| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teri Pearlstein, Kimberly A Yonker. Review of fluoxetine and its clinical applications in premenstrual dysphoric disorder. Expert opinion on pharmacotherapy. vol 3. issue 7. 2002-12-23. PMID:12083997. |
fluoxetine and other selective serotonin re-uptake inhibitors (ssris) clearly reduce premenstrual emotional and physical symptoms and improve premenstrual psychosocial functioning. |
2002-12-23 |
2023-08-12 |
Not clear |
| F C Murphy, K A Smith, P J Cowen, T W Robbins, B J Sahakia. The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacology. vol 163. issue 1. 2002-10-16. PMID:12185399. |
while accumulating evidence suggests that brain serotonin (5-ht) pathways play an important role in the neurobiology of depression, the extent to which altered 5-ht function is responsible for the associated changes in cognition and emotion remains unclear. |
2002-10-16 |
2023-08-12 |
human |
| Xiang Cai, Jorge Flores-Hernandez, Jian Feng, Zhen Ya. Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. The Journal of physiology. vol 540. issue Pt 3. 2002-09-16. PMID:11986365. |
one of the main target structures of 5-ht(4) receptors on 'cognitive and emotional' pathways is the prefrontal cortex (pfc). |
2002-09-16 |
2023-08-12 |
rat |
| F P Monne. Melatonin modulates [3h]serotonin release in the rat hippocampus: effects of circadian rhythm. Journal of neuroendocrinology. vol 14. issue 3. 2002-08-14. PMID:11999718. |
serotonin (5-ht) participates as a neurotransmitter in the control of the circadian sleep/wake rhythm, feeding and sexual behaviours, and emotional and affective states. |
2002-08-14 |
2023-08-12 |
rat |
| Stephen M Stah. Does depression hurt? The Journal of clinical psychiatry. vol 63. issue 4. 2002-05-31. PMID:12000200. |
ascending serotonergic and noradrenergic pathways may mediate the emotional and vegetative symptoms of depression and can potentially be targets of serotonin and norepinephrine reuptake inhibitors to obtain relief of these symptoms. |
2002-05-31 |
2023-08-12 |
Not clear |
| David A Shapiro, Kurt Kristiansen, David M Weiner, Wesley K Kroeze, Bryan L Rot. Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6. The Journal of biological chemistry. vol 277. issue 13. 2002-05-10. PMID:11801601. |
5-hydroxytryptamine 2a (5-ht2a) receptors are essential for the actions of serotonin (5-hydroxytryptamine (5-ht)) on physiological processes as diverse as vascular smooth muscle contraction, platelet aggregation, perception, and emotion. |
2002-05-10 |
2023-08-12 |
cattle |
| Anastasia Sfikakis, Zeta Papadopoulou-Daifotis, Nicholas Bika. Inverse relationship of hippocampal serotonin to avoidance behavior, serotonergic activation by emotional stress differentiated by estrous cycle and surgical stress. Behavioural brain research. vol 128. issue 1. 2002-04-04. PMID:11755688. |
inverse relationship of hippocampal serotonin to avoidance behavior, serotonergic activation by emotional stress differentiated by estrous cycle and surgical stress. |
2002-04-04 |
2023-08-12 |
rat |
| Anastasia Sfikakis, Zeta Papadopoulou-Daifotis, Nicholas Bika. Inverse relationship of hippocampal serotonin to avoidance behavior, serotonergic activation by emotional stress differentiated by estrous cycle and surgical stress. Behavioural brain research. vol 128. issue 1. 2002-04-04. PMID:11755688. |
after recording individual emotional reactivity (er) during handling for vaginal smear screening (vss), serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa), in the hypothalamus-preoptic area (hy-pa) and hippocampus were studied in two rat lines with different susceptibility to freund's adjuvant arthritis (faa), in relation to active avoidance behavior (ab), and under basal conditions in the faa susceptible strain, in relation to er, cycle stage and 20 h prior surgical stress. |
2002-04-04 |
2023-08-12 |
rat |
| M Tsuji, H Takeda, T Matsumiy. Protective effects of 5-HT1A receptor agonists against emotional changes produced by stress stimuli are related to their neuroendocrine effects. British journal of pharmacology. vol 134. issue 3. 2001-12-05. PMID:11588113. |
the effects of the 11beta-hydroxylase inhibitor metyrapone on the protective effects of serotonin (5-hydroxytryptamine; 5-ht)(1a) receptor agonists against emotional changes produced by acute restraint stress were examined in mice. |
2001-12-05 |
2023-08-12 |
mouse |
