| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei Zhou, Si-Qing Xie, Li-Li Zhong, Xiao-Fang Din. [Effects of propranolol on the biological behavior of human umbilical vein endothelial cells and the expression of SOX18, MMP-7, and VEGFA]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 26. issue 10. 2024-10-28. PMID:39467683. |
to investigate the effects of propranolol on the proliferation, apoptosis, migration, and tube formation ability of human umbilical vein endothelial cells (huvec), as well as its impact on the expression of sex-determining region y-box 18 (sox18), matrix metalloproteinase-7 (mmp-7), and vascular endothelial growth factor a (vegfa). |
2024-10-28 |
2024-10-31 |
human |
| Jiaru Wu, Mengjie Wen, Zecheng Wang, Kun Yu, Xinyue Jin, Chenxu Liu, Qiuhang Song, Guohong Zhang, Beibei Wu, Yunfeng L. Network pharmacological analysis and experimental verification of Zisheng Tongmai decoction in the treatment of premature ovarian failure. Naunyn-Schmiedeberg's archives of pharmacology. 2024-10-01. PMID:39352532. |
in vitro experiments, quercetin suppressed ctx-induced apoptosis in kgn cells and increased vegfa protein expression. |
2024-10-01 |
2024-10-03 |
rat |
| Ziqiang Lin, Suo Wang, Yu Cao, Jialing Lin, Ailing Sun, Wei Huang, Jun Zhou, Qingxiong Hon. Bioinformatics and Validation Reveal the Potential Target of Curcumin in the Treatment of Diabetic Peripheral Neuropathy. Neuropharmacology. 2024-08-23. PMID:39179172. |
subsequently, qrt-pcr, mtt assay, flow cytometry, caspase-3 activity detection and westernblot showed that curcumin treatment increased rsc96 cell viability, reduced cell apoptosis, increased hmox1, pten, vegfa and myc expression, and up-regulated akt phosphorylation level under high glucose environment. |
2024-08-23 |
2024-08-27 |
rat |
| Wei Liang, Yangui Li, Yihua Ji, Renjie Kang, Kaixi Zhang, Xueyuan Su, Jiangbo Li, Mingming Ji, Taiyong Wu, Xinjie Cao, Jianrui Chen, Jianzhong Hu. Exosomes derived from bone marrow mesenchymal stem cells induce the proliferation and osteogenic differentiation and regulate the inflammatory state in osteomyelitis in vitro model. Naunyn-Schmiedeberg's archives of pharmacology. 2024-08-21. PMID:39168906. |
the mrna and protein levels of factors related to proliferation, differentiation, apoptosis, autophagy, and angiogenesis including β-catenin, runx2, bcl-2, vegfa, and beclin-1 upregulated in spa-treated mc3t3-e1 cells, whereas the levels of inflammatory cytokines including tnf-α, il-1β, and il-6 decreased in the supernatant. |
2024-08-21 |
2024-08-24 |
Not clear |
| Xianzhe Huang, Shuo Jie, Wenzhao Li, Chan Li. CHRDL2 activates the PI3K/AKT pathway to ameliorate glucocorticoid-induced damages to bone microvascular endothelial cells (BMECs). Heliyon. vol 10. issue 13. 2024-07-26. PMID:39050472. |
gcs-caused cell viability suppression, cell apoptosis promotion, tubule formation suppression, and cell migration suppression were partially abolished by chrdl2 overexpression but amplified by chrdl2 knockdown; consistent trends were observed in gcs-caused alterations in the protein levels of vegfa, vegfr2, and bmp-9 levels, and the ratios of bax/bcl-2 and cleaved-caspase3/caspase3. |
2024-07-26 |
2024-07-28 |
Not clear |
| Ye Ding, Hao Li, Saisai Cao, Yong Y. Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway. Toxicology and applied pharmacology. 2024-07-15. PMID:39009138. |
the proliferation ability, cell cycle, apoptosis and migration of gastric cancer cells were detected, as well as the protein expression levels of pi3k, p-akt, and akt and the mrna expression levels of akt1, vegfa, egfr, hras, and hsp90aa1 in gastric cancer cells. |
