| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Fouchécourt, G Livera, S Messiaen, B Fumel, A-S Parent, J-C Marine, P Monge. Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility. Cell death and differentiation. vol 23. issue 3. 2016-11-01. PMID:26470726. |
inactivation of mdm2 in scs triggered p53 activation and apoptosis as early as 15.5 days post conception with significant increase in apoptotic scs. |
2016-11-01 |
2023-08-13 |
mouse |
| Nik Soriani Yaacob, Nik Nursyazni Nik Mohamed Kamal, Kah Keng Wong, Mohd Nor Norazm. Cell Cycle Modulation of MCF-7 and MDA-MB-231 by a Sub- Fraction of Strobilanthes crispus and its Combination with Tamoxifen. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 18. 2016-10-05. PMID:26745050. |
we recently reported that an active sub-fraction of s. crispus leaves (scs) caused caspase-dependent apoptosis of human breast cancer mcf-7 and mda-mb-231 cells. |
2016-10-05 |
2023-08-13 |
human |
| Iram Ahmad, Augusta Fernando, Richard Gurgel, J Jason Clark, Linjing Xu, Marlan R Hanse. Merlin status regulates p75(NTR) expression and apoptotic signaling in Schwann cells following nerve injury. Neurobiology of disease. vol 82. 2016-08-19. PMID:26057084. |
if axons fail to regenerate, denervated scs eventually undergo apoptosis due, in part, to increased expression of the low-affinity neurotrophin receptor, p75(ntr). |
2016-08-19 |
2023-08-13 |
mouse |
| Iram Ahmad, Augusta Fernando, Richard Gurgel, J Jason Clark, Linjing Xu, Marlan R Hanse. Merlin status regulates p75(NTR) expression and apoptotic signaling in Schwann cells following nerve injury. Neurobiology of disease. vol 82. 2016-08-19. PMID:26057084. |
further, they demonstrate that merlin facilitates p75(ntr)-mediated apoptosis in scs helping to explain how neoplastic scs that lack functional merlin survive long-term in the absence of axonal contact. |
2016-08-19 |
2023-08-13 |
mouse |
| Peng Duan, Chunhui Hu, Chao Quan, Tingting Yu, Wei Zhou, Meng Yuan, Yuqin Shi, Kedi Yan. 4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways. Toxicology. vol 341-343. 2016-06-29. PMID:26804764. |
in this study, 24-h exposure of scs to 20-30μm np decreased cell viability, caused g2/m arrest, triggered ΔΨm loss, increased ros production and induced caspase-dependent apoptosis, necrosis as well as autophagosome formation. |
2016-06-29 |
2023-08-13 |
rat |
| Peng Duan, Chunhui Hu, Chao Quan, Tingting Yu, Wei Zhou, Meng Yuan, Yuqin Shi, Kedi Yan. 4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways. Toxicology. vol 341-343. 2016-06-29. PMID:26804764. |
collectively, our findings provide the first evidence that np promotes apoptosis, autophagy and necrosis simultaneously in scs and that this process may involve ros-dependent jnk- and akt/ampk/mtor pathways. |
2016-06-29 |
2023-08-13 |
rat |
| Xiaotong Guo, Shikai Chi, Xia Cong, Huatao Li, Zhongling Jiang, Rongfeng Cao, Wenru Tia. Baicalin protects sertoli cells from heat stress-induced apoptosis via activation of the Fas/FasL pathway and Hsp72 expression. Reproductive toxicology (Elmsford, N.Y.). vol 57. 2016-05-27. PMID:26103447. |
the present study aimed to identify the protective effects of baicalin on the apoptosis of primary cultured bovine sertoli cells (scs) subjected to heat stress (hs). |
2016-05-27 |
2023-08-13 |
human |
| Xiaotong Guo, Shikai Chi, Xia Cong, Huatao Li, Zhongling Jiang, Rongfeng Cao, Wenru Tia. Baicalin protects sertoli cells from heat stress-induced apoptosis via activation of the Fas/FasL pathway and Hsp72 expression. Reproductive toxicology (Elmsford, N.Y.). vol 57. 2016-05-27. PMID:26103447. |
the results demonstrated that hs induced apoptosis in the scs exposed to 43°c for 1h as fas/fasl was activated and caspase-3 was cleaved, the cells apoptotic rate was decreased. |
2016-05-27 |
2023-08-13 |
human |
| Xiaotong Guo, Shikai Chi, Xia Cong, Huatao Li, Zhongling Jiang, Rongfeng Cao, Wenru Tia. Baicalin protects sertoli cells from heat stress-induced apoptosis via activation of the Fas/FasL pathway and Hsp72 expression. Reproductive toxicology (Elmsford, N.Y.). vol 57. 2016-05-27. PMID:26103447. |
in conclusion, baicalin ameliorates heat stress-induced cell apoptosis via the modulation of the cell survival rate through fas/fasl pathway activation and the upregulation of hsp72 expression in bovine scs. |
2016-05-27 |
2023-08-13 |
human |
| Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, Marco Demaria, Judith Campisi, Krishnamurthy Janakiraman, Norman E Sharpless, Sheng Ding, Wei Feng, Yi Luo, Xiaoyan Wang, Nukhet Aykin-Burns, Kimberly Krager, Usha Ponnappan, Martin Hauer-Jensen, Aimin Meng, Daohong Zho. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature medicine. vol 22. issue 1. 2016-05-24. PMID:26657143. |
we show that abt263 selectively kills scs in culture in a cell type- and species-independent manner by inducing apoptosis. |