| C Belzung, W El Hage, N Moindrot, G Griebe. Behavioral and neurochemical changes following predatory stress in mice. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522332. |
the second objective was to investigate possible neurochemical changes following cat exposure in swiss mice by measuring the turnover of dopamine (da), noradrenaline (na) and serotonin (5-ht) in several brain regions known to be involved in the modulation of emotional processes (hippocampus, hypothalamus and striatum). |
2001-12-04 |
2023-08-12 |
mouse |
| D J Knapp, L J Sim-Selley, G R Breese, D H Overstree. Selective breeding of 5-HT(1A) receptor-mediated responses: application to emotion and receptor action. Pharmacology, biochemistry, and behavior. vol 67. issue 4. 2001-05-17. PMID:11166060. |
selective breeding of 5-ht(1a) receptor-mediated responses: application to emotion and receptor action. |
2001-05-17 |
2023-08-12 |
rat |
| S Chiavegatto, V L Dawson, L A Mamounas, V E Koliatsos, T M Dawson, R J Nelso. Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 3. 2001-04-12. PMID:11158630. |
we now demonstrate that the excessive aggressiveness and impulsiveness of nnos knockout mice is caused by selective decrements in serotonin (5-ht) turnover and deficient 5-ht(1a) and 5-ht(1b) receptor function in brain regions regulating emotion. |
2001-04-12 |
2023-08-12 |
mouse |
| J Passchier, A van Waard. Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system. European journal of nuclear medicine. vol 28. issue 1. 2001-03-22. PMID:11202445. |
the 5-ht1a subtype of receptors for the neurotransmitter serotonin is predominantly located in the limbic forebrain and is involved in the modulation of emotion and the function of the hypothalamus. |
2001-03-22 |
2023-08-12 |
human |
| M Tsuji, H Takeda, T Matsumiy. Different effects of 5-HT1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naive and stressed mice: a study using the hole-board test. Psychopharmacology. vol 152. issue 2. 2001-02-08. PMID:11057519. |
the effects of 5-ht(1a) receptor agonists on the emotional behavior of naive or stressed mice were examined and compared with those of benzodiazepine anxiolytics. |
2001-02-08 |
2023-08-12 |
mouse |
| T Onodera, R Watanabe, K K Tha, Y Hayashi, T Murayama, Y Okuma, C Ono, Y Oketani, M Hosokawa, Y Nomur. Depressive behavior and alterations in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10. Japanese journal of pharmacology. vol 83. issue 4. 2001-02-02. PMID:11001177. |
we investigated the changes in emotional behavior in a forced swimming test and in receptors for dopamine and 5-hydroxytryptamine (5-ht) in samp10. |
2001-02-02 |
2023-08-12 |
mouse |
| C L Bethea, C Gundlah, S J Mirke. Ovarian steroid action in the serotonin neural system of macaques. Novartis Foundation symposium. vol 230. 2001-01-25. PMID:10965505. |
the serotonin neural system plays an important role in cognitive, emotional and endocrine processes. |
2001-01-25 |
2023-08-12 |
monkey |
| T Hata, E Itoh, H Nishikaw. [Stress-induced anxiety and endogenous anxiogenic substances]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 115. issue 1. 2000-09-28. PMID:10876811. |
emotional behavior in those stressed animals were attenuated by anxiolytics like diazepam, a benzodiazepine receptor agonist and buspirone, a serotonin (5-ht) 1a agonist. |
2000-09-28 |
2023-08-12 |
rat |
| B D Greenberg, Q Li, F R Lucas, S Hu, L A Sirota, J Benjamin, K P Lesch, D Hamer, D L Murph. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. American journal of medical genetics. vol 96. issue 2. 2000-09-06. PMID:10893498. |
the serotonin transporter (5-htt) regulates serotonergic neurotransmission and is thought to influence emotion. |
2000-09-06 |
2023-08-12 |
Not clear |
| M C Buhot, S Martin, L Seg. Role of serotonin in memory impairment. Annals of medicine. vol 32. issue 3. 2000-08-15. PMID:10821328. |
as a result of its presence in various structures of the central nervous system serotonin (5-ht) plays a role in a great variety of behaviours such as food intake, activity rythms, sexual behaviour and emotional states. |
2000-08-15 |
2023-08-12 |
mouse |
| E Melik, E Babar-Melik, T Ozgünen, S Binoka. Median raphe nucleus mediates forming long-term but not short-term contextual fear conditioning in rats. Behavioural brain research. vol 112. issue 1-2. 2000-07-20. PMID:10862945. |
the brain serotonin is involved in mediation of emotional behaviour including anxiety and related fear conditioning. |
2000-07-20 |
2023-08-12 |
rat |