| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsueh-Ning Liu, Benoit I Giasson, Walter E Mushynski, Guillermina Almaza. AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3. Journal of neurochemistry. vol 82. issue 2. 2002-08-06. PMID:12124441. |
our results indicate that overactivation of ampa receptors causes apoptosis in oligodendrocyte progenitors through mechanisms involving ca(2+) influx, depletion of glutathione, and activation of jnk, calpain, and caspase-3. |
2002-08-06 |
2023-08-12 |
rat |
| Ralf A Linker, Mathias Mäurer, Stefanie Gaupp, Rudolf Martini, Bettina Holtmann, Ralf Giess, Peter Rieckmann, Hans Lassmann, Klaus V Toyka, Michael Sendtner, Ralf Gol. CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation. Nature medicine. vol 8. issue 6. 2002-06-26. PMID:12042814. |
disease was more severe in cntf-deficient mice and recovery was poor, with a 60% decrease in the number of proliferating oligodendrocyte precursor cells (opcs) and a more than 50% increase in the rate of oligodendrocyte apoptosis. |
2002-06-26 |
2023-08-12 |
mouse |
| R S Nicholas, S Stevens, M G Wing, D A Compsto. Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitro. Journal of neuroimmunology. vol 124. issue 1-2. 2002-05-02. PMID:11958820. |
insulin-like growth factor-2 (igf-2) present in media conditioned by non-activated and interferon gamma (ifn gamma)-treated microglia reduces galactocerebroside(+) (galc) oligodendrocyte apoptosis in cultures derived both from the cg4 cell line and primary rat cortices. |
2002-05-02 |
2023-08-12 |
rat |
| E D Hal. Pharmacological treatment of acute spinal cord injury: how do we build on past success? The journal of spinal cord medicine. vol 24. issue 3. 2002-01-11. PMID:11585231. |
future sci therapy is likely to encompass various neuroprotective agents, including inhibitors of lp, inhibitors of the nitric oxide-derived reactive oxygen species peroxynitrite, inhibitors of calpain (which is responsible for degrading the spinal cord cytoskeleton), and inhibitors of post-traumatic apoptosis of neurons and myelin-forming oligodendroglia. |
2002-01-11 |
2023-08-12 |
Not clear |
| L Soane, H J Cho, F Niculescu, H Rus, M L Shi. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 4. 2001-12-05. PMID:11490019. |
in this study, we examined an involvement of the mitochondria in oligodendrocyte apoptosis and the role of c5b-9 on this process. |
2001-12-05 |
2023-08-12 |
Not clear |
| L Soane, H J Cho, F Niculescu, H Rus, M L Shi. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 4. 2001-12-05. PMID:11490019. |
the mitochondrial pathway of oligodendrocyte apoptosis is, therefore, inhibited by c5b-9 through post-translational regulation of bad. |
2001-12-05 |
2023-08-12 |
Not clear |
| J C Castro-Palomino, B Simon, O Speer, M Leist, R R Schmid. Synthesis of ganglioside GD3 and its comparison with bovine GD3 with regard to oligodendrocyte apoptosis mitochondrial damage. Chemistry (Weinheim an der Bergstrasse, Germany). vol 7. issue 10. 2001-12-04. PMID:11411990. |
synthesis of ganglioside gd3 and its comparison with bovine gd3 with regard to oligodendrocyte apoptosis mitochondrial damage. |
2001-12-04 |
2023-08-12 |
cattle |
| K Shaw, M A MacKinnon, R Raghupathi, K E Saatman, T K Mclntosh, D I Graha. TUNEL-positive staining in white and grey matter after fatal head injury in man. Clinical neuropathology. vol 20. issue 3. 2001-11-01. PMID:11430493. |
however, the histological appearances of some of the neurons (2-3%), and of oligodendroglia and macrophages in white matter (about 5%) were those of apoptosis. |
2001-11-01 |
2023-08-12 |
Not clear |
| J P Hugnot, K Mellodew, H Pilcher, D Uwanogho, J Price, J D Sinde. Direct cell-cell interactions control apoptosis and oligodendrocyte marker expression of neuroepithelial cells. Journal of neuroscience research. vol 65. issue 3. 2001-10-11. PMID:11494354. |
direct cell-cell interactions control apoptosis and oligodendrocyte marker expression of neuroepithelial cells. |
2001-10-11 |
2023-08-12 |
mouse |
| C Southwood, A Go. Molecular pathways of oligodendrocyte apoptosis revealed by mutations in the proteolipid protein gene. Microscopy research and technique. vol 52. issue 6. 2001-08-02. PMID:11276122. |
