| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maryam Raoof, Saeed Esmaeili-Mahani, Mahdieh Nourzadeh, Ramin Raoof, Mehdi Abbasnejad, Ladan Amirkhosravi, Zahra Hajializadeh, Jahangir Haghani, Forozan Rafi. Noxious Stimulation of the Rat Tooth Pulp May Impair Learning and Memory Through the Induction of Hippocampal Apoptosis. Journal of oral & facial pain and headache. vol 29. issue 4. 2016-02-01. PMID:26485387. |
noxious stimulation of the rat tooth pulp may impair learning and memory through the induction of hippocampal apoptosis. |
2016-02-01 |
2023-08-13 |
rat |
| Maryam Raoof, Saeed Esmaeili-Mahani, Mahdieh Nourzadeh, Ramin Raoof, Mehdi Abbasnejad, Ladan Amirkhosravi, Zahra Hajializadeh, Jahangir Haghani, Forozan Rafi. Noxious Stimulation of the Rat Tooth Pulp May Impair Learning and Memory Through the Induction of Hippocampal Apoptosis. Journal of oral & facial pain and headache. vol 29. issue 4. 2016-02-01. PMID:26485387. |
to determine whether noxious stimulation of the rat tooth pulp induces learning and memory impairment through the induction of apoptosis in the hippocampus. |
2016-02-01 |
2023-08-13 |
rat |
| David Cunningham, Andrea E DeBarber, Natalie Bir, Laura Binkley, Louise S Merkens, Robert D Steiner, Gail E Herma. Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development. Human molecular genetics. vol 24. issue 10. 2016-01-29. PMID:25652406. |
histological abnormalities include progressive loss of cortical and hippocampal neurons, as well as deficits in the proliferation and migration of cerebellar granule precursors and subsequent massive apoptosis of the cerebellar cortex. |
2016-01-29 |
2023-08-13 |
mouse |
| Xiang Shen, Yan-Ying Xie, Chen Chen, Xiao-Ping Wan. Effects of electroacupuncture on cognitive function in rats with Parkinson's disease. International journal of physiology, pathophysiology and pharmacology. vol 7. issue 3. 2016-01-29. PMID:26823963. |
compared with model control group, electroacupuncture group were apparently improved in learning & memory abilities, and chat activity was elevated, and apoptosis was reduced in the rat hippocampus and corpus striatum. |
2016-01-29 |
2023-08-13 |
rat |
| F D Liechti, D Grandgirard, S L Lei. The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. Neuroscience. vol 297. 2016-01-27. PMID:25839149. |
in bm the hippocampal dentate gyrus is injured by apoptosis while in cortical areas ischemic necrosis occurs. |
2016-01-27 |
2023-08-13 |
Not clear |
| Pengcheng Huang, Cai Li, Tianli Fu, Dan Zhao, Zhen Yi, Qing Lu, Lianjun Guo, Xulin X. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice. Behavioural brain research. vol 288. 2016-01-27. PMID:25869780. |
flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice. |
2016-01-27 |
2023-08-13 |
mouse |
| Pengcheng Huang, Cai Li, Tianli Fu, Dan Zhao, Zhen Yi, Qing Lu, Lianjun Guo, Xulin X. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice. Behavioural brain research. vol 288. 2016-01-27. PMID:25869780. |
the present study aimed to investigate whether flupirtine could alleviate spatial learning and memory impairment and hippocampal apoptosis induced by crs. |
2016-01-27 |
2023-08-13 |
mouse |
| Pengcheng Huang, Cai Li, Tianli Fu, Dan Zhao, Zhen Yi, Qing Lu, Lianjun Guo, Xulin X. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice. Behavioural brain research. vol 288. 2016-01-27. PMID:25869780. |
these results suggested that flupirtine exerted protective effects on the crs-induced cognitive impairment and hippocampal neuronal apoptosis, which is possibly associated with the activation of akt/gsk-3β and erk1/2 signaling pathways. |
2016-01-27 |
2023-08-13 |
mouse |
| Asieh Hosseini, Ali Mohammad Sharifi, Mohammad Abdollahi, Rezvan Najafi, Maryam Baeeri, Samira Rayegan, Jamshid Cheshmehnour, Shokoufeh Hassani, Zahra Bayrami, Majid Saf. Cerium and yttrium oxide nanoparticles against lead-induced oxidative stress and apoptosis in rat hippocampus. Biological trace element research. vol 164. issue 1. 2016-01-21. PMID:25516117. |
cerium and yttrium oxide nanoparticles against lead-induced oxidative stress and apoptosis in rat hippocampus. |
2016-01-21 |
2023-08-13 |
human |
| Chun-Sing Lam, George Lim Tipoe, Kwok-Fai So, Man-Lung Fun. Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PloS one. vol 10. issue 2. 2016-01-18. PMID:25714473. |
the effect of lbp on the spatial memory and levels of oxidative stress, inflammation, endoplasmic reticulum (er) stress, apoptosis and neurogenesis in the hippocampus was examined. |
2016-01-18 |
2023-08-13 |
rat |
| Chun-Sing Lam, George Lim Tipoe, Kwok-Fai So, Man-Lung Fun. Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PloS one. vol 10. issue 2. 2016-01-18. PMID:25714473. |
