| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P D Lambert, J P Wilding, A A al-Dokhayel, C Bohuon, E Comoy, S G Gilbey, S R Bloo. A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8100519. |
the aim of this study was to explore the role of npy, dynorphin, and na in the central control of feeding after a period of food deprivation. |
1993-08-03 |
2023-08-12 |
rat |
| P D Lambert, J P Wilding, A A al-Dokhayel, C Bohuon, E Comoy, S G Gilbey, S R Bloo. A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8100519. |
we have investigated the effect of intracerebroventricular injection of a monoclonal antibody to npy (npyab), a potent and selective kappa-opioid receptor antagonist norbinaltorphimine (norbni), and the alpha-adrenergic antagonist phentolamine on fast-induced food intake. |
1993-08-03 |
2023-08-12 |
rat |
| P D Lambert, J P Wilding, A A al-Dokhayel, C Bohuon, E Comoy, S G Gilbey, S R Bloo. A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8100519. |
these data would support a role for endogenous npy, dynorphin, and na in the mediation of fast-induced feeding. |
1993-08-03 |
2023-08-12 |
rat |
| S C Heinrichs, F Menzaghi, E M Pich, R L Hauger, G F Koo. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518948. |
central administration of neuropeptide y (npy) exerts a potent orexigenic effect in rats, whereas injection of corticotropin-releasing factor (crf) suppresses food intake. |
1993-07-29 |
2023-08-12 |
rat |
| S C Heinrichs, F Menzaghi, E M Pich, R L Hauger, G F Koo. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518948. |
injection of a 250-ng dose of alpha-hel crf within the paraventricular nucleus (pvn) of the hypothalamus significantly potentiated the feeding induced by a 500-ng dose of npy injected into the same locus. |
1993-07-29 |
2023-08-12 |
rat |
| S C Heinrichs, F Menzaghi, E M Pich, R L Hauger, G F Koo. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518948. |
in contrast, feeding induced by administration of the 500-ng dose of npy into the ventromedial hypothalamus (vmh) was not modified by intra-vmh pre-treatment with a 250-ng dose of crf antagonist. |
1993-07-29 |
2023-08-12 |
rat |
| S C Heinrichs, F Menzaghi, E M Pich, R L Hauger, G F Koo. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518948. |
no effects of npy or alpha-hel crf on feeding were observed after administration into the central nucleus of the amygdala. |
1993-07-29 |
2023-08-12 |
rat |
| S C Heinrichs, F Menzaghi, E M Pich, R L Hauger, G F Koo. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518948. |
systemic pre-treatment with the synthetic glucocorticoid dexamethasone at a dose known to downregulate the function of crf neurons in the pvn (100 micrograms/kg) enhanced feeding induced by intra-pvn administration of a 500-ng dose of npy. |
1993-07-29 |
2023-08-12 |
rat |
| M Heilig, S McLeod, M Brot, S C Heinrichs, F Menzaghi, G F Koob, K T Britto. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8099792. |
furthermore, in addition to its anxiolytic-like effects, intracerebroventricular administration of npy induces food intake through hypothalamic mechanisms, making the anxiolytic-like action of the peptide more difficult to interpret. |
1993-07-20 |
2023-08-12 |
human |
| M Heilig, S McLeod, M Brot, S C Heinrichs, F Menzaghi, G F Koob, K T Britto. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8099792. |
intracerebroventricular injection of npy produced increased food intake in free-feeding animals, and dose-dependent anticonflict/anxiolytic-like effects in an established animal model of anxiety, the geller-seifter punished responding test. |
1993-07-20 |
2023-08-12 |
human |
| M Heilig, S McLeod, M Brot, S C Heinrichs, F Menzaghi, G F Koob, K T Britto. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8099792. |
in contrast, microinjection of npy into the central nucleus of the amygdala did not increase food intake in free-feeding animals, did not affect unpunished lever pressing for food, but did reproduce the anticonflict/anxiolytic-like effect with high potency. |
1993-07-20 |
2023-08-12 |
human |
| M Heilig, S McLeod, M Brot, S C Heinrichs, F Menzaghi, G F Koob, K T Britto. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 4. 1993-07-20. PMID:8099792. |
thus, activation of y1 receptors in the central nucleus of the amygdala produces effects similar to established anxiolytics without affecting food intake, suggesting that y1-receptors in the amygdala may be a substrate for anxiolytic actions of npy. |
1993-07-20 |
2023-08-12 |
human |
| B Beck, A Burlet, R Bazin, J P Nicolas, C Burle. Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating. The Journal of nutrition. vol 123. issue 6. 1993-07-06. PMID:8505677. |
neuropeptide y (npy) mediates feeding behavior through a local hypothalamic network formed by the arcuate and paraventricular nuclei (the ap axis). |
1993-07-06 |
2023-08-12 |
rat |
| B Beck, A Burlet, R Bazin, J P Nicolas, C Burle. Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating. The Journal of nutrition. vol 123. issue 6. 1993-07-06. PMID:8505677. |
these neurons project to the paraventricular nucleus, the site where npy has the strongest stimulatory effects on food intake of sprague-dawley rats. |
1993-07-06 |
2023-08-12 |
rat |
| G A Bra. The nutrient balance hypothesis: peptides, sympathetic activity, and food intake. Annals of the New York Academy of Sciences. vol 676. 1993-06-10. PMID:8489134. |
opioids, npy and ghrh, which increase food intake, decrease sympathetic activity. |
1993-06-10 |
2023-08-12 |
Not clear |
| J P Wilding, S G Gilbey, C J Bailey, R A Batt, G Williams, M A Ghatei, S R Bloo. Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology. vol 132. issue 5. 1993-05-25. PMID:7682936. |
centrally administered neurotensin decreases food intake, whereas npy potently stimulates food intake. |
1993-05-25 |
2023-08-12 |
mouse |
| H D McCarthy, P E McKibbin, A V Perkins, E A Linton, G William. Alterations in hypothalamic NPY and CRF in anorexic tumor-bearing rats. The American journal of physiology. vol 264. issue 4 Pt 1. 1993-05-17. PMID:8476042. |
regional hypothalamic concentrations of neuropeptide y (npy) and corticotropin-releasing factor (crf), respectively a stimulant and an inhibitor of feeding behavior, were investigated in hypothalamic nuclei in rats carrying the yoshida sarcoma. |
1993-05-17 |
2023-08-12 |
rat |
| E V Borisova, T Kádá. [The participation of neuropeptide Y and the catecholaminergic systems of the brain in feeding behavior]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 43. issue 1. 1993-05-05. PMID:8385400. |
following intracerebroventricular (icv) administration of the lowest doses (100 ng) of neuropeptide y (npy) the feeding behaviour was suppressed, while higher doses (5 mcg) of npy enhanced it. |
1993-05-05 |
2023-08-12 |
Not clear |
| E V Borisova, T Kádá. [The participation of neuropeptide Y and the catecholaminergic systems of the brain in feeding behavior]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 43. issue 1. 1993-05-05. PMID:8385400. |
prazosin (9.5 nmol, icv), a selective alpha 1-adrenoceptor antagonist, attenuated the stimulatory effect of 5 mcg npy on food intake. |
1993-05-05 |
2023-08-12 |
Not clear |
| E V Borisova, T Kádá. [The participation of neuropeptide Y and the catecholaminergic systems of the brain in feeding behavior]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 43. issue 1. 1993-05-05. PMID:8385400. |
the effect of npy on feeding behaviour may, at least in part, be mediated via alpha 1-adrenoceptors. |
1993-05-05 |
2023-08-12 |
Not clear |