| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeena Joseph, Narendra Wajapeyee, Kumaravel Somasundara. Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate. International journal of cancer. vol 115. issue 1. 2005-05-31. PMID:15688418. |
nab induced p53 is functional as it activated p53-specific reporter, induced the level of p21(waf1/cip1), inhibited cellular dna synthesis and induced apoptosis. |
2005-05-31 |
2023-08-12 |
human |
| Jeena Joseph, Narendra Wajapeyee, Kumaravel Somasundara. Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate. International journal of cancer. vol 115. issue 1. 2005-05-31. PMID:15688418. |
furthermore, apoptosis induction by nab is greatly reduced in the absence of p53. |
2005-05-31 |
2023-08-12 |
human |
| Arkadiusz Orchel, Zofia Dzierzewicz, Beata Parfiniewicz, Ludmiła Weglarz, Tadeusz Wilczo. Butyrate-induced differentiation of colon cancer cells is PKC and JNK dependent. Digestive diseases and sciences. vol 50. issue 3. 2005-05-04. PMID:15810631. |
higher doses of nab (5 and 10 mm) induced apoptosis of the cells and failed to stimulate the colonocyte differentiation. |
2005-05-04 |
2023-08-12 |
human |
| Hong Duan, Caroline A Heckman, Linda M Boxe. Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Molecular and cellular biology. vol 25. issue 5. 2005-03-28. PMID:15713621. |
in this study, we examined the effects of two structurally different hdac inhibitors, trichostatin a (tsa) and sodium butyrate (nab), on the cell cycle, apoptosis, and bcl-2 expression in t(14;18) lymphoma cells. |
2005-03-28 |
2023-08-12 |
human |
| Hong Duan, Caroline A Heckman, Linda M Boxe. Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Molecular and cellular biology. vol 25. issue 5. 2005-03-28. PMID:15713621. |
we found that in addition to potent cell cycle arrest, tsa and nab also dramatically induced apoptosis and down-regulated bcl-2 expression, and overexpression of bcl-2 inhibited tsa-induced apoptosis. |
2005-03-28 |
2023-08-12 |
human |
| Debdutta Bandyopadhyay, Anupam Mishra, Estela E Medran. Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway. Cancer research. vol 64. issue 21. 2004-11-30. PMID:15520174. |
here, we show that sodium butyrate (nab), a histone deacetylase (hdac) inhibitor, induced apoptosis in human melanoma cells in a dose- and time-dependent manner. |
2004-11-30 |
2023-08-12 |
human |
| V Chopin, C Slomianny, H Hondermarck, X Le Bourhi. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1). Experimental cell research. vol 298. issue 2. 2004-10-04. PMID:15265702. |
we have previously demonstrated that an inhibitor of hdac, sodium butyrate (nab), induces apoptosis of breast cancer cells in a p53-independent and p21(waf1)-dependent manner. |
2004-10-04 |
2023-08-12 |
Not clear |
| V Chopin, C Slomianny, H Hondermarck, X Le Bourhi. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1). Experimental cell research. vol 298. issue 2. 2004-10-04. PMID:15265702. |
in mcf-7 cells, nab increased the expression of death receptors; nab alone or in combination with tnf-alpha, trail, and anti-fas agonist antibody increased the levels of bid, tbid, and that of cytosolic cytochrome c. synergistic induction of apoptosis was strongly inhibited by dominant-negative fas-associated death domain (fadd) and inhibitors of caspases-8 and -9, indicating that potentiation of apoptosis involved key elements of death receptors' signaling pathways. |
2004-10-04 |
2023-08-12 |
Not clear |
| Leonard Augenlicht, Li Shi, John Mariadason, Christian Laboisse, Anna Velcic. Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation. Oncogene. vol 22. issue 32. 2003-09-16. PMID:12902981. |
sodium butyrate (nab) inhibits proliferation, stimulates apoptosis, and promotes differentiation of human colon cancer cells along the absorptive phenotype. |
2003-09-16 |
2023-08-12 |
human |
| Dino D Klisovic, Steven E Katz, David Effron, Marko I Klisovic, Joseph Wickham, Mark R Parthun, Martin Guimond, Guido Marcucc. Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines. Investigative ophthalmology & visual science. vol 44. issue 6. 2003-06-12. PMID:12766035. |
therefore, the ability of the histone deacetylase inhibitors (hdacis), depsipeptide, sodium butyrate (nab) and trichostatin a (tsa), to induce apoptosis and inhibit cell growth of um cell lines in vitro was examined. |
2003-06-12 |
2023-08-12 |
human |
| M Suzuki, F Shinohara, K Sato, T Taniguchi, H Takada, H Rikiish. Interleukin-1beta converting enzyme subfamily inhibitors prevent induction of CD86 molecules by butyrate through a CREB-dependent mechanism in HL60 cells. Immunology. vol 108. issue 3. 2003-05-09. PMID:12603604. |
