| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Boswell, R D Richardson, M W Schwartz, D A D'Alessio, S C Woods, A J Sipols, D G Baskin, G J Kenag. NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. Brain research bulletin. vol 32. issue 4. 1993-12-03. PMID:7693306. |
we used in situ hybridization histochemistry to localize the expression of npy and galanin mrna in the hypothalamus of normally feeding animals. |
1993-12-03 |
2023-08-12 |
Not clear |
| T Boswell, R D Richardson, M W Schwartz, D A D'Alessio, S C Woods, A J Sipols, D G Baskin, G J Kenag. NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. Brain research bulletin. vol 32. issue 4. 1993-12-03. PMID:7693306. |
when npy (0.1, 0.5, 2, and 8 micrograms) or galanin (0.1, 0.5, 2, and 8 micrograms) were injected into the third cerebral ventricle, food intake was significantly and dose-dependently increased over the subsequent 30 min. |
1993-12-03 |
2023-08-12 |
Not clear |
| T Boswell, R D Richardson, M W Schwartz, D A D'Alessio, S C Woods, A J Sipols, D G Baskin, G J Kenag. NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. Brain research bulletin. vol 32. issue 4. 1993-12-03. PMID:7693306. |
npy stimulated significant increases in food intake for up to 2 h whereas galanin's effect did not extend beyond 30 min. |
1993-12-03 |
2023-08-12 |
Not clear |
| S Dryden, H D McCarthy, U H Malabu, M Ware, G William. Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: evidence that NPY may mediate serotonin's effects on food intake. Peptides. vol 14. issue 4. 1993-12-01. PMID:8234027. |
increased neuropeptide y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: evidence that npy may mediate serotonin's effects on food intake. |
1993-12-01 |
2023-08-12 |
rat |
| S Dryden, H D McCarthy, U H Malabu, M Ware, G William. Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: evidence that NPY may mediate serotonin's effects on food intake. Peptides. vol 14. issue 4. 1993-12-01. PMID:8234027. |
methysergide administration, which stimulated feeding, therefore raised npy concentrations in the arc, where npy is synthesized, and in the pvn, a major site of npy release where npy injection induces hyperphagia. |
1993-12-01 |
2023-08-12 |
rat |
| S Dryden, H D McCarthy, U H Malabu, M Ware, G William. Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: evidence that NPY may mediate serotonin's effects on food intake. Peptides. vol 14. issue 4. 1993-12-01. PMID:8234027. |
these findings suggest that npyergic and serotoninergic innervations in the hypothalamus interact to regulate food intake, and raise the possibility that increased npy release may mediate the hyperphagic effect of serotoninergic 5-ht1bc/receptor blockade. |
1993-12-01 |
2023-08-12 |
rat |
| F Menzaghi, S C Heinrichs, E M Pich, F J Tilders, G F Koo. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain research. vol 618. issue 1. 1993-11-15. PMID:8402180. |
previous work has shown that administration of corticotropin-releasing factor (crf) into the lateral ventricle antagonizes the orexigenic effect of neuropeptide y (npy), and central injection of crf antagonist, alpha-helical crf(9-41) enhanced npy-induced food intake in satiated rats. |
1993-11-15 |
2023-08-12 |
rat |
| F Menzaghi, S C Heinrichs, E M Pich, F J Tilders, G F Koo. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain research. vol 618. issue 1. 1993-11-15. PMID:8402180. |
the aim of the present study was to determine the effects of selective inactivation of hypothalamic crf neurons on food intake induced by npy injection and to delineate which hypothalamic nucleus is involved in this npy/crf interaction related to the regulation of food intake. |
1993-11-15 |
2023-08-12 |
rat |
| F Menzaghi, S C Heinrichs, E M Pich, F J Tilders, G F Koo. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain research. vol 618. issue 1. 1993-11-15. PMID:8402180. |
in contrast, injection of crf-mab/toxins into the ventromedial nucleus of the hypothalamus (vmh) did not modify the feeding induced by npy injection into this hypothalamic area. |
1993-11-15 |
2023-08-12 |
rat |
| F Menzaghi, S C Heinrichs, E M Pich, F J Tilders, G F Koo. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain research. vol 618. issue 1. 1993-11-15. PMID:8402180. |
systemic pretreatment with the synthetic glucocorticoid dexamethasone at a dose known to downregulate the levels of crf in the pvn also enhanced the feeding induced by intra-pvn injection of npy. |
