| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyu Zheng, Qian Xiang, Xiaoxu Dong, Yang Shen, Wei Fang, Hongna Yan. [Research progress on the changes of blood-brain barrier in sepsis-associated encephalopathy]. Zhonghua wei zhong bing ji jiu yi xue. vol 36. issue 8. 2024-09-06. PMID:39238417. |
above these damages caused glial cell activation (microglia and astrocyte), the imbalance of neurotransmitters, mitochondrial dysfunction and neural apoptosis, which also reversely contributed to the damage to the integrity and permeability of bbb via decreasing the expression of tight junctional protein between cells. |
2024-09-06 |
2024-09-08 |
Not clear |
| Danqing Xin, Tingting Li, Yijing Zhao, Xiaofan Guo, Chengcheng Gai, Zige Jiang, Shuwen Yu, Jiao Cheng, Yan Song, Yahong Cheng, Qian Luo, Bing Gu, Dexiang Liu, Zhen Wan. MiR-100-5p-rich small extracellular vesicles from activated neuron to aggravate microglial activation and neuronal activity after stroke. Journal of nanobiotechnology. vol 22. issue 1. 2024-09-04. PMID:39227960. |
mechanistically, evs from ischemia-evoked neuronal activity induce neuronal apoptosis and innate immune responses by transferring higher mir-100-5p to adjacent neuron and microglia. |
2024-09-04 |
2024-09-06 |
mouse |
| Wanqing Zheng, Genghua Xu, Zhengwei Lue, Xinyu Zhou, Ning Wang, Yun Ma, Wenyue Yuan, Lushan Yu, Danyan Zhu, Xiangnan Zhan. Nervonic acid protects against oligodendrocytes injury following chronic cerebral hypoperfusion in mice. European journal of pharmacology. 2024-08-25. PMID:39182543. |
chronic cerebral hypoperfusion (cch) has been acknowledged as a potential contributor to cognitive dysfunction and brain injury, causing progressive demyelination of white matter, oligodendrocytes apoptosis and microglia activation. |
2024-08-25 |
2024-08-28 |
mouse |
| Shoujiao Peng, Yao Chen, Ran Wang, Jiange Zhan. Z-ligustilide provides a neuroprotective effect by regulating the phenotypic polarization of microglia via activating Nrf2-TrxR axis in the Parkinson's disease mouse model. Redox biology. vol 76. 2024-08-24. PMID:39180982. |
mechanistically, zlg alleviates oxidative stress-induced apoptosis of microglia by triggering the endogenous antioxidant system. |
2024-08-24 |
2024-08-28 |
mouse |
| Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Fen. Corrigendum to "DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA" [Brain Behav. Immun. 73 (2018) 482-492]. Brain, behavior, and immunity. 2024-08-24. PMID:39181822. |
corrigendum to "dna binding protein hmgb1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with osa" [brain behav. |
2024-08-24 |
2024-08-28 |
Not clear |
| Xuliang Huang, Yuhao Zheng, Nan Wang, Mingming Zhao, Jinhui Liu, Wen Lin, Ye Zhu, Xiaofan Xie, Ya Lv, Junlu Wang, Yunchang M. Dichloroacetate Prevents Sepsis Associated Encephalopathy by Inhibiting Microglia Pyroptosis through PDK4/NLRP3. Inflammation. 2024-08-23. PMID:39177920. |
additionally, a co-culture environment of microglia and neuron was simply constructed to evaluate the effect of dca on activated microglia-mediated neuronal apoptosis. |
2024-08-23 |
2024-08-25 |
mouse |
| Tal Ganz, Nina Fainstein, Paschalis Theotokis, Sharona Elgavish, Oriya Vardi-Yaakov, Marva Lachish, Lihi Sofer, Omri Zveik, Nikolaos Grigoriadis, Tamir Ben-Hu. Targeting CNS myeloid infiltrates provides neuroprotection in a progressive multiple Sclerosis model. Brain, behavior, and immunity. 2024-08-23. PMID:39179123. |
the treatment regulated cell-death pathways across multiple myeloid cell populations and suppressed apoptosis, resulting in paradoxically marked increased neuroinflammatory infiltrates, consisting mainly of microglia and cns / border-associated macrophages. |
2024-08-23 |
2024-08-27 |
mouse |
| Minmin Wu, Wenjing Song, Lili Teng, Jinting Li, Jiayu Liu, Hanwen Ma, Ge Zhang, Jiongliang Zhang, Qiuxin Che. Exploring the biological basis of acupuncture treatment for traumatic brain injury: a review of evidence from animal models. Frontiers in cellular neuroscience. vol 18. 2024-08-22. PMID:39171199. |
we also proposed potential biological mechanisms, such as glial cells (microglia astrocytes), autophagy, and apoptosis. |
2024-08-22 |
2024-08-24 |
Not clear |
| Kai Zhang, Zhiquan Yang, Zhuanyi Yang, Liangchao Du, Yu Zhou, Shiyu Fu, Xiaoyue Wang, Dingyang Liu, Xinghui H. Targeting Microglial GLP1R in Epilepsy: A Novel Approach to Modulate Neuroinflammation and Neuronal Apoptosis. European journal of pharmacology. 2024-08-18. PMID:39154823. |
aberrantly reactive astrocytes, induced by cytokine release from activated microglia, may lead to neuronal apoptosis. |
2024-08-18 |
2024-08-21 |
Not clear |
| Cristian De Gregorio, Javiera Gallardo, Pablo Berríos-Cárcamo, Álex Handy, Daniela Santapau, Antonia González-Madrid, Marcelo Ezquer, Paola Morales, Alejandro Luarte, Daniela Corvalán, Úrsula Wyneken, Fernando Ezque. Methadone directly impairs central nervous system cells in vitro. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043899. |