molecular pathways of oligodendrocyte apoptosis revealed by mutations in the proteolipid protein gene. |
2001-08-02 |
2023-08-12 |
Not clear |
| A I Flores, B S Mallon, T Matsui, W Ogawa, A Rosenzweig, T Okamoto, W B Mackli. Akt-mediated survival of oligodendrocytes induced by neuregulins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027222. |
apoptosis of oligodendrocyte progenitor cells induced by growth factor deprivation was effectively blocked by heregulin in a wortmannin-sensitive manner. |
2001-06-07 |
2023-08-12 |
Not clear |
| K A Jellinger, C H Stadelman. The enigma of cell death in neurodegenerative disorders. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205141. |
apoptosis mainly involves reactive microglia and oligodendroglia, the latter often involved by deposits of insoluble fibrillary proteins, while alternative mechanisms of neuronal death may occur. |
2001-04-12 |
2023-08-12 |
human |
| R C Melcangi, I Cavarretta, V Magnaghi, E Ciusani, A Salmagg. Corticosteroids protect oligodendrocytes from cytokine-induced cell death. Neuroreport. vol 11. issue 18. 2001-03-29. PMID:11192611. |
since oligodendrocyte apoptosis represents an important event in multiple sclerosis and in several demyelinating diseases, the present observations might be considered an interesting background for further researches directed to the possibility of controlling in vivo the death of these cells. |
2001-03-29 |
2023-08-12 |
rat |
| B Yang, R A Prayso. Expression of Bax, Bcl-2, and P53 in progressive multifocal leukoencephalopathy. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 13. issue 10. 2001-02-08. PMID:11048806. |
the expression pattern of bax positive/bcl-2 negative in viral-infected glial cells suggests that the oligodendrocyte may be undergoing apoptosis which may in turn contribute to the demyelinating process in pml. |
2001-02-08 |
2023-08-12 |
Not clear |
| F M Smith, R Raghupathi, M A MacKinnon, T K McIntosh, K E Saatman, D F Meaney, D I Graha. TUNEL-positive staining of surface contusions after fatal head injury in man. Acta neuropathologica. vol 100. issue 5. 2001-02-01. PMID:11045676. |
however, the morphology of some tunel-stained neurons, and of tunel-stained oligodendroglia and macrophages in white matter was suggestive of apoptosis. |
2001-02-01 |
2023-08-12 |
Not clear |
| A Weishaupt, S Jander, W Brück, T Kuhlmann, M Stienekemeier, T Hartung, K V Toyka, G Stoll, R Gol. Molecular mechanisms of high-dose antigen therapy in experimental autoimmune encephalomyelitis: rapid induction of Th1-type cytokines and inducible nitric oxide synthase. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 12. 2001-01-25. PMID:11120847. |
neutralization of tnf-alpha by anti-tnf-alpha antiserum in vivo led to a significant decrease in the rate of t cell and oligodendrocyte apoptosis induced by high-dose ag administration, but did not change the beneficial clinical effect of ag therapy. |
2001-01-25 |
2023-08-12 |
rat |
| T Kita, T Tanaka, N Tanaka, Y Kinoshit. The role of tumor necrosis factor-alpha in diffuse axonal injury following fluid-percussive brain injury in rats. International journal of legal medicine. vol 113. issue 4. 2000-12-07. PMID:10929238. |
it is generally accepted that tnf alpha directly induces primary demyelination and oligodendrocyte apoptosis. |
2000-12-07 |
2023-08-12 |
rat |
| J L Mason, J J Jones, M Taniike, P Morell, K Suzuki, G K Matsushim. Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination. Journal of neuroscience research. vol 61. issue 3. 2000-08-29. PMID:10900072. |
mature oligodendrocyte apoptosis precedes igf-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination. |
2000-08-29 |
2023-08-12 |
mouse |
| J L Mason, P Ye, K Suzuki, A J D'Ercole, G K Matsushim. Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908609. |
insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. |
2000-08-10 |
2023-08-12 |
mouse |
| J L Mason, P Ye, K Suzuki, A J D'Ercole, G K Matsushim. Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908609. |
this rapid recovery was apparently caused by survival of the mature oligodendrocyte population because apoptosis was negligible, and by week 4, the mature oligodendrocyte population was completely restored. |
2000-08-10 |
2023-08-12 |
mouse |