| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yao Tan, Yujing Huang, Weiyan Chen, Tingyuan Lang, Lingqiao Wang, Xiaoling Chen, Haili Yu, Zhiqun Qiu, Ke Cui, Chengwei Guo, Yiqi Wang, Ziyuan Zho. Microcystin-LR induces neuronal damage through mitophagy defects resulted from the downregulated transcription of Scd2 by directly targeting IGF-1R. Environmental pollution (Barking, Essex : 1987). 2024-12-26. PMID:39725202. |
we found that administration of 10 μg/kg body weight (intraperitoneally) mc-lr impaired learning and memory abilities and induced neuronal damage and apoptosis in the ca1 region of the hippocampus in rats. |
2024-12-26 |
2024-12-29 |
rat |
| Mingsong Liu, Lei Li, Ruizhe Chen, Qilin Wang, Tongfei Zeng, Junhong Hu, Changzhi Yan, Jing Xiao, Xuewei Xi. Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats. Biogerontology. vol 26. issue 1. 2024-11-16. PMID:39546054. |
mechanistic studies demonstrated that these beneficial effects were attributed to the reduction of neuronal apoptosis in hippocampal ca1 through regulation of synaptic connections between astrocytes and neurons via 40 hz gamma oscillations. |
2024-11-16 |
2024-11-18 |
rat |
| Wenyan Shi, Xingyan Wu, Chengdong Yuan, Tao Kuang, Xiangfan Xie, Wenlu Gong, Fujia Li, Lechen Shen, Yi Zhang, Xiaoli Lian. Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action. European journal of medical research. vol 29. issue 1. 2024-11-13. PMID:39533344. |
concurrently, the extent of caspase-3 upregulation, the number of neuronal apoptosis in ca1 and ca3 regions, a downward trend of psd95 and bdnf in the hippocampus, and the inhibition of ltp were highly consistent with the behavior of short-term memory impairment. |
2024-11-13 |
2024-11-17 |
mouse |
| Sepideh Goudarzi, Razieh Mohammad Jafari, Nikou Farsiu, Behnam Amini, Mohammad Amin Manavi, Javad Fahanik-Babaei, Shahram Ejtemaei-Mehr, Ahmad Reza Dehpou. Protective Effects of Licofelone on Scopolamine-Induced Spatial Learning and Memory Impairment by Enhancing Parkin-Dependent Mitophagy and Promotion of Neural Regeneration and in Adult Mice. European journal of pharmacology. 2024-10-12. PMID:39395583. |
molecular analysis revealed that the chronic form of the drug could enhance neural regeneration in ca1 and sgz regions, reset mitophagy levels as much as the healthy state, and reduce apoptosis rate. |
2024-10-12 |
2024-10-15 |
mouse |
| Caihong Gu, Xiuwen Kang, Xiaobing Chen, Yan Sun, Xiaomin L. Intracerebroventricular Infusion of Secretoneurin Inhibits Neuronal NLRP3-Apoptosis Pathway and Preserves Learning and Memory after Cerebral Ischemia. Neurochemistry international. 2024-05-18. PMID:38761854. |
transient global cerebral ischemia (gci) results in delayed neuronal death, primarily apoptosis, in the hippocampal ca1 subregion, which leads to severe cognitive deficits. |
2024-05-18 |
2024-05-27 |
rat |
| Caihong Gu, Xiuwen Kang, Xiaobing Chen, Yan Sun, Xiaomin L. Intracerebroventricular Infusion of Secretoneurin Inhibits Neuronal NLRP3-Apoptosis Pathway and Preserves Learning and Memory after Cerebral Ischemia. Neurochemistry international. 2024-05-18. PMID:38761854. |
to further investigate underlying pathways involved, we demonstrated that, on day 5 after gci, sn could significantly inhibit gci-induced expression levels of apoptosis inducing factor (aif) and cleaved-parp1, as well as neuronal apoptosis and synaptic loss in the hippocampal ca1 region. |
2024-05-18 |
2024-05-27 |
rat |
| Jessica L Bradshaw, E Nicole Wilson, Jennifer J Gardner, Steve Mabry, Selina M Tucker, Nataliya Rybalchenko, Edward Vera, Styliani Goulopoulou, Rebecca L Cunningha. Pregnancy-induced oxidative stress and inflammation are not associated with impaired maternal neuronal activity or memory function. American journal of physiology. Regulatory, integrative and comparative physiology. 2024-05-06. PMID:38708544. |
ca1 markers of oxidative stress, neuronal activity, and apoptosis were quantified via western blotting. |
2024-05-06 |
2024-05-08 |
rat |
| Jessica L Bradshaw, E Nicole Wilson, Jennifer J Gardner, Steve Mabry, Selina M Tucker, Nataliya Rybalchenko, Edward Vera, Styliani Goulopoulou, Rebecca L Cunningha. Pregnancy-associated oxidative stress and inflammation are not associated with impaired maternal neuronal activity or memory function. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328246. |
ca1 markers of oxidative stress, neuronal activity, and apoptosis were quantified via western blotting. |
2024-02-08 |
2024-02-10 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
additionally, nissl staining assessed hippocampal ca1 area neuronal density, tunel staining evaluated hippocampal ca1 area neuronal apoptosis, and western blot determined hippocampal ca1 area protein levels, including bax, bcl-2, p-perk/perk, p-eif2/eif2, atf4, chop, grp78, bax, and bcl-2 protein levels. |
2024-01-09 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
