| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miren Ettcheto, Felix Junyent, Luisa de Lemos, Merce Pallas, Jaume Folch, Carlos Beas-Zarate, Ester Verdaguer, Raquel Gómez-Sintes, José J Lucas, Carme Auladell, Antoni Camin. Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25119776. |
mice lacking functional fas death receptors are protected from kainic acid-induced apoptosis in the hippocampus. |
2016-05-17 |
2023-08-13 |
mouse |
| Miren Ettcheto, Felix Junyent, Luisa de Lemos, Merce Pallas, Jaume Folch, Carlos Beas-Zarate, Ester Verdaguer, Raquel Gómez-Sintes, José J Lucas, Carme Auladell, Antoni Camin. Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25119776. |
in addition, treatment of lpr mice with ka did not produce significant changes in the transcriptional activity of genes related to apoptosis in the hippocampus, either in the fas and fas ligand genes or in caspase-4 and caspase-8 and the executioner caspase-3 genes, as occurred in wild-type c57bl/6 mice. |
2016-05-17 |
2023-08-13 |
mouse |
| Miren Ettcheto, Felix Junyent, Luisa de Lemos, Merce Pallas, Jaume Folch, Carlos Beas-Zarate, Ester Verdaguer, Raquel Gómez-Sintes, José J Lucas, Carme Auladell, Antoni Camin. Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25119776. |
thus, these data provide direct evidence that fas signalling plays a key role in the induction of apoptosis in the hippocampus following ka treatment, making the inhibition of the death receptor pathway a potentially suitable target for excitotoxicity neuroprotection in neurological conditions such as epilepsy. |
2016-05-17 |
2023-08-13 |
mouse |
| Jing Wu, Mingqiang Zhang, Shuangying Hao, Ming Jia, Muhuo Ji, Lili Qiu, Xiaoyan Sun, Jianjun Yang, Kuanyu L. Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25288156. |
a physiological mechanistic investigation revealed that mitochondrial function of hippocampus was severely impaired, coupled with reactive oxygen species (ros) generation, triggering neuronal apoptosis and inflammation. |
2016-05-17 |
2023-08-13 |
mouse |
| Jing Wu, Mingqiang Zhang, Shuangying Hao, Ming Jia, Muhuo Ji, Lili Qiu, Xiaoyan Sun, Jianjun Yang, Kuanyu L. Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25288156. |
in conclusion, our data demonstrate that daily treatment with mitochondria-targeted peptide ss-31 reduces mortality rate and ameliorates cognitive deficits, which is possibly through a mechanism of reversing mitochondrial dysfunction and partial inhibition of neuronal apoptosis and inflammation in the hippocampus of the sae mice. |
2016-05-17 |
2023-08-13 |
mouse |
| Wipawan Thangnipon, Nirut Suwanna, Chanati Jantrachotechatchawan, Sukonthar Ngampramuan, Patoomratana Tuchinda, Saksit Nobsathia. Protective roles of N-benzylcinnamide on cortex and hippocampus of aged rat brains. Archives of pharmacal research. vol 38. issue 7. 2016-05-16. PMID:25840686. |
pt-3 treatment improved spatial learning and memory of aged rats and caused significant changes in brain frontal cortex, hippocampus, and temporal cortex in parameters associated with oxidative stress (decreased reactive oxygen species production and inos and nnos levels), inflammation (reduced levels of il-1β and il-6), apoptosis (reduced levels of bax and activated caspase-3, and elevated level of bcl-2), and signaling pathways related to inflammation and apoptosis (decreased amounts of phospho-jnk and -p38, increased phospho-akt level and no change in phospho-erk1/2 content) compared to controls. |
2016-05-16 |
2023-08-13 |
rat |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
rhepo affects apoptosis in hippocampus of aging rats by upregulating sirt1. |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
the aim of this study was to elucidate the signaling pathway involved in the anti-aging effect of erythropoietin (epo) and to clarify whether recombinant human epo (rhepo) affects apoptosis in the aging rat hippocampus by upregulating sirtuin 1 (sirt1). |
2016-05-16 |
2023-08-13 |
human |
| Haiqin Wu, Huqing Wang, Wenting Zhang, Xuanhui Wei, Jiaxin Zhao, Pu Yan, Chao Li. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-16. PMID:26261574. |
these results suggest that rhepo regulates apoptosis-related genes and affects apoptosis in the hippocampus of aging rats by upregulating sirt. |
2016-05-16 |
2023-08-13 |
human |
| Sang-Hak Lee, Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Hyun-Hee Choi, Chang-Ju Ki. Aqueous extract of Cordyceps alleviates cerebral ischemia-induced short-term memory impairment in gerbils. Journal of exercise rehabilitation. vol 12. issue 2. 2016-05-10. PMID:27162767. |
