| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaobing Gao, Suhua Shao, Xi Zhang, Changjie Li, Qianqian Jiang, Bo L. Interaction between CD244 and SHP2 regulates inflammation in chronic obstructive pulmonary disease via targeting the MAPK/NF-κB signaling pathway. PloS one. vol 19. issue 10. 2024-10-18. PMID:39423200. |
this study delved into the interplay between cd244 and src homology 2 domain containing phosphatase-2 (shp2) in chronic obstructive pulmonary disease (copd) pathogenesis, focusing on apoptosis and inflammation in cigarette smoke extract (cse)-treated human bronchial epithelial (hbe) cells. |
2024-10-18 |
2024-10-21 |
human |
| Jay M Gamma, Qiang Liu, Erwan Beauchamp, Aishwarya Iyer, Megan C Yap, Zoulika Zak, Cassidy Ekstrom, Rony Pain, Morris A Kostiuk, John R Mackey, Joseph Brandwein, Jean Cy Wang, Luc G Berthiaum. Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signalling and Oxidative Phosphorylation Killing Acute Myeloid Leukemia Cells. Molecular cancer therapeutics. 2024-10-09. PMID:39382188. |
zelenirstat effectively inhibits myristoylation in aml cell lines and patient samples, leading to degradation of src family kinases (sfks), induction of endoplasmic reticulum (er) stress, apoptosis, and cell death. |
2024-10-09 |
2024-10-11 |
Not clear |
| Jie Liu, Lan He, Wenqing Zhang, Yinggang Tang, Jingying Fan, Yingchun H. Evodiamine inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells via the SRC/ERBB2-mediated MAPK/ERK signaling pathway. Journal of translational medicine. vol 22. issue 1. 2024-09-28. PMID:39334374. |
these changes indicated that the inhibitory effect of evo on proliferation and apoptosis of npc cells was related to the down-regulation of src and erbb2 expression, and further inhibition of the mapk/erk signaling pathway. |
2024-09-28 |
2024-10-01 |
mouse |
| Jie Zhao, Mei Wang, Qing Yu, Sanhua Zhan, Mingyang Ma. Exploring the mechanism of action of Bidens pilosa L. in combating hepatic fibrosis through network pharmacology and molecular docking: An observational study. Medicine. vol 103. issue 37. 2024-09-17. PMID:39287276. |
the possible mechanism of the active components against liver fibrosis is to regulate the pi3k-akt, mapk, and other signaling pathways by acting on core targets such as pik3r1, hsp90aa1, src, tp53, akt1, rela, and induce the apoptosis of activated hsc cells to reverse and improve liver fibrosis. |
2024-09-17 |
2024-09-20 |
Not clear |
| Abdul Hannan, Qian Wang, Yihua Wu, Neoklis Makrides, Xiuxia Qu, Junhao Mao, Jianwen Que, Wellington Cardoso, Xin Zhan. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005335. |
here, through single-cell analysis and genetic lineage tracing, we show that the pan-epithelial ablation of c-terminal src kinase (csk) in the lacrimal gland unleashes broad src signaling but specifically causes extrusion and apoptosis of acinar progenitors at a time when they are shielded by myoepithelial cells from the basement membrane. |
2024-07-15 |
2024-07-18 |
Not clear |
| Yun-Xia Li, Jinzhong Liu, Fang L. Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway. Cell biochemistry and biophysics. 2024-07-08. PMID:38976102. |
moreover, in lps-stimulated raw 264.7 cells, src overexpression partially reversed the inhibition of hinesol on cell apoptosis, pro-inflammatory factors, and oxidative stress. |
2024-07-08 |
2024-07-11 |
mouse |
| Lisa K McClendon, Rainer B Lanz, Anil Panigrahi, Kristan Gomez, Michael J Bolt, Min Liu, Fabio Stossi, Michael A Mancini, Clifford C Dacso, David M Lonard, Bert W O'Malle. Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress. Journal of molecular and cellular cardiology. 2024-07-05. PMID:38969334. |
