| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatma Guesmi, Wiem Tahri, Amel Mehrez, Taha Barkaoui, Sahdeo Prasad, Angelo Maria Giuffrè, Ahmed Landouls. Colorectal carcinoma cell targeting aromatherapy with Teucrium ramosissimum essential oil to sensitize TRAIL/Apo2L-induced HCT-116 cell death. International immunopharmacology. vol 136. 2024-06-08. PMID:38850792. |
additionally, trs potentiates apoptosis in trail-resistant tumor cells through induction of mapk signalling components, including erk, p38 kinase, jnk, and activation of chop, and sp1, involved in dr5 expression. |
2024-06-08 |
2024-06-11 |
mouse |
| Yun Li, Meijuan Cheng, Jingjing Jin, Dongxue Zhang, Shenglei Zhang, Yaling Bai, Jinsheng X. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification. Aging. vol 16. 2024-02-01. PMID:38301049. |
interaction of sp1 and setd8 promotes vascular smooth muscle cells apoptosis by activating mark4 in vascular calcification. |
2024-02-01 |
2024-02-04 |
human |
| Dhwani Jhala, Neelam Nathani, Madhvi Joshi, Amrutlal Patel, Chaitanya G Josh. Oncolytic activity of Canine Distemper virus in human ductal breast carcinoma cells. Oncology research and treatment. 2023-11-26. PMID:38008084. |
the impact of cdv infection on cell proliferation and apoptosis was studied by evaluating the expression of four target genes including the myeloid cell leukemia 1 (mcl-1), phosphoinositide-3-kinase regulatory subunit 1 (pik3r1), transcription factor (sp1) and dna (cytosine-5)-methyltransferase 3a (dnmt3a). |
2023-11-26 |
2023-11-28 |
human |
| Pan Xi, Xiaojuan Ma, Fuquan Hu, Liang Li, Huijuan Liu, Jing Zhou, Wenan W. ROS-Sp1 axis is involved in thermochemotherapy-enhanced sensitivity of pancreatic cancer cells to gemcitabine. Cell biology international. 2023-08-07. PMID:37545170. |
pancreatic cancer cells panc-1 and aspc-1 were either treated with gem or thermochemotherapy, then cell viability, apoptosis, migration, invasion, reactive oxygen species (ros) production, and sp1 expression were evaluated. |
2023-08-07 |
2023-08-14 |
Not clear |
| Pan Xi, Xiaojuan Ma, Fuquan Hu, Liang Li, Huijuan Liu, Jing Zhou, Wenan W. ROS-Sp1 axis is involved in thermochemotherapy-enhanced sensitivity of pancreatic cancer cells to gemcitabine. Cell biology international. 2023-08-07. PMID:37545170. |
in conclusion, thermochemotherapy inhibited pancreatic cell viability, migration and invasion, and promoted cell apoptosis by inducing excessive ros production, which subsequently suppressed sp1 expression and the downstream cox-2. |
2023-08-07 |
2023-08-14 |
Not clear |
| Xiongxiong Liu, Chao Sun, Qiqi Wang, Ping Li, Ting Zhao, Qiang L. Sp1 Upregulation Bolsters the Radioresistance of Glioblastoma Cells by Promoting Double Strand Breaks Repair. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445835. |
furthermore, the loss of sp1 delayed double-strand breaks (dsb) repair and increased ir-induced apoptosis of gbm cells. |
2023-07-14 |
2023-08-14 |
mouse |
| Fei Tian, Yuan Zhang, Jie Li, Zhaoping Chu, Junqin Zhang, Hua Han, Ligang Ji. Effects of the SPI/lncRNA NEAT1 Axis on Functions of Trophoblast and Decidual Cells in Patients with Recurrent Miscarriage. Critical reviews in eukaryotic gene expression. vol 33. issue 3. 2023-04-05. PMID:37017669. |
thereafter, the cell counting kit-8, transwell, flow cytometry assays detected that sp1 overexpression accelerated trophoblast cell proliferation, invasion, and migration, meanwhile, enhancing decidual cell proliferation while repressed apoptosis. |
2023-04-05 |
2023-08-14 |
Not clear |
| Fei Tian, Yuan Zhang, Jie Li, Zhaoping Chu, Junqin Zhang, Hua Han, Ligang Ji. Effects of the SPI/lncRNA NEAT1 Axis on Functions of Trophoblast and Decidual Cells in Patients with Recurrent Miscarriage. Critical reviews in eukaryotic gene expression. vol 33. issue 3. 2023-04-05. PMID:37017669. |
overall, sp1 activated neat1 transcription, accelerating trophoblast cell proliferation, invasion, and migration and mitigating decidual cell apoptosis. |
2023-04-05 |
2023-08-14 |
Not clear |
| Stephen Saf. Specificity Proteins (Sp) and Cancer. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982239. |
the pro-oncogenic functions of sp1, sp3 and sp4 in cancer cell lines were studied in knockdown studies where silencing of each individual sp tf decreased cancer growth, invasion and induced apoptosis. |
2023-03-29 |
2023-08-14 |
Not clear |
| Xiaoqin Zhou, Chuntong Liu, Daolin Xi. Sevoflurane-induced P300 promotes neuron apoptosis via Sp1/SDK9 pathway. Clinical and experimental pharmacology & physiology. 2023-03-16. PMID:36924113. |