in addition, redox-sensitive nuclear factor kappa b (nfКb) canonical pathway was activated with a translocation of nfКb members (p65, p50) and increased expression levels of nfКb-dependent inflammatory cytokines and mediator (tnfα, il-1β, cox-2); also, a significantly elevated level of er stress (grp78/bip, perk, chop) and autophagic flux in the hypoxic group, leading to neuronal apoptosis in hippocampal subfields (dg, ca1, ca3). |
2016-01-18 |
2023-08-13 |
rat |
| Moza M Al-Owais, Mark L Dallas, John P Boyle, Jason L Scragg, Chris Peer. Heme Oxygenase-1 Influences Apoptosis via CO-mediated Inhibition of K+ Channels. Advances in experimental medicine and biology. vol 860. 2016-01-04. PMID:26303499. |
similarly in hippocampal neurones, co selectively inhibited kv2.1 and protected neurones against oxidant-induced apoptosis. |
2016-01-04 |
2023-08-13 |
Not clear |
| Sohaila Erfani, Mehdi Khaksari, Shahrbanoo Oryan, Nabi Shamsaei, Nahid Aboutaleb, Farnaz Nikbakh. Nampt/PBEF/visfatin exerts neuroprotective effects against ischemia/reperfusion injury via modulation of Bax/Bcl-2 ratio and prevention of caspase-3 activation. Journal of molecular neuroscience : MN. vol 56. issue 1. 2015-12-24. PMID:25603815. |
cerebral ischemia leads to energy depletion and eventually neuronal death by apoptosis in specific brain regions specially the hippocampus. |
2015-12-24 |
2023-08-13 |
Not clear |
| S H Takada, C A Dos Santos Haemmerle, L C Motta-Teixeira, A V Machado-Nils, V Y Lee, L F Takase, R J Cruz-Rizzolo, A H Kihara, G F Xavier, I-S Watanabe, M I Nogueir. Neonatal anoxia in rats: hippocampal cellular and subcellular changes related to cell death and spatial memory. Neuroscience. vol 284. 2015-12-22. PMID:25305666. |
this study investigated the time-course of cellular and subcellular changes and hippocampal cell death in a non-invasive model of anoxia in neonatal rats, using terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) to reveal dna fragmentation, fluoro-jade® b (fjb) to show degenerating neurons, cleaved caspase-3 immunohistochemistry (ihc) to detect cells undergoing apoptosis, and transmission electron microscopy (tem) to reveal fine ultrastructural changes related to cell death. |
2015-12-22 |
2023-08-13 |
human |
| İ S Övey, M Naziroğl. Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channels. Neuroscience. vol 284. 2015-12-22. PMID:25305668. |
homocysteine and cytosolic gsh depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of trpm2 and trpv1 channels. |
2015-12-22 |
2023-08-13 |
mouse |
| İ S Övey, M Naziroğl. Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channels. Neuroscience. vol 284. 2015-12-22. PMID:25305668. |
we tested the effects of hcy, bso and gsh on oxidative stress, apoptosis and ca2+ and influx via trpm2 and trpv1 channels in the hippocampus of mice. |
2015-12-22 |
2023-08-13 |
mouse |
| Fabian D Liechti, Nicolas Stüdle, Regula Theurillat, Denis Grandgirard, Wolfgang Thormann, Stephen L Lei. The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. PloS one. vol 9. issue 11. 2015-12-22. PMID:25409333. |
the mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. |
2015-12-22 |
2023-08-13 |
rat |
| Fabian D Liechti, Nicolas Stüdle, Regula Theurillat, Denis Grandgirard, Wolfgang Thormann, Stephen L Lei. The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. PloS one. vol 9. issue 11. 2015-12-22. PMID:25409333. |
brain damage caused by this disease is characterized by apoptosis in the hippocampal dentate gyrus, a morphological correlate of learning deficits in experimental paradigms. |
2015-12-22 |
2023-08-13 |
rat |
| Fabian D Liechti, Nicolas Stüdle, Regula Theurillat, Denis Grandgirard, Wolfgang Thormann, Stephen L Lei. The mood-stabilizer lithium prevents hippocampal apoptosis and improves spatial memory in experimental meningitis. PloS one. vol 9. issue 11. 2015-12-22. PMID:25409333. |
in the hippocampus, licl significantly reduced apoptosis and gene expression of bax and p53 while it increased expression of bcl-2. |
2015-12-22 |
2023-08-13 |
rat |
| Antonio H Martins, Jing Hu, Zhenfeng Xu, Chaofeng Mu, Paloma Alvarez, Byron D Ford, Khalid El Sayed, Vesna A Eterovic, Pedro A Ferchmin, Jiukuan Ha. Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia. Neuroscience. vol 291. 2015-12-21. PMID:25677097. |
the results from in vitro experiments indicate that 4r decreased neuro2a cell (neuroblastoma cells) apoptosis induced by oxygen-glucose deprivation (ogd), and improved the population spikes' (pss) recovery in rat acute hippocampal slices under ogd; a phosphatidylinositol 3-kinase (pi3k) inhibitor, wortmannin, abolished the effect of 4r on pss recovery. |
2015-12-21 |
2023-08-13 |
mouse |