2016-05-24 |
2023-08-13 |
mouse |
| Junxiong Ma, Jun Liu, Hailong Yu, Yu Chen, Qi Wang, Liangbi Xian. Effect of metformin on Schwann cells under hypoxia condition. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261558. |
the results showed that metformin could help scs recover from hypoxia injury and inhibit hypoxia-induced apoptosis. |
2016-05-16 |
2023-08-13 |
Not clear |
| Yang Yu, Xiaoye Ma, Tao Yang, Bo Li, Keliang Xie, Daquan Liu, Guolin Wang, Yonghao Y. Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro. Molecular medicine reports. vol 12. issue 3. 2016-05-12. PMID:26035067. |
the aim of the present study was to investigate the protective effects of hydrogen‑rich medium (hm) on high glucose (hg)‑mediated oxidative stress, parp‑1 activation and the apoptosis of schwann cells (scs) in vitro. |
2016-05-12 |
2023-08-13 |
Not clear |
| Yang Yu, Xiaoye Ma, Tao Yang, Bo Li, Keliang Xie, Daquan Liu, Guolin Wang, Yonghao Y. Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro. Molecular medicine reports. vol 12. issue 3. 2016-05-12. PMID:26035067. |
hg was found to induce severe oxidative stress and promote the caspase‑dependent and caspase‑independent apoptosis of scs. |
2016-05-12 |
2023-08-13 |
Not clear |
| Yang Yu, Xiaoye Ma, Tao Yang, Bo Li, Keliang Xie, Daquan Liu, Guolin Wang, Yonghao Y. Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro. Molecular medicine reports. vol 12. issue 3. 2016-05-12. PMID:26035067. |
treatment with hm inhibited hg‑induced oxidative stress by suppressing hydroxyl and onoo‑ production, levels of 8‑ohdg, caspase‑3 activity and apoptosis in the scs. |
2016-05-12 |
2023-08-13 |
Not clear |
| Shreya Bhattacharya, Heather Wheeler, Mark Leid, Gitali Ganguli-Indra, Arup K Indr. Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1. The Journal of investigative dermatology. vol 135. issue 11. 2016-04-20. PMID:26176759. |
keratinocytes of the bulge stem cells (scs) niche of ctip2(ep-/-) mice proliferate more and undergo reduced apoptosis compared with the corresponding cells of wild-type mice. |
2016-04-20 |
2023-08-13 |
mouse |
| Ting Yu, Lei Li, Tianhua Chen, Zhen Liu, Huaxiang Liu, Zhenzhong L. Erythropoietin attenuates advanced glycation endproducts-induced toxicity of Schwann cells in vitro. Neurochemical research. vol 40. issue 4. 2016-04-05. PMID:25585642. |
the data of the present study gives, for the first time, evidence of the protective effects of epo on scs with ages-induced oxidative stress and apoptosis. |
2016-04-05 |
2023-08-13 |
rat |
| Zheqiong Yang, Anamaria Balic, Frederic Michon, Emma Juuri, Irma Theslef. Mesenchymal Wnt/β-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10. Stem cells (Dayton, Ohio). vol 33. issue 5. 2016-03-28. PMID:25693510. |
fgf10 is a key mesenchymal signal limiting apoptosis of incisor epithelial scs and its expression is negatively regulated by wnt/β-catenin. |
2016-03-28 |
2023-08-13 |
mouse |
| Liang Liu, Zhongyang Liu, Liangliang Huang, Zhen Sun, Teng Ma, Shu Zhu, Xin Quan, Yafeng Yang, Jinghui Huang, Zhuojing Lu. Pulsed magnetic field promotes proliferation and neurotrophic genes expression in Schwann cells in vitro. International journal of clinical and experimental pathology. vol 8. issue 3. 2016-03-08. PMID:26045741. |
we found that 2.0 mt was the optimal intensity that caused relatively little apoptosis with profound proliferation in scs. |
2016-03-08 |
2023-08-13 |
Not clear |
| S Sekaran, P Balaganapathy, R Parsanathan, S Elangovan, J Gunashekar, F A Bhat, A Jagadeesa. Lactational exposure of phthalate causes long-term disruption in testicular architecture by altering tight junctional and apoptotic protein expression in Sertoli cells of first filial generation pubertal Wistar rats. Human & experimental toxicology. vol 34. issue 6. 2016-03-02. PMID:25352649. |
dehp-treated rats also showed increased oxidative stress by decreasing antioxidant levels in the scs; it disrupted sc tight junctional proteins occludin, claudin, junctional adhesion molecule, zona occludens protein-1 (zo-1), zona occludens protein-2 (zo-2), and afadin-6 (af-6), increased apoptosis by altering the apoptotic genes bax, cytochrome c, caspase-8, -9, -3 and antiapoptotic gene bcl-2. |
2016-03-02 |
2023-08-13 |
rat |
| Shiying Li, Xinghui Wang, Yun Gu, Chu Chen, Yaxian Wang, Jie Liu, Wen Hu, Bin Yu, Yongjun Wang, Fei Ding, Yan Liu, Xiaosong G. Let-7 microRNAs regenerate peripheral nerve regeneration by targeting nerve growth factor. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 3. 2015-11-16. PMID:25394845. |
in addition, the inhibitory effect of let-7 mirnas on scs apoptosis might serve as an early stress response to nerve injury, but this effect seemed to be not mediated through a ngf-dependent pathway. |
2015-11-16 |
2023-08-13 |
Not clear |