| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhao, Jun Zhang, Li Hou, Can Yang, Lin Jiang, Daoxin Lian. Nanoparticle-mediated sodium butyrate delivery for repairing hypoxic-ischemic brain injury in premature infants. Materials today. Bio. vol 32. 2025-04-15. PMID:40230649. |
single-cell rna sequencing and high-throughput transcriptome analysis revealed that mns@sb promoted brain repair by upregulating neuronal sp1, activating the tgf-β1 signaling pathway, and inhibiting neuronal apoptosis. |
2025-04-15 |
2025-04-17 |
mouse |
| Huifang Sun, Lijuan Hu, Peipei Hao, Yawei Liu, Ying Tia. Baicalin inhibits cell apoptosis, inflammation and ferroptosis in ulcerative colitis by influencing SP1-mediated transcription of SLC6A14. Shock (Augusta, Ga.). 2025-03-26. PMID:40138728. |
the interaction between sp1 and slc6a14 promoter was verified by chip assay and dual-luciferase reporter assay.results: baicalin enhanced proliferation, while repressed apoptosis, inflammation and ferroptosis in tnf-α-induced fhc cells. |
2025-03-26 |
2025-03-30 |
human |
| Ruirui Wang, Qiang Wang, Jinzhuang Liao, Xinfang Yu, Wei L. Piperlongumine overcomes osimertinib resistance via governing ubiquitination-modulated Sp1 turnover. JCI insight. vol 10. issue 6. 2025-03-24. PMID:40125551. |
additionally, we discovered that piperlongumine could enhance the interaction between e3 ligase rnf4 and sp1, inhibit the phosphorylation of sp1 at thr739, facilitate the ubiquitination and degradation of sp1, lead to c-met destabilization, and trigger intrinsic apoptosis in resistant cells. |
2025-03-24 |
2025-03-26 |
Not clear |
| Yuze Wu, Bingchen Lin, Zhiyong Xie, Jingshan Huang, Yi Qiu, Xiaojing Chen, Zhongshi Hong, Chengzhi Qi. Sumoylation of RAD51 upregulates GOLPH3 expression and promotes cisplatin resistance in colon cancer cells by Sp1 transcriptional activity. Biochemical pharmacology. 2025-03-24. PMID:40127738. |
knockdown of sp1 or golph3 increased ndrg1 expression, inhibited coad cell proliferation, promoted cell apoptosis, and enhanced cell sensitivity to cisplatin (ddp). |
2025-03-24 |
2025-03-27 |
Not clear |
| Qiao Li, Yang Tang, Jie-Bin Zuo, Hao Han, Guang-Xu Tu, Cheng Che. CENP-H as a new prognostic biomarker for tumors: a real-world literature review. Frontiers in oncology. vol 15. 2025-03-12. PMID:40071086. |
cenp-h can promote cancer growth and metastasis through pi3k/akt, survivin, and mitochondrial apoptosis signaling mechanisms, and it can be regulated by long non-coding ribonucleic acid (lncrna) plasmacytoma variant translocation 1 (pvt1)/mir-612, sp1, or sp3. |
2025-03-12 |
2025-03-14 |
Not clear |
| Huimou Chen, Mengzhen Li, Yu Zhang, Mengjia Song, Yi Que, Juan Wang, Feifei Sun, Jia Zhu, Junting Huang, Juan Liu, Jiaqian Xu, Suying Lu, Yizhuo Zhan. AURKB inhibition induces rhabdomyosarcoma apoptosis and ferroptosis through NPM1/SP1/ACSL5 axis. JCI insight. vol 10. issue 3. 2025-02-10. PMID:39927464. |
the highly expressed aurkb in rms contributes to the apoptosis and ferroptosis resistance of tumor cells through the nucleophosmin 1 (npm1)/sp1 transcription factor (sp1)/acyl-coa synthetase long-chain family member 5 (acsl5) axis. |
2025-02-10 |
2025-02-13 |
Not clear |
