| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles F Yates, Jin Y Huang, Dario A Prott. Tonic Endocannabinoid Levels Modulate Retinal Signaling. International journal of environmental research and public health. vol 19. issue 19. 2022-10-14. PMID:36231760. |
the endocannabinoid (ecb) system is critically involved in the modulation of synaptic transmission in the central nervous system, playing an important role in the control of emotional responses, neurodevelopment and synaptic plasticity among other functions. |
2022-10-14 |
2023-08-14 |
mouse |
| Philippe De Deurwaerdère, Maurizio Casarrubea, Daniel Cassar, Manuela Radic, Emilie Puginier, Abdeslam Chagraoui, Giuseppe Crescimanno, Vincenzo Crunelli, Giuseppe Di Giovann. Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in Genetic Absence Epilepsy Rats From Strasbourg and Non-epileptic Control Rats. Frontiers in cellular neuroscience. vol 16. 2022-06-09. PMID:35677756. |
these data support the view of a strain-dependent alteration of the endocannabinoid system in absence epilepsy by adding evidence of a lower emotional responsiveness and a basal ganglia hypersensitivity to cannabinoids in gaers compared to nec rats. |
2022-06-09 |
2023-08-14 |
rat |
| Maria Morena, Alessia Santori, Patrizia Campolong. Circadian regulation of memory under stress: Endocannabinoids matter. Neuroscience and biobehavioral reviews. 2022-06-01. PMID:35643119. |
compelling evidence indicates that a wide array of memory processes is strongly influenced by stress- and emotional arousal-activated neurobiological systems, including the endocannabinoid system which has been extensively shown to play an integral role in mediating stress effects on memory. |
2022-06-01 |
2023-08-13 |
Not clear |
| Uri Bright, Irit Akira. Modulation of Endocannabinoid System Components in Depression: Pre-Clinical and Clinical Evidence. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628337. |
ecs components (such as receptors, endocannabinoid ligands, and degrading enzymes) are key neuromodulators in motivation and cognition as well as in the regulation of stress and emotions. |
2022-05-28 |
2023-08-13 |
Not clear |
| Christina Keller, Sebastian Rading, Laura Bindila, Meliha Karsa. Behavioral Studies of p62 KO Animals with Implications of a Modulated Function of the Endocannabinoid System. Cells. vol 11. issue 9. 2022-05-14. PMID:35563822. |
elementary emotional states and memory can be regulated by the homeostasis of the endocannabinoid system (ecs). |
2022-05-14 |
2023-08-13 |
mouse |
| Alexius Lampkin, Vaishali Baksh. Effects of Increasing Endocannabinoid 2-AG Tone on Sensorimotor Gating and Anxiety-like behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556730. |
these results raise the possibility that modulation of the endocannabinoid system, specifically 2-ag tone, could be a novel pharmacological mechanism to regulate cognitive and emotional processes related to psychiatric disorders like ptsd. |
2022-05-13 |
2023-08-13 |
rat |
| Mariana Babayeva, Haregewein Assefa, Paramita Basu, Zvi Loew. Autism and associated disorders: cannabis as a potential therapy. Frontiers in bioscience (Elite edition). vol 14. issue 1. 2022-03-23. PMID:35320905. |
the endocannabinoid system has a central role in ruling emotion and social behaviors. |
2022-03-23 |
2023-08-13 |
Not clear |
| Hye Ji J Kim, Ayat Zagzoog, Anna Maria Smolyakova, Udoka C Ezeaka, Michael J Benko, Teagan Holt, Robert B Laprairi. Frontiers in neuroscience. vol 15. 2022-01-07. PMID:34992518. |
the endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep, appetite, pain processing, and emotional behaviors related to reward. |
2022-01-07 |
2023-08-13 |
mouse |
| M Tsagareli, I Kvachadze, D Simon. ANTINOCICEPTIVE TOLERANCE TO CANNABINOIDS IN ADULT MALE MICE: A PILOT STUDY. Georgian medical news. issue 320. 2021-12-13. PMID:34897062. |
however, global targeting of the endocannabinoid system has also been associated with unwanted outcomes, including deleterious effects on cognitive and emotional functions, the development of tolerance and dependence, and withdrawal symptoms after drug cessation in humans. |
2021-12-13 |
2023-08-13 |
mouse |
| Luke J Ney, Kevin M Crombie, Leah M Mayo, Kim L Felmingham, Tim Bowser, Allison Matthew. Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next? Neuroscience and biobehavioral reviews. vol 132. 2021-12-11. PMID:34838529. |
here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in ptsd. |
2021-12-11 |
2023-08-13 |
human |
| Ahmet Onay, Abdulselam Ertaş, Veysel Süzerer, İsmail Yener, Mustafa Abdullah Yilmaz, Emine Ayaz-Tilkat, Remzi Ekinci, Nesrin Bozhan, Sevgi Irtegün-Kandemi. Cannabinoids for SARS-CoV-2 and is there evidence of their therapeutic efficacy? Turkish journal of biology = Turk biyoloji dergisi. vol 45. issue 4. 2021-11-23. PMID:34803455. |
