| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karolina Wosik, Jack Antel, Tanja Kuhlmann, Wolfgang Brück, Bernard Massie, Josephine Nalbantogl. Oligodendrocyte injury in multiple sclerosis: a role for p53. Journal of neurochemistry. vol 85. issue 3. 2003-06-17. PMID:12694389. |
we have previously shown that overexpression of the transcription factor p53 can induce oligodendrocyte apoptosis. |
2003-06-17 |
2023-08-12 |
human |
| Karolina Wosik, Jack Antel, Tanja Kuhlmann, Wolfgang Brück, Bernard Massie, Josephine Nalbantogl. Oligodendrocyte injury in multiple sclerosis: a role for p53. Journal of neurochemistry. vol 85. issue 3. 2003-06-17. PMID:12694389. |
in situ analysis of active ms lesions revealed increased p53 expression in oligodendrocytes in lesions that featured oligodendrocyte apoptosis and cell loss. |
2003-06-17 |
2023-08-12 |
human |
| Ikuo Tsunoda, Robert S Fujinam. Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination. Springer seminars in immunopathology. vol 24. issue 2. 2003-06-05. PMID:12503060. |
the latter possibility where axonal injury leads to other changes is raised from the rather unexpected similarity between spinal cord injury (sci) and ms where axonal injury, oligodendrocyte apoptosis and demyelination are all present. |
2003-06-05 |
2023-08-12 |
human |
| Ikuo Tsunoda, Robert S Fujinam. Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination. Springer seminars in immunopathology. vol 24. issue 2. 2003-06-05. PMID:12503060. |
in sci, transection of axons leads to delayed oligodendrocyte apoptosis with secondary demyelination. |
2003-06-05 |
2023-08-12 |
human |
| Ikuo Tsunoda, Robert S Fujinam. Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination. Springer seminars in immunopathology. vol 24. issue 2. 2003-06-05. PMID:12503060. |
neurofilament immunostaining of spinal cord sections demonstrates that axonal injury with oligodendrocyte apoptosis also precedes demyelination in an animal model for ms, theiler's murine encephalomyelitis virus infection. |
2003-06-05 |
2023-08-12 |
human |
| Mounira Djerbi, Khairul-Bariah Abdul-Majid, Manuchehr Abedi-Valugerdi, Tomas Olsson, Robert A Harris, Alf Grandie. Expression of the long form of human FLIP by retroviral gene transfer of hemopoietic stem cells exacerbates experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 4. 2003-04-25. PMID:12574377. |
to test this concept, we examined the effects of overexpressing the long form of human flice-inhibitory protein, a potent inhibitor of death receptor-mediated apoptosis, in myelin oligodendrocyte glycoprotein-induced eae in dba/1 mice. |
2003-04-25 |
2023-08-12 |
mouse |
| Katerina Akassoglou, Eleni Douni, Jan Bauer, Hans Lassmann, George Kollias, Lesley Prober. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 2. 2003-02-24. PMID:12522266. |
we have shown previously that human transmembrane tnf (tmtnf)p55tnfr signaling in transgenic mice triggers oligodendrocyte apoptosis, endothelial cell activation, parenchymal inflammation, and primary demyelinating lesions similar to those of acute multiple sclerosis. |
2003-02-24 |
2023-08-12 |
mouse |
| Katerina Akassoglou, Eleni Douni, Jan Bauer, Hans Lassmann, George Kollias, Lesley Prober. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 2. 2003-02-24. PMID:12522266. |
there is no evidence of oligodendrocyte apoptosis or primary demyelination in these mice. |
2003-02-24 |
2023-08-12 |
mouse |
| B M Simon, F Malisan, R Testi, P Nicotera, M Leis. Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis. Cell death and differentiation. vol 9. issue 7. 2003-01-14. PMID:12058281. |
disialoganglioside gd3 is released by microglia and induces oligodendrocyte apoptosis. |
2003-01-14 |
2023-08-12 |
Not clear |
| B M Simon, F Malisan, R Testi, P Nicotera, M Leis. Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis. Cell death and differentiation. vol 9. issue 7. 2003-01-14. PMID:12058281. |
oligodendrocyte death triggered by gd3 was preceded by degeneration of cellular processes, and associated with typical features of apoptosis, such as chromatin condensation, exposure of phosphatidylserine, release of cytochrome c from mitochondria, and loss of mitochondrial membrane potential, followed by the loss of plasma membrane integrity and detachment of disintegrated oligodendrocytes. |
2003-01-14 |
2023-08-12 |
Not clear |