following spc treatment, hibd rats exhibited improved spatial learning and memory abilities, reduced neuronal apoptosis, increased neuronal density in the hippocampal ca1 area, elevated bcl-2 protein level, decreased bax protein levels, and decreased levels of endoplasmic reticulum stress pathway related proteins (p-perk/perk, p-eif2/eif2, atf4, chop and grp78). |
2024-01-09 |
2024-01-13 |
rat |
| Qionghua Hu, Lingqin Qiu, Li Ge, Yi We. Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway. Tissue & cell. vol 86. 2024-01-09. PMID:38194851. |
in conclusion, spc alleviates neuronal apoptosis in the hippocampus ca1 area of hibd rats by inhibiting the endoplasmic reticulum stress pathway perk/atf4/chop, thereby mitigating hibd in rats. |
2024-01-09 |
2024-01-13 |
rat |
| Didem Dönmez Aydin, Oğuz Taşkınalp, Enis Uluçam, Hakan Karadağ, Gülnur Kızılay Özfidan, Ruhan Topuz, Onur Erso. The Effect of Acute and Chronic Formaldehyde Exposure on Learning and Memory in Male and Female Rats. The International journal of neuroscience. 2023-12-28. PMID:38152865. |
after acute exposure, apoptosis was observed in the hippocampal ca1 and ca3 regions in males. |
2023-12-28 |
2023-12-30 |
rat |
| Hu-Jun Xu, Xian-Peng Li, Li-Ye Ha. Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway. The Kaohsiung journal of medical sciences. 2023-11-29. PMID:38018683. |
additionally, we evaluated histopathological changes/neuronal apoptosis in the mouse hippocampal ca1 area through he/tunel stainings. |
2023-11-29 |
2023-12-07 |
mouse |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the rats fed with copper-laden diet for 12 weeks, and the effect of chr on the copper content in liver and 24-h urine, the learning and memory ability, the morphological changes and the apoptosis level of neurons in hippocampal ca1 region, the expression level of bax, bcl-2, cleaved caspase-3, p-pi3k, pi3k, p-akt, and akt proteins were detected. |
2023-11-24 |
2023-11-29 |
human |
| Adriana M Zago, Fabiano B Carvalho, Francine L Rahmeier, Marta Santin, Giuliano R Guimarães, Jessié M Gutierres, Marilda da C Fernande. Exendin-4 Prevents Memory Loss and Neuronal Death in Rats with Sporadic Alzheimer-Like Disease. Molecular neurobiology. 2023-11-03. PMID:37919602. |
stz reduced mature neuron density (neun) and increased cell apoptosis (cc3) in the dg, ca1, and ca3. |
2023-11-03 |
2023-11-08 |
rat |
| Haohong Zhan, Qiang Zhang, Chenyu Zhang, Jingge Cheng, Yilin Yang, Cong Liu, Shuhao Li, Chuyue Wang, Junqin Yang, Hanmei Ge, Dawang Zhou, Bo Li, Hongyan Wei, Chunlin H. Targeted Activation of HNF4α by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats. Neurochemical research. 2023-06-20. PMID:37338793. |
the results showed that ampk improved the 7-day memory function of rats, and reduced neuronal cell injury and apoptosis in the hippocampal ca1 region after rosc, while the use of hnf4α inhibitor weakened the protective effect of ampk. |
2023-06-20 |
2023-08-14 |
rat |
| Fatih Mete, Signem Eyuboglu, Ayca Vitrinel, Ulkan Kilic, Cihan Suleyman Erdogan, Ertugrul Kilic, Bayram Yilma. Hyperthermia alters neurobehavior by affecting cell proliferation and neuronal survival in young male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-04-08. PMID:37029601. |
neuronal survival, apoptosis, and cell proliferation were investigated in cortex, hippocampal dentate gyrus (dg) and ca1 regions, and corpus callosum (cc). |
2023-04-08 |
2023-08-14 |
rat |
| Nellysha Namela Muhammad Abdul Kadar, Fairus Ahmad, Seong Lin Teoh, Mohamad Fairuz Yahay. Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2023-03-08. PMID:36358526. |
immunohistochemistry investigations of neurogenesis (edu) and apoptosis (tunel) on the cornu ammonis 1 (ca1) and dentate gyrus (dg) areas of the hippocampus showed no changes with sbh and ca supplementation compared to the control. |
2023-03-08 |
2023-08-16 |
rat |
| Seung-Chan Kim, Jae-Yong Park, Eun Mi Hwan. Caspase-dependent apoptosis induces reactivation and gliogenesis of astrocytes in adult mice. Frontiers in cellular neuroscience. vol 16. 2022-12-19. PMID:36531137. |
we induced apoptosis of hippocampal ca1 astrocytes in ctg mice using gfap promoter-driven adeno-associated virus (aav) containing cre recombinase. |
2022-12-19 |
2023-08-14 |
mouse |
| Han-Yu Fu, Yang Cui, Qiao Li, Ding Wang, Hui Li, Long Yang, De-Juan Wang, Jing-Wei Zho. LAMP-2A ablation in hippocampal CA1 astrocytes confers cerebroprotection and ameliorates neuronal injury after global brain ischemia. Brain pathology (Zurich, Switzerland). 2022-09-05. PMID:36059143. |
conditional lamp-2a knockdown in ca1 astrocytes inhibited astrocyte activation and prevented neuronal death by inhibiting the mitochondrial pathway of apoptosis after i/r, suggesting that elevated astrocytic lamp-2a contributes to regional ischemic vulnerability. |
2022-09-05 |
2023-08-14 |
Not clear |