| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maxwell A Ruby, Daniel K Nomura, Carolyn S S Hudak, Anne Barber, John E Casida, Ronald M Kraus. Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes. PloS one. vol 6. issue 11. 2012-03-26. PMID:22073164. |
however, the sufficiency of endogenously produced endocannabinoids to cause hepatic lipid accumulation and insulin resistance, independent of food intake, has not been demonstrated. |
2012-03-26 |
2023-08-12 |
mouse |
| Young Joo Park, Seong Chul Kim, Jeehee Kim, Sayeepriyadarshini Anakk, Jae Man Lee, Hsiu-Ting Tseng, Vijay Yechoor, Junchol Park, June-Seek Choi, Hak Chul Jang, Ki-Up Lee, Colleen M Novak, David D Moore, Yoon Kwang Le. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. Journal of lipid research. vol 52. issue 12. 2012-03-19. PMID:21949050. |
compared with their c57bl/6 wild-type counterparts, shp(-/-) mice subjected to a 6 month challenge with a western diet (westd) were leaner but more glucose intolerant, showed hepatic insulin resistance despite decreased triglyceride accumulation and increased β-oxidation, exhibited alterations in peripheral tissue uptake of dietary lipids, maintained a higher respiratory quotient, which did not decrease even after westd feeding, and displayed islet dysfunction. |
2012-03-19 |
2023-08-12 |
mouse |
| Michael K Badman, Adam R Kennedy, Andrew C Adams, Pavlos Pissios, Eleftheria Maratos-Flie. A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss. American journal of physiology. Endocrinology and metabolism. vol 297. issue 5. 2012-03-13. PMID:19738035. |
kd feeding of ob/ob mice normalized fasting glycemia and substantially reduced insulin and lipid levels in the absence of weight loss. |
2012-03-13 |
2023-08-12 |
mouse |
| Chun-Xia Yi, Ewout Foppen, William Abplanalp, Yuanqing Gao, Anneke Alkemade, Susanne E la Fleur, Mireille J Serlie, Eric Fliers, Ruud M Buijs, Matthias H Tschöp, Andries Kalsbee. Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes. vol 61. issue 2. 2012-03-13. PMID:22210324. |
as glucocorticoids have pronounced effects on neuropeptide y (npy) expression and as npy neurons projecting from the arc to the pvn are pivotal for balancing feeding behavior and glucose metabolism, we investigated the effect of glucocorticoid signaling in these areas on endogenous glucose production (egp) and insulin sensitivity by local retrodialysis of the glucocorticoid receptor agonist dexamethasone into the arc or the pvn, in combination with isotope dilution and hyperinsulinemic-euglycemic clamp techniques. |
2012-03-13 |
2023-08-12 |
Not clear |
| Melissa A Burmeister, Tura Ferre, Jennifer E Ayala, Emily M King, Rochelle M Holt, Julio E Ayal. Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice. American journal of physiology. Endocrinology and metabolism. vol 302. issue 3. 2012-03-09. PMID:22094469. |
we hypothesized that acute inhibition of the central glp-1r impairs hepatic insulin action beyond the effects of hf feeding. |
2012-03-09 |
2023-08-12 |
mouse |
| Jennifer Keogh, Fiona Atkinson, Bronwyn Eisenhauer, Amar Inamdar, Jennie Brand-Mille. Food intake, postprandial glucose, insulin and subjective satiety responses to three different bread-based test meals. Appetite. vol 57. issue 3. 2012-03-07. PMID:21907743. |
food intake, postprandial glucose, insulin and subjective satiety responses to three different bread-based test meals. |
2012-03-07 |
2023-08-12 |
human |
| Benjamin J Lamont, Yazhou Li, Edwin Kwan, Theodore J Brown, Herbert Gaisano, Daniel J Drucke. Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. The Journal of clinical investigation. vol 122. issue 1. 2012-03-06. PMID:22182839. |
systemic glp-1r activation with the glp-1r agonist exendin-4 had no effect on food intake, hindbrain c-fos expression, or gastric emptying but improved glucose tolerance and stimulated insulin secretion in pdx1-hglp1r:glp1r-/- mice. |
2012-03-06 |
2023-08-12 |
mouse |
| L Borgia, S Valberg, M McCue, K Watts, J Paga. Glycaemic and insulinaemic responses to feeding hay with different non-structural carbohydrate content in control and polysaccharide storage myopathy-affected horses. Journal of animal physiology and animal nutrition. vol 95. issue 6. 2012-03-05. PMID:21198966. |
feeding hay with 17% nsc produces elevations in insulin that could be detrimental for pssm horses. |
2012-03-05 |
2023-08-12 |
Not clear |
| Megan J Dailey, Katherine C Stingl, Timothy H Mora. Disassociation between preprandial gut peptide release and food-anticipatory activity. Endocrinology. vol 153. issue 1. 2012-03-05. PMID:22128024. |
mealtime feeding not only induces an increase in activity but also appears to entrain the secretion of various peptides prior to a meal including insulin, ghrelin, and glucagon-like peptide-1 (glp-1). |
2012-03-05 |
2023-08-12 |
rat |
| b' L Malet\\xc3\\xadnsk\\xc3\\xa1, R Maty\\xc5\\xa1kov\\xc3\\xa1, J Maixnerov\\xc3\\xa1, D S\\xc3\\xbdkora, M P\\xc3\\xbdchov\\xc3\\xa1, A Spolcov\\xc3\\xa1, M Blechov\\xc3\\xa1, J Dr\\xc3\\xa1palov\\xc3\\xa1, Z Lacinov\\xc3\\xa1, M Haluz\\xc3\\xadk, B Zelezn\\xc3\\xa. The Peptidic GHS-R antagonist [D-Lys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity. Molecular and cellular endocrinology. vol 343. issue 1-2. 2012-03-02. PMID:21704671.' |