we demonstrate that an increase in hmox1 expression contributes to cf resistance to oxidative stress-mediated apoptosis via a mechanism involving src co-activation of nrf2, hence reducing inflammation and fibrosis. |
2024-07-05 |
2024-07-08 |
Not clear |
| Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma. Heliyon. vol 10. issue 11. 2024-07-04. PMID:38961933. |
the results unveiled the potential involvement of mic in apoptosis and cell migration, pinpointing src and fak as key targets. |
2024-07-04 |
2024-07-10 |
Not clear |
| Liangzhi Gong, Zhengsheng Chen, Kai Feng, Lei Luo, Juntao Zhang, Ji Yuan, Yajing Ren, Yang Wang, Xianyou Zheng, Qing L. A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression. Journal of nanobiotechnology. vol 22. issue 1. 2024-03-12. PMID:38468249. |
src silencing by upa-sevs-sisrc induced apoptosis of both senescent stromal cells and tumor cells. |
2024-03-12 |
2024-03-14 |
Not clear |
| Qi-Rui Fan, Mei Chen, Xiao-Yi Dong, Rui Tao, Jing-Rui Wang, Shun-Li Xia, Yong-Mei Lan, Tao Ha. [Mechanism of anti-hyperplasia of mammary glands of Xihuang Pills blood-entering component based on UPLC-Q-TOF-MS and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 24. 2024-01-11. PMID:38212035. |
in vitro experiments show that xihuang pills can inhibit the proliferation of mcf-10a cells, promote the apoptosis of mcf-10a cells, and reduce the expression of jak1, src, and cdk1 targets in cells. |
2024-01-11 |
2024-01-14 |
human |
| Qi-Rui Fan, Mei Chen, Xiao-Yi Dong, Rui Tao, Jing-Rui Wang, Shun-Li Xia, Yong-Mei Lan, Tao Ha. [Mechanism of anti-hyperplasia of mammary glands of Xihuang Pills blood-entering component based on UPLC-Q-TOF-MS and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 24. 2024-01-11. PMID:38212035. |
to sum up, xihuang pills can promote the apoptosis of mammary epithelial cells by regulating the expression of jak1, src, and cdk1 and then play an anti-hyperplasia role, which provides an experimental basis for clarifying the material basis of xihuang pills for anti-hyperplasia effect. |
2024-01-11 |
2024-01-14 |
human |
| Xiaobo Xu, Ye Li, Rui Xu, Yuting Meng, Zengqiang Li, Daiying Zuo, Yingliang W. CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells. The FEBS journal. 2023-12-27. PMID:38148635. |
furthermore, crizotinib treatment activated expression of src homology region 2 domain-containing phosphatase-2 (shp2; also known as ptpn11) to upregulate the mek/erk pathway, and the combination of mek inhibitors and crizotinib increased apoptosis compared with crizotinib alone. |
2023-12-27 |
2023-12-29 |
Not clear |
| Sanjiv Neupane, Yam Prasad Aryal, Hee-Jin Kwak, Sung-Gwon Lee, Tae-Young Kim, Elina Pokharel, Ji-Youn Kim, Jung-Hyeuk Kim, Wern-Joo Sohn, Seo-Young An, Chang-Hyeon An, Jae-Kwang Jung, Jung-Hong Ha, Hitoshi Yamamoto, Sung-Won Cho, Sanggyu Lee, Youngkyun Lee, Kwang-Kyun Park, Bong-Ki Min, Chungoo Park, Tae-Yub Kwon, Sung-Jin Cho, Jae-Young Ki. Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis. Cell and tissue research. 2023-11-20. PMID:37985496. |
glomerular epithelial protein-1 (glepp1), a r3 subtype family of receptor-type protein tyrosine phosphatases, plays important role in the activation of src family kinases and regulates cellular processes such as cell proliferation, differentiation, and apoptosis. |
2023-11-20 |
2023-11-29 |
mouse |
| Maedeh Bejari, Soheila Talesh Sasani, S Mohsen Asghari, Mozhgan Nabatzade Kolsha. Vascular endothelial growth factor antagonist peptides inhibit tumor growth and metastasis in breast cancer through repression of c-src and STAT3 genes. Molecular biology reports. 2023-10-03. PMID:37789224. |
