Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Feng Si, Qian Wang, Fei Chen, Xiangdong L. Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis. Discover oncology. vol 16. issue 1. 2025-02-08. PMID:39921785. |
significantly, we verified that sc suppressed the proliferation and enhanced apoptosis of gbm cells via inhibiting mir-21 while it was not entirely dependent on upregulation pten. |
2025-02-08 |
2025-02-11 |
human |
Tao Huang, Bo Shao, Zhong-Cheng Gon. The Impact of miR-141 Overexpression on Apoptosis and Proliferation in Tscca and Tca8113 Cell Lines. Journal of stomatology, oral and maxillofacial surgery. 2025-02-05. PMID:39909369. |
these findings indicate that mir-141 may regulate the expression of pten and bcl2 at both the gene and protein levels, thereby influencing cell proliferation, migration, and apoptosis. |
2025-02-05 |
2025-02-08 |
Not clear |
Jun Zhou, Fan Yang, Congsen Zheng, Yanting Chen, Meiting Chen, Qiaoer Lin, Chuanzhe Chang, Shikai Cai, Zhaoyang Sun, Hua Li, Limei Qin, Yanfeng Che. OncomiR mdv1-miR-M7-5p promotes avian lymphomatosis by modulating the BCL2/Bax mitochondrial apoptosis signaling pathway. Veterinary microbiology. vol 302. 2025-01-31. PMID:39889336. |
a marked increase was observed in apoptosis in the spleen tissues, and the expression of apoptosis-related genes including caspase-3 and tumor suppressor gene pten in immune organs, including the spleen, bursa of fabricius, and thymus, were markedly upregulated. |
2025-01-31 |
2025-02-04 |
chicken |
Haodong He, Jingjie Yang, Wenjin Peng, Moyu Li, Meiyan Shuai, Faming Tan, Zheng Cao, Chengfu Yua. MT1JP: A Pivotal Tumor-Suppressing LncRNA and its Role in Cancer Progression and Therapeutic Potential. Current drug targets. 2025-01-23. PMID:39844400. |
this regulation restores tumor suppressor genes, such as fbxw7, runx3, and pten, thereby disrupting oncogenic pathways, including pi3k/akt, wnt/βcatenin, and p53, promoting apoptosis, and inhibiting tumor progression. |
2025-01-23 |
2025-01-25 |
Not clear |
Zhaokui Zhu, Meng Meng, Sisi Mo, Xinyu Wang, Lixing Qia. M2 Microglia-Derived Exosomal miR-144-5p Attenuates White Matter Injury in Preterm Infants by Regulating the PTEN/AKT Pathway Through KLF12. Molecular biotechnology. 2025-01-22. PMID:39841378. |
mir-144-5p suppressed ogd/r-stimulated opc apoptosis and facilitated ogd/r-stimulated opc differentiation through pten downregulation. |
2025-01-22 |
2025-01-24 |
rat |
Zi-Yan Yang, Zi-Lin Li, Cui-Xiang Zhang, Li-Jin Huang, Han Wang, Xue-Ying Li, Gui-Yuan Che. [Rose roxburghii polysaccharide-induced apoptosis of prostate cancer DU145 cells by inhibiting PI3K/Akt/mTOR pathway and antioxidant effects]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 19. 2024-12-19. PMID:39701769. |
based on the signaling pathway of phosphoinositide 3-kinase(pi3k)/protein kinase b(akt)/mammalian target of rapamycin(mtor), pathway-related phosphatase and tensin homolog(pten), b-cell lymphoma-2(bcl-2), and bcl-2-associated x protein(bax), the mechanism of rose roxburghii polysaccharides in inhibiting proliferation and inducing apoptosis of prostate cancer du145 cells was explored, as well as the antioxidant activity of r. roxburghii polysaccharides. |
2024-12-19 |
2024-12-22 |
Not clear |
Zi-Yan Yang, Zi-Lin Li, Cui-Xiang Zhang, Li-Jin Huang, Han Wang, Xue-Ying Li, Gui-Yuan Che. [Rose roxburghii polysaccharide-induced apoptosis of prostate cancer DU145 cells by inhibiting PI3K/Akt/mTOR pathway and antioxidant effects]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 19. 2024-12-19. PMID:39701769. |