| Shunli Liang, You Wu, Rongbo Zhang, Linsheng Xu, Fangping Xi. TNFSF9 Silence Impedes Cerebral Ischemia-Reperfusion Injury via Modulating SLC3A2 Expression in Brain Microvascular Endothelial Cells. Journal of molecular neuroscience : MN. vol 75. issue 1. 2025-01-24. PMID:39856410. |
besides, sp1 positively regulated tnfsf9 expression as one of its transcription factors, and tnfsf9 overexpression reversed sp1 silence-mediated inhibition on ferroptosis, apoptosis, and release of inflammatory mediators in ogd/r-treated bmecs. |
2025-01-24 |
2025-01-28 |
rat |
| Shunli Liang, You Wu, Rongbo Zhang, Linsheng Xu, Fangping Xi. TNFSF9 Silence Impedes Cerebral Ischemia-Reperfusion Injury via Modulating SLC3A2 Expression in Brain Microvascular Endothelial Cells. Journal of molecular neuroscience : MN. vol 75. issue 1. 2025-01-24. PMID:39856410. |
tnfsf9 regulated by sp1 aggravated ciri via boosting ferroptosis, apoptosis, and release of inflammatory mediators of bmecs under ogd/r situation by suppressing slc3a2 expression in vitro and in vivo. |
2025-01-24 |
2025-01-28 |
rat |
| Shenyao Zhang, Min Lu, Gaoyan Kuang, Xiaotong Xu, Jun Fu, Churan Zen. HDAC1 overexpression inhibits steroid-induced apoptosis of mouse osteocyte-like MLO-Y4 cells by inducing SP1 deacetylation. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 45. issue 1. 2025-01-17. PMID:39819707. |
hdac1 overexpression inhibits steroid-induced apoptosis of mouse osteocyte-like mlo-y4 cells by inducing sp1 deacetylation. |
2025-01-17 |
2025-01-20 |
mouse |
| Khalid M Alkharfy, Ajaz Ahmad, Mohammad Raish, Maha F Alenaz. Thymoquinone Mediates Müller Cell Apoptosis via miR-29b/SP1 Pathway: A Potential Therapeutic Approach in Diabetic Retinopathy. Drug research. 2025-01-15. PMID:39814036. |
protein expressions of sp1, bax, and bcl-2 were analyzed through western blotting, while caspase-3 activity using an elisa assay kit, and apoptosis levels by annexin v.tq administration resulted in a 52% reduction in blood glucose levels. |
2025-01-15 |
2025-01-19 |
mouse |
| Yanyan Sun, Zhenzhen Hu, Jie Han, Gang L. SP1-mediated transcriptional repression of SFRP5 is correlated with cardiac fibroblast activation and atrial myocyte apoptosis in the development of atrial fibrillation. Experimental cell research. 2024-11-13. PMID:39536929. |
additionally, sp1 knockdown attenuated ang Ⅱ-induced apoptosis in hc-1 cells, but this effect was counteracted by concurrent sfrp5 knockdown. |
2024-11-13 |
2024-11-17 |
mouse |
| Yanyan Sun, Zhenzhen Hu, Jie Han, Gang L. SP1-mediated transcriptional repression of SFRP5 is correlated with cardiac fibroblast activation and atrial myocyte apoptosis in the development of atrial fibrillation. Experimental cell research. 2024-11-13. PMID:39536929. |
in conclusion, this investigation underscores that sp1 mediates sfrp5 loss during af by transcriptional repression, contributing to fibrosis and myocyte apoptosis. |
2024-11-13 |
2024-11-17 |
mouse |
| Xi Yang, Chen Wan. SGPP2 is activated by SP1 and promotes lung adenocarcinoma progression. Anti-cancer drugs. vol 35. issue 10. 2024-11-08. PMID:39514710. |
this study demonstrated that sgpp2, activated by sp1, promotes ladc cell proliferation and invasion, and suppresses apoptosis in ladc. |
2024-11-08 |
2024-11-16 |
Not clear |