given that src activates stat3 (signal transducers and activators of transcription) repressing apoptosis and promoting the cell cycle, it may be an important object for cancer treatment. |
2023-10-03 |
2023-10-07 |
Not clear |
| Madison M Rose, Kelsey W Nassar, Vibha Sharma, Rebecca E Schwepp. AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and MEK1/2 inhibition. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-15. PMID:37713162. |
we have previously demonstrated combined inhibition of src with dasatinib and mek1/2 with trametinib synergistically inhibits growth and induces apoptosis in braf- and ras-mutant thyroid cancer cells, however pik3ca-mutant cells exhibit a mixed response. |
2023-09-15 |
2023-10-07 |
Not clear |
| Fei Zhuang, Xin Shi, Sen Qiao, Bin Liu, Zhimei Wang, Huanhuan Huo, Feng Liang, Linghong Shen, Lijuan Zhu, Ben He, Hongmei Wan. Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk. Cell death discovery. vol 9. issue 1. 2023-09-06. PMID:37673878. |
allicin was proven to inhibit hypoxia-induced astrocyte apoptosis by increasing gpx1 expression, activating proto-oncogene tyrosine-protein kinase src (src)- protein kinase b (akt)-extracellular signal-regulated kinase (erk) phosphorylation, and decreasing lipid peroxidation. |
2023-09-06 |
2023-10-07 |
mouse |
| Xiao-Zheng Zou, Jun-Feng Hao, Ming-Xiao Ho. Hmgcs2 regulates M2 polarization of macrophages to repair myocardial injury induced by sepsis. Aging. vol 15. 2023-08-10. PMID:37561521. |
moreover, the inhibition of m2 polarization by an src antagonist significantly contributed to apoptosis of cardiomyocytes. |
2023-08-10 |
2023-08-16 |
mouse |
| Chaogang Wang, Mingyang Du, Zhuxiang Jiang, Rihao Cong, Wei Wang, Guofan Zhang, Li L. Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species. Ecotoxicology and environmental safety. vol 263. 2023-07-14. PMID:37451098. |
furthermore, the protein kinase a, mitogen-activated protein kinase 1, tyrosine-protein kinase src, and serine/threonine kinase akt, exhibiting differential phosphorylation modification patterns, were identified as hub regulators that may enhance glycolysis and tca cycle to increase the energy supply, distribute protein synthesis, inhibit caspase-dependent apoptosis activated by endogenous mitochondrial cytochrome release and maintain cytoskeletal stability, ultimately shaping the higher thermal resistance of c. angulata. |
2023-07-14 |
2023-08-14 |
Not clear |
| Sureyya Olgen, Sevde Nur Biltekin Kaleli, Banu Taktak Karaca, Ural U Demirel, Hacer Karatas Bristo. Synthesis and Anticancer Activity of Novel Indole Derivatives as Dual EGFR/SRC Kinase Inhibitors. Current medicinal chemistry. 2023-06-27. PMID:37365789. |
studies show that combination of src and egfr inhibitors can induce apoptosis and delay the acquired resistance to chemotherapy. |
2023-06-27 |
2023-08-14 |
Not clear |
| Shreni Agrawal, Richa Das, Amit Kumar Singh, Pradeep Kumar, Praveen Kumar Shukla, Indrani Bhattacharya, Amit Kumar Tripathi, Sunil Kumar Mishra, Kavindra Nath Tiwar. Network pharmacology-based anti-pancreatic cancer potential of kaempferol and catechin of Trema orientalis L. through computational approach. Medical oncology (Northwood, London, England). vol 40. issue 5. 2023-04-03. PMID:37010624. |
kaempferol effectively check cell migration by inhibiting erk1/2, egfr-related src, and akt pathways by scavenging ros whilst catechin inhibited tnfα-induced activation and cell cycle arrest at g1 and g2/m phases by induction of apoptosis of malignant cells. |
2023-04-03 |
2023-08-14 |
Not clear |