All Relations between apoptosis and src

Publication Sentence Publish Date Extraction Date Species
Abdul Hannan, Qian Wang, Yihua Wu, Neoklis Makrides, Xiuxia Qu, Junhao Mao, Jianwen Que, Wellington Cardoso, Xin Zhan. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005335. here, through single-cell analysis and genetic lineage tracing, we show that the pan-epithelial ablation of c-terminal src kinase (csk) in the lacrimal gland unleashes broad src signaling but specifically causes extrusion and apoptosis of acinar progenitors at a time when they are shielded by myoepithelial cells from the basement membrane. 2024-07-15 2024-07-18 Not clear
Yun-Xia Li, Jinzhong Liu, Fang L. Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway. Cell biochemistry and biophysics. 2024-07-08. PMID:38976102. moreover, in lps-stimulated raw 264.7 cells, src overexpression partially reversed the inhibition of hinesol on cell apoptosis, pro-inflammatory factors, and oxidative stress. 2024-07-08 2024-07-11 mouse
Lisa K McClendon, Rainer B Lanz, Anil Panigrahi, Kristan Gomez, Michael J Bolt, Min Liu, Fabio Stossi, Michael A Mancini, Clifford C Dacso, David M Lonard, Bert W O'Malle. Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress. Journal of molecular and cellular cardiology. 2024-07-05. PMID:38969334. we demonstrate that an increase in hmox1 expression contributes to cf resistance to oxidative stress-mediated apoptosis via a mechanism involving src co-activation of nrf2, hence reducing inflammation and fibrosis. 2024-07-05 2024-07-08 Not clear
Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma. Heliyon. vol 10. issue 11. 2024-07-04. PMID:38961933. the results unveiled the potential involvement of mic in apoptosis and cell migration, pinpointing src and fak as key targets. 2024-07-04 2024-07-10 Not clear
Liangzhi Gong, Zhengsheng Chen, Kai Feng, Lei Luo, Juntao Zhang, Ji Yuan, Yajing Ren, Yang Wang, Xianyou Zheng, Qing L. A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression. Journal of nanobiotechnology. vol 22. issue 1. 2024-03-12. PMID:38468249. src silencing by upa-sevs-sisrc induced apoptosis of both senescent stromal cells and tumor cells. 2024-03-12 2024-03-14 Not clear
Qi-Rui Fan, Mei Chen, Xiao-Yi Dong, Rui Tao, Jing-Rui Wang, Shun-Li Xia, Yong-Mei Lan, Tao Ha. [Mechanism of anti-hyperplasia of mammary glands of Xihuang Pills blood-entering component based on UPLC-Q-TOF-MS and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 24. 2024-01-11. PMID:38212035. in vitro experiments show that xihuang pills can inhibit the proliferation of mcf-10a cells, promote the apoptosis of mcf-10a cells, and reduce the expression of jak1, src, and cdk1 targets in cells. 2024-01-11 2024-01-14 human
Qi-Rui Fan, Mei Chen, Xiao-Yi Dong, Rui Tao, Jing-Rui Wang, Shun-Li Xia, Yong-Mei Lan, Tao Ha. [Mechanism of anti-hyperplasia of mammary glands of Xihuang Pills blood-entering component based on UPLC-Q-TOF-MS and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 24. 2024-01-11. PMID:38212035. to sum up, xihuang pills can promote the apoptosis of mammary epithelial cells by regulating the expression of jak1, src, and cdk1 and then play an anti-hyperplasia role, which provides an experimental basis for clarifying the material basis of xihuang pills for anti-hyperplasia effect. 2024-01-11 2024-01-14 human
Xiaobo Xu, Ye Li, Rui Xu, Yuting Meng, Zengqiang Li, Daiying Zuo, Yingliang W. CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells. The FEBS journal. 2023-12-27. PMID:38148635. furthermore, crizotinib treatment activated expression of src homology region 2 domain-containing phosphatase-2 (shp2; also known as ptpn11) to upregulate the mek/erk pathway, and the combination of mek inhibitors and crizotinib increased apoptosis compared with crizotinib alone. 2023-12-27 2023-12-29 Not clear
Sanjiv Neupane, Yam Prasad Aryal, Hee-Jin Kwak, Sung-Gwon Lee, Tae-Young Kim, Elina Pokharel, Ji-Youn Kim, Jung-Hyeuk Kim, Wern-Joo Sohn, Seo-Young An, Chang-Hyeon An, Jae-Kwang Jung, Jung-Hong Ha, Hitoshi Yamamoto, Sung-Won Cho, Sanggyu Lee, Youngkyun Lee, Kwang-Kyun Park, Bong-Ki Min, Chungoo Park, Tae-Yub Kwon, Sung-Jin Cho, Jae-Young Ki. Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis. Cell and tissue research. 2023-11-20. PMID:37985496. glomerular epithelial protein-1 (glepp1), a r3 subtype family of receptor-type protein tyrosine phosphatases, plays important role in the activation of src family kinases and regulates cellular processes such as cell proliferation, differentiation, and apoptosis. 2023-11-20 2023-11-29 mouse
Maedeh Bejari, Soheila Talesh Sasani, S Mohsen Asghari, Mozhgan Nabatzade Kolsha. Vascular endothelial growth factor antagonist peptides inhibit tumor growth and metastasis in breast cancer through repression of c-src and STAT3 genes. Molecular biology reports. 2023-10-03. PMID:37789224. given that src activates stat3 (signal transducers and activators of transcription) repressing apoptosis and promoting the cell cycle, it may be an important object for cancer treatment. 2023-10-03 2023-10-07 Not clear