2024-07-15 |
2024-07-18 |
Not clear |
| Wei Li, Jianying Li, Wei Li, Jianying Li, Wuhong Zheng, Jia Cheng, Xiaowei Zhang, Bingjing Yang, Jimin Dong, Xiangfei Su. FUS-stabilized USP35 promotes growth, invasion and angiogenesis in NSCLC through deubiquitinating VEGFA. General physiology and biophysics. vol 43. issue 4. 2024-07-02. PMID:38953570. |
interferences of vegfa inhibited nsclc cell proliferation, invasion, angiogenesis, and increased apoptosis. |
2024-07-02 |
2024-07-06 |
Not clear |
| Xiaofeng Liu, Bowen Fan, Shuai Huang, Maolin Wang, Hongbo Teng, Xu Wang, Mengqi Shi, Tianshi Li, Yan Zhao, Liyan Wan. Design and synthesis of matrine derivatives for anti myocardial ischemia-reperfusion injury by promoting angiogenesis. Bioorganic & medicinal chemistry. vol 108. 2024-06-09. PMID:38852257. |
in summary, compound 22 is a new potential cardioprotective agent that can promote angiogenesis and enhance antioxidant activity by activating adcy5, creb3l4, and vegfa, thereby protecting myocardial cell apoptosis and necrosis induced by mi/r. |
2024-06-09 |
2024-06-14 |
rat |
| Jiaying Wu, Lixia Lu, Beibei Dai, Aiyong Y. Unraveling the role of Biomolecules & biomedicine. 2024-06-03. PMID:38829380. |
under oxygen-glucose deprivation/reperfusion (ogd/r) conditions, the effects of ldha overexpression and vegfa knockdown on cell viability and apoptosis were evaluated. |
2024-06-03 |
2024-06-05 |
Not clear |
| Jiaying Wu, Lixia Lu, Beibei Dai, Aiyong Y. Unraveling the role of Biomolecules & biomedicine. 2024-06-03. PMID:38829380. |
ldha overexpression improved cell survival and reduced apoptosis, while vegfa knockdown had the opposite effect. |
2024-06-03 |
2024-06-05 |
Not clear |
| Aohang Li, Jingxuan W. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression. Open medicine (Warsaw, Poland). vol 19. issue 1. 2024-05-13. PMID:38737443. |
vegfa silencing counteracted the impacts of overexpressed stat4 upon promoting viability and angiogenesis as well as repressing the apoptosis of aml cells. |
2024-05-13 |
2024-05-27 |
Not clear |
| Manal A Othman, Mariwan Husni, Wael Amin Nasr El-Din, Abdel-Halim Salem, Nasir Sarwani, Aisha Rashid, Raouf Fade. Prenatal aripiprazole induces alterations of rat placenta: a histological, immunohistochemical and ultrastructural study. Journal of molecular histology. 2024-05-07. PMID:38713244. |
immunohistochemistry was done using anti-pcna (proliferating cell nuclear antigen), anti-bax (for apoptosis) and anti-vascular endothelial growth factor alpha (vegfa). |
2024-05-07 |
2024-05-27 |
rat |
| HaiGang Niu, ShuYing Dong, GuoMing Li, ShiLun Wu, WenBing Su. Metformin promotes the normalization of abnormal blood vessels after radiofrequency ablation deficiency in hepatocellular carcinoma by microRNA-302b-3p targeting thioredoxin-interacting protein. Acta biochimica Polonica. vol 70. issue 4. 2023-12-22. PMID:38131468. |
after treating cells with different concentrations of metformin (2.5, 5, 10 μm) or transfecting related plasmids, cell proliferation, migration, invasion, apoptosis and angiogenesis were detected, in vitro permeability test was performed, and an angiogenesis-related protein vegfa was analyzed. |
2023-12-22 |
2023-12-24 |
mouse |
| Zhujie Xu, Peng Wang, Zhenyu Wang, Hao Cui, Tianshu Gao, Zhenting Wang, Yi Li. ER-β accelerates the process of primary osteoporosis by promoting VEGFA-mediated apoptosis of osteoblasts. Genomics. 2023-11-15. PMID:37967683. |
the results of the spearman correlation analysis and protein-protein interaction (ppi) networks screening of hub genes indicated that vascular endothelial growth factor a (vegfa) may be a key target of er-β in controlling osteoblast apoptosis. |
