| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Marie Balestra, Katharina Chalk, Claudia Denke, Nashwan Mohammed, Thomas Fritzsche, Sascha Tafelsk. Influence of Cannabinoid Treatment on Trajectories of Patient-Related Outcomes in Chronic Pain: Pain Intensity, Emotional Distress, Tolerability and Physical Disability. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190645. |
the present study shows that pain intensity (mean relative reduction (-14.9 ± 22.6%), emotional distress (-9.2 ± 43.5%), pain-associated disability (-7.0 ± 46.5%) and tolerability of pain (-11 ± 23.4%)) improved with cannabinoid treatment. |
2023-05-16 |
2023-08-14 |
Not clear |
| Irene Perini, Leah M Mayo, Andrea J Capusan, Elisabeth R Paul, Adam Yngve, Robin Kampe, Emelie Gauffin, Raegan Mazurka, Bijar Ghafouri, Niclas Stensson, Anna Asratian, J Paul Hamilton, Åsa Kastbom, Per A Gustafsson, Markus Heili. Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation. Molecular psychiatry. 2023-04-11. PMID:37041416. |
resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation. |
2023-04-11 |
2023-08-14 |
human |
| Irene Perini, Leah M Mayo, Andrea J Capusan, Elisabeth R Paul, Adam Yngve, Robin Kampe, Emelie Gauffin, Raegan Mazurka, Bijar Ghafouri, Niclas Stensson, Anna Asratian, J Paul Hamilton, Åsa Kastbom, Per A Gustafsson, Markus Heili. Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation. Molecular psychiatry. 2023-04-11. PMID:37041416. |
this case-control study investigated the impact of prospectively assessed cm on biomarkers of endocannabinoid function and emotion regulation in relation to the susceptibility or resilience to developing sud. |
2023-04-11 |
2023-08-14 |
human |
| Arijana Demaili, Anna Portugalov, Michal Dudai, Mouna Maroun, Irit Akirav, Katharina Braun, Jörg Boc. Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure. Frontiers in cellular neuroscience. vol 17. 2023-03-13. PMID:36909279. |
the endocannabinoid system plays a major role in the regulation of stress responses and emotional behavior, thereby acting as a mediator of stress vulnerability and resilience. |
2023-03-13 |
2023-08-14 |
rat |
| Marialuisa de Ceglia, Maria Vittoria Micioni Di Bonaventura, Adele Romano, Marzia Friuli, Emanuela Micioni Di Bonaventura, Ana L Gavito, Luca Botticelli, Silvana Gaetani, Fernando Rodríguez de Fonseca, Carlo Cifan. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. The International journal of eating disorders. 2023-02-25. PMID:36840536. |
currently, no pharmacological treatment is effective for obesity-related anxiety, so we investigated the endocannabinoid system (ecs), and specifically the fatty acid amide hydrolase (faah), as an interesting emerging target in this context because of its key role in the regulation of both energy homeostasis and emotional behavior. |
2023-02-25 |
2023-08-14 |
Not clear |
| Daniela Matei, Dan Trofin, Daniel Andrei Iordan, Ilie Onu, Iustina Condurache, Catalin Ionite, Ioana Bucule. The Endocannabinoid System and Physical Exercise. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768332. |
the endocannabinoid system (ecs) is involved in various processes, including brain plasticity, learning and memory, neuronal development, nociception, inflammation, appetite regulation, digestion, metabolism, energy balance, motility, and regulation of stress and emotions. |
2023-02-11 |
2023-08-14 |
human |
| Roberto Colangeli, Maria Morena, Allison Werner, Roger J Thompson, Mario van der Stelt, Quentin J Pittman, Matthew N Hill, G Campbell Teske. 2-AG-mediated Control of GABAergic Signaling is Impaired in a Model of Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-12-02. PMID:36460464. |
repeated seizures result in a persistent maladaptation of endocannabinoid signaling, mediated in part by anandamide signaling deficiency in the basolateral amygdala (bla) that manifests as aberrant synaptic function and altered emotional behaviour. |
2022-12-02 |
2023-08-14 |
Not clear |
| Charles F Yates, Jin Y Huang, Dario A Prott. Tonic Endocannabinoid Levels Modulate Retinal Signaling. International journal of environmental research and public health. vol 19. issue 19. 2022-10-14. PMID:36231760. |
the endocannabinoid (ecb) system is critically involved in the modulation of synaptic transmission in the central nervous system, playing an important role in the control of emotional responses, neurodevelopment and synaptic plasticity among other functions. |
2022-10-14 |
2023-08-14 |
mouse |
| Philippe De Deurwaerdère, Maurizio Casarrubea, Daniel Cassar, Manuela Radic, Emilie Puginier, Abdeslam Chagraoui, Giuseppe Crescimanno, Vincenzo Crunelli, Giuseppe Di Giovann. Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in Genetic Absence Epilepsy Rats From Strasbourg and Non-epileptic Control Rats. Frontiers in cellular neuroscience. vol 16. 2022-06-09. PMID:35677756. |
these data support the view of a strain-dependent alteration of the endocannabinoid system in absence epilepsy by adding evidence of a lower emotional responsiveness and a basal ganglia hypersensitivity to cannabinoids in gaers compared to nec rats. |
