| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristy M Heppner, Nilika Chaudhary, Timo D Müller, Henriette Kirchner, Kirk M Habegger, Nickki Ottaway, David L Smiley, Richard Dimarchi, Susanna M Hofmann, Stephen C Woods, Bjørn Sivertsen, Birgitte Holst, Paul T Pfluger, Diego Perez-Tilve, Matthias H Tschö. Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology. vol 153. issue 10. 2012-12-11. PMID:22865372. |
ghrelin is a gastrointestinal polypeptide that acts through the ghrelin receptor (ghsr) to promote food intake and increase adiposity. |
2012-12-11 |
2023-08-12 |
mouse |
| Kristy M Heppner, Nilika Chaudhary, Timo D Müller, Henriette Kirchner, Kirk M Habegger, Nickki Ottaway, David L Smiley, Richard Dimarchi, Susanna M Hofmann, Stephen C Woods, Bjørn Sivertsen, Birgitte Holst, Paul T Pfluger, Diego Perez-Tilve, Matthias H Tschö. Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology. vol 153. issue 10. 2012-12-11. PMID:22865372. |
we therefore evaluated a series of differentially acylated peptides to determine whether alterations in length or stability of the fa side chain have an impact on the ability of ghrelin to activate ghsr in vitro or to differentially alter food intake, body weight, and body composition in vivo. |
2012-12-11 |
2023-08-12 |
mouse |
| E W Lamont, Z Patterson, T Rodrigues, O Vallejos, I D Blum, A Abizai. Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm. Neuroscience. vol 218. 2012-11-16. PMID:22641088. |
here we hypothesized that neuronal activation in reward-related areas in anticipation of a scheduled meal could be mediated by elevated ghrelin induced by scheduled feeding, and therefore this would be attenuated in ghrelin receptor knock-out (ghsr ko) animals. |
2012-11-16 |
2023-08-12 |
mouse |
| A Bahrami, S R Miraei-Ashtiani, H Mehrabani-Yegane. Associations of growth hormone secretagogue receptor (GHSR) genes polymorphisms and protein structure changes with carcass traits in sheep. Gene. vol 505. issue 2. 2012-10-11. PMID:22735618. |
growth hormone secretagogue receptor (ghsr), a g protein-coupled receptor that binds ghrelin, plays an important role in the central regulation of pituitary growth hormone secretion, food intake, and energy homeostasis. |
2012-10-11 |
2023-08-12 |
Not clear |
| Kirk M Habegger, Erin Grant, Paul Thomas Pfluger, Diego Perez-Tilve, Alan Daugherty, Dennis Bruemmer, Matthias H Tschöp, Susanna M Hofman. Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice. Frontiers in endocrinology. vol 2. 2012-08-23. PMID:22649381. |
ghrelin, a stomach-derived, secreted peptide, and its receptor (growth hormone secretagogue receptor, ghsr) are known to modulate food intake and energy homeostasis. |
2012-08-23 |
2023-08-12 |
mouse |
| Agustina Cabral, Olga Suescun, Jeffrey M Zigman, Mario Perell. Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363652. |
ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, ghsr (growth hormone secretagogue receptor). |
2012-06-29 |
2023-08-12 |
mouse |
| Ligen Lin, Pradip K Saha, Xiaojun Ma, Iyabo O Henshaw, Longjiang Shao, Benny H J Chang, Eric D Buras, Qiang Tong, Lawrence Chan, Owen P McGuinness, Yuxiang Su. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging cell. vol 10. issue 6. 2012-04-02. PMID:21895961. |
old ghsr(-/-) mice also exhibit elevated energy expenditure and resting metabolic rate, yet have similar food intake and locomotor activity. |
2012-04-02 |
2023-08-12 |
mouse |
| Rachel Potter, Andrew G Horti, Hayden T Ravert, Daniel P Holt, Paige Finley, Ursula Scheffel, Robert F Dannals, Richard L Wah. Synthesis and in vivo evaluation of (S)-6-(4-fluorophenoxy)-3-((1-[11C]methylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one, a potential PET tracer for growth hormone secretagogue receptor (GHSR). Bioorganic & medicinal chemistry. vol 19. issue 7. 2011-10-24. PMID:21388815. |
in vivo imaging of the ghsr could shed light on the mechanism by which ghrelin affects feeding behavior and thus offers a new therapeutic perspective for the development of effective treatments. |
2011-10-24 |
2023-08-12 |
Not clear |
| Susana Sangiao-Alvarellos, Fernando Cordid. Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. International journal of peptides. vol 2010. 2011-07-14. PMID:20700401. |
mice with targeted deletion of either ghrelin or the ghsr exhibit an essentially normal metabolic phenotype when fed a regular chow diet, suggesting that ghrelin may have a redundant role in the regulation of food intake. |
2011-07-14 |
2023-08-12 |
mouse |
| Daniele Campa, Barbara Pardini, Alessio Naccarati, Ludmila Vodickova, Jan Novotny, Verena Steinke, Nils Rahner, Elke Holinski-Feder, Monika Morak, Hans K Schackert, Heike Görgens, Judith Kötting, Beate Betz, Matthias Kloor, Christoph Engel, Reinhard Büttner, Peter Propping, Asta Försti, Kari Hemminki, Roberto Barale, Pavel Vodicka, Federico Canzia. Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study. BMC gastroenterology. vol 10. 2011-02-01. PMID:20920174. |
ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (ghsr), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. |
