| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela L Uliana, Leandro S Antero, Anna B Borges-Assis, Jessica Rosa, Carla Vila-Verde, Sabrina F Lisboa, Leonardo Bm Resste. Differential modulation of the contextual conditioned emotional response by CB1 and TRPV1 receptors in the ventromedial prefrontal cortex: Possible involvement of NMDA/nitric oxide-related mechanisms. Journal of psychopharmacology (Oxford, England). vol 34. issue 9. 2021-11-04. PMID:32638638. |
blockade of cannabinoid cb1 or vanilloid trpv1 receptors in the ventromedial prefrontal cortex of rats respectively increases or decreases the conditioned emotional response during re-exposure to a context previously paired with footshocks. |
2021-11-04 |
2023-08-13 |
rat |
| Ana Martín-Sánchez, Alba García-Baos, Adriana Castro-Zavala, Laia Alegre-Zurano, Olga Valverd. Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression. Neuropharmacology. vol 184. 2021-10-22. PMID:33271186. |
moreover, we investigated whether msew alters the cannabinoid agonist win55,212-2 effects regarding reward, spatial and emotional memories, tolerance to different cannabinoid responses, and physical dependence. |
2021-10-22 |
2023-08-13 |
mouse |
| Rafael Maldonado, David Cabañero, Elena Martín-Garcí. The endocannabinoid system in modulating fear, anxiety, and stress
. Dialogues in clinical neuroscience. vol 22. issue 3. 2021-10-11. PMID:33162766. |
the endocannabinoid system is widely expressed in the limbic system, prefrontal cortical areas, and brain structures regulating neuroendocrine stress responses, which explains the key role of this system in the control of emotions. |
2021-10-11 |
2023-08-13 |
Not clear |
| Rafael Maldonado, David Cabañero, Elena Martín-Garcí. The endocannabinoid system in modulating fear, anxiety, and stress
. Dialogues in clinical neuroscience. vol 22. issue 3. 2021-10-11. PMID:33162766. |
we also review the alterations in the activity of the endocannabinoid system during fear, stress, and anxiety, and the pathophysiological role of each component of this system in the control of these protective emotional responses that also trigger pathological emotional disorders. |
2021-10-11 |
2023-08-13 |
Not clear |
| Rafael Maldonado, David Cabañero, Elena Martín-Garcí. The endocannabinoid system in modulating fear, anxiety, and stress
. Dialogues in clinical neuroscience. vol 22. issue 3. 2021-10-11. PMID:33162766. |
in spite of all the evidence, we have not yet taken advantage of the therapeutic implications of this important role of the endocannabinoid system, and possible future strategies to improve the treatment of these emotional disorders are discussed.
. |
2021-10-11 |
2023-08-13 |
Not clear |
| Tarapati Rana, Tapan Behl, Aayush Sehgal, Vineet Mehta, Sukhbir Singh, Ravinder Kumar, Simona Bunga. Integrating Endocannabinoid Signalling In Depression. Journal of molecular neuroscience : MN. vol 71. issue 10. 2021-10-11. PMID:33471311. |
the endocannabinoid system (ecs) has garnered increasing attention because of its involvement in several diverse physiological brain processes including regulation of emotional, motivational and cognitive functions. |
2021-10-11 |
2023-08-13 |
human |
| Lucas Albrechet-Souza, Andrei S Nastase, Matthew N Hill, Nicholas W Gilpi. Amygdalar endocannabinoids are affected by predator odor stress in a sex-specific manner and modulate acoustic startle reactivity in female rats. Neurobiology of stress. vol 15. 2021-09-16. PMID:34522703. |
the amygdala is critical for emotional learning and generating behavioral responses to stressful stimuli, and preclinical studies indicate that amygdalar endocannabinoid (ecb) signaling regulates emotional states. |
2021-09-16 |
2023-08-13 |
rat |
| Lucinda M Sisk, Kristina M Rapuano, May I Conley, Abigail S Greene, Corey Horien, Monica D Rosenberg, Dustin Scheinost, R Todd Constable, Charles E Glatt, B J Casey, Dylan G Ge. Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth. Journal of neuroscience research. 2021-09-08. PMID:34496065. |
the endocannabinoid system is an important regulator of emotional responses such as fear, and a number of studies have implicated endocannabinoid signaling in anxiety. |
2021-09-08 |
2023-08-13 |
human |
| Sari Goldstein Ferber, Viviana Trezza, Aron Welle. Early life stress and development of the endocannabinoid system: A bidirectional process in programming future coping. Developmental psychobiology. vol 63. issue 2. 2021-08-25. PMID:31849055. |
the endocannabinoid system (ecs) critically regulates stress responsivity and emotional behavior throughout development. |
2021-08-25 |
2023-08-13 |
Not clear |
| Sari Goldstein Ferber, Viviana Trezza, Aron Welle. Early life stress and development of the endocannabinoid system: A bidirectional process in programming future coping. Developmental psychobiology. vol 63. issue 2. 2021-08-25. PMID:31849055. |
manipulations affecting the glucocorticoid and the endocannabinoid systems persistently adjust individual emotional responses and synaptic plasticity. |
2021-08-25 |
2023-08-13 |
Not clear |