we investigated the effects of cordyceps on short-term memory, neuronal apoptosis, and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils. |
2016-05-10 |
2023-08-13 |
Not clear |
| Sang-Hak Lee, Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Hyun-Hee Choi, Chang-Ju Ki. Aqueous extract of Cordyceps alleviates cerebral ischemia-induced short-term memory impairment in gerbils. Journal of exercise rehabilitation. vol 12. issue 2. 2016-05-10. PMID:27162767. |
cordyceps showed therapeutic effects through inhibiting cerebral ischemia-induced apoptosis in the hippocampus. |
2016-05-10 |
2023-08-13 |
Not clear |
| Ling Pen. Mice Brain Tissue Injury Induced by Diisononyl Phthalate Exposure and the Protective Application of Vitamin E. Journal of biochemical and molecular toxicology. vol 29. issue 7. 2016-05-02. PMID:25908391. |
through oral exposure to dinp, oxidative stress, inflammatory responses, apoptosis, and hippocampus pathological alterations were found in the mice brain. |
2016-05-02 |
2023-08-13 |
mouse |
| Chan Chen, Jingjing Cai, Shu Zhang, Lu Gan, Yuanlin Dong, Tao Zhu, Gang Ma, Tao Li, Xiyang Zhang, Qian Li, Xu Cheng, Chaomeng Wu, Jing Yang, Yunxia Zuo, Jin Li. Protective Effect of RNase on Unilateral Nephrectomy-Induced Postoperative Cognitive Dysfunction in Aged Mice. PloS one. vol 10. issue 7. 2016-05-02. PMID:26225860. |
we found that perioperative administration of rnase: 1) attenuated unilateral nephrectomy-induced cognitive impairment at day 3 after surgery; 2) reduced the hippocampal cytokines mrna production and serum cytokines protein production at day 1 and day 7 (for mcp-1) after surgery, and; 3) inhibited hippocampal apoptosis as indicated by cleaved caspase-3 western blot and tunel staining at day 1 after surgery. |
2016-05-02 |
2023-08-13 |
mouse |
| Fabian D Liechti, Denis Grandgirard, Stephen L Lei. Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies. Future microbiology. vol 10. issue 7. 2016-04-29. PMID:26119836. |
pathological correlates of neurofunctional deficits include cortical necrosis, damage of the inner ear and hippocampal apoptosis. |
2016-04-29 |
2023-08-13 |
Not clear |
| Bin Yu, Bin Zhang, Wen-Bo Zhou, Qiu-Wei Wang, Pei Yuan, Yu-Qi Yang, Jing Kon. Assessing apoptosis gene expression profiling with a PCR array in the hippocampus of Ts65Dn mice. BioMed research international. vol 2015. 2016-04-22. PMID:26075220. |
assessing apoptosis gene expression profiling with a pcr array in the hippocampus of ts65dn mice. |
2016-04-22 |
2023-08-13 |
mouse |
| Bin Yu, Bin Zhang, Wen-Bo Zhou, Qiu-Wei Wang, Pei Yuan, Yu-Qi Yang, Jing Kon. Assessing apoptosis gene expression profiling with a PCR array in the hippocampus of Ts65Dn mice. BioMed research international. vol 2015. 2016-04-22. PMID:26075220. |
first, we used transmission scanning electron microscopy to directly observe the hippocampus and confirm if apoptosis had occurred. |
2016-04-22 |
2023-08-13 |
mouse |
| Bin Yu, Bin Zhang, Wen-Bo Zhou, Qiu-Wei Wang, Pei Yuan, Yu-Qi Yang, Jing Kon. Assessing apoptosis gene expression profiling with a PCR array in the hippocampus of Ts65Dn mice. BioMed research international. vol 2015. 2016-04-22. PMID:26075220. |
there were varying degrees of changes characteristic of apoptosis in the hippocampus of ts65dn mice, which mainly included the following: nuclear membrane thinning, unevenly distributed chromosomes, the production of chromatin crescents, and pyknosis of the nuclei with some nuclear fragmentation. |
2016-04-22 |
2023-08-13 |
mouse |
| Bin Yu, Bin Zhang, Wen-Bo Zhou, Qiu-Wei Wang, Pei Yuan, Yu-Qi Yang, Jing Kon. Assessing apoptosis gene expression profiling with a PCR array in the hippocampus of Ts65Dn mice. BioMed research international. vol 2015. 2016-04-22. PMID:26075220. |
the genes we found which were differentially expressed in the hippocampus of ts65dn mice may be closely related to cell apoptosis. |
2016-04-22 |
2023-08-13 |
mouse |
| Yachen Wang, Canming Bai, Huai Guan, Ruolin Chen, Xiaoxu Wang, Bingwen Wang, Hetian Jin, Fengyuan Pia. Subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the Bcl-2/Bax pathway. Journal of occupational health. vol 57. issue 3. 2016-04-19. PMID:25787108. |
subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the bcl-2/bax pathway. |
2016-04-19 |
2023-08-13 |
mouse |
| Yachen Wang, Canming Bai, Huai Guan, Ruolin Chen, Xiaoxu Wang, Bingwen Wang, Hetian Jin, Fengyuan Pia. Subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the Bcl-2/Bax pathway. Journal of occupational health. vol 57. issue 3. 2016-04-19. PMID:25787108. |
the aim of this study was to identify whether arsenic (as) exposure could induce hippocampal neural apoptosis in vivo. |
2016-04-19 |
2023-08-13 |
mouse |