| Xuming Ma, Luzhen Wang, Wanpeng Li, Yan Huang, Yan Zhu, Jing L. SP1 MEDIATES OGD/R-INDUCED CARDIOMYOCYTE INJURY VIA ENHANCING THE TRANSCRIPTION OF USP46. Shock (Augusta, Ga.). vol 62. issue 3. 2024-08-30. PMID:38813924. |
ogd/r stimulation suppressed cardiomyocyte viability and proliferation, as well as induced cardiomyocyte inflammation, oxidative stress (oxs) injury, apoptosis, and ferroptosis, but these effects were impaired by usp46 or sp1 knockdown. |
2024-08-30 |
2024-09-01 |
Not clear |
| Xuming Ma, Luzhen Wang, Wanpeng Li, Yan Huang, Yan Zhu, Jing L. SP1 MEDIATES OGD/R-INDUCED CARDIOMYOCYTE INJURY VIA ENHANCING THE TRANSCRIPTION OF USP46. Shock (Augusta, Ga.). vol 62. issue 3. 2024-08-30. PMID:38813924. |
conclusion: sp1 mediated ogd/r-induced cardiomyocyte inflammation, oxs injury, apoptosis, and ferroptosis by inactivating the ampk signaling via enhancing the transcription of usp46. |
2024-08-30 |
2024-09-01 |
Not clear |
| Daocheng Liu, Minmin Shen, Zhaohui Liu, Dong Chen, Yuan Pan, Lei Zhang, Xiaoping X. SP1-induced circ_0017552 modulates colon cancer cell proliferation and apoptosis via up-regulation of NET1. Cancer genetics. vol 286-287. 2024-08-21. PMID:38810361. |
sp1 induced transcription of circ_0017552 to facilitate cc cell proliferation and inhibit cc cell apoptosis. |
2024-08-21 |
2024-08-24 |
human |
| Jie Ding, Aminah I Fayyaz, Yuchuan Ding, Dandan Liang, Ming Lu. Role of Specificity Protein 1 (SP1) in Cardiovascular Diseases: Pathological Mechanisms and Therapeutic Potentials. Biomolecules. vol 14. issue 7. 2024-07-27. PMID:39062521. |
sp1 is implicated in the regulation of apoptosis, cell hypertrophy, inflammation, oxidative stress, lipid metabolism, plaque stabilization, endothelial dysfunction, fibrosis, calcification, and other pathological processes. |
2024-07-27 |
2024-07-29 |
Not clear |
| Fatma Guesmi, Wiem Tahri, Amel Mehrez, Taha Barkaoui, Sahdeo Prasad, Angelo Maria Giuffrè, Ahmed Landouls. Colorectal carcinoma cell targeting aromatherapy with Teucrium ramosissimum essential oil to sensitize TRAIL/Apo2L-induced HCT-116 cell death. International immunopharmacology. vol 136. 2024-06-08. PMID:38850792. |
additionally, trs potentiates apoptosis in trail-resistant tumor cells through induction of mapk signalling components, including erk, p38 kinase, jnk, and activation of chop, and sp1, involved in dr5 expression. |
2024-06-08 |
2024-06-11 |
mouse |
| Yun Li, Meijuan Cheng, Jingjing Jin, Dongxue Zhang, Shenglei Zhang, Yaling Bai, Jinsheng X. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification. Aging. vol 16. 2024-02-01. PMID:38301049. |
interaction of sp1 and setd8 promotes vascular smooth muscle cells apoptosis by activating mark4 in vascular calcification. |
2024-02-01 |
2024-02-04 |
human |
| Dhwani Jhala, Neelam Nathani, Madhvi Joshi, Amrutlal Patel, Chaitanya G Josh. Oncolytic activity of Canine Distemper virus in human ductal breast carcinoma cells. Oncology research and treatment. 2023-11-26. PMID:38008084. |
the impact of cdv infection on cell proliferation and apoptosis was studied by evaluating the expression of four target genes including the myeloid cell leukemia 1 (mcl-1), phosphoinositide-3-kinase regulatory subunit 1 (pik3r1), transcription factor (sp1) and dna (cytosine-5)-methyltransferase 3a (dnmt3a). |
2023-11-26 |
2023-11-28 |
human |