in animal models, prenatal methadone exposure results in detrimental consequences to the central nervous system, such as: (i) increased neuronal apoptosis; (ii) disruption of oligodendrocyte maturation and increased apoptosis and (iii) increased microglia and astrocyte activation. |
2024-07-23 |
2024-07-26 |
rat |
| Cristian De Gregorio, Javiera Gallardo, Pablo Berríos-Cárcamo, Álex Handy, Daniela Santapau, Antonia González-Madrid, Marcelo Ezquer, Paola Morales, Alejandro Luarte, Daniela Corvalán, Úrsula Wyneken, Fernando Ezque. Methadone directly impairs central nervous system cells in vitro. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043899. |
furthermore, it led to increased oligodendrocyte apoptosis and a reduction in the myelinating capacity of these cells, and promoted the proinflammatory activation of microglia and astrocytes. |
2024-07-23 |
2024-07-26 |
rat |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
activation of the nlrp3 inflammasome, situated within microglia, can be triggered by diverse danger signals, leading to cell pyroptosis, apoptosis, and tauopathy. |
2024-07-14 |
2024-07-18 |
Not clear |
| Wenjing Ning, Shi Lv, Qian Wang, Yuzhen X. The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage. Neural regeneration research. 2024-07-12. PMID:38993136. |
microglia, which are the key immune cells in the central nervous system, maintain homeostasis in the neural environment, support neurons, mediate apoptosis, participate in immune regulation, and have neuroprotective effects. |
2024-07-12 |
2024-07-14 |
Not clear |
| Wenjing Ning, Shi Lv, Qian Wang, Yuzhen X. The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage. Neural regeneration research. 2024-07-12. PMID:38993136. |
this review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm, neuroinflammation, neuronal apoptosis, blood-brain barrier disruption, cerebral edema, and cerebral white matter lesions. |
2024-07-12 |
2024-07-14 |
Not clear |
| Ziwei Fan, Mengxian Jia, Jian Zhou, Zhoule Zhu, Yumin Wu, Xiaowu Lin, Yiming Qian, Jiashu Lian, Xin Hua, Jianhong Dong, Zheyu Fang, Yuqing Liu, Sibing Chen, Xiumin Xue, Juanqing Yue, Minyu Zhu, Ying Wang, Zhihui Huang, Honglin Ten. Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury. Neural regeneration research. 2024-07-12. PMID:38993129. |
finally, using a conditional co-culture system, we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal apoptosis. |
2024-07-12 |
2024-07-14 |
mouse |
| Stephen H Sinclair, Elan Miller, Kiran S Talekar, Stanley S Schwart. Diabetes mellitus associated neurovascular lesions in the retina and brain: A review. Frontiers in ophthalmology. vol 2. 2024-07-10. PMID:38983558. |
specifically, within the retina, and similarly within the brain cortex, lesions occur of the "neurovascular unit", comprised of focal microvascular occlusions, inflammatory endothelial and pericyte injury, with small vessel leakage resulting in injury to astrocytes, müller cells, and microglia, all of which occur with progressive neuronal apoptosis. |
2024-07-10 |
2024-07-12 |
Not clear |
| Chang Li, Yi Cai, Yongmin Chen, Jingyi Tong, Youbin Li, Dong Liu, Yun Wang, Zhiping Li, Yan Wang, Qifu L. ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR. Redox biology. vol 75. 2024-07-09. PMID:38981367. |
further, abcg2 overexpression significantly suppressed the oxidative stress and apoptosis induced by glutamate, kainic acid (ka), and lipopolysaccharide (lps) in neuronal and microglia cells. |
2024-07-09 |
2024-07-12 |
mouse |
| Yan Zhu, Shu-Ying Li, Lu-Jia Zhang, Bo Lei, Yong-Chen Wang, Zhongfeng Wan. Neuroprotection of the P2X7 receptor antagonist A740003 on retinal ganglion cells in experimental glaucoma. Neuroreport. 2024-07-08. PMID:38973496. |
a740003 could provide neuroprotective roles on rgcs by inhibiting the microglia activation, attenuating the retinal inflammatory response, reducing the apoptosis of rgcs, and enhancing the survival of rgcs in coh experimental glaucoma. |
2024-07-08 |
2024-07-11 |
mouse |
| Zhaoda Duan, Haolun Chen, Wei Miao, Jing He, Dongyao Xu, Zhi Qi, Li Yang, Wenji Jia, Chunyun W. Scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3 Journal of cell communication and signaling. vol 18. issue 2. 2024-07-01. PMID:38946727. |
scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the pi3k/akt/gsk3 microglia are resident immune cells in the central nervous system that are rapidly activated to mediate neuroinflammation and apoptosis, thereby aggravating brain tissue damage after ischemic stroke (is). |
2024-07-01 |
2024-07-03 |
rat |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
further analysis showed that this decrease in microglia was mediated by the initial response of microglia to unpredictable stress in the dentate gyrus of the hippocampus and their subsequent apoptosis. |
2024-06-21 |
2024-06-24 |
mouse |