p300 inhibited the binding of sp1 to dna by affecting the level of sp1 acetylation, thereby inhibiting the expression of cdk9, cell cycle arrest, and increasing neuron apoptosis. |
2023-03-16 |
2023-08-14 |
mouse |
| Xiaoqin Zhou, Chuntong Liu, Daolin Xi. Sevoflurane-induced P300 promotes neuron apoptosis via Sp1/SDK9 pathway. Clinical and experimental pharmacology & physiology. 2023-03-16. PMID:36924113. |
in summary, sevoflurane-induced p300 inhibited activity of sp1 by increasing sp1 acetylation modification, down-modulates cdk9 expression, and promotes the occurrence of neuronal apoptosis. |
2023-03-16 |
2023-08-14 |
mouse |
| Atsushi Kimura, Yo-Han Kim, Kazuyoshi Hashizume, Akira Ito, Katsuyuki Mukai, Keiichiro Kizaki, Shigeru Sat. Effects of oral β-cryptoxanthin administration on the transcriptomes of peripheral neutrophil and liver tissue using microarray analysis in post-weaned Holstein calves. Journal of animal physiology and animal nutrition. 2023-03-06. PMID:36876888. |
transcription regulators such as cdkn2a (cell growth suppressor) and sp1 (cell apoptosis enhancer) were significantly inhibited and activated, respectively, in neutrophils and liver tissue. |
2023-03-06 |
2023-08-14 |
Not clear |
| Ning Lyu, Xiaoyun L. Sevoflurane Postconditioning Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting SP1/ACSL4-Mediated Ferroptosis. Human & experimental toxicology. vol 42. 2023-02-27. PMID:36842993. |
sp1 overexpression attenuated the neuroprotective effects of sevoflurane on ogd/r-treated ht22 cells, evidenced by reduced cell viability, increased apoptosis, and cleaved caspase-3 expression. |
2023-02-27 |
2023-08-14 |
rat |
| Xin Lin, Yang Yang, Ye Ji, Guangxi Wang, Wenbo Xu, Bo Wang, Hangyu Guo, Jiyu Ren, Jinglong Yan, Nanxiang Wan. MiR-135a-5p/SP1 axis regulates spinal astrocyte proliferation and migration. Neuroscience. 2023-02-10. PMID:36764602. |
our previous study has revealed that mir-135a-5p regulates neuronal apoptosis and axonal growth by targeting specificity protein 1 (sp1). |
2023-02-10 |
2023-08-14 |
Not clear |
| Anil Kumar Kalvala, Ramesh Nimma, Arvind Bagde, Sunil Kumar Surapaneni, Nilkumar Patel, Peggy Arthur, Li Sun, Rakesh Singh, Nagavendra Kommineni, Aakash Nathani, Yan Li, Mandip Sing. The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice. Biochimie. 2022-12-19. PMID:36535544. |
transcriptomics and proteomics studies revealed that cbd and thcv, by downregulating pd-l1, tgf-β, sp1, nlrp3, p38-mapk, and upregulating ampk induced apoptosis leading to improved dox's chemosensitivity against dox resistant mda-mb-231 tumors in balb/c nude mice. |
2022-12-19 |
2023-08-14 |
mouse |
| K A Ivanenko, V S Prassolov, E R Khabushev. [Transcription Factor Sp1 in the Expression of Genes Encoding Components of MAPK, JAK/STAT, and PI3K/Akt Signaling Pathways]. Molekuliarnaia biologiia. vol 56. issue 5. 2022-09-27. PMID:36165020. |
sp1 is involved in the regulation of cell proliferation, apoptosis and differentiation, and angiogenesis. |
2022-09-27 |
2023-08-14 |
Not clear |
| Yang Cai, Ming-Ming Zhang, Ming Wang, Zhuo-Hang Jiang, Zhi-Gang Ta. Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 2022-05-24. PMID:35609560. |
bone marrow-derived mesenchymal stem cell-derived exosomes containing gli1 alleviate microglial activation and neuronal apoptosis in vitro and in a mouse parkinson disease model by direct inhibition of sp1 signaling. |
2022-05-24 |
2023-08-13 |
mouse |
| Yang Cai, Ming-Ming Zhang, Ming Wang, Zhuo-Hang Jiang, Zhi-Gang Ta. Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 2022-05-24. PMID:35609560. |
thus, bmsc-derived exosomal gli1 alleviates inflammatory damage and neuronal apoptosis by inhibiting sp1 in vitro and in vivo. |
2022-05-24 |
2023-08-13 |
mouse |
| Mei Wu, Zehong Huang, Wenfang Huang, Mengyu Lin, Weifeng Liu, Kexuan Liu, Cai L. microRNA-124-3p attenuates myocardial injury in sepsis via modulating SP1/HDAC4/HIF-1α axis. Cell death discovery. vol 8. issue 1. 2022-01-29. PMID:35091534. |
mir-124-3p overexpression and sp1 silencing assays were implemented on lps-treated h9c2 cells to explore theirs actions in inflammation, oxidative stress and cell apoptosis. |
2022-01-29 |
2023-08-13 |
rat |
| Zhao Zhu, Guoxiu Zhang, Dahuan Li, Xiaojun Yin, Tianzhong Wan. Silencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-κB signaling. Bioengineered. vol 13. issue 2. 2022-01-20. PMID:35048778. |
moreover, silencing of sp1 or cxcr4 suppressed lps-induced inflammation and cell apoptosis in h9c2 cells, as evidenced by the increase in cell viability and decrease in lactate dehydrogenase release, interleukin (il)-6, il-8, and tumor necrosis factor (tnf)-α levels, and caspase-3 activity. |
2022-01-20 |
2023-08-13 |
Not clear |