| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lorena López-Ferreras, Jennifer E Richard, Rozita H Anderberg, Fredrik H Nilsson, Kajsa Olandersson, Scott E Kanoski, Karolina P Skibick. Ghrelin's control of food reward and body weight in the lateral hypothalamic area is sexually dimorphic. Physiology & behavior. vol 176. 2018-03-08. PMID:28213203. |
females had slightly higher ghsr levels in the lha compared to males, and importantly, acute blockade of the ghsr in the lha significantly reduced food intake, body weight, and motivated behavior for sucrose in female but not male rats. |
2018-03-08 |
2023-08-13 |
rat |
| Lorena López-Ferreras, Jennifer E Richard, Rozita H Anderberg, Fredrik H Nilsson, Kajsa Olandersson, Scott E Kanoski, Karolina P Skibick. Ghrelin's control of food reward and body weight in the lateral hypothalamic area is sexually dimorphic. Physiology & behavior. vol 176. 2018-03-08. PMID:28213203. |
chronic lha ghsr reduction in female rats achieved by rna inference-mediated ghsr knockdown, resulting in a 25% reduction in lha ghsr mrna, abolished the reward-driven behavioral effects of lha-targeted ghrelin, but was not sufficient to affect baseline food intake or food reward responding. |
2018-03-08 |
2023-08-13 |
rat |
| Gimena Fernandez, Agustina Cabral, María F Andreoli, Alexandra Labarthe, Céline M'Kadmi, Jorge G Ramos, Jacky Marie, Jean-Alain Fehrentz, Jacques Epelbaum, Virginie Tolle, Mario Perell. Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice. Endocrinology. vol 159. issue 2. 2018-02-15. PMID:29300858. |
thus, the hypothalamic ghsr signaling system could affect the set point of daily food intake, independently of plasma ghrelin levels, in situations of negative energy balance. |
2018-02-15 |
2023-08-13 |
mouse |
| Shao-Rui Chen, Hong Chen, Jing-Jing Zhou, Geetali Pradhan, Yuxiang Sun, Hui-Lin Pan, De-Pei L. Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons. Journal of neurochemistry. vol 142. issue 4. 2017-09-07. PMID:28547758. |
growth hormone secretagogue receptor (ghsr) mediates the effect of ghrelin on feeding behavior and energy homeostasis. |
2017-09-07 |
2023-08-13 |
mouse |
| Mohammed Abu El-Magd, Ayman A Saleh, Tamer M Abdel-Hamid, Rasha M Saleh, Mohammed A Afif. Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH. General and comparative endocrinology. vol 237. 2017-09-04. PMID:27591070. |
chicken growth hormone secretagogue receptor (ghsr) is a receptor for ghrelin (ghrl), a peptide hormone produced by chicken proventriculus, which stimulates growth hormone (gh) release and food intake. |
2017-09-04 |
2023-08-13 |
chicken |
| Alexander Edwards, Alfonso Abizai. Clarifying the Ghrelin System's Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. International journal of molecular sciences. vol 18. issue 4. 2017-07-24. PMID:28422060. |
clarifying the ghrelin system's ability to regulate feeding behaviours despite enigmatic spatial separation of the ghsr and its endogenous ligand. |
2017-07-24 |
2023-08-13 |
Not clear |
| Harry MacKay, Valerie R Charbonneau, Veronique St-Onge, Emma Murray, Alexander Watts, Martin K Wellman, Alfonso Abizai. Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food. Physiology & behavior. vol 163. 2017-06-16. PMID:27129673. |
ghrelin acts on the ghsr to increase food intake, appetitive behaviors, and adiposity. |
2017-06-16 |
2023-08-13 |
mouse |
| Jong Han Lee, Ligen Lin, Pingwen Xu, Kenji Saito, Qiong Wei, Adelina G Meadows, Odelia Y N Bongmba, Geetali Pradhan, Hui Zheng, Yong Xu, Yuxiang Su. Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. Diabetes. vol 65. issue 8. 2017-06-05. PMID:27207529. |
our data showed that neuronal ghsr deletion abolishes ghrelin-induced spontaneous food intake but has no effect on total energy intake. |
2017-06-05 |
2023-08-13 |
mouse |
| Maria Mele, Giuseppina Iachetta, Raffaella Alò, Ennio Avolio, Gilda Fazzari, Antonio Carelli, Vincenza Laforgia, Marcello Canonac. Catestatin and GABA(A)R related feeding habits rely on dopamine, ghrelin plus leptin neuroreceptor expression variations. Physiology & behavior. vol 157. 2016-12-13. PMID:26875516. |
overall, the anorexigenic effect of cst deriving from its tight interaction with gabaars activity plus d1 and ghsr transcripts tends to propose these neuronal elements as pivotal factors responsible for feeding disorders. |
2016-12-13 |
2023-08-13 |
Not clear |
| Nicole H Rogers, Heidi Walsh, Oscar Alvarez-Garcia, Seongjoon Park, Bruce Gaylinn, Michael O Thorner, Roy G Smit. Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin. Endocrinology. vol 157. issue 4. 2016-08-17. PMID:26812158. |
inactivation of ghrelin or ghsr had no effect on al food intake or food anticipatory behavior. |
2016-08-17 |
2023-08-13 |
mouse |
