalization. Metabolism: clinical and experimental. vol 57. issue 10. 2008-10-10. PMID:18803946. |
in addition, hf feeding led to an increase in fasting insulin, that is, approximately 2-fold greater in hf- vs low-fat-fed mice at 4 and 12 weeks. |
2008-10-10 |
2023-08-12 |
mouse |
| Ilya R Bederman, Stephen F Previ. Hormonal regulation of intracellular lipolysis in C57BL/6J mice: effect of diet-induced adiposity and data normalization. Metabolism: clinical and experimental. vol 57. issue 10. 2008-10-10. PMID:18803946. |
we also observed a marked impairment in insulin-mediated inhibition of epinephrine-stimulated lipolysis after 4 and 12 weeks of hf feeding, demonstrating that diet-induced adiposity leads to insulin resistance in adipocytes. |
2008-10-10 |
2023-08-12 |
mouse |
| Ilya R Bederman, Stephen F Previ. Hormonal regulation of intracellular lipolysis in C57BL/6J mice: effect of diet-induced adiposity and data normalization. Metabolism: clinical and experimental. vol 57. issue 10. 2008-10-10. PMID:18803946. |
in conclusion, hf feeding in mice leads to greater rates of lipolysis via (1) an increase in the number of fat cells and (2) a defect in insulin signaling in adipocytes. |
2008-10-10 |
2023-08-12 |
mouse |
| J Cancelas, P G Prieto, M García-Arévalo, V Sancho, M L Villanueva-Peñacarrillo, W J Malaisse, I Valverd. Induction and reversibility of insulin resistance in rats exposed to exogenous D-fructose. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 40. issue 7. 2008-10-06. PMID:18393174. |
in both situations, a decrease in food intake and body weight gain, and the induction of insulin resistance with intolerance to d-glucose despite increased secretory response to the aldohexose of insulin-producing cells were documented. |
2008-10-06 |
2023-08-12 |
rat |
| Richard L Bradley, Justin Y Jeon, Fen-Fen Liu, Eleftheria Maratos-Flie. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. American journal of physiology. Endocrinology and metabolism. vol 295. issue 3. 2008-10-06. PMID:18577694. |
to test the hypothesis that exercise mitigates this inflammatory response, thereby improving insulin sensitivity, we developed a model of voluntary exercise in mice made obese by feeding of a high fat/high sucrose diet (hfd). |
2008-10-06 |
2023-08-12 |
mouse |
| Helga Ellingsgaard, Jan A Ehses, Eva B Hammar, Leentje Van Lommel, Roel Quintens, Geert Martens, Julie Kerr-Conte, Francois Pattou, Thierry Berney, Daniel Pipeleers, Philippe A Halban, Frans C Schuit, Marc Y Donat. Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 35. 2008-10-06. PMID:18719127. |
however, despite these alpha-cell effects, high-fat feeding of il-6 ko mice results in increased fed glycemia due to impaired insulin secretion, with unchanged insulin sensitivity and similar body weights. |
2008-10-06 |
2023-08-12 |
mouse |
| Melkam Kebede, Thierry Alquier, Martin G Latour, Meriem Semache, Caroline Tremblay, Vincent Poitou. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes. vol 57. issue 9. 2008-10-01. PMID:18559658. |
the fatty acid receptor gpr40 plays a role in insulin secretion in vivo after high-fat feeding. |
2008-10-01 |
2023-08-12 |
mouse |
| Melkam Kebede, Thierry Alquier, Martin G Latour, Meriem Semache, Caroline Tremblay, Vincent Poitou. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes. vol 57. issue 9. 2008-10-01. PMID:18559658. |
this study aimed to test the hypothesis that gpr40 plays a role in insulin secretion after high-fat feeding. |
2008-10-01 |
2023-08-12 |
mouse |
| B Guerci, C Salaun Marti. Exenatide: its position in the treatment of type 2 diabetes. Annales d'endocrinologie. vol 69. issue 3. 2008-09-30. PMID:18533126. |
it improves glycemic control by acting on the key organs involved in glucose homeostasis: it stimulates insulin secretion and suppresses glucagon secretion in a glucose-dependent way, slows gastric emptying and reduces food intake. |
2008-09-30 |
2023-08-12 |
Not clear |
| Xiufeng Pang, Jingjing Zhao, Wen Zhang, Xiuyuan Zhuang, Jiesi Wang, Ruiqi Xu, Ziliang Xu, Weijing Q. Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats. Journal of ethnopharmacology. vol 117. issue 2. 2008-09-26. PMID:18374529. |
feeding of high-sucrose diet (hs: 77% of kcal from carbohydrate, 16% from protein and 6% from lipid, respectively) for 6 weeks resulted in significant rise in systolic blood pressure (sbp) by 25.60%, plasma insulin by 114.24%, triglycerides by 85.14% and activated angiotensin || contents in heart and kidney. |
2008-09-26 |
2023-08-12 |
rat |
| Jun-Xu Li, Charles P Franc. Food restriction and streptozotocin treatment decrease 5-HT1A and 5-HT2A receptor-mediated behavioral effects in rats. Behavioural pharmacology. vol 19. issue 4. 2008-09-26. PMID:18622176. |
lower lip retraction and flat body posture (8-oh-dpat) and head twitching (doi) were measured in rats during free feeding, food restriction, after treatment with streptozotocin, and finally after insulin replacement. |
2008-09-26 |
2023-08-12 |
rat |
| Hiraku Ono, Alessandro Pocai, Yuhua Wang, Hideyuki Sakoda, Tomoichiro Asano, Jonathan M Backer, Gary J Schwartz, Luciano Rossett. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. The Journal of clinical investigation. vol 118. issue 8. 2008-09-25. PMID:18618016. |
extending previous findings that insulin suppresses hepatic glucose production (hgp) partly via its effect in the hypothalamus, we report that this effect was blunted by short-term high-fat diet (hfd) feeding, with concomitant suppression of insulin signaling and activation of s6k in the mediobasal hypothalamus (mbh). |
2008-09-25 |
2023-08-12 |
mouse |
| Hiraku Ono, Alessandro Pocai, Yuhua Wang, Hideyuki Sakoda, Tomoichiro Asano, Jonathan M Backer, Gary J Schwartz, Luciano Rossett. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. The Journal of clinical investigation. vol 118. issue 8. 2008-09-25. PMID:18618016. |
constitutive activation of s6k in the mbh mimicked the effect of the hfd in normal chow-fed animals, while suppression of s6k by overexpression of dominant-negative s6k or dominant-negative raptor in the mbh restored the ability of mbh insulin to suppress hgp after hfd feeding. |
2008-09-25 |
2023-08-12 |
mouse |