| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L B Dudnik, A N Tsiupko, L N Shingarova, M A Shupik, G G Akhaladze, E I Gal'perin, L V Platonova, N I Shono, V V Iasnetsov, A V Alesenk. [Changes in sphingomyelinase activity, tumor necrosis factor alpha level, and lipid peroxidation rate in the course of development of cholestatic liver injury]. Izvestiia Akademii nauk. Seriia biologicheskaia. issue 6. 2006-04-14. PMID:16535974. |
our results indicate that tumor necrosis factor alpha overexpression, the sphingomyelin cycle activation, and lipid peroxidation intensification may cause apoptosis of hepatocytes at the late stages of cholestasis. |
2006-04-14 |
2023-08-12 |
Not clear |
| Jesús Soto, Carlos Sainz, Domingo González-Lamuño, Samuel Co. Low doses of alpha particle irradiation modify the expression of genes regulating apoptosis in human MCF-7 breast cancer cells. Oncology reports. vol 15. issue 3. 2006-04-13. PMID:16465415. |
low doses of alpha particle irradiation modify the expression of genes regulating apoptosis in human mcf-7 breast cancer cells. |
2006-04-13 |
2023-08-12 |
human |
| Jesús Soto, Carlos Sainz, Domingo González-Lamuño, Samuel Co. Low doses of alpha particle irradiation modify the expression of genes regulating apoptosis in human MCF-7 breast cancer cells. Oncology reports. vol 15. issue 3. 2006-04-13. PMID:16465415. |
in vitro low doses of alpha particle irradiation due to radon have an antiproliferative effect on the growth of mcf-7 cells and increase the sensibility of cancer cells to taxol, a chemotherapeutic agent that induces cellular apoptosis. |
2006-04-13 |
2023-08-12 |
human |
| Lydie Sparfel, Julien Van Grevenynghe, Marc Le Vee, Caroline Aninat, Olivier Farde. Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16258175. |
pifithrin alpha (pftalpha) is a chemical compound that inhibits p53-mediated gene activation and apoptosis. |
2006-04-04 |
2023-08-12 |
human |
| Orla M Casey, Dermot G Morris, Richard Powell, Joseph M Sreenan, Richard Fitzpatric. Analysis of gene expression in non-regressed and regressed bovine corpus luteum tissue using a customized ovarian cDNA array. Theriogenology. vol 64. issue 9. 2006-03-23. PMID:15953631. |
results for five of the differentially expressed genes including matrix gla protein and collagen alpha1(i) (extracellular matrix), glutathione-s-transferase alpha i (oxygen metabolism), clusterin (apoptosis) and scavenger receptor bi (steroid biosynthesis) were confirmed by northern blot analysis and found to be significantly different (p<0.01) between non-regressed and regressed cl tissue. |
2006-03-23 |
2023-08-12 |
cattle |
| Thomas A Lagace, Neale D Ridgwa. Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha). The Biochemical journal. vol 392. issue Pt 3. 2006-03-13. PMID:16097951. |
induction of apoptosis by lipophilic activators of ctp:phosphocholine cytidylyltransferase alpha (cctalpha). |
2006-03-13 |
2023-08-12 |
Not clear |
| Thomas A Lagace, Neale D Ridgwa. Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha). The Biochemical journal. vol 392. issue Pt 3. 2006-03-13. PMID:16097951. |
interestingly, the rate-limiting enzyme in this pathway, cctalpha (ctp:phosphocholine cytidylyltransferase alpha), is rapidly activated, cleaved by caspases and exported from the nucleus during foh-induced apoptosis. |
2006-03-13 |
2023-08-12 |
Not clear |
| A Yemelyanov, A Gasparian, P Lindholm, L Dang, J W Pierce, F Kisseljov, A Karseladze, I Budunov. Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells. Oncogene. vol 25. issue 3. 2006-03-02. PMID:16170348. |
we found that ps1145 induced caspase 3/7-dependent apoptosis in pc cells and significantly sensitized pc cells to apoptosis induced by tumor necrosis factor alpha. |
2006-03-02 |
2023-08-12 |
Not clear |
| Amiram Ariel, Pin-Lan Li, Wei Wang, Wang-Xian Tang, Gabrielle Fredman, Song Hong, Katherine H Gotlinger, Charles N Serha. The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. The Journal of biological chemistry. vol 280. issue 52. 2006-02-27. PMID:16216871. |
pd1 blocked t cell migration in vivo, inhibited tumor necrosis factor alpha and interferon-gamma secretion, and promoted apoptosis mediated by raft clustering. |
2006-02-27 |
2023-08-12 |
human |
| M M Sailaja Devi, U N Da. Effect of prostaglandins against alloxan-induced diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids. vol 74. issue 1. 2006-02-27. PMID:16297610. |
previously, we observed that alloxan-induced in vitro cytotoxicity and apoptosis in an insulin secreting rat insulinoma, rin, cells was prevented by prior exposure to prostaglandin (pg) e(1), pge(2), pgi(2), pgf(1)(alpha), and pgf(3)(alpha) (p<0.05 compared to alloxan), whereas thromboxane b(2) (txb(2)) and 6-keto-pgf(1)(alpha) were ineffective. |
2006-02-27 |
2023-08-12 |
rat |
| Rebecca L Wilson, Sandra M Fuentes, Ping Wang, Erica C Taddeo, Alicia Klatt, Andrew J Henderson, Biao H. Function of small hydrophobic proteins of paramyxovirus. Journal of virology. vol 80. issue 4. 2006-02-24. PMID:16439527. |