we examined the inhibitory effects of various caspase inhibitors on the expression of cd86 in cells treated with nab, because nab also induced apoptosis with slow kinetics. |
2003-05-09 |
2023-08-12 |
Not clear |
| E U Kurz, S E Wilson, K B Leader, B P Sampey, W P Allan, J C Yalowich, D J Krol. The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines. Molecular cancer therapeutics. vol 1. issue 2. 2003-01-27. PMID:12467229. |
at concentrations with minimal effects on cell cycle kinetics (0.4 mm in hl-60; 0.5 mm in k562), nab pretreatment also modestly enhanced etoposidetriggered apoptosis in hl-60 cells, as determined morphologically after acridine orange/ethidium bromide staining, and substantially increased k562 growth inhibition and poly(adp-ribose)polymerase cleavage after etoposide exposure. |
2003-01-27 |
2023-08-12 |
human |
| Zofia Dzierzewicz, Arkadiusz Orchel, Ludmila Weglarz, Małgorzata Latocha, Tadeusz Wilczo. Changes in the cellular behaviour of human colonic cell line Caco-2 in response to butyrate treatment. Acta biochimica Polonica. vol 49. issue 1. 2003-01-22. PMID:12136943. |
they appeared to undergo a change in the phenotype induced by nab, as indicated by reduced proliferation, enhanced differentiation, stimulation of apoptosis leading to decreased viability of cells, and stimulation of interleukin-8 secretion. |
2003-01-22 |
2023-08-12 |
human |
| Cinzia Pellizzaro, Danila Coradini, Maria Grazia Daidon. Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29. Carcinogenesis. vol 23. issue 5. 2002-06-21. PMID:12016145. |
sodium butyrate (nab), a short-chain fatty acid naturally present in the human colon, is able to induce cell cycle arrest, differentiation and apoptosis in colon cancer cells. |
2002-06-21 |
2023-08-12 |
human |
| C Domon-Dell, Q Wang, S Kim, M Kedinger, B M Evers, J-N Freun. Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells. Gut. vol 50. issue 4. 2002-04-23. PMID:11889074. |
the transcription factor encoded by the intestinal cdx2 homeobox gene and treatment with sodium butyrate (nab), a byproduct of fibre fermentation by colonic bacteria, exert similar effects on colon cancer cell lines as they both inhibit cell growth and stimulate cell differentiation and apoptosis. |
2002-04-23 |
2023-08-12 |
Not clear |
| Mitsuhiro Suenaga, Hiroshi Soda, Mikio Oka, Akihiko Yamaguchi, Katsumi Nakatomi, Ken Shiozawa, Shigeru Kawabata, Takashi Kasai, Yasuaki Yamada, Shimeru Kamihira, Chuwa Tei, Shigeru Kohn. Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. International journal of cancer. vol 97. issue 5. 2002-02-08. PMID:11807787. |
these effects of tsa and nab were unlikely to be consequences of cell cycle arrest, apoptosis, or cell differentiation. |
2002-02-08 |
2023-08-12 |
Not clear |
| X X Cao, I Mohuiddin, F Ece, D J McConkey, W R Smyth. Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma. American journal of respiratory cell and molecular biology. vol 25. issue 5. 2002-01-09. PMID:11713097. |
mesothelioma cell lines (ren, i-45) were exposed to nab, and viability (colorimetric assay) and apoptosis (tunel, hoescht staining, flow cytometry) were evaluated. |
2002-01-09 |
2023-08-12 |
Not clear |
| X X Cao, I Mohuiddin, F Ece, D J McConkey, W R Smyth. Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma. American journal of respiratory cell and molecular biology. vol 25. issue 5. 2002-01-09. PMID:11713097. |
cells were sensitive to nab at low ic(50) (ren, 0.3 mm; i-45, 1 mm) and demonstrated apoptosis (percentage of cells below g1 phase by flow cytometry [sub-g1]: ren, 38.5%; i-45, 30.9%). |
2002-01-09 |
2023-08-12 |
Not clear |
| F Gautier, D Lassort, M T Le Cabellec, F Videau, L Minet, K Meflah, G Pradal, J Har. Production and characterisation of a monoclonal antibody specific for apoptotic bodies derived from several tumour cell lines. Journal of immunological methods. vol 228. issue 1-2. 1999-12-28. PMID:10556542. |
the 6e8 mab recognized apobodies derived from several rat or human colon cancer cell lines and a rat glioma cell line, regardless of the apoptosis stimulus used (nab, staurosporine or uv). |
1999-12-28 |
2023-08-12 |
human |
| J S Zhang, M Nelson, L Wang, W Liu, C P Qian, V Shridhar, R Urrutia, D I Smit. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. Genomics. vol 54. issue 1. 1999-01-07. PMID:9806841. |
sodium butyrate (nab) was shown to induce growth inhibition and apoptosis in a human pancreatic cancer cell line (aspc-1). |
1999-01-07 |
2023-08-12 |
human |