the endocannabinoid system (ecs) acts as a modulator in the activation of the microcirculation, immune system, and autonomic nervous system, along with controlling pharmacological functions such as emotional responses, homeostasis, motor functions, cognition, and motivation. |
2021-11-23 |
2023-08-13 |
human |
| Helena P G Joaquim, Alana C Costa, Cícero A C Pereira, Leda L Talib, Martinus M V Bilt, Alexandre A Loch, Wagner F Gatta. Plasmatic endocannabinoids are decreased in subjects with ultra-high risk of psychosis. The European journal of neuroscience. 2021-11-15. PMID:34716624. |
the endocannabinoid system constitutes a neuromodulatory system that plays a major role in brain development, synaptic plasticity, emotional behaviours and cognition. |
2021-11-15 |
2023-08-13 |
human |
| Yane Costa Chaves, Karina Genaro, José Alexandre Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Cannabidiol induces antidepressant and anxiolytic-like effects in experimental type-1 diabetic animals by multiple sites of action. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33464458. |
although the underlying mechanism remains unknown, the type-1a serotonin receptor (5-ht1a) and cannabinoids type-1 (cb1) and type-2 (cb2) receptors seem to play a central role in mediating the beneficial effects on emotional responses. |
2021-11-12 |
2023-08-13 |
rat |
| Daniela L Uliana, Leandro S Antero, Anna B Borges-Assis, Jessica Rosa, Carla Vila-Verde, Sabrina F Lisboa, Leonardo Bm Resste. Differential modulation of the contextual conditioned emotional response by CB1 and TRPV1 receptors in the ventromedial prefrontal cortex: Possible involvement of NMDA/nitric oxide-related mechanisms. Journal of psychopharmacology (Oxford, England). vol 34. issue 9. 2021-11-04. PMID:32638638. |
blockade of cannabinoid cb1 or vanilloid trpv1 receptors in the ventromedial prefrontal cortex of rats respectively increases or decreases the conditioned emotional response during re-exposure to a context previously paired with footshocks. |
2021-11-04 |
2023-08-13 |
rat |
| Ana Martín-Sánchez, Alba García-Baos, Adriana Castro-Zavala, Laia Alegre-Zurano, Olga Valverd. Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression. Neuropharmacology. vol 184. 2021-10-22. PMID:33271186. |
moreover, we investigated whether msew alters the cannabinoid agonist win55,212-2 effects regarding reward, spatial and emotional memories, tolerance to different cannabinoid responses, and physical dependence. |
2021-10-22 |
2023-08-13 |
mouse |
| Rafael Maldonado, David Cabañero, Elena Martín-Garcí. The endocannabinoid system in modulating fear, anxiety, and stress
. Dialogues in clinical neuroscience. vol 22. issue 3. 2021-10-11. PMID:33162766. |
the endocannabinoid system is widely expressed in the limbic system, prefrontal cortical areas, and brain structures regulating neuroendocrine stress responses, which explains the key role of this system in the control of emotions. |
2021-10-11 |
2023-08-13 |
Not clear |
| Rafael Maldonado, David Cabañero, Elena Martín-Garcí. The endocannabinoid system in modulating fear, anxiety, and stress
. Dialogues in clinical neuroscience. vol 22. issue 3. 2021-10-11. PMID:33162766. |
we also review the alterations in the activity of the endocannabinoid system during fear, stress, and anxiety, and the pathophysiological role of each component of this system in the control of these protective emotional responses that also trigger pathological emotional disorders. |
2021-10-11 |
2023-08-13 |
Not clear |
| Rafael Maldonado, David Cabañero, Elena Martín-Garcí. The endocannabinoid system in modulating fear, anxiety, and stress
. Dialogues in clinical neuroscience. vol 22. issue 3. 2021-10-11. PMID:33162766. |
in spite of all the evidence, we have not yet taken advantage of the therapeutic implications of this important role of the endocannabinoid system, and possible future strategies to improve the treatment of these emotional disorders are discussed.
. |
2021-10-11 |
2023-08-13 |
Not clear |
| Tarapati Rana, Tapan Behl, Aayush Sehgal, Vineet Mehta, Sukhbir Singh, Ravinder Kumar, Simona Bunga. Integrating Endocannabinoid Signalling In Depression. Journal of molecular neuroscience : MN. vol 71. issue 10. 2021-10-11. PMID:33471311. |
the endocannabinoid system (ecs) has garnered increasing attention because of its involvement in several diverse physiological brain processes including regulation of emotional, motivational and cognitive functions. |
2021-10-11 |
2023-08-13 |
human |
| Lucas Albrechet-Souza, Andrei S Nastase, Matthew N Hill, Nicholas W Gilpi. Amygdalar endocannabinoids are affected by predator odor stress in a sex-specific manner and modulate acoustic startle reactivity in female rats. Neurobiology of stress. vol 15. 2021-09-16. PMID:34522703. |
the amygdala is critical for emotional learning and generating behavioral responses to stressful stimuli, and preclinical studies indicate that amygdalar endocannabinoid (ecb) signaling regulates emotional states. |
2021-09-16 |
2023-08-13 |
rat |