neutralizing antibodies against tumor necrosis factor alpha (tnf-alpha) and tnf-alpha receptor 1 block rsv5deltash-induced apoptosis, suggesting that sv5 sh plays an essential role in blocking the tnf-alpha-mediated apoptosis pathway. |
2006-02-24 |
2023-08-12 |
Not clear |
| Joseph A Caruso, Patricia A Mathieu, John J Reiner. Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy. The Biochemical journal. vol 392. issue Pt 2. 2006-02-23. PMID:15943580. |
pre-treatment of 1c1c7 cultures with 3-o-mesm also suppressed the induction of apoptosis by tnfalpha (tumour necrosis factor alpha), but offered no protection against ha14-1 [ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate], staurosporine, tunicamycin or thapsigargin. |
2006-02-23 |
2023-08-12 |
Not clear |
| Stephane Supiot, Sebastien Gouard, Josiane Charrier, Christos Apostolidis, Jean-Francois Chatal, Jacques Barbet, François Davodeau, Michel Chere. Mechanisms of cell sensitization to alpha radioimmunotherapy by doxorubicin or paclitaxel in multiple myeloma cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 19 Pt 2. 2006-02-23. PMID:16203801. |
the purpose of this study was to analyze different mechanisms (cell cycle synchronization, dna damage, and apoptosis) that might underlie potential synergy between chemotherapy (paclitaxel or doxorubicin) and radioimmunotherapy with alpha radionuclides. |
2006-02-23 |
2023-08-12 |
Not clear |
| Zongbing You, Xu-Bao Shi, Grayson DuRaine, Dominik Haudenschild, Clifford G Tepper, Su Hao Lo, Regina Gandour-Edwards, Ralph W de Vere White, A Hari Redd. Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer. Cancer research. vol 66. issue 1. 2006-02-23. PMID:16397230. |
overexpression of il-17rl in tumor necrosis factor alpha (tnfalpha)-sensitive lncap cells inhibited tnfalpha-induced apoptosis by blocking activation of caspase-3 downstream to caspase-2 and caspase-8. |
2006-02-23 |
2023-08-12 |
mouse |
| Ron C Ilg, Michael H Davies, Michael R Power. Altered retinal neovascularization in TNF receptor-deficient mice. Current eye research. vol 30. issue 11. 2006-02-16. PMID:16282134. |
tumor necrosis factor alpha (tnf-alpha) has been shown to play an integral role in inflammation, apoptosis, and angiogenesis. |
2006-02-16 |
2023-08-12 |
mouse |
| Shannon Reagan-Shaw, Nihal Ahma. RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424042. |
transfection of pi3k sirna in breast cancer cells resulted in a significant decrease in cell viability and induction of apoptosis irrespective of their estrogen receptor alpha (eralpha) or erbb2 status. |
2006-02-14 |
2023-08-12 |
Not clear |
| Kai Uwe Chow, Daniel Nowak, Soo-Zin Kim, Bernd Schneider, Martina Komor, Simone Boehrer, Paris S Mitrou, Dieter Hoelzer, Eckhart Weidmann, Wolf-Karsten Hofman. In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling. Pharmacological research. vol 53. issue 1. 2006-02-09. PMID:16213748. |
among these 30 genes we found a high proportion of genes associated with apoptotic cell death, cell proliferation and cell cycle signalling including complement lysis inhibitor (clusterin/clu), beta-catenin interacting protein (icat), peroxisome proliferator activated receptor alpha (pparalpha), tnf alpha converting enzyme (adam17/tace), homeo box a3 (hox1), inositol polyphosphatase 5-phosphatase type iv (ppi5piv) and inhibitor of p53 induced apoptosis alpha (ipia-alpha/nm23-h6). |
2006-02-09 |
2023-08-12 |
Not clear |
| Ido Paz-Priel, Dong Hong Cai, Dehua Wang, Jeanne Kowalski, Amanda Blackford, Huaitian Liu, Caroline A Heckman, Adrian F Gombart, H Phillip Koeffler, Linda M Boxer, Alan D Friedma. CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50. Molecular cancer research : MCR. vol 3. issue 10. 2006-02-09. PMID:16254192. |
we find that cebpa and bcl-2 rna levels correlate highly in low-risk human amls, suggesting that inhibition of apoptosis via induction of bcl-2 by ccaat/enhancer binding protein alpha (c/ebpalpha) or its mutant variants contributes to transformation. |
2006-02-09 |
2023-08-12 |
mouse |
| Thomas L Hilder, Gerald M Carlson, Timothy A J Haystead, Edwin G Krebs, Lee M Grave. Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase. Molecular and cellular biochemistry. vol 275. issue 1-2. 2006-02-08. PMID:16335803. |
treatment of differentiated c2c12 mouse muscle myoblasts with the inducers of apoptosis staurosporine, tpen, doxorubicin, or uv irradiation resulted in the disappearance of the alpha subunit of phk as determined by immunoblotting, as well as a concurrent increase in caspase-3 activity. |
2006-02-08 |
2023-08-12 |
mouse |
| Ya-Ching Hsieh, Yen-Hsu Chen, Hsiao-Ching Jao, Hseng-Kuang Hsu, Li-Ju Huang, Chin Hs. Role of cAMP-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase C alpha suppression during sepsis. Shock (Augusta, Ga.). vol 24. issue 4. 2006-02-03. PMID:16205321. |
role of camp-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase c alpha suppression during sepsis. |
2006-02-03 |
2023-08-12 |
rat |