| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Paula Cornejo, Franco Barrile, Daniela Cassano, Julieta Paola Aguggia, Guadalupe García Romero, Mirta Reynaldo, María Florencia Andreoli, Pablo Nicolás De Francesco, Mario Perell. Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice. Psychoneuroendocrinology. vol 119. 2021-07-21. PMID:32535402. |
the dopamine (da) pathways have long been recognized to play key roles mediating ghsr effects on feeding behaviors. |
2021-07-21 |
2023-08-13 |
mouse |
| Lola J Torz, Sherri Osborne-Lawrence, Juan Rodriguez, Zhenyan He, María Paula Cornejo, Emilio Román Mustafá, Chunyu Jin, Natalia Petersen, Morten A Hedegaard, Maja Nybo, Valentina Martínez Damonte, Nathan P Metzger, Bharath K Mani, Kevin W Williams, Jesica Raingo, Mario Perello, Birgitte Holst, Jeffrey M Zigma. Metabolic insights from a GHSR-A203E mutant mouse model. Molecular metabolism. vol 39. 2021-07-08. PMID:32339772. |
these processes may also be influenced by constitutive (ghrelin-independent) ghsr activity, as suggested by findings in short people with naturally occurring ghsr-a204e mutations and reduced food intake and blood glucose in rodents administered ghsr inverse agonists, both of which impair constitutive ghsr activity. |
2021-07-08 |
2023-08-13 |
mouse |
| Bharath K Mani, Carlos M Castorena, Claudia R Vianna, Charlotte E Lee, Nathan P Metzger, Prasanna Vijayaraghavan, Sherri Osborne-Lawrence, Joel K Elmquist, Jeffrey M Zigma. Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but does not Additively Reduce Body Weight or Eating. Neuroscience. vol 447. 2021-05-14. PMID:31520709. |
in contrast, although mouse models lacking ghrelin or its receptor (growth hormone secretagogue receptor (ghsr)) exhibit life-threatening hypoglycemia in starvation-like states, they do not exhibit appreciable reductions in food intake, bw, adiposity, blood glucose, or survival when food availability is unrestricted. |
2021-05-14 |
2023-08-13 |
mouse |
| Bharath K Mani, Carlos M Castorena, Claudia R Vianna, Charlotte E Lee, Nathan P Metzger, Prasanna Vijayaraghavan, Sherri Osborne-Lawrence, Joel K Elmquist, Jeffrey M Zigma. Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but does not Additively Reduce Body Weight or Eating. Neuroscience. vol 447. 2021-05-14. PMID:31520709. |
to test this hypothesis, we assessed food intake, bw, blood glucose, survival, and plasma acyl-ghrelin in ad libitum-fed male wild-type mice and those that genetically lack ghsr (ghsr-nulls), cb1r (cb1r-nulls), or both ghsr and cb1r (double-nulls). |
2021-05-14 |
2023-08-13 |
mouse |
| Marie V Le May, Fiona Peris-Sampedro, Iris Stoltenborg, Erik Schéle, Tina Bake, Roger A H Adan, Suzanne L Dickso. Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice. Frontiers in neuroscience. vol 15. 2021-03-05. PMID:33658910. |
the receptor for the orexigenic hormone ghrelin (the growth hormone secretagogue receptor, ghsr) is also abundantly expressed in the lpbn and ghrelin delivery to this site has recently been shown to increase food intake and alter food choice. |
2021-03-05 |
2023-08-13 |
mouse |
| María P Cornejo, Emilio R Mustafá, Daniela Cassano, Jean-Louis Banères, Jesica Raingo, Mario Perell. The ups and downs of growth hormone secretagogue receptor signaling. The FEBS journal. 2021-03-02. PMID:33460513. |
ghsr is mainly expressed in the pituitary and the brain, and plays key roles regulating not only growth hormone secretion but also food intake, adiposity, body weight, glucose homeostasis and other complex functions. |
2021-03-02 |
2023-08-13 |
Not clear |