| L Sanchez-Marin, A L Gavito, J Decara, A Pastor, E Castilla-Ortega, J Suarez, R de la Torre, F J Pavon, F Rodriguez de Fonseca, A Serran. Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 33. 2021-08-10. PMID:32057593. |
here, we characterized the gene expression of the endocannabinoid system (ecs) and relevant signaling systems associated with neuroinflammation and emotional behaviors in the brain of young adult control and ethanol-exposed (etoh) rats. |
2021-08-10 |
2023-08-13 |
rat |
| Alexies Dagnino-Subiabr. Stress and Western diets increase vulnerability to neuropsychiatric disorders: A common mechanism. Nutritional neuroscience. vol 24. issue 8. 2021-07-20. PMID:31524571. |
this review suggests that both western diets and negative stress or distress increase n-6/n-3 pufa ratio in the phospholipids of the plasma membrane in neurons, allowing an over-activation of the endocannabinoid system in the limbic areas that control emotions. |
2021-07-20 |
2023-08-13 |
human |
| Shivani Jaiswal, Senthil Raja Ayyanna. Anticancer Potential of Small-Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase. ChemMedChem. vol 16. issue 14. 2021-07-19. PMID:33834617. |
both faah and magl are the endocannabinoid degrading enzymes that hydrolyze several endogenous ligands, mainly anandamide (aea) and 2-arachidonic glycerol (2-ag), which regulate various pathophysiological conditions in the body such as emotion, cognition, energy balance, pain sensation, neuroinflammation, and cancer cell proliferation. |
2021-07-19 |
2023-08-13 |
Not clear |
| Anna Brancato, Valentina Castelli, Gianluca Lavanco, Rosa Anna Maria Marino, Carla Cannizzar. In utero Δ9-tetrahydrocannabinol exposure confers vulnerability towards cognitive impairments and alcohol drinking in the adolescent offspring: Is there a role for neuropeptide Y? Journal of psychopharmacology (Oxford, England). vol 34. issue 6. 2021-07-08. PMID:32338122. |
indeed, since the endocannabinoid system regulates synaptic plasticity, emotional and cognitive processes from early stages of life interfering with it and other excitability endogenous modulators, such as neuropeptide y (npy), might contribute to the occurrence of a vulnerable phenotype later in life. |
2021-07-08 |
2023-08-13 |
Not clear |
| Jillian L Capodice, Steven A Kapla. The endocannabinoid system, cannabis, and cannabidiol: Implications in urology and men's health. Current urology. vol 15. issue 2. 2021-06-26. PMID:34168527. |
the endocannabinoid system is a neuromodulatory system responsible for partial regulation of cognitive and emotional processes in the human central nervous system such as behavior, mood disorders, and neurologic disorders such as epilepsy. |
2021-06-26 |
2023-08-13 |
human |
| Nathan J Kolla, R Mizrahi, K Karas, C Wang, R M Bagby, S McMain, A I Simpson, P M Rusjan, R Tyndale, S Houle, I Boilea. Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 11. 2021-06-23. PMID:32521537. |
fatty acid amide hydrolase (faah), the major catabolic enzyme for the endocannabinoid anandamide, has been proposed as a key regulator of the amygdala-pfc circuit that subserves emotion regulation. |
2021-06-23 |
2023-08-13 |
Not clear |
| Haley A Vecchiarelli, Maria Morena, Catherine M Keenan, Vincent Chiang, Kaitlyn Tan, Min Qiao, Kira Leitl, Alessia Santori, Quentin J Pittman, Keith A Sharkey, Matthew N Hil. Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33452437. |
the endocannabinoid (ecb) system is exquisitely sensitive to these hormonal changes and is a significant regulator of emotional behavior. |
2021-06-23 |
2023-08-13 |
rat |
| Kennia M Silveira, Gregers Wegener, Sâmia R L Joc. Targeting 2-arachidonoylglycerol signalling in the neurobiology and treatment of depression. Basic & clinical pharmacology & toxicology. vol 129. issue 1. 2021-06-10. PMID:33905617. |
through the activation of cannabinoid receptors, 2-ag can interfere with excitatory and inhibitory neurotransmission in different brain regions and modulate behavioural, endocrine and emotional components of the stress response. |
2021-06-10 |
2023-08-13 |
Not clear |
| Ahmad Mobed, Fereshteh Kohansal, Ali Ahmadalipour, Mohammad Hasanzadeh, Flor Zargar. Bioconjugation of 2-arachidonoyl glycerol (2-AG) biotinylated antibody with gold nano-flowers toward immunosensing of 2-AG in human plasma samples: A novel immuno-platform for the screening of immunomodulation and neuroprotection using biosensing. Analytical methods : advancing methods and applications. vol 13. issue 3. 2021-05-14. PMID:33367337. |
human 2-arachidonoylglycerol (2-ag) is an agonist of endocannabinoid system and acts as an important modulator of many physiological processes such as emotional state and pain sensation. |
2021-05-14 |
2023-08-13 |
human |
| Eun-Sang Hwang, Hyun-Bum Kim, Seok Lee, Min-Jeong Kim, Kwan-Joong Kim, Gaeul Han, Se-Young Han, Eun-A Lee, Jeong-Hee Yoon, Dae-Ok Kim, Sungho Maeng, Ji-Ho Par. Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression. Behavioural brain research. vol 380. 2021-05-03. PMID:31862467. |
the endocannabinoid system controls cognitive and emotional responses related with stress through the interaction with endocannabinoid receptors. |
2021-05-03 |
2023-08-13 |
Not clear |