| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Pawlak, Y Takada, T Urano, A Takad. Serotonergic and kynurenic pathways in rats exposed to foot shock. Brain research bulletin. vol 52. issue 3. 2000-07-17. PMID:10822161. |
increase in serotonin level in the hypothalamus and midbrain stabilises emotion and prevents mood disorders. |
2000-07-17 |
2023-08-12 |
rat |
| I Karlsson, J Godderis, C Augusto De Mendonça Lima, H Nygaard, M Simányi, M Taal, M Egli. A randomised, double-blind comparison of the efficacy and safety of citalopram compared to mianserin in elderly, depressed patients with or without mild to moderate dementia. International journal of geriatric psychiatry. vol 15. issue 4. 2000-07-12. PMID:10767728. |
it is, therefore, important that in this patient population antidepressants with a favourable tolerability profile, such as the selective serotonin reuptake inhibitors (ssris), are examined for both antidepressant efficacy and effect on cognitive function and emotional impairment. |
2000-07-12 |
2023-08-12 |
Not clear |
| S Ishiur. [Serotonin receptor knockout mice]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 5. 2000-06-13. PMID:10803209. |
the neurotransmitter serotonin is known to play a key role in determining emotional state in higher animals, especially in humans. |
2000-06-13 |
2023-08-12 |
mouse |
| S Ishiur. [Serotonin receptor knockout mice]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 19. issue 5. 2000-06-13. PMID:10803209. |
however, the results strongly suggest that serotonin receptors are mainly involved in emotion (i.e., anxiety, aggressive behavior, obesity and epilepsy). |
2000-06-13 |
2023-08-12 |
mouse |
| S N Young, M Leyton, C Benkelfa. Pet studies of serotonin synthesis in the human brain. Advances in experimental medicine and biology. vol 467. 2000-05-09. PMID:10721033. |
patients with borderline personality disorder, who exhibit emotional lability and impulsivity, may have lower brain serotonin synthesis rates than healthy controls. |
2000-05-09 |
2023-08-12 |
human |
| R Seidl, S T Kaehler, H Prast, N Singewald, N Cairns, M Gratzer, G Lube. Serotonin (5-HT) in brains of adult patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666678. |
as the serotonergic system plays a well known role in integrating emotion, cognition and motor function, serotonin (5-ht) and its main metabolite, 5-hydroxyindol-3-acetic acid (5-hiaa) were investigated in post-mortem tissue samples from temporal cortex, thalamus, caudate nucleus, occipital cortex and cerebellum of adult patients with ds, alzheimer's disease (ad) and controls by use of high performance liquid chromatography (hplc). |
2000-04-12 |
2023-08-12 |
Not clear |
| S L Andersen, M H Teiche. Serotonin laterality in amygdala predicts performance in the elevated plus maze in rats. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619632. |
these data support the hypothesis that the right hemisphere is involved in emotional states: increased serotonin in the right amygdala is related to anxiety, while cortical dopamine may be associated with attention to the environment. |
2000-01-19 |
2023-08-12 |
rat |
| b' M Hamon, E Doucet, K Lef\\xc3\\xa8vre, M C Miquel, L Lanfumey, R Insausti, D Frechilla, J Del Rio, D Verg\\xc3\\xa. Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432491.' |
among the recently cloned serotonin (5-hydroxytryptamine, 5-ht) receptors, the 5-ht6 subtype is of special interest for at least two reasons: 1) it is abundant in limbic areas which participate in the control of mood and emotion; and 2) some antidepressants and antipsychotics are potent 5-ht6 receptor antagonists. |
1999-09-17 |
2023-08-12 |
rat |
| M Nazar, M Siemiatkowski, A Bidziński, A Członkowska, H Sienkiewicz-Jarosz, A Płaźni. The influence of serotonin depletion on rat behavior in the Vogel test and brain 3H-zolpidem binding. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 5-6. 1999-09-14. PMID:10443543. |
altogether, the present study provides more arguments for the role of changes in the activity of brain 5-ht innervation in the control of emotional processes. |
1999-09-14 |
2023-08-12 |
rat |
| M Koprowska, M Krotewicz, A Romaniuk, M Strzelczuk, M Wieczore. Behavioral and neurochemical alterations evoked by p-Chlorophenylalanine application in rats examined in the light-dark crossing test. Acta neurobiologiae experimentalis. vol 59. issue 1. 1999-06-03. PMID:10230072. |