| Khoubaib Ben Haj Salah, Mathieu Maingot, Anne-Laure Blayo, Céline M'Kadmi, Marjorie Damian, Sophie Mary, Sonia Cantel, Jérémie Neasta, Catherine Oiry, Sylvie Péraldi-Roux, Gimena Fernandez, Guadalupe García Romero, Mario Perello, Jacky Marie, Jean-Louis Banères, Jean-Alain Fehrentz, Séverine Denoyell. Development of Nonpeptidic Inverse Agonists of the Ghrelin Receptor (GHSR) Based on the 1,2,4-Triazole Scaffold. Journal of medicinal chemistry. vol 63. issue 19. 2021-01-07. PMID:32882134. |
ghsr controls, among others, growth hormone and insulin secretion, adiposity, feeding, and glucose metabolism. |
2021-01-07 |
2023-08-13 |
mouse |
| Caishun Zhang, Junhua Yuan, Qian Lin, Manwen Li, Liuxin Wang, Rui Wang, Xi Chen, Zhengyao Jiang, Kun Zhu, Xiaoli Chang, Bin Wang, Jing Don. Ghrelin in the lateral parabrachial nucleus influences the excitability of glucosensing neurons, increases food intake and body weight. Endocrine connections. vol 9. issue 12. 2021-01-06. PMID:33112816. |
these results demonstrated that microinjection of ghrelin in lpbn could increase food intake through the interaction with growth hormone secretagogue receptor (ghsr) in c57bl/6j mice, and its chronic administration could also increase body weight gain. |
2021-01-06 |
2023-08-13 |
mouse |
| Tsung-Chieh Lin, Yuan-Ming Yeh, Wen-Lang Fan, Yu-Chan Chang, Wei-Ming Lin, Tse-Yen Yang, Michael Hsia. Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion. Cancers. vol 11. issue 3. 2020-10-01. PMID:30836712. |
ghrelin is a peptide hormone, originally identified from the stomach, that functions as an endogenous ligand of the growth hormone secretagogue receptor (ghsr) and promotes growth hormone (gh) release and food intake. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rebecca E Hay, Alex Edwards, Marianne Klein, Lindsay Hyland, David MacDonald, Ilia Karatsoreos, Matthew N Hill, Alfonso Abizai. Ghrelin Receptor Signaling Is Not Required for Glucocorticoid-Induced Obesity in Male Mice. Endocrinology. vol 161. issue 3. 2020-08-05. PMID:31748785. |
as expected, cort treatment increased food intake, weight gain, and adiposity, but contrary to expectations, mice treated with a ghsr receptor antagonist or ghsr knockout (ko) mice did not show attenuated food intake, weight gain, or adiposity in response to cort. |
2020-08-05 |
2023-08-13 |
mouse |
| Rebecca E Hay, Alex Edwards, Marianne Klein, Lindsay Hyland, David MacDonald, Ilia Karatsoreos, Matthew N Hill, Alfonso Abizai. Ghrelin Receptor Signaling Is Not Required for Glucocorticoid-Induced Obesity in Male Mice. Endocrinology. vol 161. issue 3. 2020-08-05. PMID:31748785. |
in all, we propose that blocking ghsr signaling helps to moderate glucose concentrations when cort levels are high, but blocking ghsr signaling does not prevent increased food intake, weight gain, or increased adiposity produced by chronic cort. |
2020-08-05 |
2023-08-13 |
mouse |
| Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, Masamitsu Nakazat. Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents. The Journal of endocrinology. vol 244. issue 1. 2020-07-13. PMID:31539874. |
leap2 did not inhibit neuropeptide y (npy)-induced food intake or des-acyl ghrelin-induced reduction in body temperature, indicating that the inhibitory effects of leap2 were specific for ghsr. |
2020-07-13 |
2023-08-13 |
rat |
| Cristina Torres-Fuentes, Anna V Golubeva, Alexander V Zhdanov, Shauna Wallace, Silvia Arboleya, Dimitri B Papkovsky, Sahar El Aidy, Paul Ross, Bernard L Roy, Catherine Stanton, Timothy G Dinan, John F Cryan, Harriet Schelleken. Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 12. 2020-06-09. PMID:31545915. |
the ghrelin receptor [growth hormone secretagogue receptor (ghsr)-1a] is a gpcr expressed throughout both the gut and the brain and plays a crucial role in maintaining energy balance, metabolism, and the central modulation of food intake, motivation, reward, and mood. |
