| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
to test the hypothesis that hindbrain ghsr agonism attenuates the food intake inhibitory effect of gastrointestinal (gi) satiation signals, ghrelin (at a feeding subthreshold dose) was administered to the fourth ventricle (4v) or directly to the nucleus tractus solitarius (nts) prior to systemic delivery of the gi satiation signal cholecystokinin (cck). |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
to investigate an alternate hypothesis, that hindbrain ghsr agonism enhances feeding motivation and food-seeking, intake stimulatory ghrelin doses were administered to the 4v and fixed ratio 5 (fr-5), progressive ratio (pr), and operant reinstatement paradigms for palatable food responding were evaluated. |
2023-02-27 |
2023-08-14 |
Not clear |
| Hallie S Wald, Misgana Y Ghidewon, Matthew R Hayes, Harvey J Gril. Hindbrain ghrelin and LEAP2, ligands for GHSR, bidirectionally control food intake. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-02-27. PMID:36847494. |
data support a role for hindbrain ghsr in bidirectional control of food intake through mechanisms that include interacting with the nts neural processing of gi satiation signals but not food motivation and food-seeking. |
2023-02-27 |
2023-08-14 |
Not clear |
| Xianxian Chen, Jicong Mi, Hongbin Huang, Jing Wang, Yu Wu, Xiaobing Wu, Shengzhou Zhan. Ghrelin and Ghrelin receptor (GHSR) in Chinese alligator, Alligator sinensis:Molecular characterization, tissue distribution and mRNA expression changes during the active and hibernating periods. General and comparative endocrinology. 2022-07-19. PMID:35853503. |
ghsr expression level was higher in hypothalamus, epencephalon and medulla oblongata, and moderate in multiple peripheral tissues including lung, kindey, stomach and oviduct, implicating that ghrelin/ghsr system may participate in the regulation of energy balance, food intake, water and mineral balance, gastrointestinal motility, gastric acid secretion and reproduction. |
2022-07-19 |
2023-08-14 |
Not clear |
| Sylvie Péraldi-Roux, Morgane Bayle, Céline M'Kadmi, Marjorie Damian, Justine Vaillé, Gimena Fernandez, Maria Paula Cornejo, Jacky Marie, Jean-Louis Banères, Khoubaib Ben Haj Salah, Jean-Alain Fehrentz, Sonia Cantel, Mario Perello, Séverine Denoyelle, Catherine Oiry, Jérémie Neast. Design and Characterization of a Triazole-Based Growth Hormone Secretagogue Receptor Modulator Inhibiting the Glucoregulatory and Feeding Actions of Ghrelin. Biochemical pharmacology. 2022-06-06. PMID:35659880. |
in particular, activation of ghsr in response to its endogenous agonist ghrelin promotes food intake and blood glucose increase. |
2022-06-06 |
2023-08-14 |
mouse |
| Defang Chen, Yingzi Li, Hongwei Wu, Yuanbing Wu, Ni Tang, Shuhuang Chen, Youlian Liu, Jun Wang, Xin Zhang, Zhiqiong L. Ghrelin-Ghrelin receptor (GSHR) pathway via endocannabinoid signal affects the expression of NPY to promote the food intake of Siberian sturgeon (Acipenser baerii). Hormones and behavior. vol 143. 2022-05-21. PMID:35597053. |
to investigate the feeding regulation pathway of ghrelin and cb1 in siberian sturgeon (acipenser baerii), this study first identified the ghrelin (345 bp, complete coding sequence) and ghrelin receptor (ghsr, 500 bp, partial coding sequence) sequences, and then detected their tissue distribution patterns, which showed that ghrelin is mainly distribution in peripheral tissues, while gshr is mainly in different brain divisions. |
2022-05-21 |
2023-08-13 |
Not clear |
| Defang Chen, Yingzi Li, Hongwei Wu, Yuanbing Wu, Ni Tang, Shuhuang Chen, Youlian Liu, Jun Wang, Xin Zhang, Zhiqiong L. Ghrelin-Ghrelin receptor (GSHR) pathway via endocannabinoid signal affects the expression of NPY to promote the food intake of Siberian sturgeon (Acipenser baerii). Hormones and behavior. vol 143. 2022-05-21. PMID:35597053. |
besides, the qpcr before and after feeding showed that the mrna expressions of ghrelin and ghsr were inhibited after feeding in telencephalon, diencephalon and mesencephalon. |
2022-05-21 |
2023-08-13 |
Not clear |
| Christoffer A Hagemann, Malene S Jensen, Stephanie Holm, Lærke S Gasbjerg, Sarah Byberg, Kirsa Skov-Jeppesen, Bolette Hartmann, Jens J Holst, Flemming Dela, Tina Vilsbøll, Mikkel B Christensen, Birgitte Holst, Filip K Kno. LEAP2 reduces postprandial glucose excursions and Cell reports. Medicine. vol 3. issue 4. 2022-05-02. PMID:35492241. |
leap2 reduces postprandial glucose excursions and the gastric hormone ghrelin stimulates food intake and increases plasma glucose through activation of the growth hormone secretagogue receptor (ghsr). |
2022-05-02 |
2023-08-13 |
Not clear |
| b' Joseane Morari, Roberta Haddad-T\\xc3\\xb3volli, Pedro Augusto Silva Nogueira, Caio Jord\\xc3\\xa3o Teixeira, Rafael Mar\\xc3\\xb3stica, Nat\\xc3\\xa1lia Tobar, Celso Dario Ramos, Licio Augusto Velloso, Vanessa Cristina Dias Bobbo, Gabriel Forato Anh\\xc3\\xa. Body mass variability in age-matched outbred male Swiss mice is associated to differential control of food intake by ghrelin. Molecular and cellular endocrinology. 2022-04-12. PMID:35413387.' |