| X J Wei, B Sun, K Chen, B Lv, X Luo, J Q Ya. Ghrelin signaling in the ventral tegmental area mediates both reward-based feeding and fasting-induced hyperphagia on high-fat diet. Neuroscience. vol 300. 2016-03-29. PMID:25967263. |
ghrelin is a potent orexigenic hormone that acts in the central nervous system to stimulate food intake via the growth hormone secretagogue receptor (ghsr) that is abundantly expressed in the ventral tegmental area (vta). |
2016-03-29 |
2023-08-13 |
rat |
| Clemence Girardet, Maria Mavrikaki, Mark R Southern, Roy G Smith, Andrew A Butle. Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice. Endocrinology. vol 155. issue 12. 2015-07-08. PMID:25211592. |
to investigate the interaction between ghsrs and mc3rs, we compared food anticipatory responses in ghsrko, mc3rko, and double ghsr;mc3r knockout (dko) mice subjected to a hypocaloric restricted feeding (rf) protocol in constant dark or 12-hour light, 12-hour dark settings. |
2015-07-08 |
2023-08-13 |
mouse |
| Yue Yin, Yin Li, Weizhen Zhan. The growth hormone secretagogue receptor: its intracellular signaling and regulation. International journal of molecular sciences. vol 15. issue 3. 2015-02-13. PMID:24651458. |
the growth hormone secretagogue receptor (ghsr), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase of food intake and body weight, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion, protection of neuronal and cardiovascular cells, and regulation of immune function. |
2015-02-13 |
2023-08-12 |
Not clear |
| Ligen Lin, Alli M Nuotio-Antar, Xiaojun Ma, Feng Liu, Marta L Fiorotto, Yuxiang Su. Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. The Journal of nutrition. vol 144. issue 9. 2014-12-15. PMID:24991043. |
to assess whether ghs-r regulates feeding pattern during aging, we studied meal patterns for the following cohorts of male mice fed a normal unpurified diet: 1) 3-4 mo, young wild-type (wt) mice; 2) 3-4 mo, young ghsr-null (ghsr(-/-)) mice; 3) 12-14 mo, middle-aged wt (wt-m) mice; 4) 12-14 mo, middle-aged ghsr(-/-) (ghsr(-/-)-m) mice; 5) 24-26 mo, old wt (wt-o) mice; and 6) 24-26 mo, old ghsr(-/-) (ghsr(-/-)-o) mice. |
2014-12-15 |
2023-08-13 |
mouse |
| Ligen Lin, Alli M Nuotio-Antar, Xiaojun Ma, Feng Liu, Marta L Fiorotto, Yuxiang Su. Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. The Journal of nutrition. vol 144. issue 9. 2014-12-15. PMID:24991043. |
although the total daily food intake of ghsr(-/-) mice was similar to that of wt controls, ghsr(-/-)-m and ghsr(-/-)-o mice had 9% (p = 0.07) and 16% (p < 0.05) less body weight compared with wt-m and wt-o mice, respectively, primarily due to reduced fat mass (p < 0.05, wt-m vs. ghsr(-/-)-m and wt-o vs. ghsr(-/-)-o). |
2014-12-15 |
2023-08-13 |
mouse |
| Angela K Walker, Imikomobong E Ibia, Jeffrey M Zigma. Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling. Physiology & behavior. vol 108. 2013-05-10. PMID:23063723. |
to test this hypothesis, a novel cue-potentiated feeding protocol adapted for use in mice was designed and validated, and then the effects of pharmacologic ghrelin receptor (ghsr) antagonism and ghsr transcriptional blockade (as occurs in ghsr-null mice) were assessed. |
2013-05-10 |
2023-08-12 |
mouse |
| Angela K Walker, Imikomobong E Ibia, Jeffrey M Zigma. Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling. Physiology & behavior. vol 108. 2013-05-10. PMID:23063723. |
treatment with a ghsr antagonist blocked potentiated feeding in sated c57bl/6j mice in response to the cs+. |
2013-05-10 |
2023-08-12 |
mouse |
| Angela K Walker, Imikomobong E Ibia, Jeffrey M Zigma. Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling. Physiology & behavior. vol 108. 2013-05-10. PMID:23063723. |
thus, although the observed disruptions in cue-potentiated feeding are different depending upon whether ghsr activity or ghsr expression is blocked, a key role for ghsrs in establishing a specific positive cue-food association has now been established. |
2013-05-10 |
2023-08-12 |
mouse |
| Z R Patterson, R Khazall, H Mackay, H Anisman, A Abizai. Central ghrelin signaling mediates the metabolic response of C57BL/6 male mice to chronic social defeat stress. Endocrinology. vol 154. issue 3. 2013-04-18. PMID:23341196. |
in contrast, stressed mice lacking ghrelin receptors (ghsr ko mice) or c57bl mice receiving chronic intracerebroventricular delivery of the ghrelin receptor antagonist [d-lys(3)]-ghrp-6 show attenuated weight gain and feeding responses under the same social stress paradigm. |
2013-04-18 |
2023-08-12 |
mouse |
| Letizia Puleo, Pietro Marini, Roberta Avallone, Marco Zanchet, Silvio Bandiera, Marco Baroni, Tiziano Croc. Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists. Bioorganic & medicinal chemistry. vol 20. issue 18. 2013-02-12. PMID:22901671. |
thus ghsr antagonists rapidly became an attractive target to treat obesity and feeding disorders. |
2013-02-12 |
2023-08-12 |
Not clear |