Madison M Rose, Kelsey W Nassar, Vibha Sharma, Rebecca E Schwepp. AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and MEK1/2 inhibition. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-15. PMID:37713162. we have previously demonstrated combined inhibition of src with dasatinib and mek1/2 with trametinib synergistically inhibits growth and induces apoptosis in braf- and ras-mutant thyroid cancer cells, however pik3ca-mutant cells exhibit a mixed response. 2023-09-15 2023-10-07 Not clear
Fei Zhuang, Xin Shi, Sen Qiao, Bin Liu, Zhimei Wang, Huanhuan Huo, Feng Liang, Linghong Shen, Lijuan Zhu, Ben He, Hongmei Wan. Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk. Cell death discovery. vol 9. issue 1. 2023-09-06. PMID:37673878. allicin was proven to inhibit hypoxia-induced astrocyte apoptosis by increasing gpx1 expression, activating proto-oncogene tyrosine-protein kinase src (src)- protein kinase b (akt)-extracellular signal-regulated kinase (erk) phosphorylation, and decreasing lipid peroxidation. 2023-09-06 2023-10-07 mouse
Xiao-Zheng Zou, Jun-Feng Hao, Ming-Xiao Ho. Hmgcs2 regulates M2 polarization of macrophages to repair myocardial injury induced by sepsis. Aging. vol 15. 2023-08-10. PMID:37561521. moreover, the inhibition of m2 polarization by an src antagonist significantly contributed to apoptosis of cardiomyocytes. 2023-08-10 2023-08-16 mouse
Chaogang Wang, Mingyang Du, Zhuxiang Jiang, Rihao Cong, Wei Wang, Guofan Zhang, Li L. Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species. Ecotoxicology and environmental safety. vol 263. 2023-07-14. PMID:37451098. furthermore, the protein kinase a, mitogen-activated protein kinase 1, tyrosine-protein kinase src, and serine/threonine kinase akt, exhibiting differential phosphorylation modification patterns, were identified as hub regulators that may enhance glycolysis and tca cycle to increase the energy supply, distribute protein synthesis, inhibit caspase-dependent apoptosis activated by endogenous mitochondrial cytochrome release and maintain cytoskeletal stability, ultimately shaping the higher thermal resistance of c. angulata. 2023-07-14 2023-08-14 Not clear
Sureyya Olgen, Sevde Nur Biltekin Kaleli, Banu Taktak Karaca, Ural U Demirel, Hacer Karatas Bristo. Synthesis and Anticancer Activity of Novel Indole Derivatives as Dual EGFR/SRC Kinase Inhibitors. Current medicinal chemistry. 2023-06-27. PMID:37365789. studies show that combination of src and egfr inhibitors can induce apoptosis and delay the acquired resistance to chemotherapy. 2023-06-27 2023-08-14 Not clear
Shreni Agrawal, Richa Das, Amit Kumar Singh, Pradeep Kumar, Praveen Kumar Shukla, Indrani Bhattacharya, Amit Kumar Tripathi, Sunil Kumar Mishra, Kavindra Nath Tiwar. Network pharmacology-based anti-pancreatic cancer potential of kaempferol and catechin of Trema orientalis L. through computational approach. Medical oncology (Northwood, London, England). vol 40. issue 5. 2023-04-03. PMID:37010624. kaempferol effectively check cell migration by inhibiting erk1/2, egfr-related src, and akt pathways by scavenging ros whilst catechin inhibited tnfα-induced activation and cell cycle arrest at g1 and g2/m phases by induction of apoptosis of malignant cells. 2023-04-03 2023-08-14 Not clear
Fan Fan, Susmita Ghosh, Reid Powell, Jason Roszik, Yongsun Park, Mary Sobieski, Alexey Sorokin, Clifford Stephan, Scott Kopetz, Lee M Ellis, Rajat Bhattachary. Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo. PloS one. vol 18. issue 3. 2023-03-23. PMID:36952536. analysis of markers for cell proliferation and apoptosis using fluorescence-activated cell sorting, reverse-phase protein array, or western blotting demonstrated decreased cell proliferation and increased cell death when targeting both src and mek as compared to single agents in multiple crc cell lines. 2023-03-23 2023-08-14 mouse
Yvain Desplat, Jacob F Warner, Emily J Blake, Nidhi Vijayan, Marie Cuvelier, Patricia Blackwelder, Jose V Lope. Morphological and transcriptional effects of crude oil and dispersant exposure on the marine sponge Cinachyrella alloclada. The Science of the total environment. 2023-03-16. PMID:36924960. genes that were upregulated included heat shock proteins, apoptosis, oncogenes (rab/ras, src, cmyc), and several e3 ubiquitin ligases. 2023-03-16 2023-08-14 Not clear
SanFei Peng, Yang F. FYN: emerging biological roles and potential therapeutic targets in cancer. Journal of translational medicine. vol 21. issue 1. 2023-02-05. PMID:36740671. src family protein kinases (sfks) play a key role in cell adhesion, invasion, proliferation, survival, apoptosis, and angiogenesis during tumor development. 2023-02-05 2023-08-14 Not clear
Andra Fortner, Alexandra Chera, Antoanela Tanca, Octavian Bucu. Apoptosis regulation by the tyrosine-protein kinase CSK. Frontiers in cell and developmental biology. vol 10. 2022-12-29. PMID:36578781. c-terminal src kinase (csk) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. 2022-12-29 2023-08-14 Not clear