| Andreas Weishaupt, Tanja Kuhlmann, Lisa M Schönrock, Klaus V Toyka, Wolfgang Brück, Ralf Gol. Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high-dose antigen therapy in experimental autoimmune encephalomyelitis. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200625. |
effects of intravenous immunoglobulins on t cell and oligodendrocyte apoptosis in high-dose antigen therapy in experimental autoimmune encephalomyelitis. |
2002-12-27 |
2023-08-12 |
human |
| Andreas Weishaupt, Tanja Kuhlmann, Lisa M Schönrock, Klaus V Toyka, Wolfgang Brück, Ralf Gol. Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high-dose antigen therapy in experimental autoimmune encephalomyelitis. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200625. |
tnf-alpha release at sites of inflammation increased apoptosis of autoaggressive t cells in spinal cord in situ and oligodendrocyte apoptosis. |
2002-12-27 |
2023-08-12 |
human |
| Andreas Weishaupt, Tanja Kuhlmann, Lisa M Schönrock, Klaus V Toyka, Wolfgang Brück, Ralf Gol. Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high-dose antigen therapy in experimental autoimmune encephalomyelitis. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200625. |
to explore a possible neutralizing effect of ivig on tnf-alpha secreted by antigen-specific t cells, we analyzed t cell and oligodendrocyte apoptosis as well as liver damage in rats that had been injected with myelin basic protein (mbp) and co-treated intravenously with human ivig. |
2002-12-27 |
2023-08-12 |
human |
| Andreas Weishaupt, Tanja Kuhlmann, Lisa M Schönrock, Klaus V Toyka, Wolfgang Brück, Ralf Gol. Effects of intravenous immunoglobulins on T cell and oligodendrocyte apoptosis in high-dose antigen therapy in experimental autoimmune encephalomyelitis. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200625. |
in contrast, oligodendrocyte apoptosis in animals receiving mbp/ivig was significantly higher than in eae controls. |
2002-12-27 |
2023-08-12 |
human |
| Norbert Schuster, Herdis Bender, Anja Philippi, Srinivasa Subramaniam, Jens Strelau, Ziyuan Wang, Kerstin Krieglstei. TGF-beta induces cell death in the oligodendroglial cell line OLI-neu. Glia. vol 40. issue 1. 2002-11-19. PMID:12237847. |
it has been shown that oligodendrocyte progenitors and newly formed oligodendrocytes are especially susceptible to apoptosis. |
2002-11-19 |
2023-08-12 |
Not clear |
| Eduardo Molina-Holgado, José M Vela, Angel Arévalo-Martín, Guillermina Almazán, Francisco Molina-Holgado, José Borrell, Carmen Guaz. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427829. |
oligodendrocyte progenitors undergo apoptosis with the withdrawal of trophic support, as determined by tunel assay and caspase-3 activation, and both the selective cb1 agonist arachidonyl-2'-chloroethylamide/(all z)-n-(2-cycloethyl)-5,8,11,14-eicosatetraenamide (acea) and the nonselective cannabinoid agonists hu210 and (+)-win-55212-2 enhanced cell survival. |
2002-11-18 |
2023-08-12 |
rat |
| T Kuhlmann, M Glas, C zum Bruch, W Mueller, A Weber, F Zipp, W Brüc. Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis. Journal of neuroimmunology. vol 129. issue 1-2. 2002-09-27. PMID:12161031. |
some ms cases are histopathologically characterized by a dramatic oligodendrocyte loss that is in part caused by apoptosis. |
2002-09-27 |
2023-08-12 |
Not clear |
| Arnulf H Koeppen, Yves Robitaill. Pelizaeus-Merzbacher disease. Journal of neuropathology and experimental neurology. vol 61. issue 9. 2002-09-23. PMID:12230321. |
abnormal plp is thought to impair protein trafficking and to induce apoptosis in oligodendroglia. |
2002-09-23 |
2023-08-12 |
Not clear |
| Wendy Camme. Apoptosis of oligodendrocytes in secondary cultures from neonatal rat brains. Neuroscience letters. vol 327. issue 2. 2002-09-13. PMID:12098651. |
as some apoptotic oligodendrocytes have been observed in ms plaques, it was therefore logical to determine whether oligodendrocyte apoptosis would occur in response to tnf-alpha, quinolinic acid or gsh depletion. |
2002-09-13 |
2023-08-12 |
rat |
| Wendy Camme. Apoptosis of oligodendrocytes in secondary cultures from neonatal rat brains. Neuroscience letters. vol 327. issue 2. 2002-09-13. PMID:12098651. |
quinolinic acid and bso each caused oligodendrocyte loss via apoptosis, and gsh ethyl ester partly protected the cells against bso. |
2002-09-13 |
2023-08-12 |
rat |