2020-06-09 |
2023-08-13 |
Not clear |
| Shauna E Wallace Fitzsimons, Barbara Chruścicka, Clementine Druelle, Panagiota Stamou, Ken Nally, Timothy G Dinan, John F Cryan, Harriët Schelleken. A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling. Neuropharmacology. vol 152. 2020-03-30. PMID:30582955. |
the ghrelin receptor (ghsr), known primarily for its role in centrally regulated energy balance and food intake, has in more recent years also been shown to play a role in mood disorders, including anxiety and depression. |
2020-03-30 |
2023-08-13 |
Not clear |
| L J Zallar, B J Tunstall, C T Richie, Y J Zhang, Z B You, E L Gardner, M Heilig, J Pickel, G F Koob, L F Vendruscolo, B K Harvey, L Leggi. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. International journal of obesity (2005). vol 43. issue 2. 2020-01-03. PMID:29453460. |
ghrelin, a stomach-derived hormone implicated in numerous behaviors including feeding, reward, stress, and addictive behaviors, acts by binding to the growth hormone secretagogue receptor (ghsr). |
2020-01-03 |
2023-08-13 |
rat |
| Céline M'Kadmi, Agustina Cabral, Franco Barrile, Julien Giribaldi, Sonia Cantel, Marjorie Damian, Sophie Mary, Séverine Denoyelle, Sébastien Dutertre, Sylvie Péraldi-Roux, Jérémie Neasta, Catherine Oiry, Jean-Louis Banères, Jacky Marie, Mario Perello, Jean-Alain Fehrent. N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor. Journal of medicinal chemistry. vol 62. issue 2. 2019-10-17. PMID:30543423. |
the ghrelin receptor or growth hormone secretagogue receptor (ghsr) is a g-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors. |
2019-10-17 |
2023-08-13 |
mouse |
| Sarah J Terrill, Kaylee D Wall, Nelson D Medina, Calyn B Maske, Diana L William. Lateral septum growth hormone secretagogue receptor affects food intake and motivation for sucrose reinforcement. American journal of physiology. Regulatory, integrative and comparative physiology. vol 315. issue 1. 2019-07-16. PMID:29590554. |
we examined the feeding effects of ghrelin and the ghsr antagonists ([d-lys |
2019-07-16 |
2023-08-13 |
Not clear |
| Xuecai Ge, Hong Yang, Maria A Bednarek, Hadas Galon-Tilleman, Peirong Chen, Michael Chen, Joshua S Lichtman, Yan Wang, Olivier Dalmas, Yiyuan Yin, Hui Tian, Lutz Jermutus, Joseph Grimsby, Cristina M Rondinone, Anish Konkar, Daniel D Kapla. LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor. Cell metabolism. vol 27. issue 2. 2019-06-04. PMID:29233536. |
leap2 fully inhibits ghsr activation by ghrelin and blocks the major effects of ghrelin in vivo, including food intake, gh release, and maintenance of viable glucose levels during chronic caloric restriction. |
2019-06-04 |
2023-08-13 |
Not clear |
| You Lv, Tingting Liang, Guixia Wang, Zhuo L. Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism. Bioscience reports. vol 38. issue 5. 2019-05-13. PMID:30177523. |
many previous studies have shown that ghrelin and ghsr are involved in the regulation of energy homeostasis, and its administration can increase food intake and body weight gain. |
2019-05-13 |
2023-08-13 |
human |
| Bharath K Mani, Carlos M Castorena, Sherri Osborne-Lawrence, Prasanna Vijayaraghavan, Nathan P Metzger, Joel K Elmquist, Jeffrey M Zigma. Ghrelin mediates exercise endurance and the feeding response post-exercise. Molecular metabolism. vol 9. 2019-03-04. PMID:29396372. |
in the current study, we aimed to investigate the role of the hormone ghrelin and its receptor, the growth hormone secretagogue receptor (ghsr; ghrelin receptor), in mediating the effects of exercise on food intake and blood glucose following exercise as well as in regulating exercise endurance capacity. |
2019-03-04 |
2023-08-13 |
Not clear |