ghrelin receptor antagonist [d-lys(3)]ghrp-6 after seven days of subcutaneous treatment markedly decreased food intake in ovx mice fed both hf and standard diets; furthermore, it reduced body weight and blood glucose, insulin and leptin, and increased β-hydroxybutyrate level and uncoupling-protein-1 mrna in brown adipose tissue. |
2012-03-02 |
2023-08-12 |
mouse |
| V Babitha, P T Philomina, V Dildee. Effect of extended colostrum feeding on the plasma profile of insulin, thyroid hormones and blood glucose of crossbred pre-ruminant calves. Indian journal of physiology and pharmacology. vol 55. issue 2. 2012-03-02. PMID:22319894. |
effect of extended colostrum feeding on the plasma profile of insulin, thyroid hormones and blood glucose of crossbred pre-ruminant calves. |
2012-03-02 |
2023-08-12 |
Not clear |
| Kenichi Tanabe, Sadako Nakamura, Katsuhisa Omagari, Tsuneyuki Ok. Repeated ingestion of the leaf extract from Morus alba reduces insulin resistance in KK-Ay mice. Nutrition research (New York, N.Y.). vol 31. issue 11. 2012-02-29. PMID:22118756. |
blood samples were collected to measure fasting plasma glucose and insulin levels at weeks 2, 4, and 7 after the start of feeding. |
2012-02-29 |
2023-08-12 |
mouse |
| Nicolas Lanthier, Olivier Molendi-Coste, Patrice D Cani, Nico van Rooijen, Yves Horsmans, Isabelle A Leclerc. Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 12. 2012-02-28. PMID:21873555. |
interestingly, in mice fed a normal diet, prolonged kc depletion ameliorates insulin sensitivity and decreases adiposity without altering physiological body weight gain or food intake. |
2012-02-28 |
2023-08-12 |
mouse |
| Randi Ugleholdt, Jens Pedersen, Maria Rosaria Bassi, Ernst-Martin Füchtbauer, Signe Marie Jørgensen, Hanne-Louise Kissow, Nikolaj Nytofte, Steen Seier Poulsen, Mette Marie Rosenkilde, Yutaka Seino, Peter Thams, Peter Johannes Holst, Jens Juul Hols. Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain. The Journal of biological chemistry. vol 286. issue 52. 2012-02-27. PMID:22027838. |
in contrast, glucose-dependent insulinotropic polypeptide-mediated insulin secretion does not seem to be important for regulation of body weight after high fat feeding. |
2012-02-27 |
2023-08-12 |
mouse |
| Ye-bo Zhou, Jing Zhang, Yan Cai, Xu Teng, Xiao-hui Duan, Jun-qiu Song, Jie Du, Chao-shu Tang, Yong-fen Q. Insulin resistance induces medial artery calcification in fructose-fed rats. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 1. 2012-02-27. PMID:22238287. |
after 12 weeks of fructose feeding, rats showed severe ir, with increased levels of fasting blood glucose, serum insulin and oral glucose tolerance test (ogtt). |
2012-02-27 |
2023-08-12 |
rat |
| Ewan C McNay, Andrew K Recknage. Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiology of learning and memory. vol 96. issue 3. 2012-02-22. PMID:21907815. |
understanding of the role of insulin in the brain has gradually expanded, from initial conceptions of the brain as insulin-insensitive through identification of a role in regulation of feeding, to recent demonstration of insulin as a key component of hippocampal memory processes. |
2012-02-22 |
2023-08-12 |
Not clear |
| b' R Calm, M Garc\\xc3\\xada-Jaramillo, J Bondia, M A Sainz, J Veh\\xc3\\xa. Comparison of interval and Monte Carlo simulation for the prediction of postprandial glucose under uncertainty in type 1 diabetes mellitus. Computer methods and programs in biomedicine. vol 104. issue 3. 2012-02-21. PMID:20870308.' |
simulation of a glucoregulatory model with uncertainty in insulin sensitivities, glucose absorption and food intake is carried out using both methods. |
2012-02-21 |
2023-08-12 |
Not clear |
| Shu-Qiang Li, Yong Zhou, Yong Wang, Yuan Liu, Dong-Hua Geng, Jin-Gang Li. Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes? The Tohoku journal of experimental medicine. vol 225. issue 3. 2012-02-21. PMID:22001674. |
daily food intake, body weight, glucose and insulin were measured pre- and post-operatively. |
2012-02-21 |
2023-08-12 |
rat |
| Lennart Zabeau, Annick Verhee, Dominiek Catteeuw, Liesbeth Faes, Sylvie Seeuws, Tine Decruy, Dirk Elewaut, Frank Peelman, Jan Tavernie. Selection of non-competitive leptin antagonists using a random nanobody-based approach. The Biochemical journal. vol 441. issue 1. 2012-02-16. PMID:21851341. |
as a consequence, daily intraperitoneal injection increased body weight, body fat content, food intake, liver size and serum insulin levels. |
2012-02-16 |
2023-08-12 |
human |
| John P Driver, Deanna J Lamont, Conny Gysemans, Chantal Mathieu, David V Serrez. Calcium insufficiency accelerates type 1 diabetes in vitamin D receptor-deficient nonobese diabetic (NOD) mice. Endocrinology. vol 152. issue 12. 2012-02-16. PMID:21952242. |
feeding a high-lactose calcium rescue diet that circumvents a vdr requirement for calcium absorption from the intestine normalized serum calcium levels, restored β-cell insulin secretion, corrected glucose intolerance, and eliminated accelerated t1d in vdr-deficient nod mice. |
2012-02-16 |
2023-08-12 |
mouse |