r. roxburghii polysaccharides inhibited the pi3k/akt/mtor pathway and induced apoptosis of du145 cells by up-regulating the protein and gene expression of pten and bax and down-regulating the expression of akt, pi3k, mtor, and bcl-2. |
2024-12-19 |
2024-12-22 |
Not clear |
Na Yang, Huaxin Sun, Linqiang Xi, Ling Zhang, Yanmei Lu, Qianhui Wang, Jiaru Cao, Jie Song, Baopeng Tang, Luxiang Shang, Xianhui Zho. Oroxin B Resembles Bisoprolol in Attenuating Beta1-Adrenergic Receptor Autoantibody-Induced Atrial Remodelling via the PTEN/AKT/mTOR Signalling Pathway. Clinical and experimental pharmacology & physiology. vol 52. issue 2. 2024-12-09. PMID:39648364. |
oroxin b, a pten agonist, can improve the impairment of autophagy homeostasis and apoptosis in atrial tissue by activating the pten/akt/mtor signalling pathway, thereby improving atrial structure and electrical remodelling. |
2024-12-09 |
2024-12-11 |
rat |
Seonhee Kim, Bo-Kyoung Jung, Jinju Kim, Joo Hee Jeon, Sung Hoon Jang, Minsoo Kim, Cuk-Seong Kim, Hyun Jan. Newcastle disease virus harboring the PTEN gene inhibits pancreatic cancer growth by inhibiting PI3K/AKT/mTOR signaling and activating apoptosis. Molecular therapy. Oncology. vol 32. issue 4. 2024-12-06. PMID:39640863. |
newcastle disease virus harboring the pten gene inhibits pancreatic cancer growth by inhibiting pi3k/akt/mtor signaling and activating apoptosis. |
2024-12-06 |
2024-12-08 |
mouse |
Yiren Xiong, Jiayi He, Shanshan He, Zuqing Hu, Di Ouyang, Renyi Liu, Zhenjie Gao, Weiguang Zhang, Zhujun Kang, Shuyi Lan, Yang Wang, Fatoumata Diallo, Dalin H. The toxicity of lead on human neuroblastoma cells was alleviated by HUC-MSC-derived exosomes through miR-26a-5p/PTEN pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-12-06. PMID:39642978. |
the result showed that the exposure of sh-sy5y cells to lead activated the mir-26a-5p/pten pathway by down-regulating mir-26a-5p and up-regulating pten expression, which was related to the significantly decreased cell migration and increased apoptosis, as well as significantly enhanced levels of inflammatory cytokine as compared with the control. |
2024-12-06 |
2024-12-10 |
human |
Jian Jiao, Deng Zhang, Jianbo Peng, Yunsai L. MDM2 interacts with PTEN to inhibit endothelial cell development and promote deep vein thrombosis via the JAK/STAT signaling pathway. Molecular medicine reports. vol 31. issue 2. 2024-11-22. PMID:39575482. |
however, mdm2 or pten knockdown markedly increased the proliferation, migration, invasion, apoptosis and angiogenesis of oxidized low‑density lipoprotein‑treated human umbilical vein endothelial cells (huvecs). |
2024-11-22 |
2024-11-24 |
human |
Yongzhi Lun, Jie Sun, Ling Wei, Ben Liu, Zhixue Li, Wen Dong, Wenqi Zha. SPINK13 acts as a tumor suppressor in hepatocellular carcinoma by inhibiting Akt phosphorylation. Cell death & disease. vol 15. issue 11. 2024-11-13. PMID:39537605. |
as a result, endogenous spink13 might inhibit the activity of furin protease, downregulate the notch1/hes1 pathway in a binding manner, activate the direct effector pten, inhibit akt phosphorylation, inactivate the downstream pi3k/akt pathway, and ultimately lead to mitochondrial apoptosis and cell cycle arrest in hepatoma cells. |
2024-11-13 |
2024-11-17 |
mouse |
Xin Han, Guoyong Zhang, Mingjie Pang, Changlei Hu, Tong Xu, Yuting Wu, Lingpeng Xie, Guanghong Chen, Honglin Xu, Min Liu, Yue Hua, Zhangbin Tan, Yiming Bi, Huijie Fan, Bin Liu, Yingchun Zho. Taohong siwu decoction suppresses oxidative stress-induced myocardial apoptosis post-myocardial infarction by inhibiting PTEN pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 135. 2024-11-08. PMID:39515108. |