1993-11-15 |
2023-08-12 |
rat |
| F Menzaghi, S C Heinrichs, E M Pich, F J Tilders, G F Koo. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain research. vol 618. issue 1. 1993-11-15. PMID:8402180. |
this suggests that an equilibrium between crf and npy neuronal function within the pvn may play an important role in the regulation of food intake. |
1993-11-15 |
2023-08-12 |
rat |
| N M Gruaz, D D Pierroz, F Rohner-Jeanrenaud, P C Sizonenko, M L Auber. Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology. vol 133. issue 4. 1993-11-03. PMID:8404631. |
whereas central administration of npy strongly stimulates feeding, diet restriction produces overexpression of npy in the arcuate and paraventricular nuclei that might reflect behavioral adaptations to shortage of food. |
1993-11-03 |
2023-08-12 |
rat |
| N M Gruaz, D D Pierroz, F Rohner-Jeanrenaud, P C Sizonenko, M L Auber. Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology. vol 133. issue 4. 1993-11-03. PMID:8404631. |
in order to further analyse the role of npy during sexual maturation, a model of delayed sexual maturation imposed by food restriction and return to ad-libitum feeding was used. |
1993-11-03 |
2023-08-12 |
rat |
| N M Gruaz, D D Pierroz, F Rohner-Jeanrenaud, P C Sizonenko, M L Auber. Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology. vol 133. issue 4. 1993-11-03. PMID:8404631. |
in the rats receiving npy, significantly increased food intake and weight gain were observed but only one out of the 9 rats studied experienced vaginal opening at 66 d, the other 8 animals remaining sexually immature at 67 d at sacrifice. |
1993-11-03 |
2023-08-12 |
rat |
| N M Gruaz, D D Pierroz, F Rohner-Jeanrenaud, P C Sizonenko, M L Auber. Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology. vol 133. issue 4. 1993-11-03. PMID:8404631. |
since food restriction has been shown both to increase hypothalamic npy and to reduce or inhibit sexual function, these data bring evidence for the first time that npy could be involved in the inhibition of sexual maturation imposed by food restriction, since maintenance of elevated npy levels in the hypothalamus did prolong this state of sexual immaturity despite restoration of normal food intake. |
1993-11-03 |
2023-08-12 |
rat |
| J P Wilding, S G Gilbey, P D Lambert, M A Ghatei, S R Bloo. Increases in neuropeptide Y content and gene expression in the hypothalamus of rats treated with dexamethasone are prevented by insulin. Neuroendocrinology. vol 57. issue 4. 1993-10-04. PMID:8367026. |
the neurotransmitter neuropeptide y (npy) is abundant in the hypothalamus where its actions include the potent stimulation of food intake. |
1993-10-04 |
2023-08-12 |
rat |
| J P Wilding, S G Gilbey, P D Lambert, M A Ghatei, S R Bloo. Increases in neuropeptide Y content and gene expression in the hypothalamus of rats treated with dexamethasone are prevented by insulin. Neuroendocrinology. vol 57. issue 4. 1993-10-04. PMID:8367026. |
this dual regulatory system for hypothalamic npy may be important in the control of food intake by corticosteroids and insulin. |
1993-10-04 |
2023-08-12 |
rat |
| A Stricker-Krongrad, G Barbanel, B Beck, A Burlet, J P Nicolas, C Burle. K(+)-stimulated neuropeptide Y release into the paraventricular nucleus and relation to feeding behavior in free-moving rats. Neuropeptides. vol 24. issue 5. 1993-08-06. PMID:8327072. |
neuropeptide y (npy) strongly stimulates food intake when it is injected in the central nervous system and especially in the hypothalamus. |
1993-08-06 |
2023-08-12 |
rat |
| H J Thomson, J G Geoghegan, M Farouk, L A Saperstein, K Chung, W C Meyers, T N Pappa. Exogenous neuropeptide Y blocks myoelectric activity in the upper gastrointestinal tract of starved dogs. Brain neuropeptide Y converts a fasting pattern of myoelectric activity to a fed pattern. Scandinavian journal of gastroenterology. vol 28. issue 6. 1993-08-05. PMID:8322021. |
this may reflect a central regulatory role for npy in the coordination of feeding. |
1993-08-05 |
2023-08-12 |
dog |
| P D Lambert, J P Wilding, A A al-Dokhayel, C Bohuon, E Comoy, S G Gilbey, S R Bloo. A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8100519. |
a marked increase in food intake is observed in the rat after central injection of neuropeptide-y (npy), dynorphin, or noradrenaline (na). |
1993-08-03 |
2023-08-12 |
rat |