2022-06-09 |
2023-08-14 |
rat |
| Maria Morena, Alessia Santori, Patrizia Campolong. Circadian regulation of memory under stress: Endocannabinoids matter. Neuroscience and biobehavioral reviews. 2022-06-01. PMID:35643119. |
compelling evidence indicates that a wide array of memory processes is strongly influenced by stress- and emotional arousal-activated neurobiological systems, including the endocannabinoid system which has been extensively shown to play an integral role in mediating stress effects on memory. |
2022-06-01 |
2023-08-13 |
Not clear |
| Uri Bright, Irit Akira. Modulation of Endocannabinoid System Components in Depression: Pre-Clinical and Clinical Evidence. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628337. |
ecs components (such as receptors, endocannabinoid ligands, and degrading enzymes) are key neuromodulators in motivation and cognition as well as in the regulation of stress and emotions. |
2022-05-28 |
2023-08-13 |
Not clear |
| Christina Keller, Sebastian Rading, Laura Bindila, Meliha Karsa. Behavioral Studies of p62 KO Animals with Implications of a Modulated Function of the Endocannabinoid System. Cells. vol 11. issue 9. 2022-05-14. PMID:35563822. |
elementary emotional states and memory can be regulated by the homeostasis of the endocannabinoid system (ecs). |
2022-05-14 |
2023-08-13 |
mouse |
| Alexius Lampkin, Vaishali Baksh. Effects of Increasing Endocannabinoid 2-AG Tone on Sensorimotor Gating and Anxiety-like behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556730. |
these results raise the possibility that modulation of the endocannabinoid system, specifically 2-ag tone, could be a novel pharmacological mechanism to regulate cognitive and emotional processes related to psychiatric disorders like ptsd. |
2022-05-13 |
2023-08-13 |
rat |
| Mariana Babayeva, Haregewein Assefa, Paramita Basu, Zvi Loew. Autism and associated disorders: cannabis as a potential therapy. Frontiers in bioscience (Elite edition). vol 14. issue 1. 2022-03-23. PMID:35320905. |
the endocannabinoid system has a central role in ruling emotion and social behaviors. |
2022-03-23 |
2023-08-13 |
Not clear |
| Hye Ji J Kim, Ayat Zagzoog, Anna Maria Smolyakova, Udoka C Ezeaka, Michael J Benko, Teagan Holt, Robert B Laprairi. Frontiers in neuroscience. vol 15. 2022-01-07. PMID:34992518. |
the endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep, appetite, pain processing, and emotional behaviors related to reward. |
2022-01-07 |
2023-08-13 |
mouse |
| M Tsagareli, I Kvachadze, D Simon. ANTINOCICEPTIVE TOLERANCE TO CANNABINOIDS IN ADULT MALE MICE: A PILOT STUDY. Georgian medical news. issue 320. 2021-12-13. PMID:34897062. |
however, global targeting of the endocannabinoid system has also been associated with unwanted outcomes, including deleterious effects on cognitive and emotional functions, the development of tolerance and dependence, and withdrawal symptoms after drug cessation in humans. |
2021-12-13 |
2023-08-13 |
mouse |
| Luke J Ney, Kevin M Crombie, Leah M Mayo, Kim L Felmingham, Tim Bowser, Allison Matthew. Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next? Neuroscience and biobehavioral reviews. vol 132. 2021-12-11. PMID:34838529. |
here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in ptsd. |
2021-12-11 |
2023-08-13 |
human |
| Ahmet Onay, Abdulselam Ertaş, Veysel Süzerer, İsmail Yener, Mustafa Abdullah Yilmaz, Emine Ayaz-Tilkat, Remzi Ekinci, Nesrin Bozhan, Sevgi Irtegün-Kandemi. Cannabinoids for SARS-CoV-2 and is there evidence of their therapeutic efficacy? Turkish journal of biology = Turk biyoloji dergisi. vol 45. issue 4. 2021-11-23. PMID:34803455. |
the endocannabinoid system (ecs) acts as a modulator in the activation of the microcirculation, immune system, and autonomic nervous system, along with controlling pharmacological functions such as emotional responses, homeostasis, motor functions, cognition, and motivation. |
2021-11-23 |
2023-08-13 |
human |
| Helena P G Joaquim, Alana C Costa, Cícero A C Pereira, Leda L Talib, Martinus M V Bilt, Alexandre A Loch, Wagner F Gatta. Plasmatic endocannabinoids are decreased in subjects with ultra-high risk of psychosis. The European journal of neuroscience. 2021-11-15. PMID:34716624. |
the endocannabinoid system constitutes a neuromodulatory system that plays a major role in brain development, synaptic plasticity, emotional behaviours and cognition. |
2021-11-15 |
2023-08-13 |
human |
| Yane Costa Chaves, Karina Genaro, José Alexandre Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Cannabidiol induces antidepressant and anxiolytic-like effects in experimental type-1 diabetic animals by multiple sites of action. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33464458. |
although the underlying mechanism remains unknown, the type-1a serotonin receptor (5-ht1a) and cannabinoids type-1 (cb1) and type-2 (cb2) receptors seem to play a central role in mediating the beneficial effects on emotional responses. |
2021-11-12 |
2023-08-13 |
rat |