taohong siwu decoction suppresses oxidative stress-induced myocardial apoptosis post-myocardial infarction by inhibiting pten pathway. |
2024-11-08 |
2024-11-16 |
Not clear |
Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. Correction: STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. 2024-11-07. PMID:39511405. |
correction: stat3 dictates β-cell apoptosis by modulating pten in streptozocin-induced hyperglycemia. |
2024-11-07 |
2024-11-16 |
Not clear |
Seonhee Kim, Bo-Kyoung Jung, Jinju Kim, Joo Hee Jeon, Minsoo Kim, Sung Hoon Jang, Cuk-Seong Kim, Hyun Jan. Anticancer effect of the oncolytic Newcastle disease virus harboring the PTEN gene on glioblastoma. Oncology letters. vol 29. issue 1. 2024-11-04. PMID:39492938. |
methods included infection of u87-mg cells with rndv-pten, followed by assessments of pten expression, and cell proliferation, migration and apoptosis. |
2024-11-04 |
2024-11-06 |
mouse |
Yixin Jiang, Xiaoli Fan, Yaling Yu, Hongfan Ge, Chengyin Liu, Yanyan Zhang, Lingyun Yu, Wen Yin, Zhenlei Zho. USP13 Overexpression in BMSCs Enhances Anti-Apoptotic Ability and Guards Against Methylprednisolone-Induced Osteonecrosis in Rats. Stem cells (Dayton, Ohio). 2024-10-26. PMID:39460600. |
usp13 also protected bmscs from mps-induced apoptosis by modulating pten and reducing akt phosphorylation. |
2024-10-26 |
2024-10-29 |
rat |
Xueping Huang, Dongyan Zhang, Di Zhang, Jianran Guo, Guohao Gu, Yingying Wang, Guohao Wu, Chuanbao Wang, Bo Fu, Keyi L. Decoding PTEN: from biological functions to signaling pathways in tumors. Molecular biology reports. vol 51. issue 1. 2024-10-24. PMID:39446204. |
pten aberrations disrupt critical cellular processes like proliferation, apoptosis, migration, and invasion, thereby promoting tumor growth. |
2024-10-24 |
2024-10-26 |
human |
Meng Lian, Boxuan Han, Jiaming Chen, Xixi Shen, Yanming Zhao, Qian Shi, Ling Feng, Shizhi He, Hongzhi Ma, Lizhen Hou, Qi Zhong, Hongbao Cao, Jugao Fan. Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma. Scientific reports. vol 14. issue 1. 2024-09-27. PMID:39333222. |
these genes, including egfr, pik3ca, erbb2, pten, bcl2, braf, kras, and prl, form a complex snscc-prognosis pathway and were significantly enriched in 42 kegg pathways and gene ontology (go) terms (fdr-corrected p-value < 0.001), influencing cell growth, apoptosis, and oncogenic signaling pathways. |
2024-09-27 |
2024-10-01 |
Not clear |
Huaijuan Liu, Peijun Zhang, Jingwen Yu, Jiwei Wang, Jiezhong Yu, Minfang Gu. [Fasudil improves cognitive function in APP/PS1 transgenic mice by promoting mitophagy and inhibiting NLRP3 inflammasome activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 8. 2024-08-31. PMID:39215667. |
terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) staining was used to detect neuronal apoptosis; the expression of p62 and nlrp3 was detected by immunofluorescence histochemical staining; real time fluorescence quantitative pcr was used to detect the mrna expression levels of phosphatase and tensin homolog deleted on chromosome ten (pten) -induced putative kinase 1 (pink1), parkin and nlrp3; western blot analysis was used to detect the expression of pink1, parkin, p62, microtubule-associated protein 1 light chain 3 (lc3), nlrp3, adapter protein apoptosis-associated speck-like protein (asc) and interleukin-18 (il-18). |
2024-08-31 |
2024-09-04 |
mouse |
Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
set8 inhibition preserves pten to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. |
2024-08-26 |
2024-08-28 |
Not clear |