the results of our study suggest that administration of p-cpa is effective in reduction of anxiety through depletion of 5-ht accompanied by diminution of catecholamines, especially da and its metabolites in the main emotional brain regions. |
1999-06-03 |
2023-08-12 |
rat |
| Z Nahas, K A Arlinghaus, K J Kotrla, R R Clearman, M S Georg. Rapid response of emotional incontinence to selective serotonin reuptake inhibitors. The Journal of neuropsychiatry and clinical neurosciences. vol 10. issue 4. 1999-02-05. PMID:9813792. |
rapid response of emotional incontinence to selective serotonin reuptake inhibitors. |
1999-02-05 |
2023-08-12 |
Not clear |
| L K Heisler, H M Chu, T J Brennan, J A Danao, P Bajwa, L H Parsons, L H Tecot. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 25. 1999-01-14. PMID:9844013. |
the brain serotonin (5-hydroxytryptamine; 5-ht) system is a powerful modulator of emotional processes and a target of medications used in the treatment of psychiatric disorders. |
1999-01-14 |
2023-08-12 |
mouse |
| G Fink, B E Sumner, J K McQueen, H Wilson, R Rosi. Sex steroid control of mood, mental state and memory. Clinical and experimental pharmacology & physiology. vol 25. issue 10. 1998-12-07. PMID:9784914. |
our studies in the female rat show that oestradiol, in its positive feedback mode for gonadotrophin release, increases the expression of genes for the 5-hydroxytryptamine 5-ht2a receptor and the serotonin transporter (sert) in the dorsal raphe nucleus and the density of 5-ht2a receptor and sert sites in regions of the forebrain that, in the human, are concerned with cognition, mental state, emotion and memory. |
1998-12-07 |
2023-08-12 |
human |
| A M Kumar, S Weiss, J B Fernandez, D Cruess, C Eisdorfe. Peripheral serotonin levels in women: role of aging and ethnicity. Gerontology. vol 44. issue 4. 1998-09-24. PMID:9657081. |
serotonin has been implicated to play an important role in regulating emotions and behavior, and it is well accepted that the platelet serotonergic system mirrors the presynaptic central serotonergic system. |
1998-09-24 |
2023-08-12 |
Not clear |
| M A Raskin. Psychopharmacology of noncognitive abnormal behaviors in Alzheimer's disease. The Journal of clinical psychiatry. vol 59 Suppl 9. 1998-08-28. PMID:9720484. |
trials of serotonin selective reuptake inhibitors suggest they may be effective for emotional disturbances complicating alzheimer's disease. |
1998-08-28 |
2023-08-12 |
Not clear |
| M Luciana, P F Collins, R A Depu. Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions. Cerebral cortex (New York, N.Y. : 1991). vol 8. issue 3. 1998-08-07. PMID:9617916. |
serotonin (5ht) constrains the activity of da, resulting in an opposing relationship between da and 5ht with respect to emotional and motor behaviors. |
1998-08-07 |
2023-08-12 |
human |
| A J Fulford, C A Marsde. Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat. Neuroscience. vol 83. issue 2. 1998-03-12. PMID:9460756. |
this study examined the effect of isolation-rearing in the lister hooded rat on extracellular 5-hydroxytryptamine in the medial nucleus accumbens following footshock and in relation to a conditioned emotional response. |
1998-03-12 |
2023-08-12 |
rat |
| H Agre. [A new series: serotonin and emotions]. Lakartidningen. vol 94. issue 38. 1997-11-18. PMID:9379790. |
[a new series: serotonin and emotions]. |
1997-11-18 |
2023-08-12 |
Not clear |
| G Griebe. Variability in the effects of 5-HT-related compounds in experimental models of anxiety: evidence for multiple mechanisms of 5-HT in anxiety or never ending story? Polish journal of pharmacology. vol 48. issue 2. 1997-06-27. PMID:9112642. |
furthermore, results obtained in ethologically-based animal models of anxiety with drugs stimulating 5-ht transmission are most consistent with the classic 5-ht hypothesis of anxiety in that they showed an increase in animals' emotional reactivity. |
1997-06-27 |
2023-08-12 |
Not clear |
| K Tsuchiya, T Inoue, T Izumi, S Hashimoto, T Koyam. Effects of footshock stress on regional brain monoamine metabolism and the acquisition of conditioned freezing in rats previously exposed to repeated methamphetamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 20. issue 7. 1997-03-13. PMID:8938823. |
these results suggest that not only the brain da systems but also the brain 5-ht systems play an important role for the development of ma-induced emotional hypersensitivity to stress. |
1997-03-13 |
2023-08-12 |
rat |