| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenxuan Zhang, Ziqiang Lin, Ailing Sun, Yongyong Shi, Qingxiong Hong, Gaofeng Zha. Curcumin ameliorates the experimental diabetic peripheral neuropathy through promotion of NGF expression in rats. Chemistry & biodiversity. 2022-05-10. PMID:35538560. |
increasing evidence suggested that inhibiting the apoptosis of schwann cells (scs) and promoting nerve growth factor (ngf) expression in sciatic nerves play key roles in preventing the onset of diabetic peripheral neuropathy (dpn). |
2022-05-10 |
2023-08-13 |
rat |
| Wenxuan Zhang, Ziqiang Lin, Ailing Sun, Yongyong Shi, Qingxiong Hong, Gaofeng Zha. Curcumin ameliorates the experimental diabetic peripheral neuropathy through promotion of NGF expression in rats. Chemistry & biodiversity. 2022-05-10. PMID:35538560. |
the scs apoptosis in sciatic nerves was stained using tunel kit. |
2022-05-10 |
2023-08-13 |
rat |
| Wenxuan Zhang, Ziqiang Lin, Ailing Sun, Yongyong Shi, Qingxiong Hong, Gaofeng Zha. Curcumin ameliorates the experimental diabetic peripheral neuropathy through promotion of NGF expression in rats. Chemistry & biodiversity. 2022-05-10. PMID:35538560. |
curcumin (50, 100 and 150 mg/kg) reduced scs apoptosis in sciatic nerves. |
2022-05-10 |
2023-08-13 |
rat |
| Xiaoling Zeng, Luyuan Xie, Yuxin Ge, Yue Zhou, Hui Wang, Yongyi Chen, Xiaomei Zhu, Huayun Liu, Qianjin Liao, Yu Kong, Lijun Pan, Junjun Li, Lei Xue, Sha Li, Xiao Zhou, Chunmeng Shi, Xiaowu Shen. Satellite Cells are Activated in a Rat Model of Radiation-Induced Muscle Fibrosis. Radiation research. 2022-03-16. PMID:35294551. |
apoptosis and autophagy levels, il-1β concentrations in serum and irradiated skin tissues, and the numbers of scs and central nuclear muscle fibers were increased in the irradiated groups when compared with the control group. |
2022-03-16 |
2023-08-13 |
rat |
| Hsu-Wen Tseng, Dorothée Girard, Kylie A Alexander, Susan M Millard, Frédéric Torossian, Adrienne Anginot, Whitney Fleming, Jules Gueguen, Marie-Emmanuelle Goriot, Denis Clay, Beulah Jose, Bianca Nowlan, Allison R Pettit, Marjorie Salga, François Genêt, Marie-Caroline Le Bousse-Kerdilès, Sébastien Banzet, Jean-Pierre Lévesqu. Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles. Bone research. vol 10. issue 1. 2022-02-26. PMID:35217633. |
these experiments demonstrate that following muscle injury, sci causes the upregulation of pdgfrα expression on faps but not scs and the failure of scs to regenerate myofibers in the injured muscle, with reduced apoptosis and continued proliferation of muscle resident faps enabling their osteogenic differentiation into nhos. |
2022-02-26 |
2023-08-13 |
mouse |
| Malikeh Rad Niknam, Farnoosh Attar. The Potential Applications of Stem Cells for Cancer Treatment. Current stem cell research & therapy. vol 17. issue 1. 2022-01-20. PMID:35048802. |
in this regard, engineered scs can secrete anti-cancer proteins or express enzymes used in suicide gene therapy which locally induce apoptosis in neoplastic cells via the bystander effect. |
2022-01-20 |
2023-08-13 |
Not clear |
| Chen He, Jing Sun, Donghui Yang, Wenlai He, Jingyi Wang, Dezhe Qin, Huimin Zhang, Hui Cai, Yundie Liu, Na Li, Jinlian Hua, Sha Pen. Nrf2 activation mediates the protection of mouse Sertoli Cells damage under acute heat stress conditions. Theriogenology. vol 177. 2021-11-22. PMID:34715543. |
we found that acute heat stress only affected the vitality of scs and the expression of functional molecules (tight junction-associated proteins and lactate dehydrogenase a [ldha]) but did not cause cell apoptosis. |
2021-11-22 |
2023-08-13 |
mouse |
| Mingxia Ge, Li Hu, Hongshun Ao, Meiting Zi, Qingpeng Kong, Yonghan H. Senolytic targets and new strategies for clearing senescent cells. Mechanisms of ageing and development. vol 195. 2021-11-19. PMID:33741395. |
scs are resistant to various stressors because they are protected from apoptosis by sc anti-apoptotic pathways (scaps). |
2021-11-19 |
2023-08-13 |
Not clear |
| Bianka Porubska, Daniel Vasek, Veronika Somova, Michaela Hajkova, Michaela Hlaviznova, Tereza Tlapakova, Vladimir Holan, Magdalena Krulov. Sertoli Cells Possess Immunomodulatory Properties and the Ability of Mitochondrial Transfer Similar to Mesenchymal Stromal Cells. Stem cell reviews and reports. vol 17. issue 5. 2021-11-15. PMID:34115315. |
besides, scs rescued t helper (th) cells from undergoing apoptosis, promoted the anti-inflammatory phenotype of these cells, but did not regulate th cell proliferation. |
2021-11-15 |
2023-08-13 |
Not clear |
| Chengfang Tan, Cheng Yang, Hui Liu, Chenglin Tang, Siqin Huan. Effect of Schwann cell transplantation combined with electroacupuncture on axonal regeneration and remyelination in rats with spinal cord injury. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 11. 2021-11-15. PMID:34319000. |