pharmacological blockade of ghsr with jmv3002 failed to reduce food intake in pmbg mice as it did in rbmg. |
2022-04-12 |
2023-08-13 |
mouse |
| Martin Wellman, Radek Budin, Barbara Woodside, Alfonso Abizai. Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin. Journal of neuroendocrinology. 2022-04-02. PMID:35365872. |
additional lactating and nonlactating rats were implanted with cannulae aimed at the lateral ventricles and were used to compare feeding responses to central ghrelin or ghsr antagonist infusions to those of nonlactating rats receiving similar infusions on day 14-16 postpartum (pp). |
2022-04-02 |
2023-08-13 |
rat |
| Martin Wellman, Radek Budin, Barbara Woodside, Alfonso Abizai. Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin. Journal of neuroendocrinology. 2022-04-02. PMID:35365872. |
in addition, infusions of the ghsr antagonist jmv3002 (4 μg in 1 μl of vehicle) produced greater suppression of food intake in lactating rats than in nonlactating rats. |
2022-04-02 |
2023-08-13 |
rat |
| Jong Han Lee, Bingzhong Xue, Zheng Chen, Yuxiang Su. Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204795. |
while there was no difference in total food intake of hfd in either mouse line, syn1-cre; ghsr |
2022-02-25 |
2023-08-13 |
mouse |
| Heng Liu, Dapeng Sun, Alexander Myasnikov, Marjorie Damian, Jean-Louis Baneres, Ji Sun, Cheng Zhan. Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren. Nature communications. vol 12. issue 1. 2021-11-22. PMID:34737341. |
the hunger hormone ghrelin activates the ghrelin receptor ghsr to stimulate food intake and growth hormone secretion and regulate reward signaling. |
2021-11-22 |
2023-08-13 |
human |
| Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Won. Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276562. |
furthermore, ip injection of spx was effective in reducing food intake with parallel attenuation in transcript expression of npy, agrp, npy type 5 receptor (npy5r), and ghrelin receptor (ghsr) in the hypothalamus, and these inhibitory effects could be blocked by galr3 but not galr2 antagonism. |
2021-11-18 |
2023-08-13 |
mouse |
| Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Won. Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276562. |
through galr3 activation, this spx signal can act within the hypothalamus to trigger feedback inhibition on feeding by differential modulation of feeding regulators (npy and agrp) and their receptors (npy5r, ghsr, lepr, and mc4r) involved in the feeding circuitry within the cns. |
2021-11-18 |
2023-08-13 |
mouse |
| Kripa Shankar, Nathan P Metzger, Omprakash Singh, Bharath K Mani, Sherri Osborne-Lawrence, Salil Varshney, Deepali Gupta, Sean B Ogden, Shota Takemi, Corine P Richard, Karabi Nandy, Chen Liu, Jeffrey M Zigma. LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Molecular metabolism. vol 53. 2021-11-01. PMID:34428557. |
ghsr's other well-known endogenous ligand, acyl-ghrelin, increases food intake, body weight, and gh secretion and is lowered in obesity but elevated upon fasting. |
2021-11-01 |
2023-08-13 |
mouse |
| Kripa Shankar, Nathan P Metzger, Omprakash Singh, Bharath K Mani, Sherri Osborne-Lawrence, Salil Varshney, Deepali Gupta, Sean B Ogden, Shota Takemi, Corine P Richard, Karabi Nandy, Chen Liu, Jeffrey M Zigma. LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Molecular metabolism. vol 53. 2021-11-01. PMID:34428557. |
thus, the plasma leap2/acyl-ghrelin molar ratio could be a key determinant modulating ghsr signaling in response to changes in body mass and feeding status. |
2021-11-01 |
2023-08-13 |
mouse |
| Frederick Wasinski, Franco Barrile, João A B Pedroso, Paula G F Quaresma, Willian O Dos Santos, Edward O List, John J Kopchick, Mario Perelló, Jose Donat. Ghrelin-induced Food Intake, but not GH Secretion, Requires the Expression of the GH Receptor in the Brain of Male Mice. Endocrinology. vol 162. issue 7. 2021-10-07. PMID:33972988. |
in contrast, agrp ghr ko mice showed no changes in the hypothalamic npy and ghsr mrnas and conserved ghrelin-induced food intake and c-fos expression in the arh. |
2021-10-07 |
2023-08-13 |
mouse |
| Jing-Wei Xing, Xin-Yun Tian, Man-Man Chen, Xiu-Hua Peng, Pengfei Ga. Expression of ghrelin or growth hormone secretagogue receptor in the brain of postpartum stress mice. Neuroreport. vol 32. issue 8. 2021-09-17. PMID:33913930. |
maternal body weight changes and food intake were recorded for half a month after delivery, and levels of ghrelin and its receptor, growth hormone secretagogue receptor (ghsr) were measured. |
2021-09-17 |
2023-08-13 |
mouse |
| María Paula Cornejo, Franco Barrile, Daniela Cassano, Julieta Paola Aguggia, Guadalupe García Romero, Mirta Reynaldo, María Florencia Andreoli, Pablo Nicolás De Francesco, Mario Perell. Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice. Psychoneuroendocrinology. vol 119. 2021-07-21. PMID:32535402. |
growth hormone secretagogue receptor (ghsr), the receptor for ghrelin, is expressed in key brain nuclei that regulate food intake. |
2021-07-21 |
2023-08-13 |
mouse |