2023-11-15 |
2023-11-20 |
Not clear |
| Zhujie Xu, Peng Wang, Zhenyu Wang, Hao Cui, Tianshu Gao, Zhenting Wang, Yi Li. ER-β accelerates the process of primary osteoporosis by promoting VEGFA-mediated apoptosis of osteoblasts. Genomics. 2023-11-15. PMID:37967683. |
in addition, we determined the cell cycle and apoptosis by constructing a vegfa-silenced cell model utilizing flow cytometry (fcm), and the results showed that er-β could regulate the osteoblast cycle and thus promote osteoblast apoptosis by promoting vegfa expression. |
2023-11-15 |
2023-11-20 |
Not clear |
| Zhujie Xu, Peng Wang, Zhenyu Wang, Hao Cui, Tianshu Gao, Zhenting Wang, Yi Li. ER-β accelerates the process of primary osteoporosis by promoting VEGFA-mediated apoptosis of osteoblasts. Genomics. 2023-11-15. PMID:37967683. |
in conclusion, this study identifies that the roles of er-β in the regulation of osteoblast apoptosis are closely related to vegfa and provides a new target for pop treatment. |
2023-11-15 |
2023-11-20 |
Not clear |
| I V Arutyunyan, A G Soboleva, E A Kovtunov, A M Kosyreva, V V Kudelkina, A I Alekseeva, A V Elchaninov, E D Jumaniyazova, D V Goldshtein, G B Bolshakova, T Kh Fatkhudino. Gene Expression Profile of 3D Spheroids in Comparison with 2D Cell Cultures and Tissue Strains of Diffuse High-Grade Gliomas. Bulletin of experimental biology and medicine. 2023-09-28. PMID:37770789. |
using real time pcr, we evaluated the expression of gfap, cd44, pten, s100b, vegfa, hif1a, sox2, melk, gdnf, and mgmt genes playing an important role in the progression of gliomas and regulating tumor cell proliferation, adhesion, invasion, plasticity, apoptosis, dna repair, and recruitment of tumor-associated cells. |
2023-09-28 |
2023-10-07 |
Not clear |
| Zhongbo Xu, Manyang Shen, Lin L. Exploring the active components and mechanism of modified bazhen decoction in treatment of chronic cerebral circulation insufficiency based on network pharmacology and molecular docking. Medicine. vol 102. issue 29. 2023-07-21. PMID:37478218. |
the central core targets were il6, mapk14, signal transducer and activator of transcription 3, rela, vegfa, ccnd1, casp3, ar, fos, jun, egfr, mapk1, akt1, myc, and esr1; gene ontology functional enrichment analysis yielded 911 gene ontology items (p < .01), while kyoto encyclopedia of genes and genomes pathway enrichment yielded 138 signal pathways (p < .01), primarily including oxidative reactions, vascular regulation, apoptosis, and pi3k-akt signaling pathway. |
2023-07-21 |
2023-08-14 |
Not clear |
| ChangYan Li, HuaChen Zhong, JingYuan Ma, Zhang Liang, Le Zhang, Tao Liu, WenXing Fa. Notoginsenoside R1 can inhibit the interaction between FGF1 and VEGFA to retard podocyte apoptosis. BMC endocrine disorders. vol 23. issue 1. 2023-07-06. PMID:37415174. |
notoginsenoside r1 can inhibit the interaction between fgf1 and vegfa to retard podocyte apoptosis. |
2023-07-06 |
2023-08-14 |
Not clear |
| Jia-Luo Cai, Yi-Lin Zhu, Xiao-Ping Li, Xin-Hua Xia, Gui-Ming Deng, Qiao-Zhen Tong, Gang-Qiang Yi, Bo Chen. [Mechanism of Huangjing Qianshi Decoction in treatment of prediabetic mice based on transcriptome sequencing]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 4. 2023-03-05. PMID:36872274. |
therefore, huangjing qianshi decoction can improve the state of prediabetes, and the mechanism may be related to cell cycle and apoptosis, pi3k/akt pathway, p53 pathway, and other biological pathways regulated by il-6, nr3c2, and vegfa. |
2023-03-05 |
2023-08-14 |
mouse |