2011-02-01 |
2023-08-12 |
Not clear |
| Qijiang Jin, Xing Tang Fang, Liu Yang, Chun Lei Zhang, Jia Jie Sun, Dan Xia Chen, X Y Shi, Yu Du, Chuchao Lei, Hong Che. Novel SNPs of the caprine growth hormone secretagogue receptor (GHSR) gene and their association with growth traits in goats. Biochemical genetics. vol 48. issue 9-10. 2010-12-17. PMID:20658315. |
growth hormone secretagogue receptor (ghsr), a g protein-coupled receptor that binds ghrelin, plays an important role in the central regulation of pituitary growth hormone secretion, food intake, and energy homeostasis. |
2010-12-17 |
2023-08-12 |
Not clear |
| J-P Chanoine, K De Waele, P Wali. Ghrelin and the growth hormone secretagogue receptor in growth and development. International journal of obesity (2005). vol 33 Suppl 1. 2010-04-20. PMID:19363508. |
in mice, absence of the ghsr gene is associated with lower insulin-like growth factor 1 concentrations and lower body mass in adult animals, independently of food intake. |
2010-04-20 |
2023-08-12 |
mouse |
| I D Blum, Z Patterson, R Khazall, E W Lamont, M W Sleeman, T L Horvath, A Abizai. Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19666088. |
these behavioral measures correlated with attenuated levels of fos immunoreactivity in a number of hypothalamic nuclei from ghsr ko placed on the same restricted feeding schedule for 7 days and sacrificed at zt4. |
2010-02-12 |
2023-08-12 |
mouse |
| Edwin A Garcia, Barbara Heude, Clive J Petry, Maria Gueorguiev, Zaki K Hassan-Smith, Antigoni Spanou, Susan M Ring, David B Dunger, Nicholas Wareham, Manjinder S Sandhu, Ken K Ong, Márta Korbonit. Ghrelin receptor gene polymorphisms and body size in children and adults. The Journal of clinical endocrinology and metabolism. vol 93. issue 10. 2008-11-24. PMID:18647811. |
the gh secretagogue receptor type 1a gene (ghsr) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary gh secretion. |
2008-11-24 |
2023-08-12 |
human |
| Guang Liu, Jean-Philippe Fortin, Martin Beinborn, Alan S Kopi. Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities. The Journal of pharmacology and experimental therapeutics. vol 322. issue 3. 2007-10-19. PMID:17596538. |
the growth hormone secretagogue receptor (ghsr) plays an important role in regulating food intake and energy homeostasis. |
2007-10-19 |
2023-08-12 |
human |
| Deborah J Clegg, Lynda M Brown, Jeffrey M Zigman, Christopher J Kemp, April D Strader, Stephen C Benoit, Stephen C Woods, Michela Mangiaracina, Nori Gear. Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes. vol 56. issue 4. 2007-07-19. PMID:17251274. |
to investigate sex differences in the action of ghrelin, we assessed the effects of exogenous ghrelin in intact male and female rats, the effects of exogenous ghrelin in ovariectomized (ovx) and estradiol (e2)-treated female rats, as well as the effects of ovx on plasma ghrelin and hypothalamic orexigneic neuropeptide expression in rats and on food intake and weight gain in transgenic mice lacking the ghrelin receptor (ghsr(-/-) mice). |
2007-07-19 |
2023-08-12 |
mouse |
| Deborah J Clegg, Lynda M Brown, Jeffrey M Zigman, Christopher J Kemp, April D Strader, Stephen C Benoit, Stephen C Woods, Michela Mangiaracina, Nori Gear. Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes. vol 56. issue 4. 2007-07-19. PMID:17251274. |
furthermore, ovx increased food intake and body weight in wild-type mice, but not in ghsr(-/-) mice, suggesting that ovx increases food intake by releasing ghrelin from a tonic inhibitory effect of estradiol. |
2007-07-19 |
2023-08-12 |
mouse |
| Philippe Zizzari, Romaine Longchamps, Jacques Epelbaum, Marie Thérèse Bluet-Pajo. Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology. vol 148. issue 4. 2007-04-24. PMID:17204551. |
administration of ghrelin, an endogenous ligand for the gh secretagogue receptor 1a (ghsr 1a), induces potent stimulating effects on gh secretion and food intake. |
2007-04-24 |
2023-08-12 |
mouse |
| Alfonso Abizaid, Zhong-Wu Liu, Zane B Andrews, Marya Shanabrough, Erzsebet Borok, John D Elsworth, Robert H Roth, Mark W Sleeman, Marina R Picciotto, Matthias H Tschöp, Xiao-Bing Gao, Tamas L Horvat. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17060947. |
the ghrelin receptor growth hormone secretagogue 1 receptor (ghsr) is present in hypothalamic centers controlling energy metabolism as well as in the ventral tegmental area (vta), a region important for motivational aspects of multiple behaviors, including feeding. |
2007-01-22 |
2023-08-12 |
mouse |
| Alfonso Abizaid, Zhong-Wu Liu, Zane B Andrews, Marya Shanabrough, Erzsebet Borok, John D Elsworth, Robert H Roth, Mark W Sleeman, Marina R Picciotto, Matthias H Tschöp, Xiao-Bing Gao, Tamas L Horvat. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. The Journal of clinical investigation. vol 116. issue 12. 2007-01-22. PMID:17060947. |
direct vta administration of ghrelin also triggered feeding, while intra-vta delivery of a selective ghsr antagonist blocked the orexigenic effect of circulating ghrelin and blunted rebound feeding following fasting. |
2007-01-22 |
2023-08-12 |
mouse |