by immunostaining, we found ea can not only improve survival and proliferation of transplanted scs but also inhibit sc apoptosis and block the formation of an astrocytic scar. |
2021-11-15 |
2023-08-13 |
rat |
| Li Cao, Jie Zhao, Jingru Xu, Lei Zhu, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wan. N-acetylcysteine ameliorate cytotoxic injury in piglets sertoli cells induced by zearalenone and deoxynivalenol. Environmental science and pollution research international. vol 28. issue 42. 2021-10-27. PMID:34156614. |
in summary, our results show that nac could alleviate scs injury via reducing the oxidative damage and apoptosis caused by zea and don. |
2021-10-27 |
2023-08-13 |
human |
| Anna Geueke, Giada Mantellato, Florian Kuester, Peter Schettina, Melanie Nelles, Jens Michael Seeger, Hamid Kashkar, Catherin Nieman. The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function. EMBO reports. vol 22. issue 10. 2021-10-22. PMID:34342114. |
in contrast, ectopic bcl-2 expression blocks apoptosis during hf regression, resulting in the accumulation of quiescent scs and delaying hf growth in mice. |
2021-10-22 |
2023-08-13 |
mouse |
| Li Cao, Jie Zhao, Li Ma, Jiawen Chen, Jingru Xu, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wan. Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34482067. |
zea downregulated the relative mrna and protein expression of bcl-2 in piglet scs, promoted cell apoptosis, and upregulated the relative mrna and protein expression of lc3, beclin-1, and bax. |
2021-10-05 |
2023-08-13 |
Not clear |
| Li Cao, Jie Zhao, Li Ma, Jiawen Chen, Jingru Xu, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wan. Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34482067. |
in conclusion, lyc alleviated the oxidative damage of scs caused by zea by promoting the expression of nrf2 pathway and decreased autophagy and apoptosis. |
2021-10-05 |
2023-08-13 |
Not clear |
| Xuejiao An, Taotao Li, Nana Chen, Huihui Wang, Xia Wang, Youji M. PGAM1 regulates the glycolytic metabolism of SCs in tibetan sheep and its influence on the development of SCs. Gene. vol 804. 2021-09-22. PMID:34418471. |
then the tibetan sheep primary sertoli cells (scs) were isolated to construct pgam1 gene overexpression and interference vectors, and to transfect primary scs so as to promote and inhibit pgam1 gene expression; cck-8 and flow cytometry were used to detect the proliferation effect of scs;qrt-pcr technology was employed to detect the changes in the expression of genes related to cell proliferation and apoptosis. |
2021-09-22 |
2023-08-13 |
Not clear |
| Xuejiao An, Taotao Li, Nana Chen, Huihui Wang, Xia Wang, Youji M. PGAM1 regulates the glycolytic metabolism of SCs in tibetan sheep and its influence on the development of SCs. Gene. vol 804. 2021-09-22. PMID:34418471. |
the pgam1 gene might regulate the glycolytic metabolism pathway and regulate the sperm formation and maturation process by affecting the proliferation and apoptosis of scs. |
2021-09-22 |
2023-08-13 |
Not clear |
| Shuangchan Wu, Sarrabeth Stone, Yuan Yue, Wensheng Li. Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of mature Schwann cells in adults. Glia. vol 69. issue 2. 2021-07-28. PMID:32935902. |
interestingly, sel1l deficiency had no effect on actively myelinating scs during development, but led to later-onset mature sc apoptosis and demyelination in the adult pns. |
2021-07-28 |
2023-08-13 |
mouse |
| Shuangchan Wu, Sarrabeth Stone, Yuan Yue, Wensheng Li. Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of mature Schwann cells in adults. Glia. vol 69. issue 2. 2021-07-28. PMID:32935902. |
moreover, inactivation of the pancreatic er kinase (perk) branch of the upr did not influence the viability and function of actively myelinating scs, but resulted in exacerbation of er stress and apoptosis of mature scs in sc-specific sel1l deficient mice. |
2021-07-28 |
2023-08-13 |
mouse |
| Bohan Li, Xiao Wan. Photobiomodulation enhances facial nerve regeneration via activation of PI3K/Akt signaling pathway-mediated antioxidant response. Lasers in medical science. 2021-07-24. PMID:34302577. |
the results showed that photobiomodulation improved axonal regeneration and functional recovery, and also promoted proliferation, and inhibited apoptosis of scs, both of these were considered as the most effective parameters in 250mw group. |
2021-07-24 |
2023-08-13 |
rat |
| Jing Li, Bo-Xing Sun, Da-Li Wang, Ying Liu, Jia-Jia Qi, Xiao-Wei Nie, Chun-Yan Bai, Jia-Bao Zhang, Shuang Lian. Melatonin ameliorates cypermethrin-induced impairments by regulating oxidative stress, DNA damage and apoptosis in porcine Sertoli cells. Theriogenology. vol 167. 2021-06-21. PMID:33774368. |
mechanistic investigations revealed that cyp induced oxidative stress and dna damage in porcine scs, which provoked mitochondria-associated apoptosis. |
2021-06-21 |
2023-08-13 |
Not clear |